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11. 发明授权

US08019109B2 Microphone boom with adjustable wind noise suppression 有权
标题翻译：麦克风扬声器，可调节风噪声抑制
公开(公告)号：US08019109B2
公开(公告)日：2011-09-13
申请号：US12116921
申请日：2008-05-07
申请人： Lawrence Gollbach , Timothy Johnston
发明人： Lawrence Gollbach , Timothy Johnston
IPC分类号： H04R9/08 , H04R11/04 , H04R17/02 , H04R19/04 , H04R21/02
CPC分类号： H04R1/086 , H04R2410/07
摘要： A microphone boom cap includes a porous plastic portion adapted to cover a microphone boom first aperture. The microphone boom cap includes a non-porous plastic portion affixed to the porous plastic portion. The non-porous plastic portion is adapted to cover a microphone boom second aperture in a second use position, where the porous plastic portion covers the second aperture in a first use position.
摘要翻译：麦克风吊杆盖包括适于覆盖麦克风吊杆第一孔的多孔塑料部分。麦克风臂盖包括固定到多孔塑料部分的无孔塑料部分。无孔塑料部分适于在第二使用位置覆盖麦克风臂第二孔，其中多孔塑料部分在第一使用位置覆盖第二孔。

12. 发明申请

US20050271560A1 Gas control in a reactor 审中-公开
标题翻译：反应堆中的气体控制
公开(公告)号：US20050271560A1
公开(公告)日：2005-12-08
申请号：US11147415
申请日：2005-06-07
申请人： Seth Rodgers , A. Russo , Timothy Johnston , Sean LeBlanc
发明人： Seth Rodgers , A. Russo , Timothy Johnston , Sean LeBlanc
IPC分类号： B01J19/00 , B01L3/00 , C12M20060101
CPC分类号： B01J19/0093 , B01J2219/00837 , B01J2219/00862 , B01J2219/00869 , B01J2219/00907 , B01J2219/00952 , B01J2219/00963 , B01J2219/0097 , B01L3/5025 , B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2200/0668 , B01L2200/0684 , B01L2300/0816 , B01L2300/0825 , B01L2300/0877 , B01L2300/0887 , B01L2300/10 , B01L2400/0457 , B01L2400/0688 , B01L2400/086
摘要： Chemical, biological, and/or biochemical reaction systems, including chips or reactors, may be configured so as to restrain immiscible materials such as gas bubbles from interfering with the determination of environmental factors associated with the chip according to one aspect of the invention. In another aspect, a chip or other reaction system may be configured to maintain a gas headspace in the chip or other reaction system. In certain embodiments, impediments such as physical barriers may be used to contain gas bubbles within a gas containing region, or otherwise away from a detection region. In other embodiments, surface tension properties may be used to control the location of gas bubbles. The chip or other reaction systems may include reaction site containers that can be very small, for example, having a volume of less than about 2 ml. In certain embodiments, chips or other reaction systems of the invention include one or more reaction sites, which, in some cases, may be defined by reaction site containers. According to another aspect of the invention, a reaction site container may be shaped to limit the formation of gas bubbles during the filling of the reaction site container with liquid by providing reaction site container shapes that do not include sharp angles or abrupt changes in reaction site container width.
摘要翻译：包括芯片或反应器的化学，生物和/或生物化学反应系统可以被配置为根据本发明的一个方面来抑制诸如气泡的不混溶材料干扰与芯片相关的环境因素的确定。在另一方面，芯片或其它反应系统可以被配置为在芯片或其他反应系统中保持气体顶部空间。在某些实施方案中，阻挡物例如物理屏障可以用于在含气体区域内或以其他方式远离检测区域容纳气泡。在其它实施例中，可以使用表面张力特性来控制气泡的位置。芯片或其他反应系统可以包括可以非常小的反应位点容器，例如具有小于约2ml的体积。在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点，其在一些情况下可由反应位点容器限定。根据本发明的另一方面，反应部位容器可以成形为通过提供不包括尖锐角度的反应部位容器形状或反应部位的突然变化来限制在用液体填充反应部位容器期间产生气泡的形成容器宽度。

13. 发明授权

US08008065B2 Disposable bioreactor vessel port 有权
标题翻译：一次性生物反应器血管口
公开(公告)号：US08008065B2
公开(公告)日：2011-08-30
申请号：US11728560
申请日：2007-03-26
申请人： Mark Selker , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/34 , C12M1/26 , G01N1/10
CPC分类号： C12M23/00
摘要： A port for use with a bioreactor vessel comprising: i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vessel ii) a hollow, generally tubular bushing member for containing electrical, optical, microfluidic and/or chemical monitoring components which bushing member fits inside the bore of the tubular portion of the base member, both the base member and bushing member providing access to the contents of a bioreactor by; iii) a monitoring assembly inserted into the bushing member which assembly comprises means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals resulting from the interaction of incoming optical and/or electrical signals with the contents of a bioreactor; and iv) a cover which maintains the position and alignment of components ii) and iii) relative to the base member.
摘要翻译：一种用于生物反应器容器的端口，包括：i）基部构件，其包括中空管状部分和底板，所述基座构造成密封地固定到生物反应器容器的壁的孔中ii）中空的大体管状衬套构件，电气，光学，微流体和/或化学监测部件，衬套构件配合在基部构件的管状部分的孔内，基部构件和衬套构件都提供通过生物反应器的内容物的通路; iii）监测组件，其插入到衬套构件中，该组件包括用于提供输入光学和/或电信号的装置，以及用于收集和传送由输入光学和/或电信号与生物反应器的内容物相互作用而产生的测量信号的装置; 以及iv）保持组件ii）和iii）相对于基座构件的位置和对准的盖。

14. 发明授权

US07824902B2 Optical interface for disposable bioreactors 有权
标题翻译：一次性生物反应器的光学接口
公开(公告)号：US07824902B2
公开(公告)日：2010-11-02
申请号：US11725255
申请日：2007-03-17
申请人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/34
CPC分类号： C12M23/14 , C12M29/00 , C12M41/26 , C12M41/32 , C12M41/34
摘要： A port assembly for use with a polymeric bioreactor bag includes the following components: i) a hollow port member made from a material which can be fusibly affixed to the wall surface of the bioreactor bag; ii) at least one fluorophore spot positioned on the port member; iii) a conduit for conveying excitation light from an optical source to the fluorophore, which conduit can be a lens, a curved parabolic collimator, a shaped reflector or a wave guide; and iv) a second conduit for conveying fluorescent emission light from the excited fluorophore to a photo-detector, which second conduit although different from the first, can likewise be a lens, a curved parabolic collimator, a shaped reflector or a wave guide.
摘要翻译：与聚合物生物反应器袋一起使用的端口组件包括以下部件：i）由材料制成的中空端口部件，该材料可以柔软地固定在生物反应器袋的壁表面上; ii）位于端口构件上的至少一个荧光团斑点; iii）用于将激发光从光源传输到荧光团的导管，该导管可以是透镜，弯曲抛物线准直器，成形反射器或波导管; 以及iv）用于将来自激发的荧光团的荧光发射光传送到光检测器的第二导管，该第二导管虽然不同于第一导管，但也可以是透镜，弯曲的抛物线准直器，成形反射器或波导。

15. 发明授权

US07489402B2 Optical collection geometries for phase fluorimetry 有权
标题翻译：用于相位荧光测定的光学收集几何
公开(公告)号：US07489402B2
公开(公告)日：2009-02-10
申请号：US11724818
申请日：2007-03-16
申请人： Mark Selker , Benjamin Blizard , Timothy Johnston
发明人： Mark Selker , Benjamin Blizard , Timothy Johnston
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N2021/6441
摘要： An apparatus and method for the stimulation and collection of fluorescent signals from a target analyte. The apparatus comprises: i) a frequency modulated optical source which emits excitation light of a wavelength which will stimulate a target fluorophore to emit a fluorescent signal when illuminated by the excitation light, ii) a first optical filter interposed between the optical source and the target fluorophore, iii) a second optical filter interposed between the fluorophore and a photo-detector and positioned to receive the emitted fluorescent signal. The beam path of at least one, preferably both, of the excitation light and the fluorescent signal is transmitted substantially through free space. A data processor will normally be used to calculate and record the phase delay between the excitation light and the fluorescent signal.
摘要翻译：用于刺激和收集来自目标分析物的荧光信号的装置和方法。该装置包括：i）调频光源，其发射波长的激发光，该激发光将在被激发光照射时刺激目标荧光团发出荧光信号，ii）插入在光源和靶之间的第一光学滤波器荧光团，iii）插入在所述荧光团和光检测器之间并定位成接收所发射的荧光信号的第二光学滤光器。激发光和荧光信号的至少一个，优选两个的光束路径基本上透过自由空间传播。通常将使用数据处理器来计算和记录激发光和荧光信号之间的相位延迟。

16. 发明申请

US20080032389A1 Disposable bioreactor vessel port 有权
标题翻译：一次性生物反应器血管口
公开(公告)号：US20080032389A1
公开(公告)日：2008-02-07
申请号：US11728560
申请日：2007-03-26
申请人： Mark Selker , Barbara Paldus , Timothy Johnston
发明人： Mark Selker , Barbara Paldus , Timothy Johnston
IPC分类号： C12M1/00
CPC分类号： C12M23/00
摘要： A port for use with a bioreactor vessel comprising: i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vessel ii) a hollow, generally tubular bushing member for containing electrical, optical, microfluidic and/or chemical monitoring components which bushing member fits inside the bore of the tubular portion of the base member, both the base member and bushing member providing access to the contents of a bioreactor by; iii) a monitoring assembly inserted into the bushing member which assembly comprises means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals resulting from the interaction of incoming optical and/or electrical signals with the contents of a bioreactor; and iv) a cover which maintains the position and alignment of components ii) and iii) relative to the base member.
摘要翻译：一种用于生物反应器容器的端口，包括：i）基部构件，其包括中空管状部分和底板，所述基座构造成密封地固定到生物反应器容器的壁的孔中ii）中空的大体管状衬套构件，电气，光学，微流体和/或化学监测部件，衬套构件配合在基部构件的管状部分的孔内，基部构件和衬套构件都提供通过生物反应器的内容物的通路; iii）监测组件，其插入到衬套构件中，该组件包括用于提供输入光学和/或电信号的装置，以及用于收集和传送由输入光学和/或电信号与生物反应器的内容物相互作用而产生的测量信号的装置; 以及iv）保持组件ii）和iii）相对于基座构件的位置和对准的盖。

17. 发明授权

US5173908A System for automatically adjusting the GVD of a Gires-Tournois interferometer 失效
标题翻译：用于自动调整Gires-Tournois干涉仪GVD的系统
公开(公告)号：US5173908A
公开(公告)日：1992-12-22
申请号：US772481
申请日：1991-10-07
申请人： Daniel K. Negus , Timothy Johnston
发明人： Daniel K. Negus , Timothy Johnston
IPC分类号： H01S3/098 , H01S3/106
CPC分类号： H01S3/1112 , H01S3/1062 , H01S3/105
摘要： A system is described for automatically maintaining the group velocity dispersion (GVD) of a Gires-Tournois interferometer (GTI) as the wavelength of incident light is varied. In the system, the transmission through the GTI is monitored by a photodiode as the wavelength is varied. The transmission through the GTI provides a measure of its GVD. Thus, the output of the photodiode can be used as a control signal for adjusting the GTI in a manner to maintain its GVD at the desired level. The subject system is illustrated in conjunction with a pulsed, tunable, Ti:sapphire laser which is passively mode locked with the optical Kerr effect. The system allows the wavelength of the laser to be tuned over the bandwidth of the gain medium while maintaining a selected level of GVD from the GTI which in turn maintains the desired duration of the pulses. In addition, the GTI is used to compensate for the dispersion effects created by broad band optics in the resonator.
摘要翻译：描述了当入射光的波长变化时自动维持Gires-Tournois干涉仪（GTI）的群速度色散（GVD）的系统。在系统中，当波长变化时，通过光电二极管监测通过GTI的透射。通过GTI的传输提供了其GVD的测量。因此，光电二极管的输出可以用作控制信号，以便以将其GVD保持在期望水平的方式来调节GTI。本系统结合脉冲式可调谐的Ti：蓝宝石激光器进行了说明，该激光器被动地锁定光学克尔效应。该系统允许激光器的波长在增益介质的带宽上进行调谐，同时保持来自GTI的选定电平的GVD，这继而保持脉冲的期望持续时间。此外，GTI用于补偿由谐振器中的宽带光学器件产生的色散效应。

18. 发明授权

US5163059A Mode-locked laser using non-linear self-focusing element 失效
标题翻译：使用非线性自聚焦元件的锁模激光器
公开(公告)号：US5163059A
公开(公告)日：1992-11-10
申请号：US697898
申请日：1991-05-09
申请人： Daniel K. Negus , Luis A. Spinelli , Timothy Johnston
发明人： Daniel K. Negus , Luis A. Spinelli , Timothy Johnston
IPC分类号： H01S3/098 , H01S3/16
CPC分类号： H01S3/1112 , H01S3/0805 , H01S2301/085 , H01S3/0014 , H01S3/08 , H01S3/0811 , H01S3/0816 , H01S3/106 , H01S3/1625
摘要： A passively mode-locked laser (110) is disclosed that includes a resonant cavity (112, 114) having a gain medium (116) therein. A transmissive element (116), which may be the gain medium, is also located in the cavity and is formed from a material which varies the two-dimensional, lateral spatial profile of the beam with respect to intensity due to the Kerr effect. The resonator is arranged such that the round trip gain of the system increases with respect to the intensity of the beam so that mode-locking operation can be achieved. In one approach, the variation in the spatial profile is used to increase the extraction of energy from the gain medium. In another approach, the variation in spatial profile which occurs with an increase in intensity is used to decrease the loss in the system so that pulse operation is favored. In an illustrated embodiment, wherein the gain medium (116) is formed from titanium-sapphire, the self-phase modulation of the crystal is also used to compress the pulses into the femtosecond range. In addition, a prism set (136, 138) can be used to balance the group velocity dispersion and self-phase modulation of the gain crystal to achieve stable, soliton-like operation. In the preferred embodiment, mode-locking behavior is initiating by rotating a transmissive optical element (230, 232) located in the cavity in a manner to vary the path length of the beam.
摘要翻译：公开了一种被动模式锁定激光器（110），其包括其中具有增益介质（116）的谐振腔（112,114）。可以是增益介质的透射元件（116）也位于空腔中并且由材料形成，该材料由于克尔效应而相对于强度改变梁的二维横向空间分布。谐振器布置成使得系统的往返增益相对于光束的强度增加，使得可以实现模式锁定操作。在一种方法中，空间分布的变化用于增加从增益介质中提取能量。在另一种方法中，随着强度的增加而发生的空间分布的变化被用于减少系统中的损耗，使脉冲操作受到青睐。在所示的实施例中，其中增益介质（116）由钛 - 蓝宝石形成，晶体的自相位调制也用于将脉冲压缩到飞秒范围内。此外，可以使用棱镜组（136,138）来平衡增益晶体的组速度色散和自相位调制，以实现稳定的孤子状操作。在优选实施例中，通过以改变梁的路径长度的方式旋转位于空腔中的透射光学元件（230,232）来启动锁模行为。

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