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11. 发明申请

WO2011028995A1 COMPOUNDS AS TYROSINE KINASE MODULATORS 审中-公开
标题翻译：化合物作为酪氨酸激酶调节剂
公开(公告)号：WO2011028995A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047800
申请日：2010-09-03
申请人： ALLERGAN, INC. , GUO, Xialing , ZHU, Zhen
发明人： GUO, Xialing , ZHU, Zhen
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61P35/00 , A61P27/02 , A61P29/00 , A61P3/10
CPC分类号： C07D401/04 , C07D401/14 , C07D405/00 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14
摘要： The present invention is directed to novel compounds of Formula (I). The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.
摘要翻译：本发明涉及新的式（I）化合物。本发明的化合物是有效的酪氨酸激酶调节剂，并且适用于治疗和预防与酪氨酸激酶受体的异常活性有关的疾病和病症。

12. 发明申请

WO2010030821A3 IBUPROFEN FOR TOPICAL ADMINISTRATION 审中-公开
标题翻译： IBUPROFEN用于局部管理
公开(公告)号：WO2010030821A3
公开(公告)日：2011-01-20
申请号：PCT/US2009056568
申请日：2009-09-10
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , KOZWICH DIANE
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , KOZWICH DIANE
IPC分类号： A61K47/32
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/7023 , A61K47/16 , A61K47/22 , A61K47/32
摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skm tissue Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e g, a pyrrohdone solvent or dimethylacetamide
摘要翻译：本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸）的制剂。通过在游离酸形式的布洛芬溶解游离酸形式的布洛芬或在药学上可接受的溶剂的存在下制备游离酸形式的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过skm组织布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯酮溶剂或二甲基乙酰胺

13. 发明申请

WO2010135247A1 COMPOSITIONS AND METHODS FOR INCREASING TELOMERASE ACTIVITY 审中-公开
标题翻译：用于增加TELOMERASE活性的组合物和方法
公开(公告)号：WO2010135247A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035119
申请日：2010-05-17
申请人： TA THERAPEUTICS, LTD. , HARLEY, Calvin, B. , KHOR, Soo-peang , RAMASESHAN, Mahesh , RAMIYA, Premchandran, H. , PIROT, Zhu, Zhen , FAUCE, Steven , LIN, Tong
发明人： HARLEY, Calvin, B. , KHOR, Soo-peang , RAMASESHAN, Mahesh , RAMIYA, Premchandran, H. , PIROT, Zhu, Zhen , FAUCE, Steven , LIN, Tong
IPC分类号： A01N45/00 , A61K31/56
CPC分类号： A61K31/58 , A61K31/56 , C07J17/00 , C07J53/004
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and for enhancing proliferation of stem and progenitor cells.
摘要翻译：本发明涉及增加细胞中端粒酶活性的方法和组合物。这样的组合物包括药物制剂。所述方法和组合物可用于治疗通过在患者的细胞或组织中端粒酶活性增加而治疗的疾病。它们也可用于增强培养细胞的复制能力，如离体细胞治疗和增强干细胞和祖细胞的增殖。

14. 发明申请

WO2010065922A2 METHODS AND COMPOSITIONS FOR TATTOO REMOVAL 审中-公开
标题翻译：去除TATTOO的方法和组合物
公开(公告)号：WO2010065922A2
公开(公告)日：2010-06-10
申请号：PCT/US2009/066865
申请日：2009-12-04
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L. , STEPHENS, Laura , MASIZ, John, J. , DONABEDIAN, David, H.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L. , STEPHENS, Laura , MASIZ, John, J. , DONABEDIAN, David, H.
IPC分类号： A61M37/00 , A61K8/18 , A61Q19/00
CPC分类号： A61K8/4926 , A61B18/203 , A61B2017/00769 , A61B2018/00452 , A61B2018/0047 , A61K8/0208 , A61K8/26 , A61K8/342 , A61K8/498 , A61K8/585 , A61K8/678 , A61K8/73 , A61K8/922 , A61K2800/51 , A61K2800/74 , A61K2800/81 , A61K2800/91 , A61M37/0092 , A61N1/325 , A61N5/062 , A61Q1/145 , A61Q19/02
摘要： Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.
摘要翻译：通过使用细胞破坏剂与血管扩张剂组合，以及任选的一种或多种渗透调节剂，螯合剂和闭塞性修饰剂来去除纹身的方法和制剂。实施方案任选进一步包括使用抗生素，麻醉剂，渗透增强剂，赋形剂，载体和载体中的一种或多种。

15. 发明申请

WO2009073751A2 HAIR FOLLICLE PHARMACODYNAMIC ASSAY FOR TELOMERASE ACTIVITY 审中-公开
标题翻译：用于TELOMERASE活性的发胶药物动力学测定
公开(公告)号：WO2009073751A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/085445
申请日：2008-12-03
申请人： GERON CORPORATION , GO, Ning, F. , HARLEY, Calvin, B. , BASSETT, Ekaterina , PIROT, Zhu, Zhen
发明人： GO, Ning, F. , HARLEY, Calvin, B. , BASSETT, Ekaterina , PIROT, Zhu, Zhen
IPC分类号： C12Q1/48 , C12Q1/68
CPC分类号： C12Q1/48 , C12Q1/6851 , C12Q2521/113
摘要： The invention is directed to methods for determining the efficacy of treatment with telomerase modulators in mammals by the analysis of the level of telomerase reverse transcriptase activity in mammalian hair follicle cells.
摘要翻译：本发明涉及通过分析哺乳动物毛囊细胞中端粒酶逆转录酶活性水平来确定哺乳动物端粒酶调节剂治疗功效的方法。

16. 发明申请

WO2008156758A1 BIFUNCTIONAL SYNTHETIC MOLECULES 审中-公开
标题翻译：双功能合成分子
公开(公告)号：WO2008156758A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007536
申请日：2008-06-17
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , PATEL, Kanu , ZHU, Zhen , QIAO, Lixin
发明人： CARTER, Stephen, G. , PATEL, Kanu , ZHU, Zhen , QIAO, Lixin
IPC分类号： A61K31/74 , A01N61/00
CPC分类号： C07D213/80 , C07C69/612 , C07C233/87 , C07C2601/14 , C07D207/16 , C07D217/26 , C07D233/06 , C07D233/24 , C07D233/50 , C07D417/04
摘要： The synthesis and use of bifunctional molecules to improve the topical and transdermal delivery efficiency of various types of therapeutic agents or agents designed to promote the transdermal delivery of those therapeutic agents either into the skin tissue or into the systemic circulation. Three major classes of molecules are covalently joined as bifunctional substances; chemical vasodilators, passive dermal penetration enhancers and therapeutic or diagnostic drugs. Chemical vasodilators may be delivered into the skin to increasing the blood flow in a tissue that has compromised circulation or they may be used as part of a delivery vehicle to promote the delivery of the drug. Passive dermal penetration enhancers are those chemicals that promote the passive penetration of drugs and other chemicals through the stratum corneum and epidermis of the skin tissue. Drugs and diagnostic agents are the third group of chemicals that are candidates for the linkage of molecules.
摘要翻译：双功能分子的合成和使用以改善各种类型治疗剂或试剂的局部和透皮递送效率，所述治疗剂或试剂旨在促进将这些治疗剂透皮递送至皮肤组织或进入体循环。三大类分子共价连接成双功能物质; 化学血管扩张剂，被动皮肤渗透增强剂和治疗或诊断药物。化学血管扩张剂可以被递送到皮肤中以增加已经损害循环的组织中的血液流动，或者它们可以用作递送载体的一部分以促进药物的递送。被动皮肤渗透增强剂是促进药物和其他化学物质通过角质层和皮肤组织表皮的被动穿透的化学物质。药物和诊断剂是作为分子连接的候选物的第三组化学品。

17. 发明申请

WO2006060174A1 ISOCYANATE-BASED POLYMER FOAMS WITH NANO-SCALE MATERIALS 审中-公开
标题翻译：基于异氰酸酯的聚合物与纳米尺度材料
公开(公告)号：WO2006060174A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/041716
申请日：2005-11-15
申请人： HONEYWELL INTERNATIONAL INC. , BIBB, Caroline , ZHU, Zhen , WILLIAMS, David, J.
发明人： BIBB, Caroline , ZHU, Zhen , WILLIAMS, David, J.
IPC分类号： C08J9/00 , C08L75/04 , C01B33/44 , C08K3/34
CPC分类号： C08G18/3895 , C08G18/4018 , C08G18/482 , C08G2101/00 , C08G2101/0008 , C08G2101/0025 , C08G2105/00 , C08K9/04 , C08L75/04
摘要： Isocyante-based polymer foams containing functionalized nano-scale materials in which the functional groups are OH, NH 2 , COOH or NCO groups. The incorporation of such functionalized nano-scale materials into the isocyanate-based polymer foams provides foams with improved properties such as insulation values, mechanical properties and flame retardancy performance properties, including but not limited to k-factor and dimensional stability.
摘要翻译：含有官能化纳米级材料的异氰酸酯基聚合物泡沫，其中官能团是OH，NH 2，COOH或NCO基团。将这种官能化纳米级材料并入异氰酸酯基聚合物泡沫体中提供具有改进性能的泡沫，例如绝缘值，机械性能和阻燃性能性能，包括但不限于k因子和尺寸稳定性。

18. 发明申请

WO2006009568A3 PERIPHERALLY-ACTING VASODILATORS 审中-公开
公开(公告)号：WO2006009568A3
公开(公告)日：2006-01-26
申请号：PCT/US2004/035463
申请日：2004-10-26
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu
IPC分类号： A61K31/16 , A61K31/21
摘要： A system for the delivery of chemical vasodilators into the skin for the purpose of increasing the blood flow in a tissue that exhibits compromised circulation. The designated purpose of this increased blood flow is to transiently reverse or inhibit or prevent the onset of an associated medical affliction that may in part or in whole, be either the consequence of that medical condition or participating in the clinical symptoms and etiology of that medical condition. The process and the effect of the topical delivery of a chemical vasodilator has been previously demonstrated for other medical and pharmaceutical applications, however the specific use of this class of drug molecules for the focused effect of improving blood flow to the skin and surrounding tissue with the goal of improving the metabolic health of the tissue and to possibly affect the symptoms of a medical condition is the specific aim of this patent.

19. 发明申请

WO2015069287A1 COMPOUNDS AS TYROSINE KINASE MODULATORS 审中-公开
标题翻译：化合物作为酪氨酸激酶调节剂
公开(公告)号：WO2015069287A1
公开(公告)日：2015-05-14
申请号：PCT/US2013/069337
申请日：2013-11-08
申请人： ALLERGAN, INC. , GUO, Xialing , ZHU, Zhen
发明人： GUO, Xialing , ZHU, Zhen
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61P35/00 , A61P27/02 , A61P29/00 , A61P3/10
CPC分类号： C07D413/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14
摘要： The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.
摘要翻译：本发明涉及式I的新化合物。本发明化合物是有效的酪氨酸激酶调节剂，并且适用于治疗和预防与酪氨酸激酶受体的异常活性相关的疾病和病症。

20. 发明申请

WO2011029001A1 COMPOUNDS AS TYROSINE KINASE MODULATORS 审中-公开
标题翻译：化合物作为酪氨酸激酶调节剂
公开(公告)号：WO2011029001A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047816
申请日：2010-09-03
申请人： ALLERGAN, INC. , GUO, Xialing , ZHU, Zhen
发明人： GUO, Xialing , ZHU, Zhen
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00 , A61P29/00 , A61P25/00
CPC分类号： C07D401/04 , C07D401/14 , C07D405/00 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/14
摘要： The present invention is directed to novel compounds of Formula (I). The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.
摘要翻译：本发明涉及式（I）的新型化合物。本发明的化合物是有效的酪氨酸激酶调节剂，适用于治疗和预防与酪氨酸激酶受体异常活性有关的疾病和病症。

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