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11. 发明申请

US20060189926A1 Apparatus and methods for analyzing body fluid samples 审中-公开
公开(公告)号：US20060189926A1
公开(公告)日：2006-08-24
申请号：US11316407
申请日：2005-12-21
申请人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

12. 发明申请

US20060195045A1 Fluid handling cassette having a fluid transport network 审中-公开
标题翻译：具有流体输送网络的流体处理盒
公开(公告)号：US20060195045A1
公开(公告)日：2006-08-31
申请号：US11314963
申请日：2005-12-21
申请人： Jennifer Gable , James Braig , Kenneth Li , Kenneth Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer Gable , James Braig , Kenneth Li , Kenneth Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/155
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module comprises a housing, an infusion fluid passageway, a sample fluid passageway, and a fluid component separator. The infusion fluid passageway has a first port and a second port spaced from the first port, and a lumen extending from the first port to the second port. The sample fluid passageway is connected to the infusion fluid passageway. The fluid component separator is connected to the sample fluid passageway.
摘要翻译：流体处理模块被配置为可移除地与可重复使用的主流体处理仪器接合。模块包括壳体，输液流体通道，样品流体通道和流体组分分离器。输液流体通道具有与第一端口间隔开的第一端口和第二端口，以及从第一端口延伸到第二端口的内腔。样品流体通道连接到输液流体通道。流体组分分离器连接到样品流体通道。

13. 发明申请

US20060197015A1 Method and apparatus for determining an analyte concentration in a sample having interferents 有权
公开(公告)号：US20060197015A1
公开(公告)日：2006-09-07
申请号：US11256656
申请日：2005-10-21
申请人： Bernhard Sterling , W. Hall , Kenneth Witte , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Bernhard Sterling , W. Hall , Kenneth Witte , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： G01D18/00 , G01J3/42 , G12B13/00
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1459 , A61B5/1495 , A61B2560/0223 , A61M5/14212 , A61M2230/20 , G01N21/35 , G01N35/00693 , G01N35/00712 , G01N2201/1215 , G01N2201/127
摘要： A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

14. 发明申请

US20060189858A1 Analyte detection system for multiple analytes 有权
标题翻译：多种分析物的分析物检测系统
公开(公告)号：US20060189858A1
公开(公告)日：2006-08-24
申请号：US11314176
申请日：2005-12-21
申请人： Bernhard Sterling , James Braig , Kenneth Witte , Peter Rule , Richard Keenan , W. Hall
发明人： Bernhard Sterling , James Braig , Kenneth Witte , Peter Rule , Richard Keenan , W. Hall
IPC分类号： A61B5/00 , A61M31/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过病人结束所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

15. 发明申请

US20070082342A1 Near-patient module for analyte detection system 审中-公开
标题翻译：用于分析物检测系统的近距离模块
公开(公告)号：US20070082342A1
公开(公告)日：2007-04-12
申请号：US11316681
申请日：2005-12-21
申请人： James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The at least one pump has an infusion mode in which the pump is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further includes an analyte detection system accessible via the first fluid passageway such that the analyte detection system can receive at least one component of the drawn sample of bodily fluid and determine a concentration of at least one analyte. The analyte detection system is spaced from the patient end of the first fluid passageway. The apparatus further includes a fluid sensor located at or near the patient end of the first fluid passageway and spaced from the analyte detection system. The fluid sensor is configured to sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，用于分析体液组成的装置包括具有患者端的第一流体通道，该患者端构造成提供与患者体内的体液的流体连通。该装置还包括耦合到第一流体通道的至少一个泵。所述至少一个泵具有输注模式，其中所述泵可操作以通过患者端向患者输送输注流体，以及抽样模式，其中所述泵可操作以从患者抽取体液样本通过病人结束该装置还包括可经由第一流体通道接近的分析物检测系统，使得分析物检测系统可以接收抽取的体液样本的至少一个组分并确定至少一种分析物的浓度。分析物检测系统与第一流体通道的患者端隔开。该装置还包括位于第一流体通道的患者端处或附近的流体传感器，并与分析物检测系统间隔开。流体传感器构造成感测第一流体通道内的流体的性质。

16. 发明授权

US07860543B2 Analyte detection system with reduced sample volume 有权
标题翻译：分析物检测系统，样品量减少
公开(公告)号：US07860543B2
公开(公告)日：2010-12-28
申请号：US11504139
申请日：2006-08-15
申请人： Bernhard B. Sterling , Jennifer H. Gable , James R. Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
发明人： Bernhard B. Sterling , Jennifer H. Gable , James R. Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 5 milliliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.
摘要翻译：在某些实施方案中，方法对患者的体液进行取样。该方法包括提供具有一个或多个流体通道的流体处理系统。该方法还包括通过流体处理系统通过一个或多个流体通道将输注液输入患者体内。该方法还包括通过来自患者的流体处理系统通过一个或多个流体通道获得体液样品。所得样品的体积不超过5毫升。该方法还包括通过可操作地与流体处理系统相关联的分析物检测系统分析所获得的样品的至少一部分分析物，以确定至少一种分析物的浓度。

17. 发明授权

US07860542B2 Analyte detection system with reduced sample volume 有权
标题翻译：分析物检测系统，样品量减少
公开(公告)号：US07860542B2
公开(公告)日：2010-12-28
申请号：US11316686
申请日：2005-12-21
申请人： Bernhard B. Sterling , Jennifer H. Gable , James R. Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
发明人： Bernhard B. Sterling , Jennifer H. Gable , James R. Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
IPC分类号： A61B5/1455
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 400 microliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.
摘要翻译：在某些实施方案中，方法对患者的体液进行取样。该方法包括提供具有一个或多个流体通道的流体处理系统。该方法还包括通过流体处理系统通过一个或多个流体通道将输注液输入患者体内。该方法还包括通过来自患者的流体处理系统通过一个或多个流体通道获得体液样品。所得样品的体积不超过400微升。该方法还包括通过可操作地与流体处理系统相关联的分析物检测系统分析所获得的样品的至少一部分分析物，以确定至少一种分析物的浓度。

18. 发明申请

US20080072663A1 ACCURATE AND TIMELY BODY FLUID ANALYSIS 审中-公开
标题翻译：精确和及时的体液分析
公开(公告)号：US20080072663A1
公开(公告)日：2008-03-27
申请号：US11839487
申请日：2007-08-15
申请人： Richard Keenan , Jeffrey Chiou , Roger Tong , Michael Recknor , Ken Li , James Braig , David Callicoat , Jennifer Gable
发明人： Richard Keenan , Jeffrey Chiou , Roger Tong , Michael Recknor , Ken Li , James Braig , David Callicoat , Jennifer Gable
IPC分类号： G01N33/00 , B01J19/00 , B04B5/10
CPC分类号： G01N35/1095 , A61B5/14532 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150267 , A61B5/150305 , A61B5/150755 , A61B5/150786 , A61B5/150824 , A61B5/153 , A61B5/157 , A61M1/3621 , A61M5/14 , A61M5/1415 , A61M2005/1404 , A61M2005/1726 , A61M2230/201 , B01L3/502 , B01L3/50273 , B01L3/52 , B01L2200/10 , B01L2300/0816 , B01L2400/0478 , B01L2400/0633 , G01N21/35
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. A first component of the bodily fluid is separated from the drawn portion, while the analyte detection system remains in fluid communication with the patient. The analyte detection system analyzes the first component to measure a concentration of an analyte in an accurate and timely manner.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括在患者体内建立分析物检测系统和体液之间的流体连通。体液的一部分从患者身上抽出。分析物检测系统与患者保持流体连通，将体液的第一组分与拉出部分分离。分析物检测系统分析第一个成分，以准确和及时的方式测量分析物的浓度。

19. 发明申请

US20070104616A1 FLUID HANDLING CASSETTE SYSTEM FOR BODY FLUID ANALYZER 审中-公开
标题翻译：液体流动分析仪的流体处理系统
公开(公告)号：US20070104616A1
公开(公告)日：2007-05-10
申请号：US11539534
申请日：2006-10-06
申请人： Richard Keenan , Jeff Chion , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James Braig
发明人： Richard Keenan , Jeff Chion , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James Braig
IPC分类号： B01L3/00
CPC分类号： G01N35/1097 , A61B5/14557 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/142 , A61M5/14212 , A61M5/1723 , A61M2205/12 , A61M2230/20 , B01L3/5027 , B01L3/502715 , B01L13/00 , B01L2200/027 , B01L2300/0803 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487
摘要： A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.
摘要翻译：用于体液分析的流体处理系统。该系统包括被配置为与主仪器接口的第一流体处理模块。第一流体处理模块具有第一流体处理网络，并且第一流体处理网络包括适于在输注通道内移动流体的输注通道和输液流体压力构件。流体处理系统还具有与第一模块分离的第二流体处理模块，第一模块被配置为与主仪器相接触。第二流体处理模块具有第二流体处理网络和可经由第二流体处理网络访问的至少一个样品分析单元。第一和第二模块被配置为在第一和第二流体处理网络和样品池之间互连并提供流体连通。

20. 发明申请

US20100030137A1 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
公开(公告)号：US20100030137A1
公开(公告)日：2010-02-04
申请号：US12511014
申请日：2009-07-28
申请人： W. Dale Hall , David N. Callicoat , Jennifer H. Gable , James R. Braig , Kenneth G. Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Dale Hall , David N. Callicoat , Jennifer H. Gable , James R. Braig , Kenneth G. Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M5/168
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

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