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1. 发明授权

US06287604B1 Biodegradable targetable microparticle delivery system 失效
公开(公告)号：US06287604B1
公开(公告)日：2001-09-11
申请号：US09502674
申请日：2000-02-11
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： A61K914
CPC分类号： A61K9/1647 , A61K9/167 , A61K2039/55555 , C08G63/6852 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of &agr;-hydroxy acid subunits such as D,L-lactide and &agr;-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and &agr;-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.

2. 发明授权

US08088388B2 Stabilized synthetic immunogen delivery system 有权
标题翻译：稳定的合成免疫原递送系统
公开(公告)号：US08088388B2
公开(公告)日：2012-01-03
申请号：US10076674
申请日：2002-02-14
申请人： Kenneth K. Sokoll
发明人： Kenneth K. Sokoll
IPC分类号： A61K38/00 , A61K47/00 , A61K45/00 , A61K31/70 , A61K39/00 , A61K39/38 , A61K9/50 , A61K38/16 , A01N43/04 , A01N37/18
CPC分类号： A61K39/0006 , A61K39/39 , A61K2039/55561 , A61K2039/55566 , A61K2039/622
摘要： The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide immunogen. The immunostimulatory complex is particulate and can efficiently present peptide immunogens to the cells of the immune system to produce an immune response. The immunostimulatory complex may be formulated as a suspension for parenteral administration. The immunostimulatory complex may also be formulated in the form of w/o-emulsions or in-situ gelling polymers for the efficient delivery of immunogens to the cells of the immune system of a subject following parenteral administration, to produce an immune response.
摘要翻译：本发明提供特异性适于作为佐剂和作为肽免疫原稳定剂的免疫刺激复合物。免疫刺激复合物包含CpG寡核苷酸和生物活性肽免疫原。免疫刺激复合物是微粒的并且可以有效地向免疫系统的细胞呈递肽免疫原以产生免疫应答。免疫刺激复合物可以配制成肠胃外给药的悬液。免疫刺激复合物还可以以w / o-乳剂或原位胶凝聚合物的形式配制，以在肠胃外给药后有效地将免疫原递送给受试者的免疫系统的细胞，以产生免疫应答。

3. 发明授权

US06623764B1 Biodegradable targetable microparticle delivery system 失效
标题翻译：可生物降解的可靶向微粒输送系统
公开(公告)号：US06623764B1
公开(公告)日：2003-09-23
申请号：US09331118
申请日：1999-08-31
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： A61K916
CPC分类号： A61K9/1647 , A61K9/167 , A61K2039/55555 , C08G63/6852 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligands are described. The copolymers are polyesters composed of &agr;-hydroxy acid subunits such as D,L-lactide and pseudo-&agr;-amino acid subunits which may be derived from serine or terpolymers of D,L-lactide and glycolide and pseudo-&agr;-amino acid subunits which may be derived from serine. Stable vaccine preparations useful as delayed release formulations containing antigen or antigens and adjuvants encapsulated within or physically mixed with polymeric mircoparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody and protective responses.
摘要翻译：描述了设计用作颗粒载体的共聚物，其含有用于与靶配体偶联的可官能化氨基酸亚单位。共聚物是由α-羟基酸亚基如D，L-丙交酯和拟α-氨基酸亚基组成的聚酯，其可衍生自D，L-丙交酯和乙交酯的丝氨酸或三元共聚物和假α-氨基酸亚基其可以来自丝氨酸。描述了可用作包含抗微生物或抗原的延迟释放制剂的稳定的疫苗制剂，以及包封在聚合物微粒体内或与其混合的佐剂。颗粒载体可用于通过粘膜或肠胃外途径将药剂递送至受试者的免疫系统，以产生免疫应答，包括抗体和保护性反应。

4. 发明授权

US6042820A Biodegradable copolymer containing .alpha.-hydroxy acid and .alpha.-amino acid units 失效
标题翻译：含有α-羟基酸和α-氨基酸单元的生物可降解共聚物
公开(公告)号：US6042820A
公开(公告)日：2000-03-28
申请号：US770850
申请日：1996-12-20
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： A61K9/48 , A61K9/00 , A61K9/16 , A61K9/50 , A61K39/39 , A61K47/34 , C08G63/685 , C08G63/688 , C08G63/78 , C08G75/26 , C08J3/14 , C08J5/18 , C08K5/00 , C08L101/16 , A61K31/765 , C08G63/08
CPC分类号： A61K9/1647 , A61K9/167 , C08G63/6852 , A61K2039/55555 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of .alpha.-hydroxy acid subunits such as D, L-lactide and .alpha.-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and .alpha.-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with ploymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.
摘要翻译：描述了设计用作颗粒载体的共聚物，其含有用于与靶配体偶联的可官能化氨基亚基。共聚物是由α-羟基酸亚基如D，L-丙交酯和α-氨基酸亚基如丝氨酸组成的聚酯，或在优选的实施方案中，D，L-丙交酯和乙交酯和α-氨基酸亚基的三元共聚物如丝氨酸描述了用作延迟释放制剂的稳定的疫苗制剂，其含有包封在聚合微粒内或与聚丙烯微粒物理混合的抗原或抗原和辅助佐剂。颗粒载体可用于通过粘膜或肠胃外途径将药物递送至受试者的免疫系统，以产生包括抗体反应的免疫应答。

5. 发明授权

US08084015B2 Stabilized synthetic immunogen delivery system 有权
标题翻译：稳定的合成免疫原递送系统
公开(公告)号：US08084015B2
公开(公告)日：2011-12-27
申请号：US10355161
申请日：2003-05-21
申请人： Kenneth K. Sokoll
发明人： Kenneth K. Sokoll
IPC分类号： A61K51/00 , A61K39/00 , A61K39/02 , A61K36/14 , A61K31/70 , A01N43/04
CPC分类号： A61K39/0006 , A61K39/39 , A61K2039/55561 , A61K2039/55566 , A61K2039/622
摘要： The present invention provides an immunostimulatory complex specifically adapted to act as adjuvant and as a peptide immunogen stabilizer. The immunostimulatory complex comprises a CpG oligonucleotide and a biologically active peptide immunogen. The immunostimulatory complex is particulate and can efficiently present peptide immunogens to the cells of the immune system to produce an immune response. The immunostimulatory complex may be formulated as a suspension for parenteral administration. The immunostimulatory complex may also be formulated in the form of w/o-emulsions, as a suspension in combination with a mineral salt suspension or with an in-situ gelling polymer for the efficient delivery of an immunogen to the cells of the immune system of a subject following parenteral administration, to produce an immune response which may also be a protective immune response.
摘要翻译：本发明提供特异性适于作为佐剂和作为肽免疫原稳定剂的免疫刺激复合物。免疫刺激复合物包含CpG寡核苷酸和生物活性肽免疫原。免疫刺激复合物是微粒的并且可以有效地向免疫系统的细胞呈递肽免疫原以产生免疫应答。免疫刺激复合物可以配制成肠胃外给药的悬液。免疫刺激复合物还可以以w / o-乳液的形式配制，作为与矿物质盐悬浮液或原位胶凝聚合物组合的悬浮液，用于将免疫原有效递送至免疫系统的细胞在肠胃外给药后的受试者，以产生也可以是保护性免疫应答的免疫应答。

6. 发明授权

US06471996B1 Biodegradable targetable microparticle delivery system 失效
标题翻译：可生物降解的可靶向微粒输送系统
公开(公告)号：US06471996B1
公开(公告)日：2002-10-29
申请号：US09499532
申请日：2000-02-11
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： A61K914
CPC分类号： A61K9/1647 , A61K9/167 , A61K2039/55555 , C08G63/6852 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of &agr;-hydroxy acid subunits such as D,L-lactide and &agr;-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and &agr;-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.
摘要翻译：描述了设计用作颗粒载体的共聚物，其含有用于与靶配体偶联的可官能化氨基酸亚单位。共聚物是由α-羟基酸亚基如D，L-丙交酯和α-氨基酸亚基如丝氨酸组成的聚酯，或在优选的实施方案中，D，L-丙交酯和乙交酯和α-氨基酸亚基的三元共聚物如丝氨酸描述了可用作延迟释放制剂的稳定的疫苗制剂，其含有包封在聚合物微粒内或物理混合的聚合物微粒中的抗原或抗原和辅助佐剂。颗粒载体可用于通过粘膜或肠胃外途径将药物递送至受试者的免疫系统，以产生包括抗体反应的免疫应答。

7. 发明授权

US06312732B1 Biodegradable targetable microparticle delivery system 失效
公开(公告)号：US06312732B1
公开(公告)日：2001-11-06
申请号：US09499533
申请日：2000-02-11
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： A61K916
CPC分类号： A61K9/1647 , A61K9/167 , A61K2039/55555 , C08G63/6852 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of &agr;-hydroxy acid subunits such as D,L-lactide and &agr;-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and &agr;-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.

8. 发明授权

US06228423B1 Biodegradable targetable microparticle delivery system 有权
标题翻译：可生物降解的可靶向微粒输送系统
公开(公告)号：US06228423B1
公开(公告)日：2001-05-08
申请号：US09501373
申请日：2000-02-11
申请人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
发明人： Kenneth K. Sokoll , Pele Chong , Michel H. Klein
IPC分类号： B01J1302
CPC分类号： A61K9/1647 , A61K9/167 , A61K2039/55555 , C08G63/6852 , Y10S514/952 , Y10S530/815 , Y10S530/816 , Y10T428/2982
摘要： Copolymers designed for use as particulate carriers containing functionalizable amino acid subunits for coupling with targeting ligand are described. The copolymers are polyesters composed of &agr;-hydroxy acid subunits such as D,L-lactide and &agr;-amino acid subunits such as serine or in the preferred embodiment, terpolymers of D,L-lactide and glycolide and &agr;-amino acid subunits such as serine. Stable vaccine preparations useful as delayed release formulations containing antigen(s) or antigen(s) and co-adjuvants encapsulated within or physically mixed with polymeric microparticles are described. The particulate carriers are useful for delivering agents to the immune system of a subject by mucosal or parenteral routes to produce immune responses, including antibody responses.
摘要翻译：描述了设计用作颗粒载体的共聚物，其含有用于与靶配体偶联的可官能化氨基酸亚单位。共聚物是由α-羟基酸亚基如D，L-丙交酯和α-氨基酸亚基如丝氨酸组成的聚酯，或在优选的实施方案中，D，L-丙交酯和乙交酯和α-氨基酸亚基的三元共聚物如丝氨酸描述了可用作延迟释放制剂的稳定的疫苗制剂，其含有包封在聚合物微粒内或物理混合的聚合物微粒中的抗原或抗原和辅助佐剂。颗粒载体可用于通过粘膜或肠胃外途径将药物递送至受试者的免疫系统，以产生包括抗体反应的免疫应答。

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