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1. 发明申请

US20090004647A1 Method of Judging Grade of Malignancy of Carcinoma Cell 失效
标题翻译：判断癌细胞恶性程度的方法
公开(公告)号：US20090004647A1
公开(公告)日：2009-01-01
申请号：US11658784
申请日：2005-07-29
申请人： Yutaka Miura , Makoto Kawaguchi , Hirotaka Iwase , Minoru Hamazaki , Jung Cha-Gyun , Hitoo Nishino
发明人： Yutaka Miura , Makoto Kawaguchi , Hirotaka Iwase , Minoru Hamazaki , Jung Cha-Gyun , Hitoo Nishino
IPC分类号： C12Q1/68 , C12Q1/02 , C07K16/18
CPC分类号： G01N33/57496 , C07K16/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118
摘要： Means for easily determining the grade of malignancy of cancer cells. The amount of ATBF1 in the whole cell structure of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Alternatively, the amount of ATBF1 in the nuclei of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Still alternatively, the amount of ATBF1 in the cytoplasms of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. In a preferred from, at least one of (1) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 10 of an ATBF1 gene, (2) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 11 of an ATBF1 gene, and (3) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 3 of an ATBF1 gene is detected as the amount of ATBF1.
摘要翻译：用于容易确定癌细胞恶性程度的方法。检测从生物体分离出的检测癌细胞的全细胞结构中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。或者，检测从活体分离的检测癌细胞的细胞核中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。或者，检测从活体分离的检测癌细胞的细胞质中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。优选地，（1）与ATBF1基因的外显子10相对应的区域的核内存在量和/或胞质内存在的量中的至少一种，（2）核内存在量和/或胞质内存在的量对应于 ATBF1基因的外显子11，（3）ATBF1基因的外显子3相应的区域的核内存在和/或胞质内存在量被检测为ATBF1的量。

2. 发明授权

US07871788B2 Method of judging grade of malignancy of carcinoma cell using ATBF-1 失效
标题翻译：使用ATBF-1判断癌细胞恶性程度的方法
公开(公告)号：US07871788B2
公开(公告)日：2011-01-18
申请号：US11658784
申请日：2005-07-29
申请人： Yutaka Miura , Makoto Kawaguchi , Hirotaka Iwase , Minoru Hamazaki , Jung Cha-Gyun , Hitoo Nishino
发明人： Yutaka Miura , Makoto Kawaguchi , Hirotaka Iwase , Minoru Hamazaki , Jung Cha-Gyun , Hitoo Nishino
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： G01N33/57496 , C07K16/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118
摘要： Means for easily determining the grade of malignancy of cancer cells. The amount of ATBF1 in the whole cell structure of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Alternatively, the amount of ATBF1 in the nuclei of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Still alternatively, the amount of ATBF1 in the cytoplasms of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. In a preferred from, at least one of (1) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 10 of an ATBF1 gene, (2) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 11 of an ATBF1 gene, and (3) the amount of intranuclear presence and/or intracytoplasmic presence a region corresponding to exon 3 of an ATBF1 gene is detected as the amount of ATBF1.
摘要翻译：用于容易确定癌细胞恶性程度的方法。检测从生物体分离出的检测癌细胞的全细胞结构中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。或者，检测从活体分离的检测癌细胞的细胞核中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。或者，检测从活体分离的检测癌细胞的细胞质中的ATBF1的量，根据检测结果判断检测癌细胞的恶性程度。优选地，（1）与ATBF1基因的外显子10相对应的区域的核内存在量和/或胞质内存在的量中的至少一种，（2）核内存在量和/或胞质内存在的量对应于 ATBF1基因的外显子11，（3）ATBF1基因的外显子3相应的区域的核内存在和/或胞质内存在量被检测为ATBF1的量。

3. 发明授权

US6075045A Method of treating paralysis of the extremities caused by cerebral infarction 失效
标题翻译：治疗由脑梗死引起的四肢麻痹的方法
公开(公告)号：US6075045A
公开(公告)日：2000-06-13
申请号：US300456
申请日：1999-04-28
申请人： Hitoo Nishino , Cesario V. Borlongan , Hisayuki Uneyama
发明人： Hitoo Nishino , Cesario V. Borlongan , Hisayuki Uneyama
IPC分类号： A61K31/4045 , A61P9/10
CPC分类号： A61K31/4045
摘要： The administration of a therapeutically effective amount of melatonin is an effective method for treating paralysis of the extremities caused by cerebral infarction.
摘要翻译：治疗有效量的褪黑素的施用是治疗由脑梗塞引起的四肢麻痹的有效方法。

4. 发明申请

US20070098777A1 Pharmaceutical or Food Composition for Treatment or Prevention of Brain Edema 审中-公开
标题翻译：用于治疗或预防脑水肿的药物或食物组合物
公开(公告)号：US20070098777A1
公开(公告)日：2007-05-03
申请号：US11562486
申请日：2006-11-22
申请人： Hitoo NISHINO , Kunio Torii , Hisayuki Uneyama
发明人： Hitoo NISHINO , Kunio Torii , Hisayuki Uneyama
IPC分类号： A61K31/405 , A61K9/127
CPC分类号： A61K31/4045 , A23L33/10 , A61K9/127
摘要： Melatonin has an activity of treating or preventing brain edema. Thus, the invention relates to a pharmaceutical composition comprising melatonin as an active ingredient. And, the invention relates to use of melatonin in the preparation of a pharmaceutical composition comprising melatonin as an active ingredient.
摘要翻译：褪黑激素具有治疗或预防脑水肿的活性。因此，本发明涉及包含褪黑激素作为活性成分的药物组合物。而且，本发明涉及褪黑素在制备包含褪黑素作为活性成分的药物组合物中的用途。

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