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11. 发明授权

US4532211A Coliform bacillus having a gene for the production of staphylokinase and a process for production of staphylokinase therewith 失效
标题翻译：具有葡萄球菌激酶生产基因的大肠菌杆菌及其生产葡萄球菌激酶的方法
公开(公告)号：US4532211A
公开(公告)日：1985-07-30
申请号：US434503
申请日：1982-10-15
申请人： Tomoyuki Sako , Saeko Sawaki , Toshizo Sakurai , Masahiko Mutai , Isamu Kondo
发明人： Tomoyuki Sako , Saeko Sawaki , Toshizo Sakurai , Masahiko Mutai , Isamu Kondo
IPC分类号： C12N1/21 , C07K14/31 , C12N1/20 , C12N9/52 , C12N15/09 , C12R1/19 , C12R1/92 , C12P21/00 , C07H21/04 , C12N1/00 , C12N9/48 , C12N9/50 , C12N15/00 , C12P21/02 , C12P21/04
CPC分类号： C07K14/31
摘要： Novel coliform bacillus useful for industrial production of staphylokinase, a fibrinolytic enzyme, and process for the production of staphylokinase using said microbe are provided. The novel microbe comprises a recombinant DNA, carrying genetic information for the production of staphylokinase, said genetic information being DNA derived from a temperate phage DNA of Staphylococcus aureus.
摘要翻译：提供了可用于工业生产葡萄球菌激酶，纤维蛋白溶解酶的新型大肠杆菌，以及使用所述微生物生产葡萄球菌激酶的方法。该新型微生物包含重组DNA，携带用于产生葡萄球菌激酶的遗传信息，所述遗传信息是衍生自金黄色葡萄球菌的温带噬菌体DNA的DNA。

12. 发明授权

US4435389A Composition for promoting growth of bifidobacteria 失效
标题翻译：用于促进双歧杆菌生长的组合物
公开(公告)号：US4435389A
公开(公告)日：1984-03-06
申请号：US166463
申请日：1980-07-07
申请人： Masahiko Mutai , Tsuneo Terashima , Tokutaro Takahashi , Ryuichiro Tanaka , Akio Kuroda , Sadao Ueyama , Keisuke Matsumoto
发明人： Masahiko Mutai , Tsuneo Terashima , Tokutaro Takahashi , Ryuichiro Tanaka , Akio Kuroda , Sadao Ueyama , Keisuke Matsumoto
IPC分类号： A61K35/74 , A61K36/06 , C12N1/38 , C12P19/04 , C12P19/14 , A61K31/71
CPC分类号： C12P19/14 , A61K36/06 , C12N1/38 , C12P19/04
摘要： This invention relates to a composition for promoting growth of Bifidobacteria containing as effective constituent an oligosaccharide represented by the general formula Gal-(gal).sub.n -Glc, wherein Gal denotes a galactose residue, Glc a glucose residue and n an integer of 1 to 4.This invention further relates to a method for manufacture of the material for promoting growth of Bifidobacteria characterized in that lactose or a lactose-containing material is treated with .beta.-galactosidase produced by Aspergillus oryzae.
摘要翻译：本发明涉及一种用于促进双歧杆菌生长的组合物，其含有由通式Gal-（gal）n-Glc表示的寡糖作为有效成分，其中Gal表示半乳糖残基，Glc是葡萄糖残基，n为1至4的整数本发明还涉及一种用于促进双歧杆菌生长的材料的制造方法，其特征在于用米曲霉产生的β-半乳糖苷酶处理乳糖或含乳糖的材料。

13. 发明授权

US5306730A Botulinum toxin neutralizer 失效
标题翻译：肉毒毒素中和剂
公开(公告)号：US5306730A
公开(公告)日：1994-04-26
申请号：US887652
申请日：1992-05-26
申请人： Yoshitaka Nagai , Koutaro Takamizawa , Ryuichiro Tanaka , Hiroo Takayama , Toshizo Sakurai , Masahiko Mutai
发明人： Yoshitaka Nagai , Koutaro Takamizawa , Ryuichiro Tanaka , Hiroo Takayama , Toshizo Sakurai , Masahiko Mutai
IPC分类号： A61K31/20
CPC分类号： A61K31/20
摘要： A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.
摘要翻译：包含至少一种碳原子数至少为12的脂肪酸的肉毒毒素中和剂。这种脂肪酸可以是饱和脂肪酸，如月桂酸，肉豆蔻酸，棕榈酸，硬脂酸，十九烷酸，花生四烯酸酸和山萮酸或任何不饱和脂肪酸如油酸。毒素中和剂的作用就好像是肉毒杆菌毒素的拮抗受体一样，当遇到肉毒杆菌毒素时，与毒素直接结合，使毒素与人体神经肌肉组织结合，防止肉毒杆菌爆发。因此中和并附着于肉毒毒素中和剂的毒素从人体排出。肉毒杆菌毒素中和剂可以从天然存在的甘油酯容易地和经济地制造，因此从已知的由牛脑产生的神经节苷脂GT1b的抗毒素成本远远低于成本。

14. 发明授权

US4876202A Chimeric plasmids 失效
标题翻译：嵌合质粒
公开(公告)号：US4876202A
公开(公告)日：1989-10-24
申请号：US125396
申请日：1987-11-18
申请人： Hiromi Ishiwa , Harue Shibahara , Masahiko Mutai , Nobuo Tsuchida
发明人： Hiromi Ishiwa , Harue Shibahara , Masahiko Mutai , Nobuo Tsuchida
IPC分类号： C12N15/74 , C12N15/75
CPC分类号： C12N15/74 , C12N15/75
摘要： A variety of chimeric plasmids each of which comprises (a) a tetracycline resistance gene (Tc) deriving from pAM.alpha.1, one of the plasmids retained by Streptococcus faecalis, (b) an ampicillin resistance gene (Amp) deriving from pACYC177, one of the vectors applicable to Escherichia coli and (c) either or both of origins, an origin (OripAM.alpha.1) deriving from the plasmid pAM.alpha.1 and an origin (Ori177) deriving from the vector pACYC177, the tetracycline resistance gene existing on each of which has the unique cleavage site for the restriction enzyme BalI on the entire DNA of the same plasmid and the ampicillin resistance gene existing on each of which has the unique cleavage sites for respective restriction enzymes BglI and PstI on the entire DNA on the same plasmid.There is also provided a chimeric plasmid vector containing (a) a tetracycline resistance gene region (Tc) derived from the plasmid pAM.alpha.1 of Streptococcus faecalis DS5 (ATCC14508), (b) an ampicillin resistance gene region (Amp) derived from the vector pACYC177 of E. coli, (c) a first DNA replication origin (OripAM.alpha.1) derived from the plasmid pAM.alpha.1, (d) a second DNA replication origin (Ori177) derived from the vector pACYC177, and (e) a polylinker region having recognition and cleavage sites for the restriction enzymes EcoRI at one terminal and HindIII at the other terminal of the polylinker DNA sequence.This is a Continuation-in-part of Ser. No. 574,180, filed Jan. 24, 1984 abandoned, and Ser. No. 737,038, filed May 22, 1985, abandoned.
摘要翻译：各种嵌合质粒各自包含（a）源自pAMα1的四环素抗性基因（Tc），粪便链球菌保留的质粒之一，（b）来自pACYC177的氨苄青霉素抗性基因（Amp），其中之一适用于大肠杆菌的载体和（c）起源，源自质粒pAMα1的来源（OripAMα1）和源自载体pACYC177的来源（Ori177），各自存在的四环素抗性基因其在相同质粒的整个DNA上具有针对限制酶BalI的独特的切割位点，并且其上存在的氨苄青霉素抗性基因在相同质粒上的整个DNA上具有各自的限制酶BglI和PstI的独特的切割位点。还提供了包含（a）源自粪链球菌DS5（ATCC14508）的质粒pAMα1的四环素抗性基因区（Tc）的嵌合质粒载体，（b）来源于载体的氨苄青霉素抗性基因区（Amp）大肠杆菌的pACYC177，（c）衍生自质粒pAMα1的第一DNA复制起点（OripAMα1），（d）衍生自载体pACYC177的第二DNA复制起点（Ori177），和（e）多接头具有在一个末端的限制性酶EcoRI和多接头DNA序列的另一个末端的HindIII的识别和切割位点的区域。这是Ser的继续部分。 1984年1月24日提交的第574,180号遗弃， 1985年5月22日提交的第737,038号被遗弃。

15. 发明授权

US4859488A Liquid food for curing constipation: polydextrose and oligosaccharide 失效
标题翻译：用于治疗便秘的液体食品：聚右旋糖和寡糖
公开(公告)号：US4859488A
公开(公告)日：1989-08-22
申请号：US96483
申请日：1987-09-15
申请人： Tatsuhiko Kan , Yoichi Kobayashi , Yoshiko Sonoike , Tsuneo Terashima , Masahiko Mutai
发明人： Tatsuhiko Kan , Yoichi Kobayashi , Yoshiko Sonoike , Tsuneo Terashima , Masahiko Mutai
IPC分类号： A23L33/26 , A23C9/123 , A23C9/13 , A23F5/24 , A23L1/236 , A23L2/38 , A23L2/52 , A61P1/10
CPC分类号： A23L2/52 , A23C9/1234 , A23C9/1307 , A23F5/243 , A23L29/30 , A23Y2220/17 , A23Y2300/00
摘要： A liquid food comprising polydextrose and oligosaccharides which are hard to digest and easy to ferment is provided. This liquid food has excellent effect for relieving constipation.

16. 发明授权

US4473692A Camptothecin derivatives and process for preparing same 失效
标题翻译：喜树碱衍生物及其制备方法
公开(公告)号：US4473692A
公开(公告)日：1984-09-25
申请号：US413879
申请日：1982-09-01
申请人： Tadashi Miyasaka , Seigo Sawada , Kenichiro Nokata , Masahiko Mutai
发明人： Tadashi Miyasaka , Seigo Sawada , Kenichiro Nokata , Masahiko Mutai
IPC分类号： C07D491/22 , C07D491/147 , A61K31/47
CPC分类号： C07D491/22
摘要： New Camptothecin derivatives possessing high anti-tumor activity with slight toxicity, represented by the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, a hydroxyl group, an alkoxy group or an acyloxy group, R.sup.2 for a hydrogen atom, an alkyl group, an aralkyl group, a hydroxymethyl group, a carboxymethyl group or an acyloxymethyl group, and R.sup.3 is the grouping --XR' (where R' is a hydrogen atom, an alkyl group or an acyl group and X is an oxygen atom or a sulfur atom), a nitro group, an amino group, an alkylamino group, an acylamino group or a halogen atom, with the proviso that when both of R.sup.1 and R.sup.2 are hydrogen atoms, R.sup.3 should not be a hydroxyl group, methoxy group or acetoxy group. These new camptothecin derivatives are prepared by treating a 5-R.sup.1 -7-R.sup.2 -camptothecin derivative with a peroxidant and then reacting the resultant 5-R.sup.1 -7-R.sup.2 -camptothecin-1-oxide with an active hydrogen compound under irradiation of UV-rays or by catalytically hydrogenating the ring B of camptothecin in a solvent, treating the resultant tetrahydro product with an acylating agent, introducing a nitro group into the 10-position of the acylated product by the reaction with nitric acid, splitting off the acyl group in the 10-nitro product by hydrolysis and treating the hydrolyzed tetrahydro product with an oxidizing agent for dehydrogenation, and if desired, reducing the nitro group in the resulting product to an amino group and modifying the amino group by N-alkylation, N-acylation or by diazotization followed by hydrolysis or the Sandmeyer reaction, before or after the oxidation of the 10-nitro-tetrahydro product.
摘要翻译：新的喜树碱衍生物具有高毒性的抗肿瘤活性，由以下通式表示：其中R1是氢原子，烷基，羟基，烷氧基或酰氧基，R2代表氢原子，烷基，芳烷基，羟甲基，羧甲基或酰氧基甲基，R3为分组-XR'（其中R'为氢原子，烷基或酰基，X为氧原子或硫原子），硝基，氨基，烷基氨基，酰氨基或卤素原子，条件是当R 1和R 2均为氢原子时，R 3不应为羟基，甲氧基基团或乙酰氧基。这些新的喜树碱衍生物通过用过氧化物处理5-R1-7-R2-喜树碱衍生物，然后使所得的5-R1-7-R2-喜树碱-1-氧化物与活性氢化合物在UV- 或通过在溶剂中催化氢化喜树碱的环B，用酰化剂处理所得的四氢产物，通过与硝酸的反应将硝基引入到酰化产物的10-位，将酰基分成该10-硝基产物通过水解和用脱氢的氧化剂处理水解的四氢产物，如果需要，将所得产物中的硝基还原成氨基并通过N-烷基化，N-酰化或通过重氮化随后水解或Sandmeyer反应，在10-硝基 - 四氢产物的氧化之前或之后。

17. 发明授权

US4298619A Production of foods and drinks containing bifidobacteria 失效
标题翻译：生产含有双歧杆菌的食品和饮料
公开(公告)号：US4298619A
公开(公告)日：1981-11-03
申请号：US119774
申请日：1980-02-08
申请人： Masahiko Mutai , Mitsuo Mada , Kiyohiro Shimada
发明人： Masahiko Mutai , Mitsuo Mada , Kiyohiro Shimada
IPC分类号： A23L35/00 , A23C9/123 , A23L29/00 , C12N1/20 , A23C9/12 , A23L2/02
CPC分类号： C12N1/20 , A23C9/1234 , A23L29/065
摘要： Foods and drinks containing bifidobacteria are produced by inoculating and cultivating bifidobacteria or a mixture of bifidobacteria and lactic acid bacteria in a medium containing .alpha.-starch-transformed rice and bifidobacteria-fermentable sugars, and processing the resultant cultivated medium to produce foods and drinks containing bifidobacteria. The .alpha.-starch-transformed rice is produced by cooking rice. The medium for cultivating bifidobacteria may contain milk, and cultivating may be carried out under aerobic conditions.
摘要翻译：通过在含有α-淀粉转化的水稻和双歧杆菌可发酵的糖的培养基中接种和培养双歧杆菌或双歧杆菌和乳酸菌的混合物来生产含有双歧杆菌的食物和饮料，并加工所得培养基以产生含有双歧杆菌的食物和饮料。通过煮米饭生产α-淀粉转化的水稻。用于培养双歧杆菌的培养基可能含有乳，培养可在需氧条件下进行。

18. 发明授权

US4087559A Fermented milk containing viable bifidobacteria 失效
标题翻译：含有活双歧杆菌的发酵乳
公开(公告)号：US4087559A
公开(公告)日：1978-05-02
申请号：US735412
申请日：1976-10-26
申请人： Masahiko Mutai , Mitsuo Mada , Kei Nakajima , Kiyohiro Shimada , Takashi Iijima
发明人： Masahiko Mutai , Mitsuo Mada , Kei Nakajima , Kiyohiro Shimada , Takashi Iijima
IPC分类号： A23C9/12 , A23C9/123 , A23L2/02 , C12N1/20
CPC分类号： A23C9/1234
摘要： This invention relates to a method for producing fermented milk containing viable bifidobacteria by cultivating a variant of bifidobacteria in a milk medium, characterized in that the variant of bifidobacteria can be propagated under aerobic condition in a pure milk medium which does not contain any growth-promoting substance.
摘要翻译：本发明涉及通过在乳培养基中培养双歧杆菌变异体来生产含有活双歧杆菌的发酵乳的方法，其特征在于双歧杆菌的变体可以在需氧条件下在不含生长促进剂的纯乳培养基中繁殖物质。

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