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    • 14. 发明授权
    • Method of judging grade of malignancy of carcinoma cell using ATBF-1
    • 使用ATBF-1判断癌细胞恶性程度的方法
    • US07871788B2
    • 2011-01-18
    • US11658784
    • 2005-07-29
    • Yutaka MiuraMakoto KawaguchiHirotaka IwaseMinoru HamazakiJung Cha-GyunHitoo Nishino
    • Yutaka MiuraMakoto KawaguchiHirotaka IwaseMinoru HamazakiJung Cha-GyunHitoo Nishino
    • G01N33/574G01N33/53
    • G01N33/57496C07K16/30C12Q1/6883C12Q1/6886C12Q2600/106C12Q2600/112C12Q2600/118
    • Means for easily determining the grade of malignancy of cancer cells. The amount of ATBF1 in the whole cell structure of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Alternatively, the amount of ATBF1 in the nuclei of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Still alternatively, the amount of ATBF1 in the cytoplasms of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. In a preferred from, at least one of (1) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 10 of an ATBF1 gene, (2) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 11 of an ATBF1 gene, and (3) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 3 of an ATBF1 gene is detected as the amount of ATBF1.
    • 用于容易确定癌细胞恶性程度的方法。 检测从生物体分离出的检测癌细胞的全细胞结构中的ATBF1的量,根据检测结果判断检测癌细胞的恶性程度。 或者,检测从活体分离的检测癌细胞的细胞核中的ATBF1的量,根据检测结果判断检测癌细胞的恶性程度。 或者,检测从活体分离的检测癌细胞的细胞质中的ATBF1的量,根据检测结果判断检测癌细胞的恶性程度。 优选地,(1)与ATBF1基因的外显子10相对应的区域的核内存在量和/或胞质内存在的量中的至少一种,(2)核内存在量和/或胞质内存在的量对应于 ATBF1基因的外显子11,(3)ATBF1基因的外显子3相应的区域的核内存在和/或胞质内存在量被检测为ATBF1的量。
    • 19. 发明授权
    • Plasma processing method and plasma processing apparatus
    • 等离子体处理方法和等离子体处理装置
    • US6110287A
    • 2000-08-29
    • US843129
    • 1997-04-28
    • Izumi AraiYoshifumi TaharaHiroshi NishikawaYoshinobu MitanoShunichi IimuroKazuo FukasawaYutaka MiuraShozo Hosoda
    • Izumi AraiYoshifumi TaharaHiroshi NishikawaYoshinobu MitanoShunichi IimuroKazuo FukasawaYutaka MiuraShozo Hosoda
    • C23C16/509H01J37/32H01L21/00C23C16/00
    • H01L21/67069C23C16/5096H01J37/3244
    • A plasma processing method in which a high-frequency power is supplied to a processing chamber in which an object to be processed is mounted, thereby producing a plasma in the processing chamber, and the object is processed in an atmosphere of the plasma, wherein the high-frequency power is subjected to modulation by a low-frequency power. In one embodiment a plasma is produced in a processing chamber by using an electric power with a direction of current changed with passing of time, and the object to be processed is processed in an atmosphere of the plasma, wherein a power having a basic frequency is subjected to frequency modulation with a frequency equal to n-times (n=an integer) the basic frequency. In a plasma processing apparatus of the invention, while a process gas is supplied to a processing chamber via a first gas introducing hole formed in an electrode, an object to be processed, which is held on an opposed electrode, is subjected to plasma processing. There is provided a resistance applying [means for applying] apply resistance to the process gas flowing to the processing chamber via the gas introducing hole from the gas introducing means such that a plasma discharge is prevented from occurring in the gas introducing means when a process pressure in the processing chamber is set at 0.5 Torr or less.
    • 一种等离子体处理方法,其中将高频电力供应到其中安装有被处理物体的处理室,从而在处理室中产生等离子体,并且在等离子体的气氛中对物体进行处理,其中 高频功率受到低频功率的调制。 在一个实施例中,通过使用具有随时间变化的电流方向的电力在处理室中产生等离子体,并且待处理物体在等离子体的气氛中被处理,其中具有基本频率的功率为 以频率等于基本频率的n倍(n =整数)的频率进行频率调制。 在本发明的等离子体处理装置中,当通过形成在电极中的第一气体导入孔将处理气体供给到处理室时,对被保持在对置电极上的被处理物进行等离子体处理。 提供了一种电阻,其应用[施加装置]对来自气体导入装置的气体导入孔流向处理室的工艺气体施加阻力,使得当气体导入装置中的过程压力 在处理室中设定为0.5乇以下。
    • 20. 发明申请
    • Composition for preventing and treating hepatoma
    • 用于预防和治疗肝癌的组合物
    • US20070117864A1
    • 2007-05-24
    • US10572945
    • 2004-12-24
    • Kazumi YagasakiYutaka MiuraDaiki MiuraRisto SanttiNiina Saarinen
    • Kazumi YagasakiYutaka MiuraDaiki MiuraRisto SanttiNiina Saarinen
    • A61K31/365
    • A61K36/15A23L33/105A23V2002/00A61K31/365C07D307/33A23V2200/308A23V2250/21
    • The present invention provides a liver cancer prophylactic and therapeutic composition, and the present invention relates to a liver cancer prophylactic and therapeutic composition characterized in that this composition contains compounds that have a hepatoma proliferation inhibiting effect as active ingredients, these compounds comprising enterolactone (ENL) or plant lignan precursors of the same; a liver cancer prophylactic and therapeutic drug characterized in that this drug comprises compounds that have a hepatoma proliferation inhibiting effect, these compounds being enterolactone (ENL) or plant lignan precursors of the same, and a pharmacologically permissible carrier component; and a functional food product material characterized in that this food product material is formed by mixing compounds that have a hepatoma proliferation inhibiting effect, these compounds being enterolactone (ENL) or plant lignan precursors of the same as functional components with a food product material.
    • 本发明提供肝癌预防和治疗组合物,本发明涉及肝癌预防和治疗组合物,其特征在于该组合物含有作为活性成分具有肝癌增殖抑制作用的化合物,这些化合物包括肠内酯(ENL) 或植物木酚素前体; 一种肝癌预防和治疗药物,其特征在于该药物包括具有肝癌增殖抑制作用的化合物,这些化合物是肠内酯(ENL)或其植物木酚素前体,以及药理学上允许的载体组分; 以及功能食品,其特征在于,通过混合具有肝癌增殖抑制作用的化合物,这些化合物是肠内酯(ENL)或与功能组分相同的植物木酚素前体与食品材料形成。