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1. 发明申请

US20120239102A1 IMPLANTABLE MEDICAL DEVICE FOR CARDIAC THERAPY 有权
标题翻译：用于心脏治疗的可植入医疗器械
公开(公告)号：US20120239102A1
公开(公告)日：2012-09-20
申请号：US13510873
申请日：2009-12-08
申请人： Nils Holmstrom , John Gustafsson , Michael Broome
发明人： Nils Holmstrom , John Gustafsson , Michael Broome
IPC分类号： A61N1/365 , A61N1/05 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N2001/0585
摘要： An implantable medical device, IMD, (100) is connectable to at least one ventricular lead (210) having a ventricular basal electrode (214) and a ventricular apical electrode (212). The IMD (100) comprises a pulse generator (120) for generating pacing pulses applied to a heart (10) through the ventricular lead (210). The operation of this pulse generator (120) is controlled by a controller (130) that is configured to control the pulse generator to first deliver a pacing pulse to the ventricular basal electrode (214) to stimulate the basal portion of the ventricle (12, 14) before a pacing pulse is delivered to the apical portion of the ventricle (12, 14) by the ventricular apical electrode (212). This pulse sequence achieves a biologically more correct cardiac stimulation and a contraction pattern that reduces the risk for valvular regurgitation.
摘要翻译：植入式医疗装置IMD（100）可连接到至少一个具有心室基底电极（214）和心室顶端电极（212）的心室引线（210）。 IMD（100）包括用于产生通过心室引线（210）施加到心脏（10）的起搏脉冲的脉冲发生器（120）。该脉冲发生器（120）的操作由控制器（130）控制，控制器（130）被配置为控制脉冲发生器首先将起搏脉冲递送至心室基底电极（214）以刺激心室的基部（12， 14）在通过心室顶端电极（212）将起搏脉冲输送到心室（12,14）的顶端部分之前。该脉冲序列实现了生物学更正确的心脏刺激和减少瓣膜反流风险的收缩模式。

2. 发明授权

US08781579B2 Implantable medical device for cardiac therapy 有权
标题翻译：用于心脏治疗的可植入医疗器械
公开(公告)号：US08781579B2
公开(公告)日：2014-07-15
申请号：US13510873
申请日：2009-12-08
申请人： Nils Holmstrom , John Gustafsson , Michael Broome
发明人： Nils Holmstrom , John Gustafsson , Michael Broome
IPC分类号： A61N1/368 , A61N1/362 , A61N1/05
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N2001/0585
摘要： An implantable medical device, IMD, (100) is connectable to at least one ventricular lead (210) having a ventricular basal electrode (214) and a ventricular apical electrode (212). The IMD (100) comprises a pulse generator (120) for generating pacing pulses applied to a heart (10) through the ventricular lead (210). The operation of this pulse generator (120) is controlled by a controller (130) that is configured to control the pulse generator to first deliver a pacing pulse to the ventricular basal electrode (214) to stimulate the basal portion of the ventricle (12, 14) before a pacing pulse is delivered to the apical portion of the ventricle (12, 14) by the ventricular apical electrode (212). This pulse sequence achieves a biologically more correct cardiac stimulation and a contraction pattern that reduces the risk for valvular regurgitation.
摘要翻译：植入式医疗装置IMD（100）可连接到至少一个具有心室基底电极（214）和心室顶端电极（212）的心室引线（210）。 IMD（100）包括用于产生通过心室引线（210）施加到心脏（10）的起搏脉冲的脉冲发生器（120）。该脉冲发生器（120）的操作由控制器（130）控制，控制器（130）被配置为控制脉冲发生器首先将起搏脉冲递送至心室基底电极（214）以刺激心室的基部（12， 14）在通过心室顶端电极（212）将起搏脉冲输送到心室（12,14）的顶端部分之前。该脉冲序列实现了生物学更正确的心脏刺激和减少瓣膜反流风险的收缩模式。

3. 发明申请

US20130190582A1 ISCHEMIC REGION DETECTION 审中-公开
标题翻译：分离区域检测
公开(公告)号：US20130190582A1
公开(公告)日：2013-07-25
申请号：US13358063
申请日：2012-01-25
申请人： Nils Holmstrom , Michael Broome
发明人： Nils Holmstrom , Michael Broome
IPC分类号： A61B5/145 , A61B5/02
CPC分类号： A61B5/14503 , A61B5/1118 , A61B5/1455 , A61B5/1459 , A61B5/686
摘要： An ischemia detecting system has an implantable medical device connectable to an LV cardiac catheter with sensors for generating sensor signals representative of the concentration of a constituent in coronary venous blood at different sites in the coronary venous system. The sensor signals are co-processed by the system to detect an ischemic region of the subject's heart based on a relation between the sensor signals. The detection of the particular ischemic cardiac region is possible by conducting the concentration monitoring on either sides of a branching vein in the coronary venous system and co-processing the sensor signals.
摘要翻译：缺血检测系统具有可连接到具有传感器的LV心导管的可植入医疗装置，所述传感器用于产生代表冠状静脉系统不同部位冠状静脉血中成分浓度的传感器信号。传感器信号由系统共同处理，以基于传感器信号之间的关系检测受试者心脏的缺血区域。通过在冠状静脉系统中的分支静脉的两侧进行浓度监测并共同处理传感器信号，可以检测特定的缺血性心脏区域。

4. 发明申请

US20110257696A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR MONITORING SYNCHRONICITY OF THE VENTRICLES OF A HEART 审中-公开
标题翻译：用于监测心脏通气道的同步性的可植入医疗装置和方法
公开(公告)号：US20110257696A1
公开(公告)日：2011-10-20
申请号：US13140119
申请日：2008-12-17
申请人： Nils Holmstrom , Karin Ljungstrom , Michael Broome , Cecilia Emanuelsson
发明人： Nils Holmstrom , Karin Ljungstrom , Michael Broome , Cecilia Emanuelsson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61B5/0538 , A61B5/0816 , A61B5/11 , A61B5/7239 , A61B5/7289 , A61N1/36521 , A61N1/36578 , A61N1/3684 , A61N1/3686
摘要： In an implantable medical device and a method for monitoring ventricular synchronicity of a heart, impedance signals are measured that reflect septal wall movements and impedance amplitude peaks in the impedance signal are detected. A synchronicity index indicating a degree of synchronicity is determined based on detected impedance peaks, with at least two impedance peaks detected within a predetermined time window including a cardiac cycle or a part of a cardiac cycle indicating an increased dyssynchronicity in the ventricular contractions.
摘要翻译：在可植入医疗装置和用于监测心脏心室同步性的方法中，测量阻抗信号，其反映了隔膜壁运动，并且检测阻抗信号中的阻抗幅度峰值。基于检测到的阻抗峰值确定表示同步度的同步性指标，其中在包括心动周期的预定时间窗口或心跳周期的一部分中检测到至少两个阻抗峰值，指示心室收缩中的不同步性增加。

5. 发明申请

US20130110187A1 ISCHEMIA DETECTION 有权
标题翻译： ISCHEMIA检测
公开(公告)号：US20130110187A1
公开(公告)日：2013-05-02
申请号：US13653276
申请日：2012-10-16
申请人： Nils Holmstrom , Michael Broome
发明人： Nils Holmstrom , Michael Broome
IPC分类号： A61B5/1459 , A61N1/365
CPC分类号： A61B5/14542 , A61B5/1459 , A61B5/1473 , A61N1/36557 , A61N1/3702
摘要： An implantable medical device comprises a connector connectable to an implantable oxygen sensor configured to generate a sensor signal representative of oxygen concentration in coronary sinus blood in a subject's heart. An ischemia detector is connected to the connector and configured to detect an ischemic event in the heart if the sensor signal indicates a temporary decrease in oxygen concentration in the coronary sinus blood below a normal level followed by a temporary increase in oxygen concentration in the coronary sinus blood above the normal level.
摘要翻译：可植入医疗装置包括可连接到可植入氧传感器的连接器，其被配置为产生代表受试者心脏中冠状窦血液中氧浓度的传感器信号。如果传感器信号表示冠状窦血液中的氧浓度暂时降低到正常水平以下，然后临时增加冠状窦中的氧浓度，则缺血检测器连接到连接器并被配置为检测心脏中的缺血事件血液高于正常水平。

6. 发明授权

US08761883B2 Physiologically adapted cardiac resynchronization therapy 有权
标题翻译：生理适应性心脏再同步治疗
公开(公告)号：US08761883B2
公开(公告)日：2014-06-24
申请号：US13578553
申请日：2011-08-31
申请人： Tomas Svensson , Andreas Blomqvist , Andreas Karlsson , Michael Broome
发明人： Tomas Svensson , Andreas Blomqvist , Andreas Karlsson , Michael Broome
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/36507 , A61N1/36585 , A61N1/3684 , A61N1/3702 , A61N1/371
摘要： An implantable medical device is connectable to an epicardial left ventricular lead having at least one epicardial electrode and a myocardium penetrating catheter with at least one endocardial electrode and present in a lumen of the lead. The device comprises a pulse generator controller that controls a ventricular pulse generator to generate pulses to be applied to the epicardial and endocardial electrodes. The controller uses an endocardial-to-epicardial time interval or epicardial-to-endocardial time interval to coordinate endocardial and epicardial activation of the left ventricle to thereby achieve cardiac pacing that closely mimics the natural electrical activation pattern of a healthy heart.
摘要翻译：可植入医疗装置可连接到具有至少一个心外膜电极的心外膜左心室引线和具有至少一个心内膜电极并存在于引流管腔中的心肌穿透导管。该装置包括脉冲发生器控制器，其控制心室脉冲发生器以产生要施加到心外膜和心内膜电极的脉冲。控制器使用心内膜至心外膜时间间隔或心外膜至心内膜时间间隔来协调左心室的心内膜和心外膜激活，从而实现紧密模拟健康心脏的天然电活化模式的心脏起搏。

7. 发明申请

US20130053917A1 PHYSIOLOGICALLY ADAPTED CARDIAC RESYNCHRONIZATION THERAPY 有权
标题翻译：生理适应心脏康复治疗
公开(公告)号：US20130053917A1
公开(公告)日：2013-02-28
申请号：US13578553
申请日：2011-08-31
申请人： Tomas Svensso , Andreas Blomqvist , Andreas Karlsson , Michael Broome
发明人： Tomas Svensso , Andreas Blomqvist , Andreas Karlsson , Michael Broome
IPC分类号： A61N1/37
CPC分类号： A61N1/368 , A61N1/36507 , A61N1/36585 , A61N1/3684 , A61N1/3702 , A61N1/371
摘要： An implantable medical device is connectable to an epicardial left ventricular lead having at least one epicardial electrode and a myocardium penetrating catheter with at least one endocardial electrode and present in a lumen of the lead. The device comprises a pulse generator controller that controls a ventricular pulse generator to generate pulses to be applied to the epicardial and endocardial electrodes. The controller uses an endocardial-to-epicardial time interval or epicardial-to-endocardial time interval to coordinate endocardial and epicardial activation of the left ventricle to thereby achieve cardiac pacing that closely mimics the natural electrical activation pattern of a healthy heart.
摘要翻译：可植入医疗装置可连接到具有至少一个心外膜电极的心外膜左心室引线和具有至少一个心内膜电极并存在于引流管腔中的心肌穿透导管。该装置包括脉冲发生器控制器，其控制心室脉冲发生器以产生要施加到心外膜和心内膜电极的脉冲。控制器使用心内膜至心外膜时间间隔或心外膜至心内膜时间间隔来协调左心室的心内膜和心外膜激活，从而实现紧密模拟健康心脏的天然电活化模式的心脏起搏。

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