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1. 发明授权

US5876731A Tandem synthetic HIV-1 Peptides 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5876731A
公开(公告)日：1999-03-02
申请号：US462507
申请日：1995-06-05
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K39/12 , C07K5/00 , C07K7/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，特别是p24E直接与HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列连接并含有序列GPGR，和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

2. 发明授权

US5800822A Tandem synthetic HIV-1 peptides 失效
公开(公告)号：US5800822A
公开(公告)日：1998-09-01
申请号：US465217
申请日：1995-06-05
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , C07K5/00 , C07K7/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.

3. 发明授权

US5795955A Tandem synthetic HIV-1 peptides 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5795955A
公开(公告)日：1998-08-18
申请号：US463966
申请日：1995-06-05
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K38/00 , A61K39/12 , C07K5/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，其直接连接到HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列，并含有序列 GPGR和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

4. 发明授权

US5639854A Tandem synthetic HIV-1 peptides 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5639854A
公开(公告)日：1997-06-17
申请号：US257528
申请日：1994-06-09
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K38/00 , A61K39/12 , C07K5/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，特别是p24E直接与HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列连接并含有序列GPGR，和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

5. 发明授权

US07105164B1 HIV-specific cytotoxic T-cell responses 失效
标题翻译： HIV特异性细胞毒性T细胞应答
公开(公告)号：US07105164B1
公开(公告)日：2006-09-12
申请号：US09647981
申请日：1999-04-07
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： A61K39/21
CPC分类号： A61K39/21 , A61K38/162 , A61K39/12 , A61K39/39 , A61K2039/55516 , C07K14/005 , C12N2730/10122 , C12N2740/16034 , C12N2740/16322 , C12N2740/16334
摘要： A method of generating an HIV-specific cytotoxic T-cell response in a host involves an initial administration of a T-helper molecule to the host to prime T-helper cells of the immune system of the host and a subsequent administration to the host of a mixture of the T-helper molecule and a T-cell inducing HIV-derived molecule to generate an HIV-specific T-cell response in the host.
摘要翻译：在宿主中产生HIV-特异性细胞毒性T细胞应答的方法包括向宿主初始施用T-辅助分子以引发宿主免疫系统的T辅助细胞，并随后向宿主施用 T辅助分子和诱导HIV衍生分子的T细胞的混合物在宿主中产生HIV特异性T细胞应答。

6. 发明授权

US5951986A Tandem synthetic HIV-1 peptides 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5951986A
公开(公告)日：1999-09-14
申请号：US467881
申请日：1995-06-06
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K38/00 , A61K39/12 , C07K5/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，特别是p24E直接与HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列连接并含有序列GPGR，和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

7. 发明授权

US5759769A Tandem synthetic HIV-1 peptides 失效
公开(公告)号：US5759769A
公开(公告)日：1998-06-02
申请号：US460602
申请日：1995-06-02
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , C12Q1/70 , G01N33/567
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.

8. 发明授权

US5817754A Tandem synthetic HIV-1 peptide 失效
标题翻译：串联合成HIV-1肽
公开(公告)号：US5817754A
公开(公告)日：1998-10-06
申请号：US464329
申请日：1995-06-05
申请人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
发明人： Charles D. Y. Sia , Pele Chong , Michel H. Klein
IPC分类号： G01N33/53 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C07K16/10 , C12N15/09 , C12N15/48 , G01N33/569 , A61K38/00 , C07K5/00 , C07K17/00
CPC分类号： C07K14/005 , G01N33/56988 , A61K39/00 , C07K2319/00 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16222 , Y10S977/802 , Y10S977/917 , Y10S977/92
摘要： Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directly to an amino acid sequence of a B-cell epitope of the V3 loop protein of an HIV-1 isolate and containing the sequence GPGR, and/or the gp41 containing the sequence ELKDWA. Multimeric forms of the tandem synthetic peptides are provided.
摘要翻译：提供了新的合成肽，其是针对HIV-1的候选疫苗，并且其可用于诊断应用。肽包含HIV-1的gag蛋白的T细胞表位的氨基酸序列，特别是p24E直接与HIV-1分离物的V3环蛋白的B细胞表位的氨基酸序列连接并含有序列GPGR，和/或包含序列ELKDWA的gp41。提供了串联合成肽的多聚体形式。

9. 发明授权

US07118749B2 Transferrin receptor genes 失效
公开(公告)号：US07118749B2
公开(公告)日：2006-10-10
申请号：US10043344
申请日：2002-01-14
申请人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
发明人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
IPC分类号： A61K51/00 , A61K39/395 , A61K39/00 , A61K39/02 , A61K39/38
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C12N2799/021
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.

10. 发明授权

US06471996B1 Biodegradable targetable microparticle delivery system 失效
标题翻译：可生物降解的可靶向微粒输送系统
公开(公告)号：US06471996B1
公开(公告)日：2002-10-29
申请号：US09499532
申请日：2000-02-11
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： A61K914
CPC分类号： A61K9/1647 , A61K9/167 , A61K2039/55555 , C08G63/6852 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of &agr;-hydroxy acid subunits such as D,L-lactide and &agr;-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and &agr;-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.
摘要翻译：描述了设计用作颗粒载体的共聚物，其含有用于与靶配体偶联的可官能化氨基酸亚单位。共聚物是由α-羟基酸亚基如D，L-丙交酯和α-氨基酸亚基如丝氨酸组成的聚酯，或在优选的实施方案中，D，L-丙交酯和乙交酯和α-氨基酸亚基的三元共聚物如丝氨酸描述了可用作延迟释放制剂的稳定的疫苗制剂，其含有包封在聚合物微粒内或物理混合的聚合物微粒中的抗原或抗原和辅助佐剂。颗粒载体可用于通过粘膜或肠胃外途径将药物递送至受试者的免疫系统，以产生包括抗体反应的免疫应答。

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