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11. 再颁专利

USRE38775E1 Electrode with improved signal to noise ratio 有权
标题翻译：具有提高信噪比的电极
公开(公告)号：USRE38775E1
公开(公告)日：2005-08-16
申请号：US10285659
申请日：2002-10-30
申请人： Ronald T. Kurnik , Janet Tamada , Michael J. Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael J. Tierney
IPC分类号： A61B5/0408 , A61B5/00 , A61B5/145 , A61B5/1477 , C12Q1/54 , G01N27/30 , G01N27/327
CPC分类号： A61B5/1486 , C12Q1/54
摘要： An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.
摘要翻译：公开了一种用于感测从源极扩散到工作电极的电化学信号的电极组件，其由多个基本上分离的工作电极表面组成。本发明的电极包括1）由多个工作电极表面或部件组成的工作电极，以及2）由相邻边缘限定的电绝缘间隙，1）将工作电极表面或部件彼此绝缘。工作电极部件被配置成从两个或优选三个维度同时接收电化学信号。配置在与单个电极相同的表面上的工作电极组件提供（1）通过降低噪声与单个电极相比提高了信噪比，以及（2）在感测到给定时间段之后提供总体增强的信号。

12. 发明申请

US20120172693A1 Pump Arrangement in Continuous Analyte Monitoring 审中-公开
标题翻译：连续分析物监测中的泵排列
公开(公告)号：US20120172693A1
公开(公告)日：2012-07-05
申请号：US12985234
申请日：2011-01-05
申请人： Varun Boriah , Janet Tamada , Arvind N. Jina , Michael J. Tierney , Shashi P. Desai
发明人： Varun Boriah , Janet Tamada , Arvind N. Jina , Michael J. Tierney , Shashi P. Desai
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/685
摘要： A method of monitoring an analyte (such as, e.g., glucose) including the following steps: diffusing the analyte from a sampling location into a sensing fluid within a sensing chamber; detecting a concentration of the analyte in the sensing fluid; moving flushing fluid into the sensing chamber and simultaneously removing sensing fluid from the sensing chamber; permitting the flushing fluid to remain in the sensing chamber without flowing for a dwell time; removing the flushing fluid from the sensing chamber after the dwell time expires; and, after removing the flushing fluid from the sensing chamber, moving sensing fluid into the sensing chamber. The invention also includes an analyte monitoring device performing this method.
摘要翻译：一种监测分析物（例如葡萄糖）的方法，包括以下步骤：将分析物从采样位置扩散到感测室内的感测流体中; 检测所述检测流体中的分析物的浓度; 将冲洗流体移动到所述感测室中并同时从所述感测室中移除感测流体; 允许冲洗流体保持在感测室中而不流动停留时间; 在停留时间过后，从感测室中移除冲洗液; 并且在从感测室移除冲洗流体之后，将检测流体移动到感测室中。本发明还包括执行该方法的分析物监测装置。

13. 发明申请

US20090131778A1 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING 审中-公开
标题翻译：用于连续葡萄糖监测的装置，系统，方法和工具
公开(公告)号：US20090131778A1
公开(公告)日：2009-05-21
申请号：US12275145
申请日：2008-11-20
申请人： Arvind N. Jina , Beelee Chua , Janet Tamada , Michael J. Tierney , Shashi P. Desai
发明人： Arvind N. Jina , Beelee Chua , Janet Tamada , Michael J. Tierney , Shashi P. Desai
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/14865
摘要： One aspect of the invention provides a glucose monitor having a plurality of tissue piercing elements, each tissue piercing element having a distal opening, a proximal opening and interior space extending between the distal and proximal openings; a sensing volume in fluid communication with the proximal openings of the tissue piercing elements; sensing fluid extending into the sensing volume; and a glucose sensor adapted to detect a concentration of glucose in the sensing fluid within the sensing volume. Another aspect of the invention provides A method of in vivo monitoring of an individual's interstitial fluid glucose concentration comprising: inserting distal ends of a plurality of tissue piercing elements through a stratum corneum area of the individual's skin, the tissue piercing elements each comprising a distal opening, a proximal opening, and an interior space extending between the distal and proximal opening; allowing interstitial fluid to flow into the interior space of the tissue piercing elements to substantially fill the interior space; filling substantially the entire interior space of the sensing area; and sensing a glucose concentration of the sensing fluid.
摘要翻译：本发明的一个方面提供一种具有多个组织刺穿元件的葡萄糖监测器，每个组织刺穿元件具有远端开口，在远端和近端开口之间延伸的近端开口和内部空间; 与组织刺穿元件的近端开口流体连通的感测体积; 感测流体延伸到感测体积中; 以及适于检测感测体积内的感测流体中的葡萄糖浓度的葡萄糖传感器。本发明的另一方面提供了一种体内监测个体间质液葡萄糖浓度的方法，包括：将多个组织刺穿元件的远端穿过个体皮肤的角质层区域，所述组织刺穿元件各自包括远端开口，近端开口和在远端和近端开口之间延伸的内部空间; 允许间质液体流入组织刺穿元件的内部空间以基本上填充内部空间; 基本上填充感测区域的整个内部空间; 并感测感测流体的葡萄糖浓度。

14. 发明授权

US6139718A Electrode with improved signal to noise ratio 失效
标题翻译：具有提高信噪比的电极
公开(公告)号：US6139718A
公开(公告)日：2000-10-31
申请号：US824143
申请日：1997-03-25
申请人： Ronald T. Kurnik , Janet Tamada , Michael J. Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael J. Tierney
IPC分类号： A61B5/0408 , A61B5/00 , A61B5/145 , A61B5/1477 , C12Q1/54 , G01N27/30 , G01N27/327 , G01N27/26
CPC分类号： A61B5/1486 , C12Q1/54
摘要： An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.
摘要翻译：公开了一种用于感测从源极扩散到工作电极的电化学信号的电极组件，其由多个基本上分离的工作电极表面组成。本发明的电极包括1）由多个工作电极表面或部件组成的工作电极，以及2）由相邻边缘限定的电绝缘间隙，1）将工作电极表面或部件彼此绝缘。工作电极部件被配置成从两个或优选三个维度同时接收电化学信号。配置在与单个电极相同的表面上的工作电极组件提供（1）通过降低噪声与单个电极相比提高了信噪比，以及（2）在感测到给定时间段之后提供总体增强的信号。

15. 发明授权

US06687522B2 Device for sample of substances using alternating polarity 失效
标题翻译：使用交替极性取样物质的设备
公开(公告)号：US06687522B2
公开(公告)日：2004-02-03
申请号：US09893916
申请日：2001-06-28
申请人： Janet Tamada
发明人： Janet Tamada
IPC分类号： A61B505
CPC分类号： A61B5/6833 , A61B5/14532
摘要： A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber. The device comprises an electrical power supply; a transdermal system that contains one or more sampling chambers that function as both anode and cathode during the course of sampling; a means to alternates or reverses the polarity during the iontophoretic sampling; and means for analyzing for the concentration of a substance or a substance metabolite.
摘要翻译：提供了从受检者取样物质的方法，其包括将一个或多个取样室放置在受试者的组织表面上的收集位置上; 在所述方法的过程中，在一个或多个取样室中以第一方向从所述受试者提取物质，所述取样室在所述方法的过程中作为阳极和阴极交替地起作用; 使极性反转，使得直流电流沿与第一方向相反的第二方向流动; 并分析取样室或浓缩物质或物质代谢物的浓度。还提供了一种基于在皮肤上交替极性的低强度电场（离子电渗疗法）的连续或间歇地使用交替极性法来提取物质的输送（例如，葡萄糖，乳酸，丙酮酸等）从身体组织到采样室。该装置包括电源; 一种透皮系统，其在采样过程中包含一个或多个在阳极和阴极两者之间起作用的取样室; 在离子电渗检测过程中交替或反转极性的方法; 以及用于分析物质或物质代谢物浓度的方法。

16. 发明授权

US06529755B2 Chemical signal-impermeable mask 有权
公开(公告)号：US06529755B2
公开(公告)日：2003-03-04
申请号：US10006769
申请日：2001-12-06
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： A61B500
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

17. 发明申请

US20050069925A1 Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
标题翻译：用于监测生理分析物的微处理器，装置和方法
公开(公告)号：US20050069925A1
公开(公告)日：2005-03-31
申请号：US10903672
申请日：2004-07-30
申请人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
发明人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , G06F19/00 , C12Q1/68 , G01N33/48 , G01N33/50
CPC分类号： A61B5/4283 , A61B5/14532 , A61B5/4266 , A61B5/4881 , A61B5/7267 , A61B2560/0252 , G16H40/63
摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.
摘要翻译：本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

18. 发明授权

US6141573A Chemical signal-impermeable mask 有权
公开(公告)号：US6141573A
公开(公告)日：2000-10-31
申请号：US128891
申请日：1998-08-04
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61N1/30 , C12Q1/00 , G01N27/416
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

19. 发明申请

US20060105420A1 Compositions and methods for enhancement of transdermal analyte flux 审中-公开
标题翻译：用于增强透皮分析物通量的组合物和方法
公开(公告)号：US20060105420A1
公开(公告)日：2006-05-18
申请号：US11329610
申请日：2006-01-11
申请人： Janet Tamada , Michael Tierney , Stephen Williams
发明人： Janet Tamada , Michael Tierney , Stephen Williams
IPC分类号： C12Q1/26
CPC分类号： A61B5/1486 , A61N1/0436 , A61N1/044 , A61N1/325 , C08J3/075
摘要： The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making/manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.
摘要翻译：本发明涉及用于分析物监测设备的组合物。这些组合物可用于增加分析物通过皮肤，组织或粘膜表面的通量。组合物包括包含离子导电材料的水凝胶和收集储存器系统。本发明还包括制造/制造水凝胶或收集储存器系统的方法，包括水凝胶的收集组件，与水凝胶或收集储存器系统组合的电极组件及其使用方法。

20. 发明授权

US06771995B2 Chemical signal-impermeable mask 失效
标题翻译：化学信号不透水面罩
公开(公告)号：US06771995B2
公开(公告)日：2004-08-03
申请号：US10324818
申请日：2002-12-20
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： A61B500
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.
摘要翻译：化学信号不可渗透的掩模位于电解质流中，使得掩模位于化学信号源和感测从源传输的化学信号（例如通过扩散）的工作电极之间。掩模的配置使得掩模基本上防止具有相对于掩模的平面和工作电极的催化面的径向矢量分量的化学信号源的所有化学信号传输，因此主要仅允许化学信号传输基本上垂直于掩模的位置和工作电极的催化表面。通过减少或消除朝向工作电极的化学信号径向传输，掩模因此显着地减少或消除了边缘效应。通过显着降低由化学信号的径向传输产生的边缘效应，可以获得从源材料的给定区域输送的化学信号的量（例如，浓度）的更准确的测量。

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