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1. 发明申请

US20120172693A1 Pump Arrangement in Continuous Analyte Monitoring 审中-公开
标题翻译：连续分析物监测中的泵排列
公开(公告)号：US20120172693A1
公开(公告)日：2012-07-05
申请号：US12985234
申请日：2011-01-05
申请人： Varun Boriah , Janet Tamada , Arvind N. Jina , Michael J. Tierney , Shashi P. Desai
发明人： Varun Boriah , Janet Tamada , Arvind N. Jina , Michael J. Tierney , Shashi P. Desai
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/685
摘要： A method of monitoring an analyte (such as, e.g., glucose) including the following steps: diffusing the analyte from a sampling location into a sensing fluid within a sensing chamber; detecting a concentration of the analyte in the sensing fluid; moving flushing fluid into the sensing chamber and simultaneously removing sensing fluid from the sensing chamber; permitting the flushing fluid to remain in the sensing chamber without flowing for a dwell time; removing the flushing fluid from the sensing chamber after the dwell time expires; and, after removing the flushing fluid from the sensing chamber, moving sensing fluid into the sensing chamber. The invention also includes an analyte monitoring device performing this method.
摘要翻译：一种监测分析物（例如葡萄糖）的方法，包括以下步骤：将分析物从采样位置扩散到感测室内的感测流体中; 检测所述检测流体中的分析物的浓度; 将冲洗流体移动到所述感测室中并同时从所述感测室中移除感测流体; 允许冲洗流体保持在感测室中而不流动停留时间; 在停留时间过后，从感测室中移除冲洗液; 并且在从感测室移除冲洗流体之后，将检测流体移动到感测室中。本发明还包括执行该方法的分析物监测装置。

2. 发明申请

US20100049021A1 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS ANALYTE MONITORING 审中-公开
标题翻译：用于连续分析监测的设备，系统，方法和工具
公开(公告)号：US20100049021A1
公开(公告)日：2010-02-25
申请号：US12545008
申请日：2009-08-20
申请人： Arvind N. Jina , Ashok Parmar , Beelee Chua , Janet Tamada , Jonathan Lee , Michael J. Tierney , Navneet Kaur , Paul Magginetti , Shashi P. Desai
发明人： Arvind N. Jina , Ashok Parmar , Beelee Chua , Janet Tamada , Jonathan Lee , Michael J. Tierney , Navneet Kaur , Paul Magginetti , Shashi P. Desai
IPC分类号： A61B5/1468
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/14865 , A61B2560/0223
摘要： One aspect of the invention provides an analyte monitor including a sensing volume, an analyte extraction area in contact with the sensing volume adapted to extract an analyte into the sensing volume, and an analyte sensor adapted to detect a concentration of analyte in the sensing volume. The sensing volume is defined by a first face, a second face opposite to the first face, and a thickness equal to the distance between the two faces. The surface area of the first face is about equal to the surface area of the second face and the extraction area is about equal to the surface area of the first and second face of the sensing volume. The analyte sensor includes a working electrode in contact with the sensing volume, the working electrode having a surface area at least as large as the analyte extraction area, and a second electrode in fluid communication with the sensing volume.
摘要翻译：本发明的一个方面提供一种分析物监测器，其包括感测体积，与适于将分析物提取到感测体积中的感测体接触的分析物提取区域，以及适于检测感测体积中的分析物浓度的分析物传感器。感测体积由第一面，与第一面相反的第二面和厚度等于两个面之间的距离限定。第一面的表面积约等于第二面的表面积，并且提取面积大约等于感测体积的第一和第二面的表面积。分析物传感器包括与感测体积接触的工作电极，工作电极具有至少与分析物提取区域一样大的表面积，以及与感测体积流体连通的第二电极。

3. 发明申请

US20090131778A1 DEVICES, SYSTEMS, METHODS AND TOOLS FOR CONTINUOUS GLUCOSE MONITORING 审中-公开
标题翻译：用于连续葡萄糖监测的装置，系统，方法和工具
公开(公告)号：US20090131778A1
公开(公告)日：2009-05-21
申请号：US12275145
申请日：2008-11-20
申请人： Arvind N. Jina , Beelee Chua , Janet Tamada , Michael J. Tierney , Shashi P. Desai
发明人： Arvind N. Jina , Beelee Chua , Janet Tamada , Michael J. Tierney , Shashi P. Desai
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/14865
摘要： One aspect of the invention provides a glucose monitor having a plurality of tissue piercing elements, each tissue piercing element having a distal opening, a proximal opening and interior space extending between the distal and proximal openings; a sensing volume in fluid communication with the proximal openings of the tissue piercing elements; sensing fluid extending into the sensing volume; and a glucose sensor adapted to detect a concentration of glucose in the sensing fluid within the sensing volume. Another aspect of the invention provides A method of in vivo monitoring of an individual's interstitial fluid glucose concentration comprising: inserting distal ends of a plurality of tissue piercing elements through a stratum corneum area of the individual's skin, the tissue piercing elements each comprising a distal opening, a proximal opening, and an interior space extending between the distal and proximal opening; allowing interstitial fluid to flow into the interior space of the tissue piercing elements to substantially fill the interior space; filling substantially the entire interior space of the sensing area; and sensing a glucose concentration of the sensing fluid.
摘要翻译：本发明的一个方面提供一种具有多个组织刺穿元件的葡萄糖监测器，每个组织刺穿元件具有远端开口，在远端和近端开口之间延伸的近端开口和内部空间; 与组织刺穿元件的近端开口流体连通的感测体积; 感测流体延伸到感测体积中; 以及适于检测感测体积内的感测流体中的葡萄糖浓度的葡萄糖传感器。本发明的另一方面提供了一种体内监测个体间质液葡萄糖浓度的方法，包括：将多个组织刺穿元件的远端穿过个体皮肤的角质层区域，所述组织刺穿元件各自包括远端开口，近端开口和在远端和近端开口之间延伸的内部空间; 允许间质液体流入组织刺穿元件的内部空间以基本上填充内部空间; 基本上填充感测区域的整个内部空间; 并感测感测流体的葡萄糖浓度。

4. 发明申请

US20120172692A1 Sensing Fluid Concentration for Continuous Glucose Monitoring 审中-公开
标题翻译：感测液体浓度用于连续葡萄糖监测
公开(公告)号：US20120172692A1
公开(公告)日：2012-07-05
申请号：US12985224
申请日：2011-01-05
申请人： Janet Tamada , Michael J. Tierney , Ramakrishna Madabhushi , Arvind N. Jina
发明人： Janet Tamada , Michael J. Tierney , Ramakrishna Madabhushi , Arvind N. Jina
IPC分类号： A61B5/1486
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/14865 , A61B5/685
摘要： An analyte monitor having a plurality of fluid paths, each fluid path having a distal opening adapted to be disposed on one side of a stratum corneum layer of a user's skin, a proximal opening adapted to be disposed on another side of the stratum corneum layer and an interior space extending between the distal and proximal openings; a sensing zone in fluid communication with the proximal openings of the fluid paths; sensing fluid extending from the sensing zone into substantially the entire interior space of the fluid paths; and an analyte sensor adapted to detect a concentration of analyte in the sensing fluid within the sensing zone, wherein at least one of the sensing fluid and the analyte sensor comprises a catalyst for mutarotation of glucose. The invention also includes a method of using the monitor.
摘要翻译：一种具有多个流体路径的分析物监测器，每个流体路径具有适于设置在使用者皮肤的角质层的一侧上的远端开口，适于设置在角质层的另一侧上的近侧开口，以及在远端和近端开口之间延伸的内部空间; 与流体路径的近端开口流体连通的感测区域; 从所述感测区域延伸到所述流体路径的基本上整个内部空间中的感测流体; 以及分析物传感器，其适于检测所述感测区域内的所述感测流体中的分析物的浓度，其中所述感测流体和所述分析物传感器中的至少一个包括用于葡萄糖变异的催化剂。本发明还包括使用监视器的方法。

5. 发明申请

US20080312518A1 ON-DEMAND ANALYTE MONITOR AND METHOD OF USE 审中-公开
标题翻译：需求分析监测和使用方法
公开(公告)号：US20080312518A1
公开(公告)日：2008-12-18
申请号：US11763414
申请日：2007-06-14
申请人： Arvind N. Jina , Beelee Chua , Shashi P. Desai , Abdel-Nasser Kawde
发明人： Arvind N. Jina , Beelee Chua , Shashi P. Desai , Abdel-Nasser Kawde
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/0002 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865
摘要： An analyte monitor is provided with a sensor unit body configured for mounting on tissue, a sensor configured to detect an analyte in a fluid in the sensing area, an output device configured to communicate a result from the sensor to a user; and a user input device coupled with the sensor and the output device, wherein the monitor is configured to communicate a result to the user through the output device only after the user input device is activated. Systems, sensors and methods associated with the monitor are also disclosed.
摘要翻译：分析物监视器设置有被配置为安装在组织上的传感器单元主体，被配置为检测感测区域中的流体中的分析物的传感器，被配置为将来自传感器的结果传达给用户的输出设备; 以及与传感器和输出设备耦合的用户输入设备，其中监视器被配置为仅在用户输入设备被激活之后通过输出设备将结果传达给用户。还公开了与监视器相关联的系统，传感器和方法。

6. 发明申请

US20090099427A1 MICRONEEDLE ARRAY WITH DIVERSE NEEDLE CONFIGURATIONS 审中-公开
标题翻译：带有多针配置的麦克风阵列
公开(公告)号：US20090099427A1
公开(公告)日：2009-04-16
申请号：US11871806
申请日：2007-10-12
申请人： Arvind N. Jina , Shashi P. Desai , Beelee Chua , Ashok Parmar
发明人： Arvind N. Jina , Shashi P. Desai , Beelee Chua , Ashok Parmar
IPC分类号： A61B5/00
CPC分类号： A61B17/205 , A61B5/14532 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150282 , A61B5/150755 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/157 , A61B5/685 , A61M37/0015
摘要： The invention relates to a surface penetration device, a method to use the device, and an analyte monitor. Embodiments of the surface penetration device include a substrate with first and second surfaces, and first and second tissue piercing elements, the elements differing in configuration, but each associated with the first surface of the substrate. At least some of the tissue piercing elements have a distal and a proximal opening and a lumen extending between the openings. The proximal openings are in fluid communication with an opening in the second surface of the substrate. Embodiments of the analyte monitor include the features of the penetration device plus an analyte sensor that detects an analyte in a fluid. Embodiments of the method of penetrating tissue include providing a surface penetration device and urging the surface penetration device against a tissue surface until some of the first and second tissue piercing elements penetrate the tissue surface.
摘要翻译：本发明涉及一种表面穿透装置，一种使用该装置的方法和一种分析物监测器。表面穿透装置的实施例包括具有第一和第二表面的基底以及第一和第二组织刺穿元件，所述元件的构造不同，但每个与基底的第一表面相关联。组织穿刺元件中的至少一些具有远端和近端开口以及在开口之间延伸的内腔。近端开口与衬底的第二表面中的开口流体连通。分析物监测器的实施例包括穿透装置的特征加上检测流体中分析物的分析物传感器。穿透组织的方法的实施例包括提供表面穿透装置并且将表面穿透装置推向组织表面，直到第一和第二组织刺穿元件中的一些穿透组织表面。

7. 发明申请

US20110257497A1 Flux Enhancement in Continuous Glucose Monitoring 审中-公开
标题翻译：连续葡萄糖监测中的助焊剂增强
公开(公告)号：US20110257497A1
公开(公告)日：2011-10-20
申请号：US12985229
申请日：2011-01-05
申请人： Janet Tamada , Arvind N. Jina , Jonathan Lee
发明人： Janet Tamada , Arvind N. Jina , Jonathan Lee
IPC分类号： A61B5/145
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/1486 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150717 , A61B5/150755 , A61B5/150946 , A61B5/150969 , A61B5/150984 , A61B5/157
摘要： One aspect of the invention is a method of in vivo monitoring of an individual's interstitial fluid glucose concentration comprising inserting a plurality of tissue piercing elements through a stratum corneum layer of an area of the individual's skin. The tissue piercing elements each comprise a distal end in fluid communication with interstitial fluid of the individual, and a proximal end in fluid communication with a sensing zone located outside of the patient's body. An interior space extends between the distal and proximal ends of the tissue piercing elements. A sensing fluid fills substantially the entire interior space and the sensing fluid concentration comprises a concentration of citrate in a buffer solution. The concentration of citrate may range from 100 mM to 200 mM, preferably 135-165 mM.
摘要翻译：本发明的一个方面是体内监测个体间质液葡萄糖浓度的方法，其包括将多个组织刺穿元件穿过个体皮肤区域的角质层。组织刺穿元件各自包括与个体的间质液体流体连通的远端，以及与位于患者身体外部的感测区域流体连通的近端。内部空间在组织刺穿元件的远端和近端之间延伸。感测流体基本上填充整个内部空间，并且感测流体浓度包含缓冲溶液中柠檬酸盐的浓度。柠檬酸盐的浓度可以为100mM至200mM，优选135-165mM。

8. 发明申请

US20100190268A1 Assay Device, System and Method 审中-公开
标题翻译：测定装置，系统和方法
公开(公告)号：US20100190268A1
公开(公告)日：2010-07-29
申请号：US12713066
申请日：2010-02-25
申请人： Arvind N. Jina
发明人： Arvind N. Jina
IPC分类号： G01N33/558
CPC分类号： G01N33/723 , G01N33/558 , G01N33/721 , Y10S436/805 , Y10S436/808 , Y10S436/81
摘要： A system for treating a blood sample (700) having an analyte of interest comprises a strip (200) having a membrane (218), respective portions (216, 220 and 222, or 300) which are provided for receiving the sample, for lysing cells of the sample to liberate hemoglobin, and for capturing glycated hemoglobin. The latter two portions (220 and 222, or 300) of the membrane are treated with lysing and capture agents, respectively. A portion of the strip (214 or 230 or 240) is provided for holding an eluting agent and for releasing the agent upon a release condition. A system for detecting analyte comprises an optical subsystem (550) that is aligned with the strip to provide a signal corresponding to an amount of analyte, and an electronic subsystem (650) for processing the signal (560) to provide a result, such as an amount or percentage of glycated hemoglobin. To use these systems, the user simply applies a small sample (700) to the membrane (218) and closes a door (10) of the detection system over the strip (200) such that the door triggers the release of the eluting agent. No sample pre-treatment is required. The preferably handheld system (100) is a simple and convenient monitoring tool for the user, such as a diabetic patient who must monitor blood glucose on an on-going basis. While the systems are useful in the monitoring of blood glucose, they may be used for treating a sample other than blood and detecting an analyte other than an analyte in blood.
摘要翻译：用于处理具有感兴趣分析物的血液样品（700）的系统包括具有膜（218）的条带（200），被设置用于接收样品的相应部分（216,220和222或300），用于裂解样品的细胞释放血红蛋白，并用于捕获糖化血红蛋白。膜的后两部分（220和222或300）分别用裂解和捕获剂处理。提供条带（214或230或240）的一部分用于容纳洗脱剂并在释放条件下释放该药剂。用于检测分析物的系统包括光学子系统（550），其与条带对准以提供对应于分析物的量的信号;以及电子子系统（650），用于处理信号（560）以提供结果，例如糖化血红蛋白的量或百分数。为了使用这些系统，用户简单地将小样品（700）施加到膜（218）并且关闭带（200）上的检测系统的门（10），使得门触发洗脱剂的释放。不需要样品预处理。优选的手持系统（100）是用于用户的简单和方便的监测工具，例如必须一直监测血糖的糖尿病患者。虽然这些系统可用于监测血糖，但它们可用于治疗血液以外的样品，并检测血液中的分析物以外的分析物。

9. 发明授权

US6046051A Method and device for measuring blood coagulation or lysis by viscosity changes 失效
公开(公告)号：US6046051A
公开(公告)日：2000-04-04
申请号：US884027
申请日：1997-06-27
申请人： Arvind N. Jina
发明人： Arvind N. Jina
IPC分类号： G01N33/49 , G01N33/86
CPC分类号： G01N33/86 , G01N33/4905
摘要： The present invention provides a single-use electronic device and test card for use therein which performs a coagulation or lysis assay of a blood sample. The device includes a housing having an exterior surface and defining an interior area and means for receiving the sample through the housing into the interior space. A non-porous substrate is positioned within the interior space for receiving the sample thereon. A reagent accelerates the coagulation of the sample and is positioned on the substrate and in contact with the sample. Optionally, an electroactive species may also be reacted with the sample. The device also includes means for measuring the viscosity of the sample and generating an electrical signal which correlates to a curve of the coagulation/lysis assay. Processing means positioned within the interior space is connected to the measuring means for receiving and converting the electrical signal into a digital output corresponding to the coagulation/lysis assay using assay calibration information stored therein. Display means visually displays the digital output external to the housing and is connected to the processing means. A method of determining the coagulation or lysis of a sample provides for accelerating the coagulation of the sample by chemically reacting the sample with at least one reagent on the substrate to produce a detectable change in the viscosity of the sample which correlates with the state of coagulation or lysis of the sample and measuring the viscosity of the sample and generating an electrical signal which correlates to a curve of the coagulation/lysis assay.

10. 发明授权

US06338821B1 Method and device for measuring blood coagulation or lysis by viscosity changes 有权
标题翻译：用于通过粘度变化测量凝血或溶解的方法和装置
公开(公告)号：US06338821B1
公开(公告)日：2002-01-15
申请号：US09542886
申请日：2000-04-04
申请人： Arvind N. Jina
发明人： Arvind N. Jina
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N33/4905
摘要： The present invention provides a single-use electronic device and test card for use therein which performs a coagulation or lysis assay of a blood sample. The device includes a housing having an exterior surface and defining an interior area and means for receiving the sample through the housing into the interior space. A non-porous substrate is positioned within the interior space for receiving the sample thereon. A reagent accelerates the coagulation of the sample and is positioned on the substrate and in contact with the sample. Optionally, an electroactive species may also be reacted with the sample. The device also includes means for measuring the viscosity of the sample and generating an electrical signal which correlates to a curve of the coagulation/lysis assay. Processing means positioned within the interior space is connected to the measuring means for receiving and converting the electrical signal into a digital output corresponding to the coagulation/lysis assay using assay calibration information stored therein. Display means visually displays the digital output external to the housing and is connected to the processing means. A method of determining the coagulation or lysis of a sample provides for accelerating the coagulation of the sample by chemically reacting the sample with at least one reagent on the substrate to produce a detectable change in the viscosity of the sample which correlates with the state of coagulation or lysis of the sample and measuring the viscosity of the sample and generating an electrical signal which correlates to a curve of the coagulation/lysis assay.
摘要翻译：本发明提供一种用于其中的一次性电子装置和测试卡，其执行血液样品的凝固或裂解测定。该装置包括具有外表面并限定内部区域的壳体和用于通过壳体将样品接收到内部空间中的装置。无孔基材位于内部空间内用于在其上接收样品。试剂加速了样品的凝固，并且定位在基底上并与样品接触。任选地，电活性物质也可以与样品反应。该装置还包括用于测量样品的粘度并产生与凝血/裂解测定曲线相关的电信号的装置。位于内部空间内的处理装置连接到测量装置，用于使用存储在其中的测定校准信息，将电信号接收并转换成对应于凝固/裂解测定的数字输出。显示装置可视地显示外壳外部的数字输出并连接到处理装置。确定样品的凝固或裂解的方法提供了通过使样品与基底上的至少一种试剂化学反应来加速样品的凝固，以产生与凝固状态相关的样品粘度的可检测变化或裂解样品并测量样品的粘度并产生与凝固/裂解测定曲线相关的电信号。

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