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1. 发明授权

US06861034B1 Priming mechanisms for drop ejection devices 有权
标题翻译：液滴喷射装置的启动机构
公开(公告)号：US06861034B1
公开(公告)日：2005-03-01
申请号：US09721388
申请日：2000-11-22
申请人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Scott A. Elrod , Joy Roy , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , David A. Horine
IPC分类号： C12M1/00 , B01L3/02 , B05B1/04 , B05B17/06 , B01L3/00 , B41J23/00 , B41J29/38
CPC分类号： B05B17/0607 , B01L3/0268
摘要： Provided is a priming mechanism for priming a biofluid drop ejection device having a drop ejection opening leading to an ejection reservoir. The priming mechanism includes a vacuum unit which generates a vacuum force, connected to a vacuum nozzle. The vacuum nozzle is located over the drop ejection opening. A disposable sleeve or tubing is attached to the vacuum nozzle and is placed in operational contact with the drop ejection opening. A fluid height detection sensor is positioned to sense a fluid height within at least one of the disposable tubing and the vacuum nozzle. Upon sensing a predetermined fluid height, by the fluid height detection sensor, the priming operation is completed, and the primer mechanism is removed from the operational contact with the drop ejection opening.
摘要翻译：提供了一种用于起动生物流体液滴喷射装置的起动机构，其具有通向喷射储存器的液滴喷射开口。起动机构包括产生与真空喷嘴连接的真空力的真空单元。真空喷嘴位于液滴喷射口的上方。一次性套筒或管道连接到真空喷嘴并且与液滴喷射口处于操作接触。液体高度检测传感器被定位成感测至少一个一次性管道和真空喷嘴中的流体高度。通过流体高度检测传感器感测到预定的流体高度时，完成起动操作，并且将底漆机构从与液滴喷射口的操作接触部分移开。

2. 发明授权

US06740530B1 Testing method and configurations for multi-ejector system 失效
标题翻译：多喷射器系统的测试方法和配置
公开(公告)号：US06740530B1
公开(公告)日：2004-05-25
申请号：US09718733
申请日：2000-11-22
申请人： Richard H. Bruce , Scott A. Elrod , Jaan Noolandi , David A. Horine , Babur B. Hadimioglu
发明人： Richard H. Bruce , Scott A. Elrod , Jaan Noolandi , David A. Horine , Babur B. Hadimioglu
IPC分类号： G01N110
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00693 , B41J2/14008 , B41J2002/14322 , C40B60/14 , Y10T436/25 , Y10T436/2575
摘要： Methods for testing proper operation of drop ejection units in a multi-ejector system are provided to determine whether the drop ejectors have been properly filled and/or the ejectors are emitting fully formed droplets. The methods include testing the ejectors prior to drop ejection. In this method, a priming system is used wherein fluid received by the priming system is ejected onto a test substrate to allow a scanner to determine the existence of the fluids at selected locations. The selected locations are correlated to the drop ejection units to determine which ejection units do not have biofluid or sufficient biofluid. A further method allows for ejection prior to printing, on a test substrate wherein testing for both the fullness of the ejector units as well as proper emission of the ejectors of droplets may be tested. The ejectors after being primed, eject the biofluids which are then scanned and correlated to each individual ejector. A further method provided is a laser scattering method wherein a laser beam is interposed between the drop emission path of the ejectors. Laser detection then determines whether a correlated drop ejector is properly emitting droplets.
摘要翻译：提供了用于测试多喷射器系统中液滴喷射单元的正确操作的方法，以确定液滴喷射器是否已经被适当地填充和/或喷射器正在发射完全形成的液滴。这些方法包括在喷射之前测试喷射器。在该方法中，使用起动系统，其中由起动系统接收的流体被喷射到测试基板上，以允许扫描仪确定在选定位置处的流体的存在。所选择的位置与液滴喷射单元相关，以确定哪些喷射单元不具有生物流体或足够的生物流体。另外的方法允许在打印之前在测试基板上进行喷射，其中可以测试喷射器单元的充满度以及液滴喷射器的适当发射。喷射器被喷涂后，喷射生物流体，然后将其扫描并与每个喷射器相关联。提供的另一种方法是激光散射方法，其中激光束插入在喷射器的液滴发射路径之间。然后，激光检测确定相关的液滴喷射器是否正确地发射液滴。

3. 发明授权

US06713022B1 Devices for biofluid drop ejection 有权
标题翻译：生物流体液滴喷射装置
公开(公告)号：US06713022B1
公开(公告)日：2004-03-30
申请号：US09724987
申请日：2000-11-22
申请人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
发明人： Jaan Noolandi , David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Joy Roy , Scott A. Elrod
IPC分类号： B41J2175
CPC分类号： B01L3/0268 , B01L2400/0439 , G01N35/1002 , G01N2035/102 , G01N2035/1041
摘要： A biofluid drop ejection unit for ejecting biofluid drops. A biofluid drop ejection mechanism of such a unit includes a transducer, which generates energy used to emit the biofluid drop. Further provided is a reagent cartridge or biofluid containment area which holds the biofluid. The reagent cartridge or biofluid containment area is configured to hold low volumes of biofluid and to avoid contamination of the biofluid. The reagent cartridge or biofluid containment area is in operational connection with the drop ejection mechanism such that upon operation of the drop ejection mechanism, biofluid drops are emitted. The biofluid drop ejection mechanism is a high efficiency device, and may be configured as two separate pieces or as a single disposable unit.
摘要翻译：用于喷射生物流体滴的生物流体滴落喷射单元。这种单元的生物流体液滴喷射机构包括换能器，其产生用于发射生物流体滴的能量。另外还提供了一个保持生物流体的试剂盒或生物流体容纳区域。试剂盒或生物流体容纳区域被配置为保持低体积的生物流体并避免污染生物流体。试剂盒或生物流体容纳区域与液滴喷射机构操作连接，使得在液滴喷射机构的操作时，发射生物流体液滴。生物流体液滴喷射机构是高效率的装置，并且可以被配置为两个分开的部件或者作为单个一次性部件。

4. 发明授权

US06623700B1 Level sense and control system for biofluid drop ejection devices 失效
标题翻译：生物流体喷射装置的液位感应和控制系统
公开(公告)号：US06623700B1
公开(公告)日：2003-09-23
申请号：US09721386
申请日：2000-11-22
申请人： David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , Scott A. Elrod
发明人： David A. Horine , Babur B. Hadimioglu , Richard H. Bruce , Jaan Noolandi , Scott A. Elrod
IPC分类号： B01L302
CPC分类号： B41J2/17566 , B41J2/1714 , Y10T436/2575
摘要： A level control mechanism is provided for a biofluid drop ejection device which ejects biofluid drops in small volumes. The biofluid drop device includes a drop ejection mechanism having a transducer which generates energy used to emit the biofluid drops. A reagent cartridge or biofluid holding area holds a biofluid, isolated from the drop ejection mechanism to avoid contamination between the biofluid drop ejection mechanism and the reagent cartridge. The reagent cartridge is connected to the drop ejection mechanism such that upon operation of the mechanism, the biofluid is emitted in controlled biofluid drops. A level sensor is positioned to sense a height of the biofluid within the cartridge. Upon sensing the height of the biofluid below a certain level, an adjustment is made to the height by providing at least one of additional biofluid to the cartridge, and raising the level of the entire reagent cartridge.
摘要翻译：为生物流体液滴喷射装置提供液面控制机构，其以小体积喷射生物流体液滴。生物流体液滴装置包括液滴喷射机构，其具有产生用于发射生物流体滴的能量的换能器。试剂盒或生物流体保持区域保持与液滴喷射机构隔离的生物流体，以避免生物流体液滴喷射机构和试剂盒之间的污染。试剂盒连接到液滴喷射机构，使得在机构操作时，生物流体在受控的生物流体滴下发射。水平传感器被定位成感测盒内的生物流体的高度。当感测到生物流体的高度低于一定水平时，通过向盒提供至少一种额外的生物流体，并提高整个试剂盒的水平来调节高度。

5. 发明授权

US06514704B2 Quality control mechanism and process for a biofluid multi-ejector system 失效
公开(公告)号：US06514704B2
公开(公告)日：2003-02-04
申请号：US09773804
申请日：2001-02-01
申请人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
发明人： Richard H. Bruce , Scott A. Elrod , Babur B. Hadimioglu , David A. Horine , Jaan Noolandi , Joy Roy , Robert A. Sprague
IPC分类号： C12Q168
CPC分类号： G01N35/10 , G01N35/00712 , G01N35/1009 , G01N2035/1037 , G06F19/00
摘要： A method and mechanism for ensuring quality control in printed biological assays is provided. A multi-ejector system having a plurality of individual drop ejectors is loaded with a variety of biofluids. Biofluids include at least a carrier fluid, a biological material to be used in the testing, and markers, such as fluorescent dyes. Data regarding the biofluid loaded in each of the drop ejectors is stored along with an expected signature output of the biofluid. Particularly, the signature output represents signals from individual ones of the fluorescent markers included within the biofluid. Once a biological assay consisting of the biofluid drops has been printed, a scanner capable of detecting the markers scans the biological assay and obtains signature output signals for each of the drops of the biological assay. A comparing operation is undertaken to compare the obtained signature output through the scanning operation, with the expected signature output signals for the biofluid loaded in the corresponding drop ejector. The biological material itself may also be tagged with a marker to ensure its inclusion in the biofluid. By the comparing operation, it is possible to verify the biofluids were loaded in the proper drop ejector, including the proper biological material, and that the drop ejectors are functioning properly.

6. 发明授权

US06503454B1 Multi-ejector system for ejecting biofluids 有权
标题翻译：用于喷射生物流体的多喷射器系统
公开(公告)号：US06503454B1
公开(公告)日：2003-01-07
申请号：US09721389
申请日：2000-11-22
申请人： Babur B. Hadimioglu , Scott A. Elrod , Richard H. Bruce , Jaan Noolandi , David A. Horine
发明人： Babur B. Hadimioglu , Scott A. Elrod , Richard H. Bruce , Jaan Noolandi , David A. Horine
IPC分类号： B01L302
CPC分类号： B01L3/0268 , G01N2035/1039 , Y10T436/2575
摘要： A multiple-ejector system for printing arrays of biofluids include a tooling plate having a plurality of sets of tooling pins extending outward from the surface of the tooling plate. A printed circuit board is provided having pairs of power connection pins and ground return pins extending from a surface of the circuit board. A plurality of biofluid drop ejection units are provided and include alignment grooves and at least a transducer. Each of the plurality of biofluid drop ejection units are connected to a corresponding one of a set of tooling pins by connection of the tooling pins and alignment grooves. The power connection pins of the pairs are in operational connection with respective transducers and the ground return connection pins of the pairs are in operational connection with a body portion of the drop ejection units. The different drop ejection units will contain different biofluids which are to be emitted onto a substrate. Verification of drop ejection units containing biofluids, may be obtained in one embodiment through the use of an optical scanner. Detection of drops at defined locations provides a verification that validates a properly formed spot is present on a substrate, and is in the correct position.
摘要翻译：用于打印生物流体阵列的多喷射器系统包括具有从工具板的表面向外延伸的多组工具销的工具板。提供一个印刷电路板，其具有从电路板的表面延伸的成对的电源连接引脚和接地返回引脚。提供多个生物流体液滴喷射单元，并且包括对准凹槽和至少一个换能器。多个生物流体滴落喷射单元中的每一个通过工具销和对准槽的连接连接到一组加工销中的对应的一个。成对的电源连接引脚与相应的换能器操作连接，并且对的接地返回连接引脚与液滴喷射单元的主体部分操作连接。不同的液滴喷射单元将包含将被发射到基底上的不同生物流体。通过使用光学扫描仪可以在一个实施例中获得包含生物流体的液滴喷射单元的验证。在限定位置处检测液滴提供验证，验证正确形成的斑点存在于基底上，并处于正确的位置。

7. 发明授权

US5765279A Methods of manufacturing power supply distribution structures for multichip modules 失效
标题翻译：制造多芯片模块电源分配结构的方法
公开(公告)号：US5765279A
公开(公告)日：1998-06-16
申请号：US445672
申请日：1995-05-22
申请人： Larry Louis Moresco , Richard L. Wheeler , Solomon I. Beilin , David A. Horine
发明人： Larry Louis Moresco , Richard L. Wheeler , Solomon I. Beilin , David A. Horine
IPC分类号： H01L23/12 , H01L21/48 , H01L21/822 , H01L23/50 , H01L23/538 , H01L27/01 , H01L27/04 , H05K3/34
CPC分类号： H01L21/4857 , H01L23/50 , H01L2224/16 , H01L2924/3011 , Y10T29/49144
摘要： A power distribution structure for a multichip module and a method for fabricating the same are shown. According to the method of the present invention, a base plate is provided, a plurality of mesas arranged in a pattern are formed on the base plate, the mesas having electrically conductive upper surfaces which lie substantially in a single plane. A thin, conformal dielectric layer is then formed over the exposed surfaces of the mesas and the support base and a conductive material is deposited over the dielectric material filling the area between and surrounding the mesas. The resulting structure is then planarized, as by polishing, such that the upper surfaces of the mesas and the upper surface of the conductive material surrounding the mesas lie in substantially one plane and are electrically isolated from each other by the dielectric material. A multilayered thin film structure for a multichip module may then be formed over the power distribution structure and power and ground potentials supplied to microelectronic components, such as integrated circuit chips, mounted on the surface of the thin film structure using vias routed through the thin film structure.
摘要翻译：示出了用于多芯片模块的配电结构及其制造方法。根据本发明的方法，提供一种基板，在基板上形成多个以图案布置的台面，台面具有基本上在单个平面内的导电上表面。然后在台面和支撑基底的暴露的表面上形成薄的共形绝缘层，并且将导电材料沉积在填充台面之间并围绕台面的区域的电介质材料上。然后将所得结构平坦化，如通过抛光，使得台面的上表面和围绕台面的导电材料的上表面位于基本上一个平面中并且通过电介质材料彼此电隔离。然后可以在功率分配结构上形成用于多芯片模块的多层薄膜结构，并且使用安装在薄膜结构的表面上的微电子部件（例如集成电路芯片）提供的功率和接地电位使用通过薄膜结构体。

8. 发明授权

US5374196A High-density/long-via laminated connector 失效
标题翻译：高密度/长通孔层压连接器
公开(公告)号：US5374196A
公开(公告)日：1994-12-20
申请号：US236675
申请日：1994-05-02
申请人： David A. Horine
发明人： David A. Horine
IPC分类号： H01R11/01 , H01R12/50 , H01R12/52 , H01R12/57 , H05K3/36 , H01R9/09
CPC分类号： H01R12/52 , H01R12/57
摘要： A high-density laminated connector comprises a plurality of layers of rigid dielectric material which are laminated together. The rigid construction of the connector permits precise dimensions of the connecter and, thus, accurate attachment of adjacent circuit boards. The dielectric contains traces which are joined to contact pads, connecting the traces to adjacent circuit boards. The contact pads are comprised of soft gold, solder, and various elastomeric materials. The use of soft gold contacts allows the connector to be easily removed from the adjacent circuit board. Alternatively, the rigid dielectric layers contain recesses where the contact pads are placed. This ensures physical alignment of the circuit board and the connector, so that dimensional integrity is maintained when pressure is applied to the connector. The traces within the connector can be of a varied width, pitch, and direction. Thus, right-angle interconnections can be made. Cross-traces can be placed on each individual layer of dielectric or vias made through the dielectric layers, to interconnect traces. The trace width can be economically and accurately narrowed to produce high aspect ratios and thus provide high signal density.
摘要翻译：高密度层压连接器包括层压在一起的多层刚性介电材料。连接器的刚性结构允许连接器的精确尺寸，从而准确地附接相邻的电路板。电介质包含连接到接触焊盘的迹线，将迹线连接到相邻的电路板。接触垫由软金，焊料和各种弹性体材料组成。使用软金触点允许连接器从相邻电路板容易地移除。或者，刚性介电层包含凹部，其中接触垫被放置。这确保电路板和连接器的物理对准，使得当对连接器施加压力时维持尺寸完整性。连接器内的迹线可以具有不同的宽度，间距和方向。因此，可以进行直角互连。交叉迹线可以放置在通过电介质层制成的电介质或通孔的每个单独层上，以互连迹线。迹线宽度可以经济地和精确地缩小以产生高纵横比，从而提供高信号密度。

9. 发明授权

US06350405B2 Apparatus for manufacturing three dimensional parts using an inert gas 有权
标题翻译：使用惰性气体制造三维零件的装置
公开(公告)号：US06350405B2
公开(公告)日：2002-02-26
申请号：US09833186
申请日：2001-04-11
申请人： David A. Horine
发明人： David A. Horine
IPC分类号： C21C100
CPC分类号： C22B4/00 , B05D1/02 , B41J2/14008 , B41J2202/04 , C21C1/00 , C23C4/123 , H05K3/14 , H05K3/3457
摘要： A method for manufacturing metal structures in which minute drops of a liquid metal are emitted from an acoustic device through an inert gas. The presence of the inert gas at the surface of the liquid metal prevent the formation of an oxide skin which would absorb acoustic energy and hinder droplet formation and emission. The droplets are then emitted towards a substrate, which may form as a carrier, where they may be used to form solder bumps, circuit traces, or accreted to form a three dimensional device.
摘要翻译：一种用于制造金属结构的方法，其中液体金属的液滴通过惰性气体从声学装置发射。在液态金属表面存在惰性气体防止氧化皮肤的形成，其将吸收声能并阻止液滴形成和发射。然后将液滴发射到衬底，衬底可以形成为载体，其中它们可以用于形成焊料凸块，电路迹线或者形成三维器件。

10. 发明授权

US6007183A Acoustic metal jet fabrication using an inert gas 失效
标题翻译：使用惰性气体的声学金属喷射制造
公开(公告)号：US6007183A
公开(公告)日：1999-12-28
申请号：US977819
申请日：1997-11-25
申请人： David A. Horine
发明人： David A. Horine
IPC分类号： B22F3/115 , B22F9/08 , B41J2/14 , C23C4/12 , B41J2/135
CPC分类号： B41J2/14008 , B22F3/115 , B22F9/08 , C23C4/123 , B22F2009/0836 , B22F2999/00
摘要： A method for manufacturing metal structures in which minute drops of a liquid metal are emitted from an acoustic device through an inert gas. The presence of the inert gas at the surface of the liquid metal prevent the formation of an oxide skin which would absorb acoustic energy and hinder droplet formation and emission. The droplets are then emitted towards a substrate, which may form as a carrier, where they may be used to form solder bumps, circuit traces, or accreted to form a three dimensional device.
摘要翻译：一种用于制造金属结构的方法，其中液体金属的液滴通过惰性气体从声学装置发射。在液态金属表面存在惰性气体防止氧化皮肤的形成，其将吸收声能并阻止液滴形成和发射。然后将液滴发射到衬底，衬底可以形成为载体，其中它们可以用于形成焊料凸块，电路迹线或者形成三维器件。

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