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    • 11. 发明申请
    • METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS
    • 用于生产二氟吡唑
    • WO2008152138A3
    • 2009-05-28
    • PCT/EP2008057506
    • 2008-06-13
    • BASF SENETT MARKUSGROTE THOMASLOHMANN JAN KLAASDIETZ JOCHENSMIDT SEBASTIAN PEERRACK MICHAELZIERKE THOMAS
    • NETT MARKUSGROTE THOMASLOHMANN JAN KLAASDIETZ JOCHENSMIDT SEBASTIAN PEERRACK MICHAELZIERKE THOMAS
    • C07D231/12C07D231/14
    • C07D231/12C07D231/14
    • The invention relates to a method for producing 3-difluoromethyl-substituted pyrazole compounds of formula (I), wherein R1 represents H, halogen, nitro, C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, phenyl, naphthyl, hetaryl, cyano, -C(=O)-OR1a, -C(=O)-NR1bR1c, -C(=O)-SR1d or -C(=S)-SR1 e; R2 represents H, C1-C4 alkyl, benzyl or phenyl; R3 represents H, halogen, C1-C8 alkoxy, C1-C8 haloalkoxy, C3-C8 cycloalkoxy, C2-C8 alkenyloxy, C1-C8 alkylthio, C1-C8 haloalkylthio, C3-C8 cycloalkylthio or C2-C8 alkenylthio; to compounds of formula (II.a) or (II.b), wherein R1 and R3 have one of the above definitions; R4 represents halogen, -OR4a, -SR4a , -O-SO2-R4a or a group -NR4bR4c; R5 and R6 represent C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, benzyl or phenyl or together with the nitrogen atom to which they are bound represent a 3- to 8-membered heterocycle; to Lewis acid adducts of compounds of formula (II.b); to the use of compounds of formula (II.a) or (II.b) and of the Lewis acid adducts thereof for producing compounds of formula (I) or (VI); and to a method for converting said compounds to the corresponding 3-difluoromethylpyrazole-4-yl carboxylic acids.
    • 本发明涉及一种用于制备式-3-二氟甲基吡唑(I)化合物其中R1是H,卤素,硝基,C1-C8烷基,C1-C8卤代烷基,C3-C8环烷基,苯基,萘基,杂芳基, 氰基,-C(= O)-OR1a,-C(= O)-NR1bR1c,-C(= O)-SR1d或-C(= S)-SR1e基; R2是H,C1-C4烷基,苄基或苯基; R 3为H,卤素,C1-C8烷氧基,C1-C8卤代烷氧基,C3-C8环烷氧基,C2-C8链烯氧基,C1-C8烷硫基,C1-C8卤代烷硫基,C3-C8-环烷硫基或C 2 -C C8-烯硫基;式(二.a)或(二.b)的化合物,其中R 1和R 3具有以上给出的含义之一; R 4是卤素,-OR4a,-SR4a,-O-SO2-R4A或一组-NR4bR4c基; R5和R6是C1-C8烷基,C1-C8卤代烷基,C3-C8环烷基,苄基或苯基或一起与氮原子到它们所键合的,代表3-至8-元杂环; 式(二.b)化合物的路易斯酸加合物;使用(二.a)或(二.b)和路易斯酸加合物,式I化合物的对式(I)或(VI)的化合物的制备方法; 并且这些化合物转变成相应的3-二氟甲基吡唑-4-基甲磺酸的方法。
    • 14. 发明申请
    • AMIDRAZONE COMPOUNDS FOR COMBATING ANIMAL PESTS
    • 用于组合动物疫苗的咪唑啉酮化合物
    • WO2006097279A8
    • 2007-05-18
    • PCT/EP2006002331
    • 2006-03-14
    • BASF AGKORADIN CHRISTOPHERDEYN WOLFGANG VONRACK MICHAELKUHN DAVID GCULBERTSON DEBORAH LANSPAUGH DOUGLASOLOUMI-SADEGHI HASSAN
    • KORADIN CHRISTOPHERVON DEYN WOLFGANGRACK MICHAELKUHN DAVID GCULBERTSON DEBORAH LANSPAUGH DOUGLASOLOUMI-SADEGHI HASSAN
    • A01N37/52A01P5/00A01P7/00A01P7/04C07C259/20
    • C07C259/20A01N37/52C07C2601/02
    • The present invention relates to new amidrazone compounds which are useful for combating animal pests, in particular insects, arachnids and nematodes. The invention also relates to a method for combating insects, nematodes and arachnids. The amidrazone compounds are of the general formula (I) including the tautomers of I and the salts thereof; wherein X and Y are hydrogen or together form a chemical bond; Ar is an aromatic radical selected from phenyl and a 5- or 6-membered heteroaryl having 1 , 2, 3 or 4 heteroatoms as ring members, which are selected, independently of one another, from O, N and S, and where the aromatic radical may have 1 , 2, 3, 4 or 5 substituents R a ; R 1 is selected from the group consisiting of C 1 -C 1O -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, cyano-C 1 -C 4 -alkyl, hydroxy-C 1- C 4 -alkyl, C 1 -C 10 -haloalkyl, tri-(C 1 -C 4 -alkyl)-silyl-C 1 - C 4 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -haloalkenyl, C 2 -C 10 -alkynyl, C 2 -C 10 -haloalkynyl, C 3 -C 10 -cycloalkyl, phenyl, heteroaryl, C 3 -C 10 -cycloalkyl-C 1 C 4 -alkyl, phenyl-C 1 -C 4 - alkyl and heteroaryl-C 1 C 4 alkyl, wherein C 3 -C 10 -cycloalkyl, heteroaryl and phenyl in the last six mentioned radicals may be unsubstituted or carry 1 , 2, 3, 4 or 5 substituents R b as defined above; R 2 is selected from the group consisiting of C 1- C 1 0-alkyl, c 1- c 4 -alkoxy- C 1- C 4 -alkyl, C 1- C 10 -haloalkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -haloalkenyl, C 2 -C 10 -alkynyl, C 2 -C 10 - haloalkynyl,c 3 -C 10 -cycloalkyl, phenyl, heteroaryl, C 3 -C 10 -cycloalkyl-C 1- C 4 -alkyl, phenyl-C 1 -C 4 -alkyl and heteroaryI-C 1- C 4 -alkyl, wherein C 3 -C 10 -cycloalkyl, heteroaryl and phenyl in the last six mentioned radicals may be unsubstituted or carry 1 , 2, 3, 4 or 5 substituents R b as defined above.
    • 本发明涉及可用于对抗动物害虫,特别是昆虫,蜘蛛和线虫的新的氨基腙化合物。 本发明还涉及一种防治昆虫,线虫和蜘蛛的方法。 氨基腙化合物具有通式(I),其包括I的互变异构体及其盐; 其中X和Y是氢或一起形成化学键; Ar是选自苯基和具有1,2,3或4个杂原子作为环成员的5-或6-元杂芳基的芳族基团,其彼此独立地选自O,N和S,并且其中芳族 基团可以具有1,2,3,4或5个取代基R a, R 1选自C 1 -C 10 - 烷基,C 1 -C 1 - 烷基, C 1 -C 4烷基,C 1 -C 4烷基,C 1 -C 4烷基,氰基-C 1 -C 4烷基, C 1 -C 6烷基,羟基-C 1 -C 4 - 亚烷基,C 1 -C 10 - 烷基, 卤代烷基,三 - (C 1 -C 4 - 烷基) - 甲硅烷基-C 1 -C 4 - 烷基,C 2 -C 10 - 烯基,C 2 -C 10 - 卤代烯基,C 1 -C 10 - C 2 -C 10 - 炔基,C 2 -C 10 - 卤代炔基,C 3 - C 10 - 环烷基,苯基,杂芳基,C 3 -C 10 - 环烷基-C 1 -C C 1-4烷基,苯基-C 1 -C 4 - 烷基和杂芳基-C 1 -C 4烷基, 其中C 3 -C 10 - 环烷基,杂芳基和苯基在后面六个提及的基团中可以是未取代的或携带1,2,3,4或4个 5个取代基R b如上所定义; R 2选自C 1 -C 1-4烷基,C 1 -C 4烷基, C 1-4烷基,C 1 -C 10烷基,C 1 -C 4烷基,C 1〜 亚烷基,C 2 -C 10 - 烯基,C 2 -C 10 - 卤代烯基,C C 2 -C 10 - 炔基,C 2 -C 10 - 卤代炔基,C 3 - C 1 -C 10 - 环烷基,苯基,杂芳基,C 3 -C 10 - 环烷基-C 1 - C 1 -C 4 - 烷基,苯基-C 1 -C 4 - 烷基和杂芳基C 1 -C 其中C 3 -C 10 - 环烷基,最后六个所述基团中的杂芳基和苯基可以是未取代的或携带1, 2,3,4或5个如上定义的取代基R b。
    • 17. 发明申请
    • RESORCINE DERIVATIVES AND THEIR USE AS PESTICIDES
    • RESORCINE衍生物及其作为杀虫剂的用途
    • WO2007054558A2
    • 2007-05-18
    • PCT/EP2006068329
    • 2006-11-10
    • BASF AGPUHL MICHAELKORDES MARKUSPOHLMAN MATTHIASGOETZ NORBERTRACK MICHAELLANGEWALD JUERGENSCHNEIDER FELIXANSPAUGH DOUGLAS DCULBERTSON DEBORAH LOLOUMI-SADEGHI HASSANKUHN DAVID G
    • PUHL MICHAELKORDES MARKUSPOHLMAN MATTHIASGOETZ NORBERTRACK MICHAELLANGEWALD JUERGENSCHNEIDER FELIXANSPAUGH DOUGLAS DCULBERTSON DEBORAH LOLOUMI-SADEGHI HASSANKUHN DAVID G
    • C07D213/64C07D277/34C07D307/80
    • This invention relates to resorcine derivatives of formula (I) wherein R 1 is phenyl or a 5- to 6-membered heteroaromatic ring which may contain 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur, wherein phenyl or the heteroaromatic ring may be fused to a ring selected from phenyl and a 5- to 6-membered saturated, partially unsaturated or aromatic heterocyclic ring which may contain 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur, wherein phenyl or the 5- to 6-membered heteroaromatic ring or the respective fused ring systems may be unsubstituted or substituted by any combination of 1 to 6 optionally substituted groups R 3 , wherein R 3 is halogen, cyano, nitro, hydroxy, mercapto, amino, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, haloalkyl, haloalkenyl, haloalkynyl, halocycloalkyl, halocycloalkenyl, alkoxy, alkenyloxy, alkynyloxy, haloalkoxy, haloalkenyloxy, haloalkynyloxy, alkylthio, alkenylthio, alkynylthio, haloalkylthio, haloalkenylthio, haloalkynylthio, alkylamino, alkenylamino, alkynylamino, dialkylamino, dialkenylamino, dialkynylamino, alkyl-alkenylamino, alkyl-alkynylamino, alkenyl- alkynylamino, trialkylsilyl, or phenyl or a 5-to 7-membered saturated or partially unsaturated heterocyclic ring which may contain 1 to 3 heteroatoms selected from oxygen, sulfur and nitrogen or a 5- to 6-membered heteraromatic ring system which may contain 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur, which phenyl and which heteroaromatic ring may be bonded via an oxygen or a sulfur atom, or -C(=G)Ra, -C(=G)ORa, -C(=G)NRa2, -C(=G)[N=SRa2], -C(=NORa)Ra, -C(=NORa)NRa2, -C(=NNRa2)Ra , -OC(=G)-OC(=G)ORa, N=SRa2, -NRaC(=G)Ra, -N[C(=G)Ra]2, - NRaC(=G)ORa, -C(=G)NRa-NRa2, -C(=G)NRa-NRa [C(=G)Ra], -NRa-C(=G)NRa2, -NRa-NRaC(=G)Ra, -NRa-N[C(=G)Ra]2, -N[(C=G)Ra]-NRa2, -NRa-NRa[(C=G)GRa], -NRa[(C=G)NRa2, -NRa[C=NRa]Ra, -NRa(C=NRa)NRa2, -O-NRa2, -O-NRa(C=G)Ra, - SO2NRa2, -NRaSO2Ra, -S(=O)Ra, -S(=O)2Ra, -SO2ORa, or -OSO2Ra, wherein G is oxygen or sulfur and Ra is as defined in the description, R 2 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, or haloalkoxy, x is 2, 3, 4, 5, 6, or 7, or the diastereomers, enantiomers, salts or N-oxides thereof, with the proviso that R 1 is not 5-chloro-2,2,-dimethyl-2,3-dihydrobenzo[b]furan-7-yl when R 2 is hydrogen and x is 3 or 4, processes and intermediates for the preparation of compounds I, use of compounds I for combating insects, acarids, or nematodes, and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites using compounds I.
    • 本发明涉及其中R 1为苯基或可含有1-3个选自氧,氮和硫的杂原子的5至6元杂芳环的式(I)的间苯二酚衍生物,其中苯基 或杂芳环可以与选自苯基和5-至6-元饱和,部分不饱和或芳族杂环的环稠合,所述杂环可以含有1-3个选自氧,氮和硫的杂原子,其中苯基或5- 至6元杂芳环或相应的稠环体系可以是未取代的或被1至6个任选取代的基团R 3 3的任何组合取代,其中R 3是卤素, 氰基,硝基,羟基,巯基,氨基,烷基,烯基,炔基,环烷基,环烯基,卤代烷基,卤代烯基,卤代炔基,卤代环烷基,卤代环烯基,烷氧基,烯氧基,炔氧基,卤代烷氧基,卤代烯氧基,卤代炔氧基,烷硫基,烯硫基,炔硫基,卤代烷硫基, H 烯基氨基,炔基氨基,二烷基氨基,二链烷基氨基,二炔基氨基,烷基 - 链烯基氨基,烷基 - 炔基氨基,烯基 - 炔基氨基,三烷基甲硅烷基或苯基或5至7元饱和或部分不饱和的杂环, 至3个选自氧,硫和氮的杂原子或5至6元杂芳环体系,其可以含有1至4个选自氧,氮和硫的杂原子,该苯基和杂芳环可以通过氧或 硫原子或-C(= G)R a,-C(= G)OR a,-C(= G)NR a 2,-C(= G)[N = SR a 2] (= NORa)NRa2,-C(= NNRa2)Ra,-OC(= G)-OC(= G)ORa,N = SRa2,-NRaC(= G)Ra,-N [C(= G)Ra] 2,-NR a C(= G)OR a,-C(= G)NR a -NR a 2,-C(= G)NR a -NR a [C(= G)R a] -NRaC(= G)Ra,-NRa-N [C(= G)Ra] 2,-N [(C = G)Ra] -NRa2,-NRa-NRa [(C = G) [(C = G)NRa2,-NRa [C = NRa] Ra,-NRa(C = NRa)NRa2,-O-NRa2,-O-NRa(C = G)Ra,-SO2NRa2,-NRaSO2Ra,-S (= O)R a,-S(= O)2 R a,-SO 2 OR a或-O SO 2 R a,其中G是氧或硫,Ra如说明书中所定义,R 2是氢,卤素,氰基,烷基,卤代烷基,烯基,卤代烯基,炔基,卤代炔基,烷氧基或卤代烷氧基, x是2,3,4,5,6或7,或其非对映异构体,对映异构体,盐或N-氧化物,条件是R 1不是5-氯-2,2 ,当R 2是氢并且x是3或4时,制备化合物I的方法和中间体,使用化合物I,其中R 1,R 2,R 3, 用于防治昆虫,螨虫或线虫,以及用化合物I治疗,控制,预防或保护动物免受寄生虫侵袭或感染的方法。