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11. 发明申请

WO2019002065A1 A SYSTEM AND A METHOD FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2019002065A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/066519
申请日：2018-06-21
申请人： GAMBRO LUNDIA AB
发明人： NILSSON, Roger , ERICSON, Björn , STERNBY, Jan , HERTZ, Thomas , JANSSON, Olof , HOBRO, Sture , LINDGREN, Henrik , FORS, Jonas , HÅKANSSON, Annmargret , WALLENBORG, Anders
IPC分类号： G16H40/40
摘要： A system (1) and method for renal replacement therapy, where the system comprises a blood treatment unit (4) connected to a blood circuit (2) for extracorporeal circulation of blood, and a method for operating the system (1). The system (1) comprises inter alia a blood pump (19), a pre-dilution line (10), a post-dilution line (11), flow control means (12) and a control unit (31) configured to control the system (1) according to control instructions. The control instructions comprise to, during a treatment, determine a system parameter value and an indication of membrane fouling of the membrane (7), and to activate an automatic anti-fouling measure in order to create a flushing of the blood treatment unit (4) comprising an increase of a pre-dilution flow rate Qpre to more than 100% of a present value of the post-dilution flow rate Qpost.

12. 发明申请

WO2018229174A3 SYSTEM AND METHOD FOR FILTRATION AND/OR DILUTION OF FLUIDS 审中-公开
公开(公告)号：WO2018229174A3
公开(公告)日：2018-12-20
申请号：PCT/EP2018/065759
申请日：2018-06-14
申请人： GAMBRO LUNDIA AB
发明人： JANSSON, Olof , ERICSON, Bjoern , HALL, Henrik
IPC分类号： B01D61/24 , B01D61/28 , B01D61/32 , B01D63/02 , A61M1/34 , B01D63/04 , A61M1/16 , B01D61/58
摘要： The present invention relates to systems and methods for filtration and/or dilution of fluids, in particular for the dialysis of blood. The systems comprise a filter device (10) having a fluid chamber (18) and comprising a first lid (20) having arranged thereon a first fluid port (22). The filter device (10) further comprises a second lid (30) having arranged thereon at least a second fluid port (32). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12),wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). Also, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18).

13. 发明申请

WO2018229125A1 A WATER PURIFICATION APPARATUS AND A METHOD FOR CONTROLLING AT LEAST ONE FLUID PROPERTY IN A WATER PURIFICATION APPARATUS 审中-公开
公开(公告)号：WO2018229125A1
公开(公告)日：2018-12-20
申请号：PCT/EP2018/065655
申请日：2018-06-13
申请人： GAMBRO LUNDIA AB
发明人： JANSSON, Olof , SENDELIUS, Peter , LINDGREN, Henrik , HALLSTRÖM, Robert , ÖRNDAL, Carl-Henry
IPC分类号： C02F1/44 , B01D61/02 , B01D61/12 , C02F1/469
摘要： The present disclosure relates to a water purification apparatus that comprises a reverse osmosis device, RO-device, producing a purified water flow and to a corresponding method. The proposed method comprises detecting at least one fluid property of purified water in the purified water path and regulating a flow rate of water in the recirculation path to fulfil one or more predetermined criteria of the purified water in the purified water path, based on the at least one detected fluid property. The present disclosure also relates to a computer program and a computer program product implementing the method.

14. 发明申请

WO2018099758A1 A CONNECTOR ARRANGEMENT, A SYSTEM FOR EXTRACORPOREAL BLOOD TREATMENT AND A METHOD FOR PRIMING A FLUID CHAMBER OF A BLOOD TREATMENT UNIT 审中-公开
公开(公告)号：WO2018099758A1
公开(公告)日：2018-06-07
申请号：PCT/EP2017/079850
申请日：2017-11-21
申请人： GAMBRO LUNDIA AB
发明人： JANSSON, Olof , PETTERSSON, Michael
IPC分类号： A61M1/16 , A61M1/36 , A61M39/10
摘要： A connector arrangement (10) for connecting to a fluid chamber (6) of a blood treatment unit (4) for extracorporeal blood treatments. The connector arrangement (10) includes a connector device (11) with a connector body (47) comprising a port opening (43) and an interior wall (50) defining a port space (39) designed to receive a first fluid port (8A) of the fluid chamber (6). The connector device (11) also incorporates a fluid path (35a) extending from the port space (39) to a first end opening (51) of the connector device (11), and an air path (36a) extending from the port space (39) to a second end opening (52) of the connector device (11), wherein the fluid path (35a) and the air path (36a) are separate paths. Also a system (1) for extracorporeal blood treatment including the connector arrangement (10) and a method for priming the fluid chamber (6).

15. 发明申请

WO2014090746A1 CASSETTE FOR PUMPING A TREATMENT SOLUTION THROUGH A DIALYZER 审中-公开
标题翻译：通过DIALYZER泵送处理溶液的CASSETTE
公开(公告)号：WO2014090746A1
公开(公告)日：2014-06-19
申请号：PCT/EP2013/075950
申请日：2013-12-09
申请人： GAMBRO LUNDIA AB
发明人： JANSSON, Olof , HOBRO, Sture , JÖNSSON, Lennart , PERSSON, Anton
IPC分类号： A61M1/16 , F04F1/02 , F04F1/06
CPC分类号： A61M1/1656 , A61M1/16 , A61M1/1635 , A61M1/166 , A61M1/3413 , A61M2205/128 , F04F1/02 , F04F1/06
摘要： A cassette is provided for installation in a dialysis monitor to pump a treatment solution through a dialyzer. The cassette is a unitary component with a hydraulic manifold (53) and a pneumatic manifold (54) integrated into a body (52). The body (52) has connectors for connecting the hydraulic manifold (53) to the dialyzer and the pneumatic manifold (54) to a pneumatic pressure source. A set of solution pumps is integrated in the cassette, and each solution pump includes a pump cavity inside the body. The solution pumps are operable to displace the treatment solution through the hydraulic manifold (53) to and/or from the dialyzer by action of a reciprocating gas- liquid interface in the pump cavity (30) of the respective solution pump. The gas-liquid interface is formed directly between a gaseous substance and the treatment solution. A valve arrangement (58) is attached to the body (52) and operable to control admission of the gaseous substance and the treatment solution to the pump cavity (30) so as to reciprocate the gas-liquid interface and thereby pump the treatment solution through the hydraulic manifold (53). The cassette is configured to pump the treatment solution without moving parts inside the body (52).
摘要翻译：提供盒式磁带，用于安装在透析监测器中以通过透析器泵送治疗溶液。该盒是具有集成到主体（52）中的液压歧管（53）和气动歧管（54）的整体部件。主体（52）具有用于将液压歧管（53）与透析器和气动歧管（54）连接到气动压力源的连接器。一组解决方案泵集成在盒中，每个溶液泵在体内包括泵腔。解决方案泵可操作以通过来自相应溶液泵的泵腔（30）中往复运动的气 - 液界面的作用将处理溶液通过液压歧管（53）移动到和/或从透析器移出。气 - 液界面直接形成在气态物质和处理溶液之间。阀装置（58）附接到主体（52）并且可操作以控制气态物质和处理溶液进入泵腔（30）的入口，以使气 - 液界面往复运动，从而将处理溶液泵送通过液压歧管（53）。所述盒被构造成泵送所述处理溶液而不移动所述主体（52）内的部件。

16. 发明申请

WO2013092283A1 DIALYSIS PRECURSOR COMPOSITION 审中-公开
标题翻译： DIALYSIS前身组成
公开(公告)号：WO2013092283A1
公开(公告)日：2013-06-27
申请号：PCT/EP2012/075007
申请日：2012-12-11
申请人： GAMBRO LUNDIA AB
发明人： JANSSON, Olof , GUSTAFSSON, Jens , LINDEN, Torbjörn
IPC分类号： A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/14 , A61K9/00
CPC分类号： A61K33/14 , A61K9/08 , A61K31/194 , A61K31/7004 , A61K33/00 , A61K33/06 , A61M1/14 , A61M1/1654 , A61K2300/00
摘要： The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consist of powder components comprising sodium chloride, at least one dry acid and at least one magnesium salt, and optionally potassium salt, calcium salt, and glucose. According to the invention said optional glucose is present as anhydrous component in said dialysis acid precursor composition and said at least one magnesium salt is present as magnesium chloride 4.5-hydrate (MgCl 2 · 4.5H 2 0).
摘要翻译：本发明涉及一种透析酸前体组合物，用于制备透析酸浓缩液，并与水和含碳酸氢盐的浓缩液混合成即用型透析溶液。所述透析酸前体组合物由包含氯化钠，至少一种干酸和至少一种镁盐，以及任选的钾盐，钙盐和葡萄糖的粉末组分组成。根据本发明，所述可选的葡萄糖以所述透析酸前体组合物中的无水组分存在，并且所述至少一种镁盐以氯化镁4.5水合物（MgCl 2·4.5H 2 O）存在。

17. 发明申请

WO2012175354A1 DIALYSIS PRECURSOR COMPOSITION 审中-公开
标题翻译： DIALYSIS前身组成
公开(公告)号：WO2012175354A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/060971
申请日：2012-06-11
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , LINDEN, Torbjörn , WIESLANDER, Anders
发明人： JANSSON, Olof , LINDEN, Torbjörn , WIESLANDER, Anders
IPC分类号： A61K9/00 , A61K31/185 , A61K31/7004 , A61K33/10
CPC分类号： A61K33/10 , A61K9/0029 , A61K9/0095 , A61K9/08 , A61K31/185 , A61K31/194 , A61K31/7004 , A61K33/14 , A61M1/1654 , B65B1/00 , B65B29/06 , A61K2300/00
摘要： The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising sodium chloride, at least one dry acid and at least one calcium salt, and optionally potassium salt, magnesium salt, and glucose. According to the invention said at least one calcium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.
摘要翻译：本发明涉及一种透析酸前体组合物，用于制备透析酸浓缩液，并与水和含碳酸氢盐的浓缩液混合成即用型透析溶液。所述透析酸前体组合物由包含氯化钠，至少一种干酸和至少一种钙盐，以及任选的钾盐，镁盐和葡萄糖的粉末组分组成。根据本发明，所述至少一种钙盐和任选的葡萄糖以所述透析酸前体组合物中的无水组分存在。

18. 发明申请

WO2009127624A3 BLOOD TREATMENT APPARATUS 审中-公开
公开(公告)号：WO2009127624A3
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054406
申请日：2009-04-14
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
摘要： A proposed blood treatment apparatus includes : a blood treatment unit (8), a pair of fluid pumps (14, 15) and a pair of blood pumps (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (14, 15) are configured to pass blood treatment fluid through the blood treatment unit (8). The blood pumps (1a, 1b) are configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, the fluid pumps (14, 15) are configured to control the operation of the blood pumps (1a, 1b) via the blood treatment fluid. Moreover, a flow control means (16a) is configured to control a trans- membrane flow between the blood side (8B) and the a fluid side (8F) of the blood treatment unit (8). Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

19. 发明申请

WO2023016955A1 GENERATING MEDICAL FLUID FOR RENAL REPLACEMENT THERAPY 审中-公开
公开(公告)号：WO2023016955A1
公开(公告)日：2023-02-16
申请号：PCT/EP2022/072179
申请日：2022-08-08
申请人： GAMBRO LUNDIA AB
发明人： POUCHOULIN, Dominique , PETTERSSON, Michael , BORGQVIST, Per-Olof , FORS, Jonas , JANSSON, Olof
IPC分类号： A61M1/16
摘要： A medical fluid for use in treatment of blood by renal replacement therapy, RRT, is generated in a system (20) comprising pumps (25A, 25B) for pumping fluids from containers (23A, 23B) into a fluid channel (21) for mixing therein. The pumps (25A, 5 25B) are controlled based on output signals (S1, S2) from scales (24A, 24B), on which the containers (23A, 23B) are arranged, to achieve a given mixing ratio between the fluids. The system may be configured by arranging a disposable arrangement on a machine comprising the pumps (25A, 25B) and the scales (24A, 24B). The disposable arrangement may define the fluid channel (21) and the containers (23A, 23B), and the machine may be an RRT apparatus. The system (20) may be operated to generate the medical fluid on-line for the RRT apparatus.

20. 发明申请

WO2023016952A1 SYSTEMS FOR SUPPLYING MEDICAL FLUID FOR RENAL REPLACEMENT THERAPY AND METHODS OF OPERATING SUCH SYSTEMS 审中-公开
公开(公告)号：WO2023016952A1
公开(公告)日：2023-02-16
申请号：PCT/EP2022/072174
申请日：2022-08-08
申请人： GAMBRO LUNDIA AB
发明人： JANSSON, Olof , PETTERSSON, Michael , BORGQVIST, Per-Olof , HERTZ, Thomas , FORS, Jonas
IPC分类号： A61M1/16
摘要： A system comprises a first device (10) and a second device (30) which are connected to establish a fluid path (21) between a pump (15) in the first device (10) and a container (38) in the second device (30) through a valve (32) in the second device (30). A control unit (31) in the second device (30) selectively operates the valve (32) to open the fluid path (21). The second device (30) is configured to supply a medical fluid for renal replacement therapy by use of a first fluid (F1) received from the first device on the fluid path (21). A control unit (11) in the first device (10) directly or indirectly measures fluid pressure in the fluid path (21) and operates to, intermittently during operation of the second device (30), activate the pump (15) to pump the first fluid (F1) into the fluid path (21) and, when the fluid pressure in the fluid path (21) indicates that the valve (32) is closed, deactivate the pump (15). The first device (30) is thereby operable to replenish the container (38) without being synchronized with the second device (30).

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