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11. 发明授权

US07416897B2 Method for high-throughput screening assay sample preparation and analysis 有权
标题翻译：高通量筛选测定方法样品制备和分析方法
公开(公告)号：US07416897B2
公开(公告)日：2008-08-26
申请号：US10719961
申请日：2003-11-21
申请人： Richard H. Bruce , Francisco E. Torres , Alan G. Bell , Eric Peeters
发明人： Richard H. Bruce , Francisco E. Torres , Alan G. Bell , Eric Peeters
IPC分类号： G01K17/00 , G01K17/20 , G01N35/00 , G01N25/20
CPC分类号： G01N25/4866 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.
摘要翻译：公开了用于高通量筛选测定样品制备和用于鉴定药物靶标和文库化合物之间的结合的测试的方法，用于测量结合反应焓的量热器件。该方法包括将文库化合物与指定溶剂混合，并将目标化合物溶液与第二指定溶剂混合在量热装置上。文库化合物/溶剂与目标化合物/溶剂溶液合并，文库化合物/溶剂溶液也与量热装置上的第三溶剂溶液合并。对于两个合并的溶液检测反应热，并进行比较。

12. 发明授权

US07150813B2 Isoelectric focusing (IEF) of proteins with sequential and oppositely directed traveling waves in gel electrophoresis 有权
标题翻译：蛋白质的等电聚焦（IEF）在凝胶电泳中具有顺序和相对定向的行波
公开(公告)号：US07150813B2
公开(公告)日：2006-12-19
申请号：US10460724
申请日：2003-06-12
申请人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
发明人： Meng H. Lean , Huangpin Ben Hsieh , John S. Fitch , Armin R. Völkel , Bryan Preas , Scott Elrod , Richard H. Bruce , Eric Peeters , Frank Torres , Michael Chabinyc
IPC分类号： B01D57/02
CPC分类号： G01N27/44795 , G01N27/44713
摘要： Various gel electrophoretic assemblies and techniques are disclosed for providing unique isoelectric focusing (IEF) strategies. Several particular systems, assemblies and methods are provided that significantly reduce processing time, enable the use of reduced operating voltages, and produce analytical results with improved resolution.
摘要翻译：公开了各种凝胶电泳组件和技术，用于提供独特的等电聚焦（IEF）策略。提供了几个特定的系统，组件和方法，其显着地减少了处理时间，使得能够使用降低的工作电压，并且以改进的分辨率产生分析结果。

13. 发明授权

US07961326B2 Method of detecting the concentration of an analyte 有权
标题翻译：检测分析物浓度的方法
公开(公告)号：US07961326B2
公开(公告)日：2011-06-14
申请号：US12195997
申请日：2008-08-21
申请人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
发明人： Joerg Martini , Richard H. Bruce , Francisco E. Torres , Peter Kiesel , Michael I. Recht , Jeffrey N. Roe
IPC分类号： A61B5/00 , G01J3/46
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/14532 , G01N21/33 , G01N21/359
摘要： A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.
摘要翻译：提供了用于检测流体中分析物的浓度的系统和方法。该方法包括检测系统中两个或更多个区域的第一区域的光学性质，位于容器中的第一区域具有用于一个或多个第一区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应于分析物浓度的变化。下一步骤检测系统中两个或更多个区域的第二区域的光学性质，位于容器中的第二区域具有用于一个或多个第二区域的一个或多个光学特性的改性剂的储存器。一种或多种改性剂的运动响应化合物浓度的变化，其中化合物是除分析物以外的物质。检测到的第一区域的光学特性和第二区域的检测光学特性用于实施例中以将分析物对第一区域的检测光学性质的影响与化合物的影响分开，其中化合物是干扰复合。

14. 发明授权

US07419835B2 Screening for ligand binding at specific target sites 有权
标题翻译：筛选特定靶位点上的配体结合
公开(公告)号：US07419835B2
公开(公告)日：2008-09-02
申请号：US10719457
申请日：2003-11-21
申请人： Francisco E. Torres , Richard H. Bruce , Rodney Turner
发明人： Francisco E. Torres , Richard H. Bruce , Rodney Turner
IPC分类号： G01K17/20 , G01N35/00 , G01N25/20
CPC分类号： G01N25/4846 , B01J2219/00599 , B01J2219/00702 , C40B50/08 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/2575
摘要： A method for screening of compounds for binding differentiation at various drug target binding sites is used with a device measuring the enthalpy of reaction for the binding. The method includes merging test ligand with target compound and merging test ligand with target compound in the presence of at least one blocking agent. A first heat of reaction is detected for the merged test ligand and target compound solution and a second heat of reaction is detected for the merged test ligand and target compound solution in the presence of a blocking agent. The two heats of reaction are compared to determine whether a reaction has occurred.
摘要翻译：使用用于筛选用于结合各种药物靶标结合位点的分化的化合物的方法，其中测量用于结合的反应焓的装置。该方法包括在至少一种封闭剂的存在下将试验配体与目标化合物合并，并将试验配体与目标化合物合并。检测合并的试验配体和目标化合物溶液的第一反应热，并在封闭剂存在下检测合并的试验配体和目标化合物溶液的第二反应热。比较两个反应热，以确定是否发生反应。

15. 发明授权

US07286224B2 Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems 有权
标题翻译：多探头多激光荧光检测系统的多路复用扫描光源
公开(公告)号：US07286224B2
公开(公告)日：2007-10-23
申请号：US11018759
申请日：2004-12-21
申请人： Douglas N. Curry , Richard H. Bruce
发明人： Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/64 , G01N21/25 , G01J3/24 , A61B5/00 , G01N21/76
CPC分类号： G01N21/6456 , G01N15/1468 , G01N2201/1085
摘要： An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and parallel to the surface, and a second end defining an output aperture. A plurality of radiation beams linearly scan and interact in time-multiplexed alternating turns with the surface below the input aperture to produce a time-multiplexed light signal that is collected by the input aperture and transmitted by the light path to the output aperture. A photodetector arrangement detects the light signal at the output aperture. A processor processes the detected time-multiplexed light.
摘要翻译：装置对表面进行成像。成像器台沿第一方向线性平移表面。光路具有限定垂直于第一方向并平行于表面的输入孔的第一端，以及限定输出孔的第二端。多个辐射束在时间多路复用的交替匝中线性扫描并与输入孔下方的表面相互作用，以产生由输入孔收集并由光路传输到输出孔的时间复用光信号。光电检测器装置检测输出孔处的光信号。处理器处理检测到的时间复用光。

16. 发明授权

US07280261B2 Method of scanning and light collection for a rare cell detector 有权
标题翻译：稀有细胞检测器的扫描和光采集方法
公开(公告)号：US07280261B2
公开(公告)日：2007-10-09
申请号：US11017440
申请日：2004-12-20
申请人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic
发明人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic
IPC分类号： G02B26/08
CPC分类号： G01N21/6456 , G01N21/6428 , G01N2021/6484 , G01N2201/1085
摘要： An apparatus images a surface. An imager stage has a planar surface for supporting a sample. A fiber optic bundle has a first end of parallel first fiber ends that are arranged to define an input aperture for viewing the sample on the imager stage. A distal bundle end is arranged to define an output aperture disposed away from the imager stage. A scanning radiation source scans a radiation beam along a path that is perpendicular to the sample on the imager stage. The input aperture of the fiber optic bundle receives a light signal that is produced by the radiation source scan of the imager stage sample. The light signal is transmitted to the bundle output aperture. A photodetector detects the light signal at the distal bundle end, and a processor processes the detected light.
摘要翻译：装置对表面进行成像。成像器台具有用于支撑样品的平坦表面。光纤束具有平行的第一光纤端的第一端，其布置成限定用于观察成像器台上的样品的输入孔。远侧束端布置成限定远离成像器台布置的输出孔。扫描辐射源沿着与成像器台上的样品垂直的路径扫描辐射束。光纤束的输入孔径接收由成像器台样品的辐射源扫描产生的光信号。光信号被传输到束输出孔径。光电检测器检测远侧束端处的光信号，并且处理器处理检测到的光。

17. 发明授权

US06740530B1 Testing method and configurations for multi-ejector system 失效
标题翻译：多喷射器系统的测试方法和配置
公开(公告)号：US06740530B1
公开(公告)日：2004-05-25
申请号：US09718733
申请日：2000-11-22
申请人： Richard H. Bruce , Scott A. Elrod , Jaan Noolandi , David A. Horine , Babur B. Hadimioglu
发明人： Richard H. Bruce , Scott A. Elrod , Jaan Noolandi , David A. Horine , Babur B. Hadimioglu
IPC分类号： G01N110
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00693 , B41J2/14008 , B41J2002/14322 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： Methods for testing proper operation of drop ejection units in a multi-ejector system are provided to determine whether the drop ejectors have been properly filled and/or the ejectors are emitting fully formed droplets. The methods include testing the ejectors prior to drop ejection. In this method, a priming system is used wherein fluid received by the priming system is ejected onto a test substrate to allow a scanner to determine the existence of the fluids at selected locations. The selected locations are correlated to the drop ejection units to determine which ejection units do not have biofluid or sufficient biofluid. A further method allows for ejection prior to printing, on a test substrate wherein testing for both the fullness of the ejector units as well as proper emission of the ejectors of droplets may be tested. The ejectors after being primed, eject the biofluids which are then scanned and correlated to each individual ejector. A further method provided is a laser scattering method wherein a laser beam is interposed between the drop emission path of the ejectors. Laser detection then determines whether a correlated drop ejector is properly emitting droplets.
摘要翻译：提供了用于测试多喷射器系统中液滴喷射单元的正确操作的方法，以确定液滴喷射器是否已经被适当地填充和/或喷射器正在发射完全形成的液滴。这些方法包括在喷射之前测试喷射器。在该方法中，使用起动系统，其中由起动系统接收的流体被喷射到测试基板上，以允许扫描仪确定在选定位置处的流体的存在。所选择的位置与液滴喷射单元相关，以确定哪些喷射单元不具有生物流体或足够的生物流体。另外的方法允许在打印之前在测试基板上进行喷射，其中可以测试喷射器单元的充满度以及液滴喷射器的适当发射。喷射器被喷涂后，喷射生物流体，然后将其扫描并与每个喷射器相关联。提供的另一种方法是激光散射方法，其中激光束插入在喷射器的液滴发射路径之间。然后，激光检测确定相关的液滴喷射器是否正确地发射液滴。

18. 发明授权

US06713022B1 Devices for biofluid drop ejection 有权
标题翻译：生物流体液滴喷射装置
公开(公告)号：US06713022B1
公开(公告)日：2004-03-30
申请号：US09724987
申请日：2000-11-22
申请人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
发明人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
IPC分类号： B41J2175
CPC分类号： B01L3/0268 , B01L2400/0439 , G01N35/1002 , G01N2035/102 , G01N2035/1041
摘要： A biofluid drop ejection unit for ejecting biofluid drops. A biofluid drop ejection mechanism of such a unit includes a transducer, which generates energy used to emit the biofluid drop. Further provided is a reagent cartridge or biofluid containment area which holds the biofluid. The reagent cartridge or biofluid containment area is configured to hold low volumes of biofluid and to avoid contamination of the biofluid. The reagent cartridge or biofluid containment area is in operational connection with the drop ejection mechanism such that upon operation of the drop ejection mechanism, biofluid drops are emitted. The biofluid drop ejection mechanism is a high efficiency device, and may be configured as two separate pieces or as a single disposable unit.
摘要翻译：用于喷射生物流体滴的生物流体滴落喷射单元。这种单元的生物流体液滴喷射机构包括换能器，其产生用于发射生物流体滴的能量。另外还提供了一个保持生物流体的试剂盒或生物流体容纳区域。试剂盒或生物流体容纳区域被配置为保持低体积的生物流体并避免污染生物流体。试剂盒或生物流体容纳区域与液滴喷射机构操作连接，使得在液滴喷射机构的操作时，发射生物流体液滴。生物流体液滴喷射机构是高效率的装置，并且可以被配置为两个分开的部件或者作为单个一次性部件。

19. 发明授权

US5632029A Multi-segmented bus and method of operation 失效
标题翻译：多段总线和运行方式
公开(公告)号：US5632029A
公开(公告)日：1997-05-20
申请号：US449398
申请日：1995-05-23
申请人： Richard H. Bruce , Jean Gastinel , William F. Gunning , Michael Overton
发明人： Richard H. Bruce , Jean Gastinel , William F. Gunning , Michael Overton
IPC分类号： G06F13/36 , G06F13/40 , G06F13/42 , G06F9/38 , G06F13/14
CPC分类号： G06F13/409 , G06F13/4022
摘要： A multi-level hierarchical bus architecture implemented with a multi-chip package and a modular shared-bus provides high bandwidth. All IC components are mounted on standardized multi-chip packages. Each multi-chip package includes bus interface chips for providing communication from the integrated circuits to a board bus. One multi-chip package contains additional bus interface circuitry for providing communication from the board bus to a backplane bus.
摘要翻译：采用多芯片封装和模块化共享总线实现的多级分层总线结构提供了高带宽。所有IC组件均安装在标准化的多芯片封装上。每个多芯片封装包括用于提供从集成电路到板总线的通信的总线接口芯片。一个多芯片封装包含用于提供从板总线到背板总线的通信的附加总线接口电路。

20. 发明授权

US08723140B2 Particle analyzer with spatial modulation and long lifetime bioprobes 有权
标题翻译：具有空间调制和长寿命生物探针的粒子分析仪
公开(公告)号：US08723140B2
公开(公告)日：2014-05-13
申请号：US13206439
申请日：2011-08-09
申请人： Peter Kiesel , Richard H. Bruce , Michael Bassler
发明人： Peter Kiesel , Richard H. Bruce , Michael Bassler
IPC分类号： F21V9/16
CPC分类号： G01N21/6408 , G01N21/05 , G01N2021/6413
摘要： An analyzer includes a flow cell having a flow channel through which a sample passes. A light source excites at least a first particle type in the sample in one or more excitation region(s), and a detector detects light emitted by the excited particle. A spatial filter defines detection regions, wherein light emitted by the particle is transmitted to the detector, and interspersed shielded regions, wherein such light is at least partially blocked from reaching the detector. The light emitted by the excited particle has a response time τ1, and the sample may also contain a component that is excited by the light source and that has a response time τ2
摘要翻译：分析器包括具有样品通过的流动通道的流动池。光源在一个或多个激发区域中激发样品中的至少第一颗粒类型，并且检测器检测被激发颗粒发射的光。空间滤波器定义检测区域，其中由颗粒发射的光被传输到检测器和散布的屏蔽区域，其中这样的光被至少部分地阻挡到达检测器。由激发的粒子发射的光具有响应时间τ1，并且样品还可以包含由光源激发的并且具有响应时间τ2<τ1的分量。激励区域和检测区域被布置成在激发和检测之间提供时间延迟，所述时间延迟被定制以将由第一粒子发射的光与由该部件发射的光隔离。

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