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11. 发明申请

US20090097808A1 Fluid waveguide and uses thereof 审中-公开
标题翻译：流体波导及其用途
公开(公告)号：US20090097808A1
公开(公告)日：2009-04-16
申请号：US11658339
申请日：2005-08-01
申请人： Daniel B. Wolfe , Kateri E. Paul , Dmitri V. Vezenov , Brian T. Mayers , Richard S. Conroy , Piotr Garstecki , Michael A. Fischbach , Valentine I. Vullev , Kam Yan Tang , Mara G. Prentiss , George M. Whitesides
发明人： Daniel B. Wolfe , Kateri E. Paul , Dmitri V. Vezenov , Brian T. Mayers , Richard S. Conroy , Piotr Garstecki , Michael A. Fischbach , Valentine I. Vullev , Kam Yan Tang , Mara G. Prentiss , George M. Whitesides
IPC分类号： G02B6/032
CPC分类号： G02B6/032 , G02B6/10 , G02B6/122
摘要： The invention relates to methods and apparatuses for guiding and emitting electromagnetic radiation from a fluid waveguide. Various methods for changing optical properties (e.g., refractive index, absorption, and fluorescence) and/or physical properties (e.g., magnetic susceptibility, electrical conductivity, and temperature) of either the waveguide core or the cladding, or both, are provided herein. In one embodiment, electromagnetic radiation is guided and/or emitted at multiple distinct wavelengths, including emission in the form of an essentially continuous band, in some cases covering at least 150 nanometers. In another embodiment, methods for splitting a waveguide core and/or the joining of at least two waveguide cores in a waveguide are provided. In yet another embodiment, the invention includes the use of thermal gradients to generate a waveguide and/or to change the properties of waveguides. Embodiments of the waveguides may be used for optical detection or spectroscopic analysis.
摘要翻译：本发明涉及用于引导和发射来自流体波导的电磁辐射的方法和装置。本文提供用于改变波导芯或包层或两者的光学性质（例如，折射率，吸收和荧光）和/或物理性质（例如磁化率，导电性和温度）的各种方法。在一个实施例中，电磁辐射是以多个不同的波长被引导和/或发射的，包括基本连续带形式的发射，在某些情况下覆盖至少150纳米。在另一个实施例中，提供了用于在波导中分离波导芯和/或至少两个波导芯的接合的方法。在另一个实施例中，本发明包括使用热梯度来产生波导和/或改变波导的性质。波导的实施例可以用于光学检测或光谱分析。

12. 发明授权

US07282240B1 Elastomeric mask and use in fabrication of devices 有权
标题翻译：弹性面膜和用于制造器件
公开(公告)号：US07282240B1
公开(公告)日：2007-10-16
申请号：US09694074
申请日：2000-10-20
申请人： Rebecca J. Jackman , David C. Duffy , George M. Whitesides , Kathleen Vaeth , Klavs F. Jensen
发明人： Rebecca J. Jackman , David C. Duffy , George M. Whitesides , Kathleen Vaeth , Klavs F. Jensen
IPC分类号： B05D1/32
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/3211 , H01L27/3244 , H01L27/3281 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain un-shielded, while other openings of the lower mask are shielded. A first deposition step, following by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.
摘要翻译：提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。然后可以从掩模的表面简单地剥离掩模，留下图案化材料。描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。第一沉积步骤，随后通过上掩模的重新定向以暴露不同的一组下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。通过所述技术提供像素化的有机电致发光器件。

13. 发明申请

US20080124663A1 Microfluidic systems including three-dimensionally arrayed channel networks 审中-公开
公开(公告)号：US20080124663A1
公开(公告)日：2008-05-29
申请号：US11983425
申请日：2007-11-08
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
IPC分类号： G03F7/38
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.

14. 发明授权

US07323143B2 Microfluidic systems including three-dimensionally arrayed channel networks 有权
公开(公告)号：US07323143B2
公开(公告)日：2008-01-29
申请号：US10303642
申请日：2002-11-25
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , Justin Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , Justin Cooper McDonald , George M. Whitesides
IPC分类号： B01L3/02 , B01L11/00 , B32B5/05 , B32B27/04 , B32B27/12
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.

15. 发明授权

US06893850B2 Method for cell patterning 有权
标题翻译：细胞图案化方法
公开(公告)号：US06893850B2
公开(公告)日：2005-05-17
申请号：US09808745
申请日：2001-03-15
申请人： Emanuele Ostuni , Ravi Kane , George M. Whitesides , Rebecca J. Jackman , David C. Duffy
发明人： Emanuele Ostuni , Ravi Kane , George M. Whitesides , Rebecca J. Jackman , David C. Duffy
IPC分类号： G01N33/48 , B01J19/00 , C12N1/00 , C12N11/06 , C40B60/14 , B32B31/00 , C12N11/08 , C12B11/14
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00427 , B01J2219/0043 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00659 , B01J2219/00743 , B82Y5/00 , C12M21/08 , C12M25/04 , C12M25/08 , C12M33/00 , C12N11/06 , C40B60/14
摘要： The present invention provides a masking system for selectively applying cells to predetermined regions of a surface. A mask is positioned adjacent to a surface to cover some portions of the surface while allowing other portions of the surface to remain uncovered. Cells then are applied to uncovered portions of the surface and the mask removed. Alternatively, a cell-adhesion promoter is applied to uncovered portions of the surface, and then cells are applied to the surface before or after removal of the mask from the surface. The masking system can be pre-coated, at least on those surfaces which will come into contact with cells, with a cell-adhesion inhibitor to resist absorption of cells and thereby avoid cell damage when the mask is removed (if cells are deposited prior to removal of the mask). A polymeric elastomeric mask that comes into cohesive-conformal contact with a surface to be patterned can be used.
摘要翻译：本发明提供了一种用于选择性地将电池施加到表面的预定区域的掩模系统。掩模邻近表面定位以覆盖表面的一些部分，同时允许表面的其它部分保持未被覆盖。然后将细胞施加到表面的未覆盖部分并除去掩模。或者，将细胞粘附促进剂施加到表面的未覆盖部分，然后在从表面除去掩模之前或之后将细胞施加到表面。掩蔽系统可以至少在与细胞接触的那些表面上预先涂覆有细胞粘附抑制剂以抵抗细胞的吸收，从而在去除掩模时避免细胞损伤（如果细胞在去除面膜）。可以使用与要图案化的表面粘合保形接触的聚合物弹性体掩模。

16. 发明授权

US06645432B1 Microfluidic systems including three-dimensionally arrayed channel networks 有权
公开(公告)号：US06645432B1
公开(公告)日：2003-11-11
申请号：US09578589
申请日：2000-05-25
申请人： Janelle R. Anderson , Oksana Cherniavskaya , Daniel T. Chiu , Rebecca J. Jackman , Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Oksana Cherniavskaya , Daniel T. Chiu , Rebecca J. Jackman , Cooper McDonald , George M. Whitesides
IPC分类号： B01L302
CPC分类号： B01L3/0258 , B01F13/0059 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/405 , B29C33/424 , B29C39/02 , B29C39/24 , B29C66/7373 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/034 , B81C2201/036 , B82Y30/00 , Y10T137/2191 , Y10T137/2224 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.

17. 发明申请

US20080122140A1 Microfluidic systems including three-dimensionally arrayed channel networks 审中-公开
标题翻译：微流体系统包括三维排列的通道网络
公开(公告)号：US20080122140A1
公开(公告)日：2008-05-29
申请号：US11983405
申请日：2007-11-08
申请人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
发明人： Janelle R. Anderson , Daniel T. Chiu , Rebecca J. Jackman , Oksana Cherniavskaya , J. Cooper McDonald , George M. Whitesides
IPC分类号： B29C35/08
CPC分类号： B29C33/3857 , B01D61/18 , B01D67/003 , B01D67/0034 , B01D69/02 , B01D71/70 , B01D2323/24 , B01D2323/34 , B01D2325/028 , B01D2325/08 , B01L3/502707 , B01L2300/0874 , B01L2300/0887 , B29C33/3892 , B29C33/52 , B29C35/0888 , B29C39/021 , B29C39/34 , B29C2035/0827 , B33Y80/00 , B81B2201/058 , B81C1/00119 , B81C2201/019 , Y10T436/11 , Y10T436/2575
摘要： The present invention provides, in certain embodiments, improved microfluidic systems and methods for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The inventive methods can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems provided according to the invention can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks of the invention can be fabricated via replica molding processes, also provided by the invention, utilizing mold masters including surfaces having topological features formed by photolithography. The microfluidic networks of the invention are, in some cases, comprised of a single replica molded layer, and, in other cases, are comprised of two, three, or more replica molded layers that have been assembled to form the overall microfluidic network structure. The present invention also describes various novel applications for using the microfluidic network structures provided by the invention.
摘要翻译：本发明在某些实施方案中提供了改进的微流体系统和用于制造包含一个或多个微流体通道水平的改进的微流体系统的方法。本发明的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。根据本发明提供的微流体系统可以包括其中流体流动路径的三维排列的网络，其中包括跨过网络的其它通道的通道，而在交叉点处没有物理交叉点。本发明的微流体网络可以通过本发明提供的复制模制工艺，利用模具主体，其包括具有通过光刻形成的拓扑特征的表面。在一些情况下，本发明的微流体网络由单个复制模制层组成，并且在其它情况下由两个，三个或更多个复制模制层组成，以形成整个微流体网络结构。本发明还描述了使用本发明提供的微流体网络结构的各种新颖应用。

18. 发明授权

US06753131B1 Transparent elastomeric, contact-mode photolithography mask, sensor, and wavefront engineering element 有权
标题翻译：透明弹性体，接触模式光刻掩模，传感器和波前工程元件
公开(公告)号：US06753131B1
公开(公告)日：2004-06-22
申请号：US09422611
申请日：1999-10-21
申请人： John A. Rogers , Rebecca J. Jackman , Kateri E. Paul , Olivier J. A. Schueller , Tricia Lynn Breen , George M. Whitesides
发明人： John A. Rogers , Rebecca J. Jackman , Kateri E. Paul , Olivier J. A. Schueller , Tricia Lynn Breen , George M. Whitesides
IPC分类号： G03C500
CPC分类号： B82Y40/00 , B82Y10/00 , G03F1/34 , G03F1/50 , G03F1/60 , G03F7/0002
摘要： A contact-mode photolithography phase mask includes a diffracting surface having a plurality of indentations and protrusions. The protrusions are brought into contact with a surface of positive photoresist, and the surface exposed to electromagnetic radiation through the phase mask. The phase shift due to radiation passing through the indentations as opposed to the protrusions is essentially complete. Minima in intensity of electromagnetic radiation are thereby produced at boundaries between the indentations and protrusions. The elastomeric mask conforms well to the surface of photoresist and, following development, features smaller than 100 nm can be obtained. Patterns including curved portions are obtained, as well as curved and/or linear patterns on non-planar surfaces. An elastomeric transparent diffraction grating serves also as a spatial light modulator photothermal detector, strain gauge, and display device. A technique for simplified photolithography is also described. A photoreactive, contoured surface is exposed to electricmagnetic radiation and contours in the surface alters the electromagnetic radiation to promote selective surface photoreaction. The contours can act as lenses, gratings, or the like, such that the photoreactive surface itself can selectively direct uniform radiation to promote selective photoreaction within itself. A photoresist layer having a contoured surface thus can be exposed to uniform radiation, without a mask, followed by development and lift-off to create a photoresist pattern that can be used in any of a variety of ways. The invention provides methods of making contoured, photoreactive surfaces, and contoured photoreactive surfaces themselves.
摘要翻译：接触模式光刻相位掩模包括具有多个凹陷和突起的衍射表面。突起与正性光致抗蚀剂的表面接触，并且表面暴露于通过相位掩模的电磁辐射。与突起相反的通过压痕的辐射的相移基本上完成。因此，在凹陷和突起之间的边界处产生电磁辐射强度的微小。弹性体掩模与光致抗蚀剂的表面相适应，并且在显影之后，可以获得小于100nm的特征。获得包括弯曲部分的图案，以及在非平面表面上的曲线和/或线性图案。弹性透明衍射光栅还用作空间光调制器光热检测器，应变计和显示装置。还描述了用于简化光刻的技术。光反应的轮廓表面暴露于电磁辐射，并且表面中的轮廓改变电磁辐射以促进选择性表面光反应。轮廓可以用作透镜，光栅等，使得光反应表面本身可以选择性地引导均匀的辐射以促进其本身内的选择性光反应。因此，具有轮廓表面的光致抗蚀剂层可以暴露于均匀的辐射，而不需要掩模，然后显影和剥离以产生可以以各种方式中的任何一种使用的光致抗蚀剂图案。本发明提供了制造轮廓，光反应表面和轮廓光反应表面本身的方法。

19. 发明授权

US5951881A Fabrication of small-scale cylindrical articles 失效
标题翻译：小型圆柱形制品的制造
公开(公告)号：US5951881A
公开(公告)日：1999-09-14
申请号：US681235
申请日：1996-07-22
申请人： John A. Rogers , Rebecca J. Jackman , George M. Whitesides
发明人： John A. Rogers , Rebecca J. Jackman , George M. Whitesides
IPC分类号： B05D1/28 , G03F7/00 , G03F7/16 , G03F7/18 , G03F7/24 , H01F41/04 , H01L22/027
CPC分类号： G02B6/02142 , B05D1/283 , B82Y30/00 , B82Y40/00 , G02B6/02138 , G03F7/00 , G03F7/161 , G03F7/18 , G03F7/24 , H01F41/042 , G02B6/02152
摘要： Techniques for fabrication of small-scale metallic structures such as microinductors, microtransformers and stents are described. A chemically active agent such as a catalyst is applied from an applicator in a pattern to an exterior surface of an article, metal is deposited according to the pattern and optionally, removed from the substrate. Where the substrate is cylindrical, the pattern can serve as a stent. Alternatively, a pattern of a self-assembled monolayer can be printed on a surface, which pattern can dictate metal plating or etching resulting in a patterned metal structure that can be cylindrical. In another embodiment, a structure is patterned on a surface that serves as a phase-modulating pattern or amplitude-modulating pattern. The article subsequently is exposed to radiation that can induce a change in refractive index within the article, and the phase-modulating or amplitude-modulating pattern results in different indices of refraction being created in different portions of the article. By this technique, a grating can be written into a core of an optical fiber.
摘要翻译：描述了微型电感器，微型变压器和支架等小型金属结构的制造技术。将化学活性剂如催化剂从涂布器以图案施加到制品的外表面，根据图案沉积金属，并任选地从基材上除去金属。在基底为圆柱形的情况下，图案可用作支架。或者，自组装单层的图案可以印刷在表面上，该图案可以规定金属电镀或蚀刻，导致可以是圆柱形的图案化金属结构。在另一个实施例中，在用作相位调制图案或幅度调制图案的表面上图案化结构。该物品随后暴露于可引起制品内的折射率变化的辐射，并且相位调制或幅度调制图案导致在制品的不同部分产生不同的折射率。通过这种技术，可以将光栅写入光纤的核心。

20. 发明授权

US06304364B1 Elastomeric light valves 失效
标题翻译：弹性光阀
公开(公告)号：US06304364B1
公开(公告)日：2001-10-16
申请号：US08873191
申请日：1997-06-11
申请人： Dong Qin , Younan Xia , George M. Whitesides
发明人： Dong Qin , Younan Xia , George M. Whitesides
IPC分类号： G02B2600
CPC分类号： B82Y30/00 , B82Y10/00 , G02B5/122 , G02B5/201 , G02B5/206 , G02B5/24
摘要： Electromagnetic radiation valves are provided. In one system, a transparent, elastomeric article is provided having a contoured surface including protrusions and intervening indentations. The contoured surface is placed adjacent a transparent plate and a void pattern defined by indentations of the contoured surface is filled with an opaque fluid. The protrusions decrease in cross-sectional area in the direction in which they extend away from the bulk of the elastomeric article, thus compression of the elastomeric protrusions against the transparent plate results in an increase in surface area in elastomeric protrusions against the transparent plate due to deformation of the protrusions, and the opaque fluid is displaced from the voids. Increased transmission of the electromagnetic radiation results. In another system, a similar elastomeric article includes an array of corner cubes that are totally internally reflective of the electromagnetic radiation. Increased deformation of the protrusions of the transparent plate results in decreased total internal reflection of light, due to the progressive destruction of the corner-cube geometry, and the passage of light is increased with compression.
摘要翻译：提供电磁辐射阀。在一个系统中，提供透明的弹性制品，其具有包括突起和中间凹口的轮廓表面。轮廓表面放置在透明板附近，并且由不规则表面的凹痕限定的空隙图案填充有不透明流体。突出部分在其远离弹性体制品的本体延伸的方向上的横截面积减小，因此弹性体突起抵靠透明板的压缩导致弹性体突出物相对于透明板的表面积增加，由于突起的变形，不透明的液体从空隙中移位。增加电磁辐射的传播结果。在另一系统中，类似的弹性体制品包括完全内反射电磁辐射的角立方体阵列。由于角立方几何形状的逐渐破坏，透明板的突起的增加变形导致光的全内反射减少，并且光的通过随着压缩而增加。

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