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11. 发明授权

US07653431B2 Arrhythmia discrimination based on determination of rate dependency 有权
标题翻译：基于速率依赖性确定的心律失常辨别
公开(公告)号：US07653431B2
公开(公告)日：2010-01-26
申请号：US11312280
申请日：2005-12-20
申请人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
发明人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/7264
摘要： Cardiac systems and methods provide for discriminating between supraventricular tachyarrhythmia and ventricular tachyarrhythmia based on a determination that the patient's supraventricular rhythm exhibits rate dependency. One approach involves determining if a patient's supraventricular rhythm exhibits rate dependent morphology. If the patient's supraventricular rhythm is determined to exhibit rate dependent morphology, an implantable device classifies a detected tachyarrhythmia episode based on one or more templates selected from a plurality of rate-indexed templates stored in the device. Determining if the supraventricular rhythm exhibits rate dependent morphology may also include determining one or more rates at which the rate dependent morphology occurs.
摘要翻译：心脏系统和方法基于确定患者的室上节律表现出速率依赖性，确定了室上性快速性心律失常与室性快速性心律失常之间的区别。一种方法涉及确定患者的室上节律是否表现出速率依赖性形态。如果确定患者的室上节律表现出与速率相关的形态，则可植入装置基于从存储在装置中的多个速率索引模板中选择的一个或多个模板来分类检测到的快速性心律失常发作。确定室性心律显示出速率依赖性形态还可以包括确定发生速率依赖形态的一个或多个速率。

12. 发明申请

US20070142737A1 Arrhythmia discrimination based on determination of rate dependency 有权
标题翻译：基于速率依赖性确定的心律失常辨别
公开(公告)号：US20070142737A1
公开(公告)日：2007-06-21
申请号：US11312280
申请日：2005-12-20
申请人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
发明人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/7264
摘要： Cardiac systems and methods provide for discriminating between supraventricular tachyarrhythmia and ventricular tachyarrhythmia based on a determination that the patient's supraventricular rhythm exhibits rate dependency. One approach involves determining if a patient's supraventricular rhythm exhibits rate dependent morphology. If the patient's supraventricular rhythm is determined to exhibit rate dependent morphology, an implantable device classifies a detected tachyarrhythmia episode based on one or more templates selected from a plurality of rate-indexed templates stored in the device. Determining if the supraventricular rhythm exhibits rate dependent morphology may also include determining one or more rates at which the rate dependent morphology occurs.
摘要翻译：心脏系统和方法基于确定患者的室上节律表现出速率依赖性，确定了室上性快速性心律失常与室性快速性心律失常之间的区别。一种方法涉及确定患者的室上节律是否表现出速率依赖性形态。如果确定患者的室上节律表现出与速率相关的形态，则可植入装置基于从存储在装置中的多个速率索引模板中选择的一个或多个模板来分类检测到的快速性心律失常发作。确定室性心律显示出速率依赖性形态还可以包括确定发生速率依赖形态的一个或多个速率。

13. 发明申请

US20090306486A1 SENSING VECTOR CONFIGURATION IN ICD TO ASSIST ARRHYTHMIA DETECTION AND ANNOTATION 有权
标题翻译： ICD中的感应矢量配置，以帮助ARRHYTHMIA检测和报告
公开(公告)号：US20090306486A1
公开(公告)日：2009-12-10
申请号：US12478476
申请日：2009-06-04
申请人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
发明人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
IPC分类号： A61B5/046 , A61B5/02 , A61B5/0464
CPC分类号： A61B5/0464 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61N1/3622 , A61N1/3702
摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.
摘要翻译：一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，到心脏信号感测电路。所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定是否快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

14. 发明授权

US08285371B2 Dynamic selection of algorithms for arrhythmia detection 有权
标题翻译：动态选择心律失常检测算法
公开(公告)号：US08285371B2
公开(公告)日：2012-10-09
申请号：US12754955
申请日：2010-04-06
申请人： Dan Li , Jaeho Kim , Julie A. Thompson , Arjun Sharma
发明人： Dan Li , Jaeho Kim , Julie A. Thompson , Arjun Sharma
IPC分类号： A61B5/02
CPC分类号： A61B5/0215 , A61B5/0008 , A61B5/024 , A61B5/0245 , A61B5/029 , A61B5/053 , A61B5/1455 , A61B5/7264 , A61B7/00 , A61N1/3621 , A61N1/36521 , A61N1/3655 , A61N1/36557 , A61N1/36578 , A61N1/36592 , A61N1/3702 , A61N1/3962
摘要： An apparatus comprises a first implantable sensor produces a first electrical sensor signal representative of cardiac depolarization events of a heart of a subject, a second implantable sensor that produces a second electrical sensor signal representative of hemodynamic function of the heart, a signal analyzer circuit, and an arrhythmia discrimination circuit. The signal analyzer circuit detects an arrhythmic event from the first sensor signal and calculates hemodynamic stability in response to the arrhythmic event detection using the second sensor signal. The arrhythmia discrimination circuit selects, according to a calculated hemodynamic stability produced by the signal analyzer circuit, an arrhythmia discrimination algorithm from among a plurality of candidate arrhythmia discrimination algorithms that are implementable by the arrhythmia discrimination circuit, classifies the detected arrhythmia using the selected arrhythmia discrimination algorithm, and provides the arrhythmia classification to a user or process.
摘要翻译：一种装置包括第一可植入传感器产生代表受试者心脏的心脏去极化事件的第一电传感器信号，产生代表心脏的血液动力学功能的第二电传感器信号的第二可植入传感器，信号分析仪电路和心律失常鉴别电路。信号分析器电路检测来自第一传感器信号的心律不齐事件，并且响应于使用第二传感器信号的心律不齐事件检测来计算血流动力学稳定性。心律失常鉴别电路根据由信号分析仪电路产生的计算出的血液动力学稳定性选择可由心律失常鉴别电路实施的多种候选心律失常辨别算法中的心律失常鉴别算法，使用选择的心律失常辨别对所检测到的心律失常进行分类算法，并向用户或进程提供心律失常分类。

15. 发明申请

US20120215273A1 METHOD AND APPARATUS FOR CONCURRENT ATRIO-VENTRICULAR ANTI-TACHYCARDIA PACING 有权
标题翻译：相关性ATRIO-VENTRICULAR ANTI-TACHYCARDIA PACING的方法和装置
公开(公告)号：US20120215273A1
公开(公告)日：2012-08-23
申请号：US13457630
申请日：2012-04-27
申请人： Dan Li , Jaeho Kim , Joseph M. Bocek
发明人： Dan Li , Jaeho Kim , Joseph M. Bocek
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/3688
摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.
摘要翻译：植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式，根据检测到的快速性心律失常的特点。并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间心房和心室起搏脉冲同时传递，但可以独立计时。

16. 发明授权

US08170669B2 Method and apparatus for concurrent atrio-ventricular anti-tachycardia pacing 有权
标题翻译：并发房室性心动过速起搏方法及装置
公开(公告)号：US08170669B2
公开(公告)日：2012-05-01
申请号：US12234840
申请日：2008-09-22
申请人： Dan Li , Jaeho Kim , Joseph M. Bocek
发明人： Dan Li , Jaeho Kim , Joseph M. Bocek
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/3688
摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.
摘要翻译：植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式，根据检测到的快速性心律失常的特点。并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间心房和心室起搏脉冲同时传递，但可以独立计时。

17. 发明授权

US07904142B2 Self-adjusting ECG morphological feature correlation threshold 有权
标题翻译：自适应心电图形态特征相关阈值
公开(公告)号：US07904142B2
公开(公告)日：2011-03-08
申请号：US11749283
申请日：2007-05-16
申请人： Jaeho Kim , Joseph M. Bocek , Dan Li
发明人： Jaeho Kim , Joseph M. Bocek , Dan Li
IPC分类号： A61B5/0402
CPC分类号： A61B5/0422 , A61N1/3622 , A61N1/3931 , A61N1/3962
摘要： An apparatus comprising an implantable cardiac signal sensing circuit configured for sensing an intrinsic cardiac signal, a memory to store a template of a morphology of normal atrial-ventricular conduction, and a controller that includes a tachyarrhythmia detection circuit and a correlation circuit. The tachyarrhythmia detection circuit is configured for detecting a rhythm with elevated ventricular rate using the sensed intrinsic cardiac signal. The correlation circuit is configured for iteratively calculating a correlation between the sensed intrinsic cardiac signal and the template, and comparing the calculated correlation to a variable correlation threshold to determine whether the detected rhythm correlates to the template. The apparatus also includes a therapy circuit configured for inhibiting a ventricular tachycardia therapy when the detected rhythm correlates to the template. Other apparatuses and methods are described.
摘要翻译：一种装置，包括被配置为感测本征心脏信号的可植入心脏信号感测电路，存储器以存储正常心室传导形态的模板，以及包括快速性心律失常检测电路和相关电路的控制器。快速心律失常检测电路被配置为使用感测到的本征心脏信号来检测具有升高的心室率的节律。相关电路被配置为迭代地计算所感测的本征心脏信号与模板之间的相关性，并将所计算的相关性与可变相关阈值进行比较，以确定检测到的节律是否与模板相关。该装置还包括治疗电路，其被配置为当检测到的节律与模板相关时抑制室性心动过速治疗。描述其他设备和方法。

18. 发明申请

US20100274146A1 DYNAMIC SELECTION OF ALGORITHMS FOR ARRHYTHMIA DETECTION 有权
标题翻译：动态选择ARRHYTHMIA检测算法
公开(公告)号：US20100274146A1
公开(公告)日：2010-10-28
申请号：US12754955
申请日：2010-04-06
申请人： Dan Li , Jaeho Kim , Julie A. Thompson , Arjun Sharma
发明人： Dan Li , Jaeho Kim , Julie A. Thompson , Arjun Sharma
IPC分类号： A61B5/0452
CPC分类号： A61B5/0215 , A61B5/0008 , A61B5/024 , A61B5/0245 , A61B5/029 , A61B5/053 , A61B5/1455 , A61B5/7264 , A61B7/00 , A61N1/3621 , A61N1/36521 , A61N1/3655 , A61N1/36557 , A61N1/36578 , A61N1/36592 , A61N1/3702 , A61N1/3962
摘要： An apparatus comprises a first implantable sensor produces a first electrical sensor signal representative of cardiac depolarization events of a heart of a subject, a second implantable sensor that produces a second electrical sensor signal representative of hemodynamic function of the heart, a signal analyzer circuit, and an arrhythmia discrimination circuit. The signal analyzer circuit detects an arrhythmic event from the first sensor signal and calculates hemodynamic stability in response to the arrhythmic event detection using the second sensor signal. The arrhythmia discrimination circuit selects, according to a calculated hemodynamic stability produced by the signal analyzer circuit, an arrhythmia discrimination algorithm from among a plurality of candidate arrhythmia discrimination algorithms that are implementable by the arrhythmia discrimination circuit, classifies the detected arrhythmia using the selected arrhythmia discrimination algorithm, and provides the arrhythmia classification to a user or process.
摘要翻译：一种装置包括第一可植入传感器产生代表受试者心脏的心脏去极化事件的第一电传感器信号，产生代表心脏的血液动力学功能的第二电传感器信号的第二可植入传感器，信号分析仪电路和心律失常鉴别电路。信号分析器电路检测来自第一传感器信号的心律不齐事件，并且响应于使用第二传感器信号的心律不齐事件检测来计算血流动力学稳定性。心律失常鉴别电路根据由信号分析仪电路产生的计算出的血液动力学稳定性选择可由心律失常鉴别电路实施的多种候选心律失常辨别算法中的心律失常鉴别算法，使用选择的心律失常辨别对所检测到的心律失常进行分类算法，并向用户或进程提供心律失常分类。

19. 发明授权

US08620429B2 Method and apparatus for concurrent atrio-ventricular anti-tachycardia pacing 有权
标题翻译：并发房室性心动过速起搏方法及装置
公开(公告)号：US08620429B2
公开(公告)日：2013-12-31
申请号：US13457630
申请日：2012-04-27
申请人： Dan Li , Jaeho Kim , Joseph M. Bocek
发明人： Dan Li , Jaeho Kim , Joseph M. Bocek
IPC分类号： A61N1/39
CPC分类号： A61N1/3621 , A61N1/368 , A61N1/3688
摘要： An implantable medical device delivers anti-tachyarrhythmia therapies including anti-tachycardia pacing (ATP). If a detected tachyarrhythmia is classified as a type suitable for treatment using ATP, the implantable medical device selects one of an atrial ATP (A-ATP) mode, a ventricular ATP (V-ATP) mode, and a concurrent atrio-ventricular ATP (concurrent AV-ATP) mode according to the characteristics of the detected tachyarrhythmia. The concurrent ATP mode is an ATP mode during which the atrial pacing pulses and the ventricular pacing pulses are delivered concurrently. In one embodiment, the concurrent AV-ATP mode includes a synchronized atrio-ventricular ATP (synchronized AV-ATP) mode during which atrial and ventricular pacing pulses are delivered synchronously and an independent atrio-ventricular ATP (independent AV-ATP) mode during which atrial and ventricular pacing pulses are delivered concurrently but timed independently.
摘要翻译：植入式医疗装置提供抗心律失常疗法，包括抗心动过速起搏（ATP）。如果检测到的快速性心律失常被分类为适合于使用ATP治疗的类型，则可植入医疗装置选择心房ATP（A-ATP）模式，心室ATP（V-ATP）模式和并发心室ATP 并发AV-ATP）模式根据检测到的快速性心律失常的特点。并发ATP模式是ATP模式，其中心房起搏脉冲和心室起搏脉冲同时传递。在一个实施方案中，并发的AV-ATP模式包括同步的心房ATP（同步的AV-ATP）模式，其中同步递送心房和心室起搏脉冲以及独立的心房ATP（独立的AV-ATP）模式，在此期间心房和心室起搏脉冲同时传递，但可以独立计时。

20. 发明授权

US08401628B2 Sensing vector configuration in ICD to assist arrhythmia detection and annotation 有权
标题翻译：感应ICD中的矢量配置，以协助心律失常检测和注释
公开(公告)号：US08401628B2
公开(公告)日：2013-03-19
申请号：US12478476
申请日：2009-06-04
申请人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
发明人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
IPC分类号： A61B5/024
CPC分类号： A61B5/0464 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61N1/3622 , A61N1/3702
摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.
摘要翻译：一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，其通信耦合到心脏信号感测电路。所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。

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