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11. 发明申请

US20080137172A1 ARRAY OF GRADUATED PRE-TILTED MEMS MIRRORS 审中-公开
标题翻译：研磨抛光MEMS微镜阵列
公开(公告)号：US20080137172A1
公开(公告)日：2008-06-12
申请号：US11567723
申请日：2006-12-06
申请人： Bryan P. Staker , Andres Fernandez , Windsor E. Owens , Alexander P. Kindwall
发明人： Bryan P. Staker , Andres Fernandez , Windsor E. Owens , Alexander P. Kindwall
IPC分类号： G02B26/00
CPC分类号： G02B6/3556 , G02B6/357 , G02B26/0841
摘要： An array of MEMS devices is formed on a planar substrate having in each of a plurality of annular regions or sectors a plurality of MEMS mirrors of substantially identical structure, wherein the MEMS mirrors in each region have an identical pre-tilt. The pre-tilt is achieved by embedding each dual-axis tiltable mirror within a pre-tilted microplatform or gimbal. In a specific embodiment, one microplatform of a preselected pre-tilt is provided for each micromirror and an underlying electrode is provided having a shape conforming with the pre-tilt. In a specific embodiment, the annular regions are contiguous elliptical or ovoidal regions. By pre-tilt, it is meant that the rest state or nonactuated state of the micro-mirror is such that a reflected beam from a fixed source is directed to the center of a target array.
摘要翻译：在平面基板上形成MEMS器件的阵列，其具有在多个环形区域或扇区中的每一个中具有基本相同结构的多个MEMS反射镜，其中每个区域中的MEMS反射镜具有相同的预倾斜。预倾斜是通过将每个双轴可倾斜镜嵌入预倾斜的微平台或万向节来实现的。在具体实施例中，为每个微反射镜提供预选的预倾角的一个微平台，并且提供具有与预倾斜一致的形状的底层电极。在具体实施例中，环形区域是相邻的椭圆形或椭圆形区域。通过预倾斜，意味着微镜的静止状态或非激活状态使得来自固定源的反射光束被引导到目标阵列的中心。

12. 发明授权

US06791742B2 MEMS structure with raised electrodes 有权
公开(公告)号：US06791742B2
公开(公告)日：2004-09-14
申请号：US10700734
申请日：2003-11-03
申请人： Bryan P. Staker , Lawrence P. Muray , Andres Fernandez
发明人： Bryan P. Staker , Lawrence P. Muray , Andres Fernandez
IPC分类号： G02B2600
CPC分类号： G02B26/0841 , B81B3/0086 , B81B2201/042
摘要： In an electrostatically controlled deflection apparatus, such as a MEMS array having cavities formed around electrodes and which is mounted directly on a dielectric or controllably resistive substrate in which are embedded electrostatic actuation electrodes disposed in alignment with the individual MEMS elements, a mechanism is provided to mitigate the effects of uncontrolled dielectric surface potentials between the MEMS elements and the electrostatic actuation electrodes, the mechanism being raised electrodes relative to the dielectric or controllably resistive surface of the substrate. The aspect ratio of the gaps between elements (element height to element separation ratio) is at least 0.1 and preferably at least 0.5 and preferably between 0.75 and 2.0 with a typical choice of about 1.0, assuming a surface fill factor of 50% or greater. Higher aspect ratios at these fill factors are believed not to provide more than marginal improvement.

13. 发明申请

US20120099852A1 METHOD AND SYSTEM FOR IMAGING HIGH DENSITY BIOCHEMICAL ARRAYS WITH SUB-PIXEL ALIGNMENT 有权
标题翻译：用于用子像素对准成像高密度生物化学阵列的方法和系统
公开(公告)号：US20120099852A1
公开(公告)日：2012-04-26
申请号：US12912641
申请日：2010-10-26
申请人： Bryan P. Staker , Craig E. Uhrich
发明人： Bryan P. Staker , Craig E. Uhrich
IPC分类号： G02B21/36 , H04N17/00
CPC分类号： G02B21/365 , G01B11/272 , G02B21/002 , G02B21/025 , G02B21/361 , H04N5/37206 , H04N7/18
摘要： A system and associated method for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays.
摘要翻译：用于对高密度生物化学阵列进行成像的系统和相关方法包括共享共同物镜的一个或多个成像通道和具有光学对准机构的相应的一个或多个时间延迟积分型成像相机，其允许独立的通道间和通道内四度调整：X，Y，旋转和刻度。成像通道被配置为独立地检查生物化学阵列的图像的不同光谱。

14. 发明申请

US20120224050A1 HIGH-DENSITY BIOCHEMICAL ARRAY CHIPS 有权
标题翻译：高密度生物化学阵列
公开(公告)号：US20120224050A1
公开(公告)日：2012-09-06
申请号：US13221648
申请日：2011-08-30
申请人： Bryan P. Staker
发明人： Bryan P. Staker
IPC分类号： H04N7/18 , C40B40/06
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00531 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , C40B20/02 , G01N21/6428 , G01N21/6458
摘要： An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.
摘要翻译：提供了一种可用于生物化学测定的阵列芯片，其中芯片包括根据第一间距布置有附接位置的场区域和至少一个具有根据第二节距排列的一维点图案的轨道区域，该第二间距不太密集，第一节距的非整数倍，使得可以在轨道区域中施加一维莫尔平均，从而以更高密度的附着位置实现芯片与光学仪器的对准。

15. 发明授权

US06917733B1 Three-dimensional optical switch with offset input-output ports 有权
标题翻译：具有偏移输入输出端口的三维光开关
公开(公告)号：US06917733B1
公开(公告)日：2005-07-12
申请号：US10406947
申请日：2003-04-03
申请人： Eugene W. Campbell , Bryan P. Staker
发明人： Eugene W. Campbell , Bryan P. Staker
IPC分类号： G02B6/35
CPC分类号： G02B6/3556 , G02B6/3512
摘要： An optical switch globally minimizes maximum tilt angles used to route optical signals from input to output by disposition of an input array of first tiltable micromirrors within a first boundary typically having top-bottom reflection symmetry and left-right reflection symmetry and by disposition of an output array of second tiltable micromirrors within a second boundary a symmetry which matches the symmetry for the input array, the output array and the input array being disposed opposing one another and normal to parallel central axes and further being offset from one another in the plane of the normals to the arrays, so that a collimated beamlet impinging on the center the input array and reflected off at an equivalent angle intersects the output array at an offset.
摘要翻译：光学开关全局地最小化用于通过在通常具有顶部底部反射对称性和左右反射对称性的第一边界内的第一可倾斜微反射器的输入阵列的布置和通过布置输出来将输入到输出的光信号路由到的最大倾斜角度最小化在第二边界内的第二可倾斜微镜的阵列，其对应于输入阵列的对称性，输出阵列和输入阵列被布置为彼此相对并垂直于平行的中心轴，并且还在第二边界的平面中彼此偏移使阵列上的准直子束入射到输入阵列的中心并以等效的角度反射，与偏移的输出阵列相交。

16. 发明授权

US5661592A Method of making and an apparatus for a flat diffraction grating light valve 失效
$Method of making and an apparatus for a flat diffraction grating light valve$
标题翻译：制造方法和平面衍射光栅光阀的装置
公开(公告)号：US5661592A
公开(公告)日：1997-08-26
申请号：US480459
申请日：1995-06-07
申请人： Jonathan G. Bornstein , William C. Banyai , David M. Bloom , Ralph G. Whitten , Bryan P. Staker
发明人： Jonathan G. Bornstein , William C. Banyai , David M. Bloom , Ralph G. Whitten , Bryan P. Staker
IPC分类号： G02B5/18 , G02B26/08 , G02B26/00
CPC分类号： G02B5/1828 , G02B26/0808 , Y10S359/904
摘要： A deformable grating aparatus for modulating light is made by forming an insulating layer on a substrate, forming a first conductive layer on the insulating layer and then forming a sacrificial layer thereon. The sacrificial layer and the first conducting layer are then etched to define bit lines and busses to bonding pads. Then a layer of resilient material is formed onto the etched layers and a reflective conducting layer is formed on the resilient layer. A dielectric layer is deposited on the reflective conducting layer. The dielectric layer, the reflective conducting layer, the resilient layer and the sacrificial layer are all then etched to form a grating including a plurality of parallel elements. Thereafter the sacrificial layer is removed below the parallel elements, to suspend the parallel elements over the first conducting layer. The surface is treated to prevent the grating from adhering to the first conducting layer. A light modulator includes a substrate with an insulating layer, and a plurality of parallel conductive layers formed on the insulating layer. The ribbons are spaced apart from the conductive layers by an air space and mounted to the substrate in gaps between the conductive layers.
摘要翻译：通过在衬底上形成绝缘层，在绝缘层上形成第一导电层，然后在其上形成牺牲层，制成用于调制光的可变形光栅装置。然后蚀刻牺牲层和第一导电层以将位线和总线限定到接合焊盘。然后在蚀刻层上形成一层弹性材料，并在弹性层上形成反射导电层。电介质层沉积在反射导电层上。然后对电介质层，反射导电层，弹性层和牺牲层进行蚀刻以形成包括多个平行元件的光栅。此后，牺牲层在平行元件下方被移除，以将平行元件悬挂在第一导电层上。处理表面以防止光栅粘附到第一导电层。光调制器包括具有绝缘层的衬底和形成在绝缘层上的多个平行导电层。带通过空气间隔与导电层间隔开，并且在导电层之间的间隙中安装到基板上。

17. 发明授权

US09671344B2 High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging 有权
公开(公告)号：US09671344B2
公开(公告)日：2017-06-06
申请号：US13221648
申请日：2011-08-30
申请人： Bryan P. Staker
发明人： Bryan P. Staker
IPC分类号： G01N33/00 , G01N21/64 , B01J19/00 , C40B20/02
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00531 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , C40B20/02 , G01N21/6428 , G01N21/6458
摘要： An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.

18. 发明申请

US20120200692A1 METHOD AND SYSTEM FOR IMAGING HIGH DENSITY BIOCHEMICAL ARRAYS WITH SUB-PIXEL ALIGNMENT 有权
标题翻译：用于用子像素对准成像高密度生物化学阵列的方法和系统
公开(公告)号：US20120200692A1
公开(公告)日：2012-08-09
申请号：US13451678
申请日：2012-04-20
申请人： Bryan P. Staker , Craig E. Uhrich
发明人： Bryan P. Staker , Craig E. Uhrich
IPC分类号： H04N7/18
CPC分类号： G02B21/365 , G01B11/272 , G02B21/002 , G02B21/025 , G02B21/361 , H04N5/37206 , H04N7/18
摘要： A method and associated system for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays.
摘要翻译：用于高密度生物化学阵列成像的方法和相关系统包括共享共同物镜的一个或多个成像通道和具有光学对准机构的相应的一个或多个时间延迟积分型成像相机，其允许独立的通道间和通道内四度调整：X，Y，旋转和刻度。成像通道被配置为独立地检查生物化学阵列的图像的不同光谱。

19. 发明授权

US08175452B1 Method and system for imaging high density biochemical arrays with sub-pixel alignment 有权
标题翻译：用于对具有亚像素对准的高密度生物化学阵列进行成像的方法和系统
公开(公告)号：US08175452B1
公开(公告)日：2012-05-08
申请号：US12912641
申请日：2010-10-26
申请人： Bryan P. Staker , Craig E. Uhrich
发明人： Bryan P. Staker , Craig E. Uhrich
IPC分类号： G02B21/36
CPC分类号： G02B21/365 , G01B11/272 , G02B21/002 , G02B21/025 , G02B21/361 , H04N5/37206 , H04N7/18
摘要： A system and associated method for imaging high density biochemical arrays comprises one or more imaging channels that share a common objective lens and a corresponding one or more time delay integration-type imaging cameras with optical alignment mechanisms that permit independent inter-channel and intra-channel adjustment of each of four degrees: X, Y, rotation and scale. The imaging channels are configured to independently examine different spectra of the image of the biochemical arrays.
摘要翻译：用于对高密度生物化学阵列进行成像的系统和相关方法包括共享共同物镜的一个或多个成像通道和具有光学对准机构的相应的一个或多个时间延迟积分型成像相机，其允许独立的通道间和通道内四度调整：X，Y，旋转和刻度。成像通道被配置为独立地检查生物化学阵列的图像的不同光谱。

20. 发明申请

US20110268347A1 METHOD AND SYSTEM FOR ACCURATE ALIGNMENT AND REGISTRATION OF ARRAY FOR DNA SEQUENCING 有权
标题翻译：用于DNA序列的精确对准和阵列注册的方法和系统
公开(公告)号：US20110268347A1
公开(公告)日：2011-11-03
申请号：US13092618
申请日：2011-04-22
申请人： Bryan P. Staker
发明人： Bryan P. Staker
IPC分类号： G06K9/00 , C40B60/10
CPC分类号： C12Q1/6874 , G06K9/32 , G06K9/42 , G06K2209/07 , G06T7/0012 , G06T7/32 , G06T7/337 , G06T7/74 , G06T2207/10056 , G06T2207/30072
摘要： In a genome sequencing system and methodology, a protocol is provided to achieve precise alignment and accurate registration of an image of a planar array of nanoballs subject to optical analysis. Precise alignment correcting for fractional offsets is achieved by correcting for errors in subperiod x-y offset, scale and rotation by use of minimization techniques and Moiré averaging. In Moiré averaging, magnification is intentionally set so that the pixel period of the imaging element is a noninteger multiple of the site period. Accurate registration is achieved by providing for pre-defined pseudo-random sets of sites, herein deletion or reserved sites, where nanoballs are prevented from attachment to the substrate so that the sites of the array can be used in a pattern matching scheme as registration markers for absolute location identification. Information can be extracted with a high degree of confidence that it is correlated to a known location, while at the same time the amount of information that can be packed on a chip is maximized.
摘要翻译：在基因组测序系统和方法学中，提供了一种协议，以实现经受光学分析的纳米棒的平面阵列的图像的精确对准和精确配准。通过使用最小化技术和莫尔平均来校正子周期x-y偏移，刻度和旋转中的误差来实现分数偏移的精确对准校正。在莫尔平均中，有意地设置放大率，使得成像元件的像素周期是站点周期的非整数倍。通过提供预定义的伪随机组的位点（这里是删除或保留位点）来实现精确的注册，其中防止了纳米线附着到基底，使得阵列的位点可以以模式匹配方案用作对准标记用于绝对位置识别。可以高信度地提取信息，使其与已知位置相关联，同时可将芯片上打包的信息量最大化。

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