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1. 发明申请

US20090097808A1 Fluid waveguide and uses thereof 审中-公开
标题翻译：流体波导及其用途
公开(公告)号：US20090097808A1
公开(公告)日：2009-04-16
申请号：US11658339
申请日：2005-08-01
申请人： Daniel B. Wolfe , Kateri E. Paul , Dmitri V. Vezenov , Brian T. Mayers , Richard S. Conroy , Piotr Garstecki , Michael A. Fischbach , Valentine I. Vullev , Kam Yan Tang , Mara G. Prentiss , George M. Whitesides
发明人： Daniel B. Wolfe , Kateri E. Paul , Dmitri V. Vezenov , Brian T. Mayers , Richard S. Conroy , Piotr Garstecki , Michael A. Fischbach , Valentine I. Vullev , Kam Yan Tang , Mara G. Prentiss , George M. Whitesides
IPC分类号： G02B6/032
CPC分类号： G02B6/032 , G02B6/10 , G02B6/122
摘要： The invention relates to methods and apparatuses for guiding and emitting electromagnetic radiation from a fluid waveguide. Various methods for changing optical properties (e.g., refractive index, absorption, and fluorescence) and/or physical properties (e.g., magnetic susceptibility, electrical conductivity, and temperature) of either the waveguide core or the cladding, or both, are provided herein. In one embodiment, electromagnetic radiation is guided and/or emitted at multiple distinct wavelengths, including emission in the form of an essentially continuous band, in some cases covering at least 150 nanometers. In another embodiment, methods for splitting a waveguide core and/or the joining of at least two waveguide cores in a waveguide are provided. In yet another embodiment, the invention includes the use of thermal gradients to generate a waveguide and/or to change the properties of waveguides. Embodiments of the waveguides may be used for optical detection or spectroscopic analysis.
摘要翻译：本发明涉及用于引导和发射来自流体波导的电磁辐射的方法和装置。本文提供用于改变波导芯或包层或两者的光学性质（例如，折射率，吸收和荧光）和/或物理性质（例如磁化率，导电性和温度）的各种方法。在一个实施例中，电磁辐射是以多个不同的波长被引导和/或发射的，包括基本连续带形式的发射，在某些情况下覆盖至少150纳米。在另一个实施例中，提供了用于在波导中分离波导芯和/或至少两个波导芯的接合的方法。在另一个实施例中，本发明包括使用热梯度来产生波导和/或改变波导的性质。波导的实施例可以用于光学检测或光谱分析。

2. 发明申请

US20100172803A1 METHOD AND APPARATUS FOR FLUID DISPERSION 有权
标题翻译：流体分散方法及装置
公开(公告)号：US20100172803A1
公开(公告)日：2010-07-08
申请号：US12726223
申请日：2010-03-17
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

3. 发明授权

US08337778B2 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US08337778B2
公开(公告)日：2012-12-25
申请号：US12726223
申请日：2010-03-17
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

4. 发明授权

US08986628B2 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US08986628B2
公开(公告)日：2015-03-24
申请号：US13679190
申请日：2012-11-16
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren Roy Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow R. Diluzio , George M. Whitesides
IPC分类号： B01L3/00 , B01F3/08 , B01F5/06 , B01F13/00 , B05B7/04
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

5. 发明授权

US07708949B2 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US07708949B2
公开(公告)日：2010-05-04
申请号：US11024228
申请日：2004-12-28
申请人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
发明人： Howard A. Stone , Shelley L. Anna , Nathalie Bontoux , Darren R. Link , David A. Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George M. Whitesides
IPC分类号： B01L3/02 , G01N11/04 , B01L99/00 , G05D7/00
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

6. 发明申请

US20060280029A1 Microfluidic mixer 审中-公开
标题翻译：微流控搅拌机
公开(公告)号：US20060280029A1
公开(公告)日：2006-12-14
申请号：US11151738
申请日：2005-06-13
申请人： Piotr Garstecki , Michael Fischbach , George Whitesides
发明人： Piotr Garstecki , Michael Fischbach , George Whitesides
IPC分类号： B01F5/00 , B81B1/00
CPC分类号： B01F13/0059 , B01F5/064
摘要： The present invention relates generally to microfluidic systems and, more specifically, to apparatuses and methods associated with mixing in microfluidic systems. In some embodiments, a mixer is constructed and arranged to mix at least a portion of a first and a second fluid component. The mixer may include a channel having an inlet that separates into at least two branches, the branches then recombining into a single outlet. In some cases, plugs of fluid (e.g., a gas) are flowed into the branches, which causes changes in resistance, and thus the amount of fluid flow, in each of the branches. The motion of the plugs through the network of branched channels can create unsteady mixing flows. For instance, for two fluid components, e.g., two streams of fluid flowing laminarly in the channel, these changes in resistance can cause the crossing of laminar streamlines of the fluid, which can lead to exponential stretching and folding of the interface between the two unmixed streams.
摘要翻译：本发明一般涉及微流体系统，更具体地涉及与微流体系统中的混合有关的装置和方法。在一些实施例中，混合器被构造和布置成混合第一和第二流体组分的至少一部分。混合器可以包括具有分离成至少两个分支的入口的通道，然后分支重新组合成单个出口。在一些情况下，流体（例如气体）的塞子流入分支，这导致每个分支中的阻力变化，从而导致流体流量的变化。插塞通过分支通道网络的运动可能产生不稳定的混合流。例如，对于两个流体部件，例如在通道中层流的两股流体流，这些阻力变化可导致流体的层流流线的交叉，这可导致两个未混合的界面的指数拉伸和折叠流。

7. 发明申请

US20060234051A1 System and method of obtaining entrained cylindrical fluid flow 审中-公开
标题翻译：获得夹带圆柱形流体流动的系统和方法
公开(公告)号：US20060234051A1
公开(公告)日：2006-10-19
申请号：US11341096
申请日：2006-01-27
申请人： Wendy Zhang , Eric Ginsburg , Alfonso Calvo , Jose Lopez-Herrera , Pascual Riesco-Chueca , Miguel-Angel Herrada-Gutierrez , Piotr Garstecki
发明人： Wendy Zhang , Eric Ginsburg , Alfonso Calvo , Jose Lopez-Herrera , Pascual Riesco-Chueca , Miguel-Angel Herrada-Gutierrez , Piotr Garstecki
IPC分类号： D02G3/00
CPC分类号： D01D5/098 , Y10T428/2929 , Y10T428/2931
摘要： A method and system for entraining fluids is provided. The method and system may be used to create filaments. As one example, a filament may be produced by entraining a first fluid within a second fluid by flowing a third fluid, the flowing third fluid at least partly constraining the second fluid in at least one dimension. As another example, a filament may be produced by entraining a first fluid within a second fluid based on a model of a dynamic response of the first and second fluids as functions of densities of the first and second fluids, viscosities of the first and second fluids, Reynolds numbers of the first and second fluids, and Weber numbers of the first and second fluids.
摘要翻译：提供了一种夹带流体的方法和系统。该方法和系统可用于产生长丝。作为一个示例，可以通过使第三流体流动而将第一流体夹带在第二流体内来产生丝束，流动的第三流体至少部分地限制第二流体至少一个维度。作为另一示例，可以通过基于第一和第二流体的动态响应的模型将第一流体夹带在第二流体内，作为第一和第二流体的密度的函数，第一和第二流体的粘度，第一和第二流体的雷诺数，以及第一和第二流体的韦伯数。

8. 发明申请

US20140147908A1 METHOD FOR SPLITTING DROPLETS ON DEMAND IN MICROFLUIDIC JUNCTION 审中-公开
标题翻译：在微流体结中分散滴剂的方法
公开(公告)号：US20140147908A1
公开(公告)日：2014-05-29
申请号：US14235448
申请日：2012-07-25
申请人： Slawomir Jakiela , Tomasz Kaminski , Piotr Garstecki
发明人： Slawomir Jakiela , Tomasz Kaminski , Piotr Garstecki
IPC分类号： G01N1/28 , C12N1/20
CPC分类号： G01N1/28 , B01L3/502784 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , C12M23/16 , C12M25/01 , C12N1/20 , Y10T137/0324
摘要： The invention relates to a method for splitting droplets on demand in a microfluidic junction, comprising the supply channel, the first drain channel and the second drain channel, the method comprises the following steps: a. delivering a droplet (1) to the said microfluidic junction (3) through said supply channel (2) by means of a flow of continuous liquid through the supply channel (2) and said first drain channel, b. stopping the flow in said first drain channel and opening the flow in said second drain channel until a fraction (7) of the droplet (1) is present in the second drain channel, c. resuming the flow in the first drain channel and closing the flow in the second drain channel, at least until the fraction (7) of the said droplet (1) being present in the first drain channel separates from the rest of the droplet.
摘要翻译：本发明涉及一种用于在微流体结中按需分解液滴的方法，包括供给通道，第一排水通道和第二排水通道，该方法包括以下步骤：a。 b。将液滴（1）通过所述供应通道（2）通过供应通道（2）和所述第一排水通道b的连续液体流输送到所述微流体结（3）。停止在所述第一排水通道中的流动并打开所述第二排水通道中的气流，直到液滴（1）的一部分（7）存在于第二排水通道中。恢复第一排水通道中的流动并关闭第二排水通道中的流动，至少直到存在于第一排水通道中的所述液滴（1）的分数（7）与液滴的其余部分分离。

9. 发明申请

US20050172476A1 Method and apparatus for fluid dispersion 有权
标题翻译：流体分散方法和装置
公开(公告)号：US20050172476A1
公开(公告)日：2005-08-11
申请号：US11024228
申请日：2004-12-28
申请人： Howard Stone , Shelley Anna , Nathalie Bontoux , Darren Link , David Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George Whitesides
发明人： Howard Stone , Shelley Anna , Nathalie Bontoux , Darren Link , David Weitz , Irina Gitlin , Eugenia Kumacheva , Piotr Garstecki , Willow Diluzio , George Whitesides
IPC分类号： B01F3/08 , B01F5/06 , B01F13/00 , B01L3/00 , B05B7/04 , B01D61/42
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

10. 发明申请

US20150079617A1 METHOD FOR DETERMINING BIOCHEMICAL PARAMETERS OF A BODY FLUID 审中-公开
标题翻译：测定体液生物化学参数的方法
公开(公告)号：US20150079617A1
公开(公告)日：2015-03-19
申请号：US14359184
申请日：2012-09-12
申请人： Piotr Garstecki , Marcin Izydorzak , Magdalena Sulima , Adam Warchulski
发明人： Piotr Garstecki , Marcin Izydorzak , Magdalena Sulima , Adam Warchulski
IPC分类号： G01N21/75
CPC分类号： G01N21/75 , B01L3/502707 , B01L3/502784 , B01L3/502792 , B01L2200/0673 , B01L2300/0816 , B01L2300/12
摘要： The invention relates to a method for determining biochemical parameters of a body fluid, wherein a sample of said body fluid in the form of a droplet is transported through a channel of a microfluidic system using a carrier liquid, mixed with a reagent thus initiating a chemical reaction between the sample and the reagent, and the result of the chemical reaction is measured, preferably with a spectrophotometer, whereby the said biochemical parameters of the body fluid are determined, characterised in that the material used for fabrication of the microfluidic system and the said carrier liquid is pair of Teflon and Fluorinert HFE-7100.
摘要翻译：本发明涉及一种用于确定体液生物化学参数的方法，其中以液滴形式的所述体液样品通过载体液体通过微流体系统的通道输送，从而与试剂混合从而引发化学物质测量样品和试剂之间的反应，并且优选用分光光度计测量化学反应的结果，由此确定体液的所述生物化学参数，其特征在于用于制造微流体系统的材料和所述载体液体是一对特氟龙和Fluorinert HFE-7100。

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