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11. 发明申请

US20070085232A1 Method of making a hand access laparoscopic device 有权
标题翻译：手动腹腔镜手术方法
公开(公告)号：US20070085232A1
公开(公告)日：2007-04-19
申请号：US11548746
申请日：2006-10-12
申请人： John Brustad , Jeremy Albrecht , Nabil Hilal , Gary Johnson , Charles Hart
发明人： John Brustad , Jeremy Albrecht , Nabil Hilal , Gary Johnson , Charles Hart
IPC分类号： B28B3/02
CPC分类号： A61B17/0293 , A61B17/02 , A61B17/0218 , A61B17/3423 , A61B17/3431 , A61B17/3439 , A61B17/3462 , A61B17/3496 , A61B17/3498 , A61B90/40 , A61B2017/00477 , A61B2017/00526 , A61B2017/0225 , A61B2017/0287 , A61B2017/3419 , A61B2017/347 , A61B2050/005 , A61B2050/0051
摘要： The invention relates to a hand access laparoscopy device having a gelcap, a retainer, a sleeve and a retention ring. The gelcap includes gel that is bonded to a cap. The cap includes an inner cylindrical wall to which the gel in bonded, thereby providing a sealing area between the device and the wound in a body wall. By securing the gel to the inner cylindrical wall, the thickness of the gel and corresponding cap is minimized along with the overall footprint of the device. With the gel thickness reduced and able to be substantially flush, the “doming” phenomenon produced by insufflation of a patient's abdomen is reduced.
摘要翻译：本发明涉及具有凝胶帽，保持器，套筒和保持环的手动腹腔镜装置。凝胶帽包括结合到帽的凝胶。该盖包括内部圆柱形壁，凝胶粘合到该内壁上，由此在该体壁中在该装置和该伤口之间提供密封区域。通过将凝胶固定到内圆柱形壁上，凝胶和相应的盖的厚度与装置的总体占地面积最小化。随着凝胶厚度降低并且能够基本上平齐，减少了通过吹入患者腹部产生的“穹隆”现象。

12. 发明申请

US20060264991A1 Seal housing having anti-inversion features 有权
公开(公告)号：US20060264991A1
公开(公告)日：2006-11-23
申请号：US11119189
申请日：2005-04-29
申请人： Gary Johnson , Jeremy Albrecht , Nabil Hilal , Charles Hart
发明人： Gary Johnson , Jeremy Albrecht , Nabil Hilal , Charles Hart
IPC分类号： A61B17/32
CPC分类号： A61B17/3498 , A61B17/34 , A61B17/3417 , A61B17/3462 , A61B2017/3464 , A61M39/06 , A61M2039/0626 , A61M2039/0633 , A61M2039/0646 , A61M2039/0653
摘要： The invention is directed to a trocar adapted to form a seal around a surgical instrument, the trocar comprising a cannula having an axis extending between a proximal end and a distal end; a housing having a proximal wall and forming with the cannula a working channel sized and configured to receive the instrument; a septum seal disposed in the housing and extending transverse to the axis of the cannula across the working channel, the septum seal having a normal state when the instrument is absent from the working channel and a stretched state when the instrument is being withdrawn from the working channel; portions of the proximal wall of the housing defining an orifice sized and configured to receive the instrument into the working channel; and an elastomeric ring-shaped projection extending axially distally between the proximal wall and the septum seal, the ring-shaped projection having an axial length adapted to deform to prevent inversion and binding of the septum seal and the orifice upon withdrawal of the surgical instrument. In particular, the septum seal is prevented from reaching the orifice in the proximal wall of the housing when the instrument is withdrawn. The projection may be bonded, insert-molded, or compressively fitted to the proximal wall of the housing. The projection may be formed of an elastomeric material such as natural or synthetic rubber. The projection may further comprise a plurality of portions or fingers extending axially distally from the proximal wall, each of the extending portions or fingers may further include a living hinge. In another aspect, the ring-shaped projection may be formed on the surface of the septum seal instead of the proximal wall of the housing. That is, the ring-shaped projection may be formed to extend axially proximally from the surface of the septum seal toward the proximal wall of the housing.

13. 发明申请

US20060148023A1 Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels 审中-公开
标题翻译：亲和标记丝氨酸蛋白酶同时检测多个丝氨酸蛋白酶活性水平
公开(公告)号：US20060148023A1
公开(公告)日：2006-07-06
申请号：US10872824
申请日：2004-06-21
申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
发明人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N33/5091 , G01N33/573 , G01N2500/04 , G01N2510/00 , G01N2800/52
摘要： The invention provides assay methods and reagents useful for evaluating the level of enzyme activities within living cells. Enzyme activity levels within living cells, such as Serine proteases, can be key determinates in assessing; 1) the presence of tumor (cancer) cells, 2) the predictive efficacy of a chemotherapeutic treatment regimen using a particular therapeutic agent or process, 4) the probability of graft rejection or acceptance, and 5) the disease state status of a cell. The identification of the up or down regulation relationships of serine proteases within living cell systems, provides a rapid, yet finely tuned mechanism for predicting the current and future physiological state of these cell populations.
摘要翻译：本发明提供了可用于评估活细胞内酶活性水平的测定方法和试剂。活细胞内的酶活性水平，如丝氨酸蛋白酶，可能是评估中的关键决定因素; 1）肿瘤（癌症）细胞的存在，2）使用特定治疗剂或过程的化学治疗方案的预测效果，4）移植排斥或接受的概率，以及5）细胞的疾病状态。识别活细胞系统中丝氨酸蛋白酶的上调或下调调节关系，为预测这些细胞群体的当前和未来生理状态提供了一种快速但精细调节的机制。

14. 发明申请

US20060051853A1 Human MEKK proteins, corresponding nucleic acid molecules and uses therefor 审中-公开
标题翻译：人类MEKK蛋白质，相应的核酸分子及其用途
公开(公告)号：US20060051853A1
公开(公告)日：2006-03-09
申请号：US11210471
申请日：2005-08-23
申请人： Gary Johnson
发明人： Gary Johnson
IPC分类号： C12Q1/68 , A01K67/00 , C12N9/12 , C12P21/06 , C07K16/40
CPC分类号： C12N9/1205 , A01K2207/15 , A01K2217/00 , A01K2217/05 , C07K16/40 , C07K2319/00
摘要： Isolated nucleic acid molecules encoding human MEKK proteins, and isolated MEKK proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a human MEKK transgene. The invention further provides human MEKK fusion proteins and anti-human MEKK antibodies. Methods of using the human MEKK proteins and nucleic acid molecules of the invention are also disclosed, including methods for detecting human MEKK activity in a biological sample, methods of modulating human MEKK activity in a cell, and methods for identifying agents that modulate the activity of human MEKK.
摘要翻译：提供了编码人MEKK蛋白的分离的核酸分子和分离的MEKK蛋白。本发明进一步提供反义核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和携带人MEKK转基因的非人转基因动物。本发明还提供人MEKK融合蛋白和抗人MEKK抗体。还公开了使用本发明的人MEKK蛋白质和核酸分子的方法，包括用于检测生物样品中的人MEKK活性的方法，调节细胞中人MEKK活性的方法，以及用于鉴定调节细胞活性的试剂的方法人类MEKK。

15. 发明申请

US20050275439A1 Switched capacitor for a tunable delay circuit 有权
公开(公告)号：US20050275439A1
公开(公告)日：2005-12-15
申请号：US11210290
申请日：2005-08-24
申请人： Gary Johnson
发明人： Gary Johnson
IPC分类号： H03L7/081 , H03L7/06
CPC分类号： H03L7/0814 , H03L7/0818
摘要： A method and apparatus is provided for providing a fine delay by switching on a capacitor delay. A coarse delay and/or a fine delay are implemented upon a reference signal based upon a phase shift between the reference signal and a feedback signal. A fine delay is implemented upon the reference signal based upon a phase shift between the reference signal and a feedback signal. Providing the fine delay includes switching on a capacitive delay. A synchronized output signal is generated based upon the fine delay.

16. 发明申请

US20050134000A1 Throwing game 失效
标题翻译：投掷游戏
公开(公告)号：US20050134000A1
公开(公告)日：2005-06-23
申请号：US10982227
申请日：2004-11-03
申请人： Gary Johnson , Joe Lessard
发明人： Gary Johnson , Joe Lessard
IPC分类号： A63B63/00 , A63B63/06
CPC分类号： A63B63/00 , A63B63/06 , A63B67/06
摘要： A game including a frame, a rotatable scoring assembly, and at least one playing piece. The at least one playing piece is thrown toward the rotatable scoring assembly, and points are scored by the playing piece coming to rest on predetermined portions of the scoring bar assembly.
摘要翻译：一种包括框架，可旋转刻痕组件和至少一个玩具的游戏。将至少一个玩具投掷到可旋转打分组件上，并且通过播放片在打标杆组件的预定部分上放置点进行刻痕。

17. 发明申请

US20050065537A1 Surgicals metals with improved hardness and methods for making same 审中-公开
标题翻译：手术金属具有改善的硬度和制作方法
公开(公告)号：US20050065537A1
公开(公告)日：2005-03-24
申请号：US10479351
申请日：2002-05-30
申请人： Vincent Tangherlini , Russell Ahlberg , Arkadiusza Strokosz , Gary Johnson , Matthew Wixey , Linda Phinuwong
发明人： Vincent Tangherlini , Russell Ahlberg , Arkadiusza Strokosz , Gary Johnson , Matthew Wixey , Linda Phinuwong
IPC分类号： A61B17/12 , A61B17/06 , A61B17/064 , A61B17/08 , A61B17/122 , A61B17/128 , A61B17/82 , A61L31/00 , A61L31/02 , C23C8/10
CPC分类号： C23C8/10 , A61B17/06066 , A61B17/064 , A61B17/0644 , A61B17/083 , A61B17/122 , A61B17/128 , A61B17/1285 , A61B17/82 , A61L31/022
摘要： A surgical device includes a structural portion which is formed of a first element, such as titanium, which has an outer surface and an inner core. A second element, such as oxygen, is combined with the first element without creating a shear plane, to create a concentration of the second element in the first element which varies from the outer surface to the inner core. In an associated method, the second element is driven into the first element under other than ambient conditions to develop a concentration gradient of the second element between the outer surface and the inner core of the first element.
摘要翻译：手术装置包括由诸如钛的第一元件形成的结构部分，其具有外表面和内核。诸如氧的第二元件与第一元件组合而不产生剪切平面，以产生第一元件中从外表面到内芯变化的浓度。在相关联的方法中，第二元件在环境条件之外被驱动到第一元件中，以在第一元件的外表面和内芯之间形成第二元件的浓度梯度。

18. 发明授权

US06690918B2 Networking by matching profile information over a data packet-network and a local area network 有权
标题翻译：通过在数据分组网络和局域网上匹配简档信息进行联网
公开(公告)号：US06690918B2
公开(公告)日：2004-02-10
申请号：US09755768
申请日：2001-01-05
申请人： Michael Evans , Robert Evans , Charles Carinalli , Gary Johnson
发明人： Michael Evans , Robert Evans , Charles Carinalli , Gary Johnson
IPC分类号： H04B700
CPC分类号： H04L67/306 , H04W8/18 , H04W8/20 , H04W28/18 , H04W84/12
摘要： A system for anonymously initiating communication between system-connected communications devices is provided wherein the initiation of communication results from comparison and priority matching of profile information shared between the devices. The system in one aspect comprises at least two communications devices connected to the system, the communications devices having at least a microprocessor, a data-input mechanism, a display screen, a wireless local-area-network protocol application enhanced with short-wave radio communication capability installed per instance to each of the devices, and a profile comparison and matching application installed per instance to each of the devices. When any two of the devices come into short-wave radio range of each other, the devices activated, a wireless local-area-network is established and the in-range devices swap profiles, which are compared to profiles held locally on each device such that a profile match registering on at least one device enables the device matching the profile to signal the sending device of the matched profile in order to request communication between the devices.
摘要翻译：提供了一种用于在系统连接的通信设备之间进行匿名发起通信的系统，其中通信的发起来自于在设备之间共享的简档信息的比较和优先级匹配。该系统在一个方面包括连接到系统的至少两个通信设备，通信设备至少具有微处理器，数据输入机制，显示屏幕，利用短波无线电增强的无线局域网协议应用每个实例向每个设备安装通信能力，以及每个实例安装到每个设备的配置文件比较和匹配应用程序。当任何两个设备进入彼此的短波无线电范围时，激活设备，建立无线局域网，并且在范围内的设备交换配置文件与每个设备本地保存的配置文件进行比较在至少一个设备上登记的配置文件匹配使能够匹配配置文件的设备向匹配配置文件的发送设备发信号，以便请求设备之间的通信。

19. 发明授权

US5394665A Stud wall framing construction 失效
标题翻译：螺柱墙框架施工
公开(公告)号：US5394665A
公开(公告)日：1995-03-07
申请号：US147518
申请日：1993-11-05
申请人： Gary Johnson
发明人： Gary Johnson
IPC分类号： E04B2/74 , E04B2/72 , E04B2/76 , E04C3/32 , E04C2/38 , E04C3/04
CPC分类号： E04C3/32 , E04B2/766 , E04B2/723
摘要： A stud wall framing construction comprises a lower track; an upper track aligned with and vertically spaced from the lower track; and a plurality of vertically aligned studs positioned between the lower and upper tracks. The lower and upper end portions of the studs are positioned within the lower and upper tracks, respectively. Each of the lower and upper tracks includes a channel with opposed track sidewalls and a track base wall. The track sidewalls have a plurality of inwardly projecting track protrusions formed from the sidewalls. Each of the track protrusions on one of the sidewalls is paired with another track protrusion disposed across the opposite sidewall. The lower and upper end portions of the studs has opposed stud sidewalls and plurality of inwardly projecting stud protrusions formed from the stud sidewalls. Each of the stud protrusions on one of the stud sidewalls is paired with another stud protrusion disposed across the opposite stud sidewall. The track and stud protrusions are adapted such that each of the pair track protrusions nest into a respective pair of stud protrusions, thereby locking the studs in the tracks.
摘要翻译：螺柱壁框架结构包括下轨道; 与所述下轨道对准并垂直间隔开的上轨道; 以及位于下轨道和上轨道之间的多个垂直排列的螺柱。螺柱的下端部和上端部分别位于下轨道和上轨道内。下轨道和上轨道中的每一个包括具有相对的轨道侧壁和轨道基座壁的通道。轨道侧壁具有从侧壁形成的多个向内突出的轨道突起。一个侧壁上的每个轨道突起与另一个跨越相对的侧壁设置的轨道突起配对。螺柱的下端部和上端部具有相对的螺柱侧壁和由螺柱侧壁形成的多个向内突出的突出突起。一个螺柱侧壁上的每个螺柱突起与另一个跨越相对的螺柱侧壁设置的螺柱突起配对。轨道和螺柱突起适于使得每对轨道突起嵌入相应的一对螺柱突起中，从而将螺柱锁定在轨道中。

20. 发明授权

US5179959A Allergy testing apparatus and method 失效
标题翻译：过敏试验装置及方法
公开(公告)号：US5179959A
公开(公告)日：1993-01-19
申请号：US780128
申请日：1991-10-29
申请人： Henry Fishman , Robert Olshaker , Gary Johnson
发明人： Henry Fishman , Robert Olshaker , Gary Johnson
IPC分类号： A61B17/20
CPC分类号： A61B17/205
摘要： An allergy testing system, for testing a patient for a plurality of allergies at substantially the same time, comprises a housing containing a plurality of packages or capsules containing an allergen and a needle, the needles being spaced apart from each other. The needles preferably carry the respective allergens on their tips. The housing is placed against the skin of a patient and an actuator is operated to engage the packages to move the needles to pierce or prick the skin of the patient, thereby applying the respective allergens to the pierced or pricked skin of the patient.
摘要翻译：一种过敏测试系统，用于在基本上同时测试多个过敏症的患者，包括含有多个包含变应原和针的包装或胶囊的外壳，所述针彼此间隔开。针优选地在其尖端携带相应的过敏原。将壳体放置在患者的皮肤上，并且致动器被操作以接合包装以移动针刺穿或刺穿患者的皮肤，从而将相应的变应原施加到患者的刺穿或刺伤的皮肤。

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