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1. 发明申请

US20080171383A1 Optical interface for disposable bioreactors 有权
标题翻译：一次性生物反应器的光学接口
公开(公告)号：US20080171383A1
公开(公告)日：2008-07-17
申请号：US11725255
申请日：2007-03-17
申请人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/34
CPC分类号： C12M23/14 , C12M29/00 , C12M41/26 , C12M41/32 , C12M41/34
摘要： A port assembly for use with a polymeric bioreactor bag said assembly comprising: i) a hollow port member comprised at least in part of a material suitable to be fusibly affixed to the wall surface of said bioreactor bag; ii) at least one fluorophore spot positioned on said port member; iii) conduit means for conveying excitation light from an optical source to said fluorophore, said conduit means being an assembly comprising at least one of a lens, an optic fiber, a curved parabolic collimator, a shaped reflector or a wave guide; iv) conduit means for conveying fluorescent emission light from said fluorophore to a photo-detector, said conduit means being an assembly comprising at least one of a lens, an optic fiber, a curved parabolic collimator, a shaped reflector or a wave guide.
摘要翻译：一种与聚合物生物反应器袋一起使用的端口组件，所述组件包括：i）中空端口构件，其至少部分地包括适于被柔性地固定到所述生物反应器袋的壁表面的材料; ii）位于所述端口构件上的至少一个荧光团斑点; iii）用于将来自光源的激发光传送到所述荧光团的导管装置，所述导管装置是包括透镜，光纤，弯曲抛物线准直器，成形反射器或波导中的至少一个的组件; iv）用于将来自所述荧光团的荧光发射光传送到光检测器的导管装置，所述导管装置是包括透镜，光纤，弯曲抛物线准直仪，成形反射器或波导中的至少一个的组件。

2. 发明申请

US20080170224A1 Optical collection geometries for phase fluorimetry 有权
标题翻译：用于相位荧光测定的光学收集几何
公开(公告)号：US20080170224A1
公开(公告)日：2008-07-17
申请号：US11724818
申请日：2007-03-16
申请人： Mark Selker , Benjamin Blizard , Timothy Johnston
发明人： Mark Selker , Benjamin Blizard , Timothy Johnston
IPC分类号： G01J3/30
CPC分类号： G01N21/6428 , G01N2021/6441
摘要： Apparatus and method for the stimulation and collection of fluorescent signals, said apparatus comprising: i) a frequency modulated optical source which emits excitation light of a wavelength which will stimulate a target fluorophore to emit a fluorescent signal when illuminated by said excitation light: ii) a first optical filter interposed between said optical source and said target fluorophore, iii) a second optical filter interposed between said fluorophore and a photo-detector positioned to receive said emitted fluorescent signal, and iv) a data processor which calculates and records the phase delay between said excitation light and said fluorescent signal wherein the beam path of at least one of the excitation light and the fluorescent signal is transmitted substantially through free space.
摘要翻译：用于刺激和收集荧光信号的装置和方法，所述装置包括：i）调频光源，其发射波长的激发光，其将在被所述激发光照射时刺激目标荧光团发射荧光信号：ii）插入在所述光源和所述目标荧光团之间的第一滤光器，iii）置于所述荧光团和位于接收所述发射的荧光信号的光检测器之间的第二滤光器，以及iv）数据处理器，其计算并记录相位延迟在所述激发光和所述荧光信号之间，其中激发光和荧光信号中的至少一个的光束路径基本上透过自由空间传播。

3. 发明授权

US07824902B2 Optical interface for disposable bioreactors 有权
标题翻译：一次性生物反应器的光学接口
公开(公告)号：US07824902B2
公开(公告)日：2010-11-02
申请号：US11725255
申请日：2007-03-17
申请人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Benjamin Blizard , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/34
CPC分类号： C12M23/14 , C12M29/00 , C12M41/26 , C12M41/32 , C12M41/34
摘要： A port assembly for use with a polymeric bioreactor bag includes the following components: i) a hollow port member made from a material which can be fusibly affixed to the wall surface of the bioreactor bag; ii) at least one fluorophore spot positioned on the port member; iii) a conduit for conveying excitation light from an optical source to the fluorophore, which conduit can be a lens, a curved parabolic collimator, a shaped reflector or a wave guide; and iv) a second conduit for conveying fluorescent emission light from the excited fluorophore to a photo-detector, which second conduit although different from the first, can likewise be a lens, a curved parabolic collimator, a shaped reflector or a wave guide.
摘要翻译：与聚合物生物反应器袋一起使用的端口组件包括以下部件：i）由材料制成的中空端口部件，该材料可以柔软地固定在生物反应器袋的壁表面上; ii）位于端口构件上的至少一个荧光团斑点; iii）用于将激发光从光源传输到荧光团的导管，该导管可以是透镜，弯曲抛物线准直器，成形反射器或波导管; 以及iv）用于将来自激发的荧光团的荧光发射光传送到光检测器的第二导管，该第二导管虽然不同于第一导管，但也可以是透镜，弯曲的抛物线准直器，成形反射器或波导。

4. 发明授权

US07489402B2 Optical collection geometries for phase fluorimetry 有权
标题翻译：用于相位荧光测定的光学收集几何
公开(公告)号：US07489402B2
公开(公告)日：2009-02-10
申请号：US11724818
申请日：2007-03-16
申请人： Mark Selker , Benjamin Blizard , Timothy Johnston
发明人： Mark Selker , Benjamin Blizard , Timothy Johnston
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01N2021/6441
摘要： An apparatus and method for the stimulation and collection of fluorescent signals from a target analyte. The apparatus comprises: i) a frequency modulated optical source which emits excitation light of a wavelength which will stimulate a target fluorophore to emit a fluorescent signal when illuminated by the excitation light, ii) a first optical filter interposed between the optical source and the target fluorophore, iii) a second optical filter interposed between the fluorophore and a photo-detector and positioned to receive the emitted fluorescent signal. The beam path of at least one, preferably both, of the excitation light and the fluorescent signal is transmitted substantially through free space. A data processor will normally be used to calculate and record the phase delay between the excitation light and the fluorescent signal.
摘要翻译：用于刺激和收集来自目标分析物的荧光信号的装置和方法。该装置包括：i）调频光源，其发射波长的激发光，该激发光将在被激发光照射时刺激目标荧光团发出荧光信号，ii）插入在光源和靶之间的第一光学滤波器荧光团，iii）插入在所述荧光团和光检测器之间并定位成接收所发射的荧光信号的第二光学滤光器。激发光和荧光信号的至少一个，优选两个的光束路径基本上透过自由空间传播。通常将使用数据处理器来计算和记录激发光和荧光信号之间的相位延迟。

5. 发明授权

US09267100B2 Composite sensor assemblies for single use bioreactors 有权
标题翻译：用于单次生物反应器的复合传感器组件
公开(公告)号：US09267100B2
公开(公告)日：2016-02-23
申请号：US13385100
申请日：2012-02-02
申请人： Mark Selker , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/00 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/85
CPC分类号： C12M27/14 , C12M23/00 , C12M29/00 , C12M29/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/8507
摘要： A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
摘要翻译：一种用于监测适用于聚合物生物过程容器或与下游设备的生物过程的复合传感器组件，包括：i）包含具有中空管状部分和底板部分的高表面张力热塑性塑料的端口，板部分在其壁的孔处易于密封到生物反应器容器; ii）包括电和/或光学测量部件的通常不透明的聚合物监测传感器组件。传感器组件装配在端口的中空管状部分的孔内，并且粘合地保持在其中。

6. 发明授权

US08008065B2 Disposable bioreactor vessel port 有权
标题翻译：一次性生物反应器血管口
公开(公告)号：US08008065B2
公开(公告)日：2011-08-30
申请号：US11728560
申请日：2007-03-26
申请人： Mark Selker , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/34 , C12M1/26 , G01N1/10
CPC分类号： C12M23/00
摘要： A port for use with a bioreactor vessel comprising: i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vessel ii) a hollow, generally tubular bushing member for containing electrical, optical, microfluidic and/or chemical monitoring components which bushing member fits inside the bore of the tubular portion of the base member, both the base member and bushing member providing access to the contents of a bioreactor by; iii) a monitoring assembly inserted into the bushing member which assembly comprises means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals resulting from the interaction of incoming optical and/or electrical signals with the contents of a bioreactor; and iv) a cover which maintains the position and alignment of components ii) and iii) relative to the base member.
摘要翻译：一种用于生物反应器容器的端口，包括：i）基部构件，其包括中空管状部分和底板，所述基座构造成密封地固定到生物反应器容器的壁的孔中ii）中空的大体管状衬套构件，电气，光学，微流体和/或化学监测部件，衬套构件配合在基部构件的管状部分的孔内，基部构件和衬套构件都提供通过生物反应器的内容物的通路; iii）监测组件，其插入到衬套构件中，该组件包括用于提供输入光学和/或电信号的装置，以及用于收集和传送由输入光学和/或电信号与生物反应器的内容物相互作用而产生的测量信号的装置; 以及iv）保持组件ii）和iii）相对于基座构件的位置和对准的盖。

7. 发明申请

US20080032389A1 Disposable bioreactor vessel port 有权
标题翻译：一次性生物反应器血管口
公开(公告)号：US20080032389A1
公开(公告)日：2008-02-07
申请号：US11728560
申请日：2007-03-26
申请人： Mark Selker , Barbara Paldus , Timothy Johnston
发明人： Mark Selker , Barbara Paldus , Timothy Johnston
IPC分类号： C12M1/00
CPC分类号： C12M23/00
摘要： A port for use with a bioreactor vessel comprising: i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vessel ii) a hollow, generally tubular bushing member for containing electrical, optical, microfluidic and/or chemical monitoring components which bushing member fits inside the bore of the tubular portion of the base member, both the base member and bushing member providing access to the contents of a bioreactor by; iii) a monitoring assembly inserted into the bushing member which assembly comprises means for providing incoming optical and/or electrical signals and means for collecting and transmitting measurement signals resulting from the interaction of incoming optical and/or electrical signals with the contents of a bioreactor; and iv) a cover which maintains the position and alignment of components ii) and iii) relative to the base member.
摘要翻译：一种用于生物反应器容器的端口，包括：i）基部构件，其包括中空管状部分和底板，所述基座构造成密封地固定到生物反应器容器的壁的孔中ii）中空的大体管状衬套构件，电气，光学，微流体和/或化学监测部件，衬套构件配合在基部构件的管状部分的孔内，基部构件和衬套构件都提供通过生物反应器的内容物的通路; iii）监测组件，其插入到衬套构件中，该组件包括用于提供输入光学和/或电信号的装置，以及用于收集和传送由输入光学和/或电信号与生物反应器的内容物相互作用而产生的测量信号的装置; 以及iv）保持组件ii）和iii）相对于基座构件的位置和对准的盖。

8. 发明申请

US20120244609A1 Composite sensor assemblies for single use bioreactors 有权
标题翻译：用于单次生物反应器的复合传感器组件
公开(公告)号：US20120244609A1
公开(公告)日：2012-09-27
申请号：US13385100
申请日：2012-02-02
申请人： Mark Selker , Barbara Paldus , Timothy Johnston
发明人： Mark Selker , Barbara Paldus , Timothy Johnston
IPC分类号： C12M1/34 , C12M1/02 , B32B38/00 , C12M1/08
CPC分类号： C12M27/14 , C12M23/00 , C12M29/00 , C12M29/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/8507
摘要： A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
摘要翻译：一种用于监测适用于聚合物生物过程容器或与下游设备的生物过程的复合传感器组件，包括：i）包含具有中空管状部分和底板部分的高表面张力热塑性塑料的端口，板部分在其壁的孔处易于密封到生物反应器容器; ii）包括电和/或光学测量部件的通常不透明的聚合物监测传感器组件。传感器组件装配在端口的中空管状部分的孔内，并且粘合地保持在其中。

9. 发明授权

US10227555B2 Composite sensor assemblies for single use bioreactors 有权
公开(公告)号：US10227555B2
公开(公告)日：2019-03-12
申请号：US13134157
申请日：2011-05-31
申请人： Mark Selker , Barbara Paldus , Timothy Johnston
发明人： Mark Selker , Barbara Paldus , Timothy Johnston
IPC分类号： C12M1/34 , C12M1/00 , C12M3/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/78 , G01N21/80 , G01N21/77
摘要： A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.

10. 发明申请

US20120244608A1 Composite sensor assemblies for single use bioreactors 审中-公开
标题翻译：用于单次生物反应器的复合传感器组件
公开(公告)号：US20120244608A1
公开(公告)日：2012-09-27
申请号：US13134157
申请日：2011-05-31
申请人： Mark Selker , Barbara Paldus , Timothy Johnston
发明人： Mark Selker , Barbara Paldus , Timothy Johnston
IPC分类号： C12M1/34 , B32B38/16 , C12M1/00
CPC分类号： C12M41/00 , C12M23/14 , C12M23/28 , C12M27/16 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/783 , G01N21/80 , G01N2021/7786
摘要： A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
摘要翻译：一种用于监测适用于聚合物生物过程容器或与下游设备的生物过程的复合传感器组件，包括：i）包含具有中空管状部分和底板部分的高表面张力热塑性塑料的端口，板在其壁的孔处易于密封到生物反应器容器; ii）包括电和/或光学测量部件的通常不透明的聚合物监测传感器组件。传感器组件装配在端口的中空管状部分的孔内，并且粘合地保持在其中。

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