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1. 发明申请

WO2008152138A3 METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS 审中-公开
标题翻译：用于生产二氟吡唑
公开(公告)号：WO2008152138A3
公开(公告)日：2009-05-28
申请号：PCT/EP2008057506
申请日：2008-06-13
申请人： BASF SE , NETT MARKUS , GROTE THOMAS , LOHMANN JAN KLAAS , DIETZ JOCHEN , SMIDT SEBASTIAN PEER , RACK MICHAEL , ZIERKE THOMAS
发明人： NETT MARKUS , GROTE THOMAS , LOHMANN JAN KLAAS , DIETZ JOCHEN , SMIDT SEBASTIAN PEER , RACK MICHAEL , ZIERKE THOMAS
IPC分类号： C07D231/12 , C07D231/14
CPC分类号： C07D231/12 , C07D231/14
摘要： The invention relates to a method for producing 3-difluoromethyl-substituted pyrazole compounds of formula (I), wherein R1 represents H, halogen, nitro, C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, phenyl, naphthyl, hetaryl, cyano, -C(=O)-OR1a, -C(=O)-NR1bR1c, -C(=O)-SR1d or -C(=S)-SR1 e; R2 represents H, C1-C4 alkyl, benzyl or phenyl; R3 represents H, halogen, C1-C8 alkoxy, C1-C8 haloalkoxy, C3-C8 cycloalkoxy, C2-C8 alkenyloxy, C1-C8 alkylthio, C1-C8 haloalkylthio, C3-C8 cycloalkylthio or C2-C8 alkenylthio; to compounds of formula (II.a) or (II.b), wherein R1 and R3 have one of the above definitions; R4 represents halogen, -OR4a, -SR4a , -O-SO2-R4a or a group -NR4bR4c; R5 and R6 represent C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, benzyl or phenyl or together with the nitrogen atom to which they are bound represent a 3- to 8-membered heterocycle; to Lewis acid adducts of compounds of formula (II.b); to the use of compounds of formula (II.a) or (II.b) and of the Lewis acid adducts thereof for producing compounds of formula (I) or (VI); and to a method for converting said compounds to the corresponding 3-difluoromethylpyrazole-4-yl carboxylic acids.
摘要翻译：本发明涉及一种用于制备式-3-二氟甲基吡唑（I）化合物其中R1是H，卤素，硝基，C1-C8烷基，C1-C8卤代烷基，C3-C8环烷基，苯基，萘基，杂芳基，氰基，-C（= O）-OR1a，-C（= O）-NR1bR1c，-C（= O）-SR1d或-C（= S）-SR1e基; R2是H，C1-C4烷基，苄基或苯基; R 3为H，卤素，C1-C8烷氧基，C1-C8卤代烷氧基，C3-C8环烷氧基，C2-C8链烯氧基，C1-C8烷硫基，C1-C8卤代烷硫基，C3-C8-环烷硫基或C 2 -C C8-烯硫基;式（二.a）或（二.b）的化合物，其中R 1和R 3具有以上给出的含义之一; R 4是卤素，-OR4a，-SR4a，-O-SO2-R4A或一组-NR4bR4c基; R5和R6是C1-C8烷基，C1-C8卤代烷基，C3-C8环烷基，苄基或苯基或一起与氮原子到它们所键合的，代表3-至8-元杂环; 式（二.b）化合物的路易斯酸加合物;使用（二.a）或（二.b）和路易斯酸加合物，式I化合物的对式（I）或（VI）的化合物的制备方法; 并且这些化合物转变成相应的3-二氟甲基吡唑-4-基甲磺酸的方法。

2. 发明专利

ES2369215T3 PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE PIRAZOL SUBSTITUIDOS CON DIFLUORMETILO. 未知
公开(公告)号：ES2369215T3
公开(公告)日：2011-11-28
申请号：ES08761025
申请日：2008-06-13
申请人： BASF SE
发明人： NETT MARKUS , GROTE THOMAS , LOHMANN JAN KLAAS , DIETZ JOCHEN , SMIDT SEBASTIAN PEER , RACK MICHAEL , ZIERKE THOMAS
IPC分类号： C07D231/12 , C07D231/14
摘要： Procedimiento para la obtención de compuestos de la fórmula (I) donde R1 representa hidrógeno, alquilo con 1 a 8 átomos de carbono, fenilo, ciano o -C (=O) -OR1a , no estando substituido el grupo fenilo, o presentando el mismo 1 o 2 substituyentes, seleccionados independientemente entre sí a partir de halógeno, nitro, alquilo con 1 a 4 átomos de carbono, alquilo halogenado con 1 a 4 átomos de carbono y alcoxi con 1 a 4 átomos de carbono, representando R1a alquilo con 1 a 8 átomos de carbono, alquilo halogenado con 1 a 8 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono, alcoxi con 1 a 4 átomos de carbono-alquilo con 1 a 4 átomos de carbono, cicloalcoxi con 3 a 8 átomos de carbono-alquilo con 1 a 4 átomos de carbono, alquenilo con 2 a 8 átomos de carbono, bencilo o fenilo, no estando substituido el grupo fenilo en bencilo y fenilo respectivamente, o presentando el mismo 1, 2 o 3 substituyentes seleccionados independientemente entre sí a partir de halógeno, CN, nitro, alquilo con 1 a 4 átomos de carbono, alquilo halogenado con 1 a 4 átomos de carbono, alcoxi con 1 a 4 átomos de carbono y alcoxi halogenado con 1 a 4 átomos de carbono; y R2 representa metilo, que comprende A) la reacción de un compuesto de la fórmula (III) donde R5 y R6, independientemente entre sí, representan alquilo con 1 a 4 átomos de carbono, o, junto con el átomo de nitrógeno al que están unidos, un heterociclo de 5 a 6 eslabones enlazado a N, que puede presentar, además del átomo de nitrógeno, 1 o 2 heteroátomos adicionales seleccionados entre N, O y S como átomos de anillo, y no está substituido, o presenta 1, 2, 3 o 4 substituyentes, seleccionados independientemente entre sí entre halógeno, CN, nitro, alquilo con 1 a 4 átomos de carbono, alquilo halogenado con 1 a 4 átomos de carbono, alcoxi con 1 a 4 átomos de carbono y alcoxi halogenado con 1 a 4 átomos de carbono; con un ácido y un compuesto de la fórmula (IV) donde R1 posee uno de los significados dados anteriormente, y R4 representa halógeno, -OR4a, -SR4a o -O-SO2-R4a, donde R4a representa hidrógeno, alquilo con 1 a 8 átomos de carbono, alquilo halogenado con 1 a 8 átomos de carbono, alquenilo con 2 a 8 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono, bencilo o fenilo, no estando substituido el grupo fenilo en bencilo y fenilo respectivamente, o presentando 1, 2 o 3 substituyentes seleccionados independientemente entre sí a partir de halógeno, CN, nitro, alquilo con 1 a 4 átomos de carbono, alquilo halogenado con 1 a 4 átomos de carbono, alcoxi con 1 a 4 átomos de carbono y alcoxi halogenado con 1 a 4 átomos de carbono, obteniéndose un producto de reacción (II) , y B) la reacción del producto de reacción (II) con un compuesto de hidrazina de la fórmula H2N-NHR2, donde R2 posee uno de los significados dados anteriormente, bajo obtención de un compuesto de la fórmula (I) .

3. 发明专利

DK2158185T3 Fremgangsmåde til fremstilling af difluormethylsubstituerede pyrazolforbindelser 未知
公开(公告)号：DK2158185T3
公开(公告)日：2011-11-21
申请号：DK08761025
申请日：2008-06-13
申请人： BASF SE
发明人： NETT MARKUS , GROTE THOMAS , RACK MICHAEL , ZIERKE THOMAS , LOHMANN JAN KLAAS , DIETZ JOCHEN , SMIDT SEBASTIAN PEER
IPC分类号： C07D231/12 , C07D231/14

4. 发明专利

CA2690460A1 METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS 未知
公开(公告)号：CA2690460A1
公开(公告)日：2008-12-18
申请号：CA2690460
申请日：2008-06-13
申请人： BASF SE
发明人： NETT MARKUS , GROTE THOMAS , LOHMANN JAN KLAAS , DIETZ JOCHEN , SMIDT SEBASTIAN PEER , RACK MICHAEL , ZIERKE THOMAS
IPC分类号： C07D231/12 , C07D231/14
摘要： The invention relates to a method for producing 3-difluoromethyl-substituted pyrazole compounds of formula (I), wherein R1 represents H, halogen, nitro, C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, phenyl, naphthyl, hetaryl, cyano, -C(=O)-OR1a, -C(=O)-NR1bR1c, -C(=O)-SR1d or -C(=S)-SR1e; R2 represents H, C1-C4 alkyl, benzyl or phenyl; R3 represents H, halogen, C1-C8 alkoxy, C1-C8 haloalkoxy, C3-C8 cycloalkoxy, C2-C8 alkenyloxy, C1-C8 alkylthio, C1-C8 haloalkylthio, C3-C8 cycloalkylthio or C2-C8 alkenylthio; to compounds of formula (II.a) or (II.b), wherein R1 and R3 have one of the above definitions; R4 represents halogen, -OR4a, -SR4a , -O-SO2-R4a or a group -NR4bR4c; R5 and R6 represent C1-C8 alkyl, C1-C8 haloalkyl, C3-C8 cycloalkyl, benzyl or phenyl or together with the nitrogen atom to which they are bound represent a 3- to 8-membered heterocycle; to Lewis acid adducts of compounds of formula (II.b); to the use of compounds of formula (II.a) or (II.b) and of the Lewis acid adducts thereof for producing compounds of formula (I) or (VI); and to a method for converting said compounds to the corresponding 3-difluoromethylpyrazole-4-yl carboxylic acids.

5. 发明专利

AU2008263883A1 Method for producing difluoromethyl-substituted pyrazole compounds 未知
公开(公告)号：AU2008263883A1
公开(公告)日：2008-12-18
申请号：AU2008263883
申请日：2008-06-13
申请人： BASF SE
发明人： SMIDT SEBASTIAN PEER , LOHMANN JAN KLAAS , DIETZ JOCHEN , ZIERKE THOMAS , NETT MARKUS , RACK MICHAEL , GROTE THOMAS
IPC分类号： C07D231/12 , C07D231/14
摘要： The present invention relates to a process for preparing 3-difluoromethyl-Substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.

6. 发明专利

BR112012015040A2 processo para a preparação de grupos tio-triazol substituídos da fórmula geral (i) e compostos (lla) 未知
公开(公告)号：BR112012015040A2
公开(公告)日：2015-09-22
申请号：BR112012015040
申请日：2010-12-13
申请人： BASF SE
发明人： RENNER JENS , GEBHARDT JOACHIM , DIETZ JOCHEN , NETT MARKUS , KEIL MICHAEL , GROTE THOMAS
IPC分类号： C07D249/12

7. 发明专利

ZA201000204B METHOD FOR PRODUCING DIFLUOROMETHYL-SUBSTITUTED PYRAZOLE COMPOUNDS 未知
公开(公告)号：ZA201000204B
公开(公告)日：2011-10-26
申请号：ZA201000204
申请日：2010-01-12
申请人： BASF SE
发明人： NETT MARKUS , GROTE THOMAS , LOHMANN JAN KLAAS , DIETZ JOCHEN , SMIDT SEBASTIAN PEER , RACK MICHAEL , ZIERKE THOMAS
IPC分类号： C07D20060101
摘要： The present invention relates to a process for preparing 3-difluoromethyl-Substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.

8. 发明专利

MX2009013059A PROCEDIMIENTOS PARA LA PREPARACION DE COMPUESTOS DE PIRAZOL SUSTITUIDOS CON DIFLUOROMETILO. 未知
公开(公告)号：MX2009013059A
公开(公告)日：2010-01-15
申请号：MX2009013059
申请日：2008-06-13
申请人： BASF SE
发明人： GROTE THOMAS , ZIERKE THOMAS , RACK MICHAEL , NETT MARKUS , DIETZ JOCHEN , LOHMANN JAN KLAAS , SMIDT SEBASTIAN PEER
IPC分类号： C07D231/12 , C07D231/14
摘要： La presente invención se refiere a un procedimiento para la preparación de compuestos de pirazol sustituidos con 3-difluorometilo de la formula (I) (ver fórmula I) en donde R1 es H, halógeno, nitro, alquilo C1-C8, haloalquilo C1-C8, cicloalquilo C3-C8, fenilo, naftilo, hetarilo, ciano, -C(=O)-OR1a, -C(=O)-NR1bR1c, -C(=O)SR1d o -C(=S)- SR1e; R2 es H, alquilo C,-C4, bencilo o fenilo; R3 es H, halógeno, alcoxi C1-C8, haloalcoxi C1-C8, cicloalcoxi C3-C8, alquenil C2-C8-oxi, alquil C1-C8-tio, haloalquil C1-C8-tio, cicloalquil C3-C8-tio o alquenil C2-C8,-tio; así como a un procedimiento para convertir estos compuestos en los correspondientes ácidos 3-difluorometilpirazol-4 -ilcarboxílicos.

9. 发明专利

BRPI0812958A2 未知
公开(公告)号：BRPI0812958A2
公开(公告)日：2014-12-09
申请号：BRPI0812958
申请日：2008-06-13
申请人： BASF SE
发明人： NETT MARKUS , GROTE THOMAS , LOHMANN JAN KLASS , DIETZ JOCHEN , SMIDT SEBASTIAN PEER , RACK MICHAEL , ZIERKE THOMAS
IPC分类号： C07D231/12 , C07D231/14
摘要： The present invention relates to a process for preparing 3-difluoromethyl-Substituted pyrazole compounds of the formula (I) in which R1 is H, halogen, nitro, C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, phenyl, naphthyl, hetaryl, cyano, —C(═O)—OR1a, —C(═O)—NR1bR1c, —C(═O)—SR1d or —C(═S)—SR1e; R2 is H, C1-C4-alkyl, benzyl or phenyl; R3 is H, halogen, C1-C8-alkoxy, C1-C8-haloalkoxy, C3-C8-cycloalkoxy, C2-C8-alkenyloxy, C1-C8-alkylthio, C1-C8-haloalkylthio, C3-C8-cyclo-alkylthio or C2-C8-alkenylthio; compounds of the formula (II.a) or (II.b), in which R1 and R3 each have one of the definitions given above; R4 is halogen, —OR4a, —SR4a, —O—SO2—R4a or an —NR4bR4c group; R5 and R6 are each C1-C8-alkyl, C1-C8-haloalkyl, C3-C8-cycloalkyl, benzyl or phenyl, or, together with the nitrogen atom to which they are bonded, are a 3- to 8-membered heterocycle; Lewis acid adducts of compounds of the formula (II.b); the use of compounds of the formula (II.a) or (II.b) and of the Lewis acid adducts for preparing compounds of the formula (I) or (VI); and to a process for converting such compounds to the corresponding 3-difluoro-pyrazol-4-ylcarboxylic acids.

10. 发明专利

AU2008263883B2 Method for producing difluoromethyl-substituted pyrazole compounds 未知
公开(公告)号：AU2008263883B2
公开(公告)日：2014-03-13
申请号：AU2008263883
申请日：2008-06-13
申请人： BASF SE
发明人： LOHMANN JAN KLAAS , NETT MARKUS , SMIDT SEBASTIAN PEER , ZIERKE THOMAS , GROTE THOMAS , RACK MICHAEL , DIETZ JOCHEN
IPC分类号： C07D231/12 , C07D231/14
摘要： The invention relates to a method for producing 3-difluoromethyl-substituted pyrazole compounds of formula (I), wherein R

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