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1. 发明申请

US20060105420A1 Compositions and methods for enhancement of transdermal analyte flux 审中-公开
标题翻译：用于增强透皮分析物通量的组合物和方法
公开(公告)号：US20060105420A1
公开(公告)日：2006-05-18
申请号：US11329610
申请日：2006-01-11
申请人： Janet Tamada , Michael Tierney , Stephen Williams
发明人： Janet Tamada , Michael Tierney , Stephen Williams
IPC分类号： C12Q1/26
CPC分类号： A61B5/1486 , A61N1/0436 , A61N1/044 , A61N1/325 , C08J3/075
摘要： The present invention relates to compositions for use in analyte monitoring devices. These compositions are useful to increase the flux of analyte across skin, tissue or mucosal surfaces. The compositions include hydrogels and collection reservoir systems comprising ionically conductive materials. The present invention also includes methods of making/manufacturing hydrogels or collection reservoir systems, collection assemblies comprising the hydrogels, electrode assemblies in combination with the hydrogels or collection reservoir systems, and methods of using the same.
摘要翻译：本发明涉及用于分析物监测设备的组合物。这些组合物可用于增加分析物通过皮肤，组织或粘膜表面的通量。组合物包括包含离子导电材料的水凝胶和收集储存器系统。本发明还包括制造/制造水凝胶或收集储存器系统的方法，包括水凝胶的收集组件，与水凝胶或收集储存器系统组合的电极组件及其使用方法。

2. 发明申请

US20060127964A1 Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
标题翻译：用于监测生理分析物的微处理器，装置和方法
公开(公告)号：US20060127964A1
公开(公告)日：2006-06-15
申请号：US11350193
申请日：2006-02-08
申请人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
发明人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
IPC分类号： C12Q1/54 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/4266 , A61B5/4283 , A61B5/4881 , A61B5/7267 , G16H40/63
摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.
摘要翻译：本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

3. 发明授权

US06370410B2 Methods of producing an assembly for use in a monitoring device 有权
标题翻译：制造用于监测装置的组件的方法
公开(公告)号：US06370410B2
公开(公告)日：2002-04-09
申请号：US09764550
申请日：2001-01-18
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： A61B507
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.
摘要翻译：化学信号不可渗透的掩模位于电解质流中，使得掩模位于化学信号源和感测从源传输的化学信号（例如通过扩散）的工作电极之间。掩模的配置使得掩模基本上防止具有相对于掩模的平面和工作电极的催化面的径向矢量分量的化学信号源的所有化学信号传输，因此主要仅允许化学信号传输基本上垂直于掩模的位置和工作电极的催化表面。通过减少或消除朝向工作电极的化学信号径向传输，掩模因此显着地减少或消除了边缘效应。通过显着降低由化学信号的径向传输产生的边缘效应，可以获得从源材料的给定区域输送的化学信号的量（例如，浓度）的更准确的测量。

4. 发明申请

US20070142721A1 Monitoring of physiological analytes 有权
标题翻译：生理分析物的监测
公开(公告)号：US20070142721A1
公开(公告)日：2007-06-21
申请号：US11699850
申请日：2007-01-30
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
摘要翻译：提供了用于测量生物系统中存在的目标化学分析物浓度的方法和装置。采用器件配置和/或测量技术来降低干扰物质对传感器灵敏度的影响。本发明的一个重要应用涉及用于监测血糖值的方法和装置。

5. 发明申请

US20050069925A1 Microprocessors, devices, and methods for use in monitoring of physiological analytes 审中-公开
标题翻译：用于监测生理分析物的微处理器，装置和方法
公开(公告)号：US20050069925A1
公开(公告)日：2005-03-31
申请号：US10903672
申请日：2004-07-30
申请人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
发明人： Russell Ford , Matthew Lesho , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , G06F19/00 , C12Q1/68 , G01N33/48 , G01N33/50
CPC分类号： A61B5/4283 , A61B5/14532 , A61B5/4266 , A61B5/4881 , A61B5/7267 , A61B2560/0252 , G16H40/63
摘要： Described herein are microprocessors, devices, and methods useful for sweat and/or temperature detection that correlate more closely with changes in amperometric or charge signals related to analyte amount or concentration. The present invention provides methods for the establishment of more accurate sweat and/or temperature thresholds and new methods of compensation, such as correcting for the effects of sweat and rapidly changing temperature on measured analyte values. The present invention reduces the number of skipped or unuseable readings provided by analyte monitoring devices during periods of sweating or changing temperatures. Further, the present invention provides methods for improving the accuracy of reported readings of analyte amount or concentration. In one aspect, the present invention provides passive collection reservoir/sensing devices used in combination with active collection reservoir/sensing devices for detection of sweat and/or temperature related parameters.
摘要翻译：本文描述的是用于汗液和/或温度检测的微处理器，装置和方法，其更接近于与分析物量或浓度相关的电流或电荷信号的变化。本发明提供了用于建立更准确的汗液和/或温度阈值和新的补偿方法的方法，例如校正汗液和快速变化的温度对测量的分析物值的影响。本发明在出汗或变化的温度期间减少由分析物监测装置提供的跳过或不可用读数。此外，本发明提供了提高分析物量或浓度的报告读数精度的方法。在一个方面，本发明提供与用于检测汗和/或温度相关参数的主动收集储存器/感测装置组合使用的被动收集储存器/感测装置。

6. 发明申请

US20050027179A1 Biosensor and methods of use thereof 有权
标题翻译：生物传感器及其使用方法
公开(公告)号：US20050027179A1
公开(公告)日：2005-02-03
申请号：US10936095
申请日：2004-09-08
申请人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Lynn Kim , Norman Parris , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/00 , A61B5/0408 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/28 , G01N27/30 , G01N27/416 , G01N33/487 , G01N33/66 , A61B5/05
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61N1/30
摘要： An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.
摘要翻译：提供了一种用于连续透皮提取生物系统中存在的分析物的自动化系统。该系统可用于使用电化学生物传感器检测装置来检测和/或测量分析物的浓度。该系统可选择使用反向离子电渗法进行分析物的连续经皮提取。

7. 发明授权

US6141573A Chemical signal-impermeable mask 有权
公开(公告)号：US6141573A
公开(公告)日：2000-10-31
申请号：US128891
申请日：1998-08-04
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1486 , A61N1/30 , C12Q1/00 , G01N27/416
CPC分类号： A61B5/1486 , A61N1/30 , C12Q1/001 , C12Q1/002 , C12Q1/006
摘要： A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g., concentration) of chemical signal that is transported from a given area of source material.

8. 发明申请

US20050215872A1 Monitoring of physiological analytes 有权
公开(公告)号：US20050215872A1
公开(公告)日：2005-09-29
申请号：US10982166
申请日：2004-11-05
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/327 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

9. 发明授权

US06309351B1 Methods for monitoring a physiological analyte 有权
公开(公告)号：US06309351B1
公开(公告)日：2001-10-30
申请号：US09650024
申请日：2000-08-28
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney , Russell Owen Potts
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney , Russell Owen Potts
IPC分类号： A61B500
CPC分类号： A61B5/14532
摘要： A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection reservoir being in operative communication with a detector, collecting the analyte in the collection reservoir, using the detector to detect the analyte in the collection reservoir, and, once the analyte has been detected, rendering the analyte undetectable by the detector. Also, apparatus for continual monitoring of a physiologic analyte in a subject includes a collection reservoir for receiving the analyte from the subject, the contents of the collection reservoir being in operative relationship with a detector that detects the analyte in the reservoir, and means for rendering the analyte, once detected, undetectable by the reservoir.

10. 发明授权

US06284126B1 Electrode with improved signal to noise ratio 有权
标题翻译：具有提高信噪比的电极
公开(公告)号：US06284126B1
公开(公告)日：2001-09-04
申请号：US09650025
申请日：2000-08-28
申请人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
发明人： Ronald T. Kurnik , Janet Tamada , Michael Tierney
IPC分类号： G02N2726
CPC分类号： A61B5/1486 , C12Q1/54
摘要： An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.
摘要翻译：公开了一种用于感测从源极扩散到工作电极的电化学信号的电极组件，其由多个基本上分离的工作电极表面组成。本发明的电极包括1）由多个工作电极表面或部件组成的工作电极，以及2）由相邻边缘限定的电绝缘间隙，1）将工作电极表面或部件彼此绝缘。工作电极部件被配置成从两个或优选三个维度同时接收电化学信号。配置在与单个电极相同的表面上的工作电极组件提供（1）通过降低噪声与单个电极相比提高了信噪比，以及（2）在感测到给定时间段之后提供总体增强的信号。

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