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11. 发明申请

US20090076560A1 Biventricular Heart Stimulator and Method of Controlling a Biventricular Heart Stimulator 有权
标题翻译：双心室心脏刺激器和控制双心室心脏刺激器的方法
公开(公告)号：US20090076560A1
公开(公告)日：2009-03-19
申请号：US11885326
申请日：2005-03-02
申请人： Anders Bjorling , Nils Holmstrom
发明人： Anders Bjorling , Nils Holmstrom
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： In a biventricular heart stimulator and a method for controlling such a biventricular heart stimulator, successive stimulation pulses are delivered to the ventricles of a heart such that stimulation pulses in a single heartbeat cycle are respectively first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventative measures are taken for preventing loss of capture in the other ventricle.
摘要翻译：在双心室心脏刺激器和用于控制这种双心室心脏刺激器的方法中，连续的刺激脉冲被递送到心脏的心室，使得单个心跳周期中的刺激脉冲分别首先被传送到第一脑室，然后被传送到第二脑室。检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。由于检测到的捕获损失，采取预防措施来防止在另一脑室中的捕获损失。

12. 发明授权

US09162066B2 Method and system for stimulating a heart 有权
标题翻译：刺激心脏的方法和系统
公开(公告)号：US09162066B2
公开(公告)日：2015-10-20
申请号：US13508968
申请日：2011-05-31
申请人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
发明人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： A first ventricle is stimulated at a stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node is computed. A similar process is used to compute a second activation time interval for the other ventricle. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined.
摘要翻译：在刺激部位刺激第一脑室，估计从刺激产生的至少一个去极化波到达AV节点的时间点，并且基本对应于至少一个去极化所需的时间间隔的第一激活时间间隔计算从第一脑室的刺激部位到AV节点的波。使用类似的过程来计算另一个心室的第二激活时间间隔。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗。

13. 发明授权

US09138583B2 Method and system for determining pacing settings 有权
标题翻译：确定起搏设置的方法和系统
公开(公告)号：US09138583B2
公开(公告)日：2015-09-22
申请号：US13596585
申请日：2012-08-28
申请人： Nils Holmstrom , Andreas Karlsson
发明人： Nils Holmstrom , Andreas Karlsson
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/368
CPC分类号： A61N1/36585 , A61N1/365 , A61N1/36514 , A61N1/3682 , A61N1/3704
摘要： Systems and methods for optimizing the stimulation of a heart of a patient are disclosed herein. The method comprises delivering pacing therapy to the patient according to a pacing therapy setting schedule, using specific pacing intervals via specific electrode configurations. Further, sinus rate values are recorded over at least one cardiac cycle at each pacing therapy setting and it is determined whether a sinus rate value satisfies predetermined measurement conditions, wherein sinus rate values are used for trending the sinus rate over time if the measurement conditions are satisfied. The accepted sinus rate values, i.e. values that satisfy the measurement conditions, are trended over time, wherein each trended sinus rate value is created based on recordings from at least one cardiac cycle. A preferred pacing therapy setting is determined to be the pacing therapy setting that provides a lowest sinus rate.
摘要翻译：本文公开了用于优化患者心脏刺激的系统和方法。该方法包括根据起搏治疗设置时间表，通过特定电极配置使用特定的起搏间隔向患者输送起搏治疗。此外，在每个起搏治疗设置中，在至少一个心动周期上记录窦速率值，并且确定窦速率值是否满足预定的测量条件，其中如果测量条件是窦性速率值，则使用窦速率值来随着时间推移窦速率满意。接受的窦速率值，即满足测量条件的值随时间趋势，其中每个趋势窦速率值是基于至少一个心动周期的记录创建的。优选的起搏治疗设置被确定为提供最低窦速率的起搏治疗设置。

14. 发明申请

US20090030470A1 IMPLANTABLE HEART STIMULATION DEVICE WITH REMEDIAL RESPONSE TO ANODAL CAPTURE 审中-公开
标题翻译：具有针对阳极捕获的补救措施的可植入心脏刺激装置
公开(公告)号：US20090030470A1
公开(公告)日：2009-01-29
申请号：US12160849
申请日：2006-01-26
申请人： Nils Holmstrom , Anders Bjorling
发明人： Nils Holmstrom , Anders Bjorling
IPC分类号： A61N1/368
CPC分类号： A61N1/371 , A61N1/3684
摘要： An implantable heart stimulating device has a left ventricular coronary sinus electrode lead provided with a tip electrode, a right ventricular electrode lead provided with a ring electrode, and a pulse generator connected to the leads that applies stimulation pulses between the tip electrode and the ring electrode, with the tip electrode serving as the anode. A monitoring unit monitors for and detects anodal capture at the right ventricular ring electrode subsequent to a stimulation. If anodal capture is detected, either a threshold search is performed by varying the pulse width and/or pulse amplitude of stimulation pulses in order to identify stimulation pulse characteristics that avoid anodal capture at the ring electrode, or at least one further electrode is activated to function as an indifferent electrode together with the ring electrode, also in order to avoid anodal capture at the ring electrode.
摘要翻译：可植入心脏刺激装置具有设置有尖端电极的左心室冠状窦电极引线，设置有环形电极的右心室电极引线和连接到引线的脉冲发生器，其在尖端电极和环形电极之间施加刺激脉冲，尖端电极用作阳极。监测单元在刺激之后监测和检测右心室环电极处的阳极捕获。如果检测到阳极捕获，则通过改变刺激脉冲的脉冲宽度和/或脉冲幅度来执行阈值搜索，以便识别避免在环形电极处的阳极捕获的刺激脉冲特性，或者至少一个另外的电极被激活与环形电极一起作为无关电极，也是为了避免在环形电极处的阳极捕获。

15. 发明申请

US20080281373A1 Implantable Heart Stimulator and Method for Operation Thereof 有权
标题翻译：可植入心脏刺激仪及其操作方法
公开(公告)号：US20080281373A1
公开(公告)日：2008-11-13
申请号：US11793478
申请日：2004-12-17
申请人： Anders Bjorling , Nils Holmstrom
发明人： Anders Bjorling , Nils Holmstrom
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61N1/3712
摘要： In an implantable heart stimulator and a method for operation thereof, stimulation pulses are delivered to a heart. The amplitude of the delivered stimulation pulses can be selectively set. For setting the amplitude, threshold searches are performed at selected time intervals. Each threshold search determines a threshold value required for achieving capture. The amplitudes of the respective stimulation pulses are set to a value that exceeds the determined threshold value by a safety margin. The safety margin is selected as a function of the selected time intervals.
摘要翻译：在可植入心脏刺激器及其操作方法中，将刺激脉冲输送到心脏。输送的刺激脉冲的幅度可以选择性地设定。为了设置幅度，以选定的时间间隔执行阈值搜索。每个阈值搜索确定实现捕获所需的阈值。相应的刺激脉冲的振幅被设置为超过所确定的阈值的安全裕度的值。根据所选择的时间间隔选择安全裕度。

16. 发明授权

US5728281A Implantable medical device including an arrangement for measuring a blood property having a carbon reference electrode 失效
标题翻译：可植入医疗装置，包括用于测量具有碳参考电极的血液性质的装置
公开(公告)号：US5728281A
公开(公告)日：1998-03-17
申请号：US748543
申请日：1996-11-13
申请人： Nils Holmstrom , Pia Hagel , Kenth Nilsson
发明人： Nils Holmstrom , Pia Hagel , Kenth Nilsson
IPC分类号： A61B5/0408 , A61N1/05 , A61N1/365 , A61N1/375 , G01N27/26
CPC分类号： A61N1/375 , A61N1/05 , A61N1/36557
摘要： An implantable medical device for in vivo electrochemical measurements of blood properties, such as measurements of, inter alia, oxygen pressure, glucose and pH, avoids the problem with the reference electrodes currently in use which cause inflammatory reactions of tissue, by forming the reference electrode of carbon, preferably activated pyrolytic carbon.
摘要翻译：用于血液性质的体内电化学测量的植入式医疗装置，例如氧压，葡萄糖和pH的测量，避免了当前使用的参考电极的问题，其通过形成参比电极而引起组织的炎性反应的碳，优选活性热解碳。

17. 发明申请

US20130289641A1 METHOD AND SYSTEM FOR OPTIMIZING CARDIAC PACING SETTINGS 审中-公开
标题翻译：优化心脏瓣膜设置的方法和系统
公开(公告)号：US20130289641A1
公开(公告)日：2013-10-31
申请号：US13997620
申请日：2010-12-23
申请人： John Gustafsson , Andreas Karlsson , Andreas Blomqvist , Hedberg Sven-Erik , Nils Holmstrom
发明人： John Gustafsson , Andreas Karlsson , Andreas Blomqvist , Hedberg Sven-Erik , Nils Holmstrom
IPC分类号： A61N1/365
CPC分类号： A61N1/36571 , A61B5/02028 , A61B5/0215 , A61B5/028 , A61B5/029 , A61B5/0472 , A61B5/0538 , A61B5/1116 , A61B5/686 , A61B8/06 , A61B2562/0219 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3682
摘要： The present invention relates generally to methods and systems for optimizing stimulation of a heart of a patient. Hemodynamical index signals reflecting a mechanical functioning of a heart of a patient are recorded at different hemodynamical states. Corresponding hemodynamical reference signals at corresponding hemodynamical states are recorded. At least one hemodynamical index parameter is extracted from the recorded hemodynamical index signals. The at least one hemodynamical index parameter is a measure of the mechanical functioning of the heart and a hemodynamical index model is created, wherein the hemodynamical index model is based on the at least one hemodynamical index parameter and a comparison between output results from the hemodynamical index model and corresponding hemodynamical reference signals. From this hemodynamical index model, a hemodynamical index can be derived, which then can be used in determining patient customized cardiac pacing settings of the cardiac stimulator.
摘要翻译：本发明一般涉及优化患者心脏的刺激的方法和系统。在不同的血液动力学状态下记录反映患者心脏的机械功能的血液动力学指标信号。记录相应血液动力学状态下的相应血液动力学参考信号。从记录的血液动力学指标信号中提取至少一个血液动力学指标参数。所述至少一个血液动力学指数参数是心脏的机械功能的度量，并且创建血液动力学指标模型，其中所述血液动力学指标模型基于所述至少一个血液动力学指数参数和来自所述血液动力学指标的输出结果之间的比较模型和相应的血液动力学参考信号。从该血液动力学指标模型可以得出血流动力学指标，然后可以用于确定心脏刺激器患者定制的心脏起搏设置。

18. 发明申请

US20120239102A1 IMPLANTABLE MEDICAL DEVICE FOR CARDIAC THERAPY 有权
标题翻译：用于心脏治疗的可植入医疗器械
公开(公告)号：US20120239102A1
公开(公告)日：2012-09-20
申请号：US13510873
申请日：2009-12-08
申请人： Nils Holmstrom , John Gustafsson , Michael Broome
发明人： Nils Holmstrom , John Gustafsson , Michael Broome
IPC分类号： A61N1/365 , A61N1/05 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N2001/0585
摘要： An implantable medical device, IMD, (100) is connectable to at least one ventricular lead (210) having a ventricular basal electrode (214) and a ventricular apical electrode (212). The IMD (100) comprises a pulse generator (120) for generating pacing pulses applied to a heart (10) through the ventricular lead (210). The operation of this pulse generator (120) is controlled by a controller (130) that is configured to control the pulse generator to first deliver a pacing pulse to the ventricular basal electrode (214) to stimulate the basal portion of the ventricle (12, 14) before a pacing pulse is delivered to the apical portion of the ventricle (12, 14) by the ventricular apical electrode (212). This pulse sequence achieves a biologically more correct cardiac stimulation and a contraction pattern that reduces the risk for valvular regurgitation.
摘要翻译：植入式医疗装置IMD（100）可连接到至少一个具有心室基底电极（214）和心室顶端电极（212）的心室引线（210）。 IMD（100）包括用于产生通过心室引线（210）施加到心脏（10）的起搏脉冲的脉冲发生器（120）。该脉冲发生器（120）的操作由控制器（130）控制，控制器（130）被配置为控制脉冲发生器首先将起搏脉冲递送至心室基底电极（214）以刺激心室的基部（12， 14）在通过心室顶端电极（212）将起搏脉冲输送到心室（12,14）的顶端部分之前。该脉冲序列实现了生物学更正确的心脏刺激和减少瓣膜反流风险的收缩模式。

19. 发明申请

US20090118666A1 Method and implantable device for measuring hematocrit 审中-公开
标题翻译：用于测量血细胞比容的方法和可植入装置
公开(公告)号：US20090118666A1
公开(公告)日：2009-05-07
申请号：US11363922
申请日：2006-02-28
申请人： Andreas Blomqvist , Malin Ohlander , Nils Holmstrom
发明人： Andreas Blomqvist , Malin Ohlander , Nils Holmstrom
IPC分类号： A61B5/145 , A61B5/02 , A61M37/00
CPC分类号： A61B5/053 , A61B5/14535 , A61N1/36521
摘要： In a method for detecting a change of a condition of a patient using an implantable medical device being connectable to the patient in at least one electrode configuration, at least one impedance measurement session is initiated to obtain at least one impedance value corresponding to an impedance of whole blood of the patient. At least one relative or absolute value of an amount of hematocrit in the blood of the patient is calculated using the at least one impedance value. A present hematocrit level is determined dependent on the at least one hematocrit value, with a change of the condition being derived from the present hematocrit level of the patient.
摘要翻译：在用至少一个电极配置中使用可连接到患者的可植入医疗装置来检测患者病情变化的方法中，开始至少一个阻抗测量会话以获得至少一个阻抗值对应于患者的全血。使用至少一个阻抗值来计算患者血液中血细胞比容量的至少一个相对值或绝对值。取决于至少一个血细胞比容值确定目前的血细胞比容水平，条件的变化来自患者的当前血细胞比容水平。

20. 发明申请

US20080243025A1 Medical Device 审中-公开
标题翻译：医疗装置
公开(公告)号：US20080243025A1
公开(公告)日：2008-10-02
申请号：US11793849
申请日：2004-12-23
申请人： Nils Holmstrom , Malin Ohlander , Sven Kalling
发明人： Nils Holmstrom , Malin Ohlander , Sven Kalling
IPC分类号： A61B5/053
CPC分类号： A61B5/0535 , A61B5/0809 , A61N1/3627 , A61N1/3702
摘要： In a medical device and a method for operating the medical device, it is first determined whether a patient, at whom a medical measurement is to be made, satisfied specified criteria that will ensure comparability of the measurement results obtained from the patient. Only when the specified criteria had been satisfied is an electrical bio-impedance signal obtained from the patient. The cardiac component of the electrical bio-impedance signal is extracted, and is analyzed to identify a change in a medical condition of the patient.
摘要翻译：在用于医疗装置的医疗装置和方法中，首先确定是否要进行医疗测量的患者满足将确保从患者获得的测量结果的可比性的指定标准。只有当满足指定的标准是从患者获得的电生物阻抗信号。提取电生物阻抗信号的心脏分量，并进行分析以识别患者的医疗状态的变化。

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