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11. 发明授权

US06627397B1 Measuring chip for surface plasmon resonance biosensor and method for producing the same 失效
公开(公告)号：US06627397B1
公开(公告)日：2003-09-30
申请号：US09274321
申请日：1999-03-23
申请人： Runa Nakamura , Hiroyuki Nakamura , Ryohei Nagata , Isao Karube , Hitoshi Muguruma
发明人： Runa Nakamura , Hiroyuki Nakamura , Ryohei Nagata , Isao Karube , Hitoshi Muguruma
IPC分类号： C12Q168
CPC分类号： G01N21/553
摘要： An objective of the present invention is to provide a measuring chip for a surface plasmon resonance sensor that can detect a small amount of target substances in high sensitivity. The present invention provides a measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more plasma polymerization layers formed on said metal layer, and a biologically active substance immobilized on the surface of said plasma polymerization layer.

12. 发明授权

US06391546B1 Method for detecting target nucleotide sequence 有权
标题翻译：检测靶核苷酸序列的方法
公开(公告)号：US06391546B1
公开(公告)日：2002-05-21
申请号：US09147251
申请日：1998-11-12
申请人： Isao Karube , Shinya Sawata , Ryohei Nagata
发明人： Isao Karube , Shinya Sawata , Ryohei Nagata
IPC分类号： C12Q168
CPC分类号： C12Q1/6832 , C12Q1/686 , C12Q2531/107 , C12Q2565/501
摘要： An object of the present invention is to provide a method for detecting a target nucleotide sequence using a complementary nucleotide sequence that has an excellent sensitivity of detection. The method comprises the steps of converting the target nucleotide sequence to a partially double-stranded nucleotide sequence which is double-stranded at one part and single-stranded in the remaining part and detecting said partially double stranded nucleotide sequence using a nucleotide sequence that is complementary to the target nucleotide sequence.
摘要翻译：本发明的目的是提供使用检测灵敏度优异的互补核苷酸序列检测靶核苷酸序列的方法。该方法包括以下步骤：将目标核苷酸序列转化为部分双链核苷酸序列，其一部分为双链，其余部分为单链，并使用互补的核苷酸序列检测所述部分双链核苷酸序列到目标核苷酸序列。

13. 发明授权

US5804047A Enzyme-immobilized electrode, composition for preparation of the same and electrically conductive enzyme 失效
标题翻译：固定酶的电极，用于制备相同导电性酶的组合物
公开(公告)号：US5804047A
公开(公告)日：1998-09-08
申请号：US357987
申请日：1994-12-16
申请人： Isao Karube , Susan Anne Clark , Ryohei Nagata
发明人： Isao Karube , Susan Anne Clark , Ryohei Nagata
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/005 , C12Q1/003 , C12Q1/004 , Y10S435/817
摘要： An enzyme sensor system capable of quantitatively determining a particular component contained in a biological sample in a rapid and easy manner is disclosed. More particularly, an electrically conductive enzyme, an enzyme-immobilized electrode using the same and a composition for use in the preparation of the enzyme electrode are disclosed. The composition for an enzyme-immobilized electrode according to the present invention enables electrodes of various patterns to be produced by screen printing.
摘要翻译：公开了能够以快速和容易的方式定量测定生物样品中所含的特定组分的酶传感器系统。更具体地，公开了导电酶，使用该电极的酶固定电极和用于制备酶电极的组合物。根据本发明的酶固定化电极的组合物能够通过丝网印刷制造各种图案的电极。

14. 发明授权

US4975175A Miniaturized oxygen electrode and miniaturized biosensor and production process thereof 失效
标题翻译：小型化氧电极及小型化生物传感器及其制造方法
公开(公告)号：US4975175A
公开(公告)日：1990-12-04
申请号：US366365
申请日：1989-06-15
申请人： Isao Karube , Hiroaki Suzuki
发明人： Isao Karube , Hiroaki Suzuki
IPC分类号： C12Q1/00 , G01N27/49 , G01N27/404
CPC分类号： G01N27/404 , C12Q1/005 , Y10S435/817 , Y10T29/417
摘要： Miniaturized Clark-type oxygen electrodes includes a substrate having at least one recess groove formed on a surface thereof for receiving an electrolyte solution, and two electrodes acting as a cathode and an anode formed through an insulating layer on the surface of the substrate. Each of the electrodes is at least partially disposed in a bottom area of the recess. A solid or semi-solid, porous, electrolyte solution-containing material fills the recess, and an oxygen gas-permeable membrane covers and seals the recess and porous material received therein. Miniaturized biosensors are made using the oxygen electrode as a transducer. The oxygen electrodes and biosensors, which are extremely accurate, can be mass-produced and can be widely used in various fields such as clinical analysis, industrial processing, and in the determination of environmental conditions. The biosensors can be particularly used in clinical diagnosis and in monitoring devices for both in vivo and in vitro measurements.

15. 发明授权

US4789804A Analytical device and method utilizing a piezoelectric crystal biosensor 失效
标题翻译：利用压电晶体生物传感器的分析装置和方法
公开(公告)号：US4789804A
公开(公告)日：1988-12-06
申请号：US908371
申请日：1986-09-17
申请人： Isao Karube , Hiroshi Muramatsu
发明人： Isao Karube , Hiroshi Muramatsu
IPC分类号： G01N27/00 , G01N33/543 , H01L41/08
CPC分类号： G01N29/036 , G01N33/54373 , G01N2291/0256 , Y10S436/827 , Y10S436/828 , Y10S436/829
摘要： A bio-sensor is mounted in a container and comprised of a receptor for selectively reacting with a specific biochemical substance in a sample liquid held in the container to bind thereon the specific biochemical substance and a resonator integrated with the receptor for detecting the amount of the specific biochemical substance bound to the receptor in terms of a resonant frequency shift of the resonator. A measuring circuit is connected to the sensor for measuring the resonant frequency shift of the resonator within the container; a switching valve operates during the reaction of the receptor with the specific biochemical substance to charge a sample liquid into the container to contact the sample liquid with the receptor to thereby effect the reaction and operates during the measurement of the resonant frequency shift to replace the sample liquid by a buffer liquid in the container to immerse the sensor in the buffer liquid to thereby prevent a fluctuation of the resonant frequency shift.
摘要翻译：生物传感器安装在容器中并且包括用于选择性地与容纳在容器中的样品液体中的特定生物化学物质反应的受体，以在其上结合特定的生物化学物质和与受体一体化的谐振器，用于检测在谐振器的共振频移方面根据受体结合的特定生物化学物质。测量电路连接到传感器，用于测量容器内谐振器的谐振频率偏移; 切换阀在受体与特定生物化学物质的反应期间操作，以将样品液体装入容器中以使样品液体与受体接触，从而进行反应并在测量谐振频率移位期间操作以取代样品液体通过容器中的缓冲液体将传感器浸入缓冲液中，从而防止谐振频率偏移的波动。

16. 发明授权

US4384936A System for determining the concentration of an L-amino acid in fermentation 失效
标题翻译：确定发酵中L-氨基酸浓度的系统
公开(公告)号：US4384936A
公开(公告)日：1983-05-24
申请号：US237668
申请日：1981-02-24
申请人： Haruo Obana , Tadashi Shirakawa , Motohiko Hikuma , Takeo Yasuda , Isao Karube , Shuichi Suzuki
发明人： Haruo Obana , Tadashi Shirakawa , Motohiko Hikuma , Takeo Yasuda , Isao Karube , Shuichi Suzuki
IPC分类号： C12Q1/00 , C12Q1/02 , G01N33/487 , C12M1/40
CPC分类号： C12Q1/02 , C12Q1/001 , Y10S435/817
摘要： Electrochemical method for determining the concentration of a carbon source and L-amino acid in a fermentation medium or cultured broth by contacting a microbial electrode consisting of an oxygen-sensitive electrode or a carbon dioxide gas-sensitive electrode combined with fixed microbial cells of a microorganism capable of assimilating said carbon source or decarboxylating said L-amino acid with a sample solution and sensing electrically the rate of current decrease which is caused by the consumed oxygen in the solution in proportion to the concentration of carbon source; or the electric motive force which is caused by the liberation of carbon dioxide in the sample solution in proportion to the concentration of L-amino acid. Microbial electrodes and systems useful in carrying out the aforementioned method are disclosed.
摘要翻译：通过使由氧敏电极或二氧化碳气体敏感电极组成的微生物电极与微生物的固定微生物细胞结合来测定发酵培养基或培养肉汤中碳源和L-氨基酸的浓度的电化学方法能够吸收所述碳源或用样品溶液脱羧所述L-氨基酸，并且电化学检测溶液中消耗的氧与碳源的浓度成比例的电流降低速率; 或者与样品溶液中的二氧化碳的释放成比例的L-氨基酸的电动力。公开了用于实施上述方法的微生物电极和系统。

17. 发明授权

US08379724B2 Image coding apparatus and image coding method 有权
标题翻译：图像编码装置和图像编码方法
公开(公告)号：US08379724B2
公开(公告)日：2013-02-19
申请号：US11727206
申请日：2007-03-23
申请人： Hiroaki Ito , Tomokazu Murakami , Isao Karube , Taku Nakamura , Yusuke Yatabe
发明人： Hiroaki Ito , Tomokazu Murakami , Isao Karube , Taku Nakamura , Yusuke Yatabe
IPC分类号： H04N7/12 , G06K9/36
CPC分类号： H04N19/51 , H04N19/53 , H04N19/57 , H04N19/577
摘要： An image coding apparatus and an image coding method are provided for reducing arithmetic processing while keeping a high compression ratio. A coding process necessary for the bi-prediction motion search can be effectively reduced by determining a block size for a bi-prediction motion search or a center position for a motion search on the basis of a result of a motion search of a unidirectional prediction. Further, a compression ratio can be also kept as high as possible, because the block size or the center position are obtained on the basis of the result of the motion search of the unidirectional prediction.
摘要翻译：提供一种图像编码装置和图像编码方法，用于在保持高压缩比的同时减少运算处理。基于单向预测的运动搜索的结果，可以通过确定用于双预测运动搜索的块大小或运动搜索的中心位置来有效地减少双预测运动搜索所需的编码处理。此外，由于根据单向预测的运动搜索的结果获得块大小或中心位置，因此压缩比也可以保持尽可能高。

18. 发明申请

US20100228149A1 SENSOR DEVICE 审中-公开
标题翻译：传感器设备
公开(公告)号：US20100228149A1
公开(公告)日：2010-09-09
申请号：US12528660
申请日：2008-02-25
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Shingo Kaimori , Takahiko Kitamura , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1468 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150519 , A61B5/150633 , A61B5/150702 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/157 , A61B2562/0295
摘要： A sensor device has a needle-integrated type sensor element which is detachably mounted therein and which has a sensor chip, a lancet needle fixed to an end portion of the sensor chip, and a flow path forming element provided compressibly and restorably at the end portion of the sensor chip, to which the lancet needle is fixed. The sensor device includes a puncture mechanism (a drive spring) configured to cause the sensor element to puncture a target, and a pressing mechanism (a pressure spring) configured to urge the sensor element to the extent that the sensor element is prevented from being detached from the target by a restoring force of the flow path forming element after the target is punctured.
摘要翻译：传感器装置具有可拆卸地安装在其中的针式集成型传感器元件，其具有传感器芯片，固定到传感器芯片的端部的刺血针，以及可流动地且可修复地设置在端部处的流路形成元件传感器芯片，刺针针固定到该传感器芯片上。传感器装置包括构造成使传感器元件刺穿目标的穿刺机构（驱动弹簧）以及构造成将传感器元件推压到防止传感器元件脱离的程度的按压机构（压力弹簧）在目标被刺破之后，通过流路形成元件的恢复力从目标射出。

19. 发明申请

US20100101953A1 Methods for producing microchannel chips, microchannel chips, methods for separating biomolecules using the microchannel chips, and electrophoretic apparatus having the microchannel chips 失效
标题翻译：用于生产微通道芯片的方法，微通道芯片，使用微通道芯片分离生物分子的方法，以及具有微通道芯片的电泳装置
公开(公告)号：US20100101953A1
公开(公告)日：2010-04-29
申请号：US10591335
申请日：2005-03-03
申请人： Kenji Yokoyama , Satoshi Koide , Koji Sakairi , Kazuyoshi Yano , Isao Karube
发明人： Kenji Yokoyama , Satoshi Koide , Koji Sakairi , Kazuyoshi Yano , Isao Karube
IPC分类号： B01D57/02 , B01J19/00 , B03C5/00 , G01N27/447 , C23C14/12 , B32B37/00
CPC分类号： B32B27/08 , B01D67/0006 , B01D67/0062 , B01D2323/40 , B01J2219/00783 , B01J2219/00804 , B01J2219/00837 , B01J2219/00853 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2400/0421 , B29C65/02 , B29C66/53461 , B29C66/71 , B29L2031/756 , B32B3/26 , B32B2255/26 , B82Y30/00 , G01N21/05 , G01N27/44791 , G01N2021/0346 , B29K2023/06 , B29K2023/12 , B29K2025/06 , B29K2033/08 , B29K2033/12 , B29K2067/003 , B29K2069/00
摘要： The methods for producing microchannel chips of the present invention comprise the steps of shielding substrate surfaces on which groove-like channels have been formed, using a mask that exposes the channels, and then forming polymer membranes on the exposed surfaces of the substrates; and the step of laminating cover materials onto the side of the substrate surfaces on which the channels have been formed.
摘要翻译：用于制造本发明的微通道芯片的方法包括使用暴露通道的掩模，然后在基板的暴露表面上形成聚合物膜来屏蔽已经形成沟槽状沟道的基板表面的步骤。以及将覆盖材料层压到其上形成有通道的基板表面的侧面上的步骤。

20. 发明申请

US20100069792A1 BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, SAMPLE COLLECTING METHOD, MANUFACTURING METHOD OF BIOSENSOR CARTRIDGE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译：生物传感器盒，生物传感器装置，样品采集方法，生物传感器盒的制造方法和针状集成传感器
公开(公告)号：US20100069792A1
公开(公告)日：2010-03-18
申请号：US12513458
申请日：2007-11-01
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Tomoko Ishikawa , Masao Gotoh , Isao Karube , Takahiko Kitamura , Shingo Kaimori , Akira Harada , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151 , H01R43/00
CPC分类号： A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B2562/0295 , Y10T29/49002
摘要： A biosensor cartridge capable of performing puncturing in an exact position, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When tip portion 11a of biosensor chip body 11 is pushed against a subject M, elastic body 20 protruding from a tip portion 11a of biosensor chip body 11 is compressed, and puncturing tool 12 for puncturing protrudes. Thus, the subject M can be punctured. Additionally, if a pushing force is weakened, puncturing tool 12 is extracted from the subject M by the restoring force of elastic body 20, and the sample R flows out of the puncture hole. Additionally, cover member 19 is provided around biosensor chip body 11. Thus, when puncturing is performed by thin plate-shaped biosensor cartridge 10, biosensor chip body 11 can be prevented from deforming, and puncturing can be accurately performed in a desired puncturing position.
摘要翻译：本发明提供一种生物传感器盒，其能够在精确位置进行穿刺，并且容易地收集和测量穿刺孔的样本，而不需要使样本收集开口靠近穿刺孔的操作。当生物传感器芯体11的尖端部分11a被压靠在被检体M上时，从生物传感器芯体11的尖端部分11a突出的弹性体20被压缩，并且用于穿刺的穿刺工具12突出。因此，可以对被检体M进行穿刺。此外，如果推力减弱，则通过弹性体20的恢复力从被检体M取出穿刺工具12，并且样本R流出穿刺孔。另外，盖体19设置在生物传感器芯体11周围。因此，当通过薄板状生物传感器盒10进行穿刺时，可以防止生物传感器芯体11变形，并且可以在期望的穿刺位置精确地进行穿刺。

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