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1. 发明申请

WO2012107435A1 METHOD FOR MANUFACTURING ANTIMICROBIAL ACRYLIC MATERIALS 审中-公开
标题翻译：制造抗微生物丙烯酸酯材料的方法
公开(公告)号：WO2012107435A1
公开(公告)日：2012-08-16
申请号：PCT/EP2012/052030
申请日：2012-02-07
申请人： EVONIK RÖHM GMBH , DIMOV, Dimo K. , GABRIEL, Lawrence N. , LYON, Florian , SPAIN, Christopher R. , COLBURN, Peter D , SCHMIDTER, T. Craig , ZHU, Zhen
发明人： DIMOV, Dimo K. , GABRIEL, Lawrence N. , LYON, Florian , SPAIN, Christopher R. , COLBURN, Peter D , SCHMIDTER, T. Craig , ZHU, Zhen
IPC分类号： C08K3/00 , C08K5/00 , C08L33/06
CPC分类号： A01N59/16 , C08K3/015 , C08K5/0058 , C08L33/08 , C08L33/06
摘要： Acrylic materials with antimicrobial activity are tumble blended, melted and extruded through an extruder. The resulting polymer compounds include an acrylic resin, such as methylmethacrylate polymers, copolymers and multipolymers, and blends thereof, silver-containing antimicrobial additives; and optional additives such as impact modifiers, flow promoters, stabilizers and coloring agents. The properties of the acrylic materials, especially the antimicrobial performance, are strongly dependent on the manufacturing process conditions, including feed resins pre-drying, residual moisture content, screw speed and melt temperature. The materials composition and manufacturing procedures are equally significant.
摘要翻译：具有抗菌活性的丙烯酸树脂材料通过挤出机滚筒混合，熔融和挤出。所得的聚合物化合物包括丙烯酸树脂，例如甲基丙烯酸甲酯聚合物，共聚物和多聚物，及其共混物，含银抗微生物添加剂; 和任选的添加剂，如抗冲改性剂，流动促进剂，稳定剂和着色剂。丙烯酸材料的性能，特别是抗微生物性能，主要取决于制造工艺条件，包括进料树脂预干燥，残留水分含量，螺杆速度和熔体温度。材料组成和制造程序同样重要。

2. 发明申请

WO2011023592A1 WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：无线通信系统
公开(公告)号：WO2011023592A1
公开(公告)日：2011-03-03
申请号：PCT/EP2010/061960
申请日：2010-08-17
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , LIN, Yong Hua , ZHU, Zhen Bo , CHEN, Lin , WANG, Qing , YAN, Rong , CHEN, Jian Wen
发明人： LIN, Yong Hua , ZHU, Zhen Bo , CHEN, Lin , WANG, Qing , YAN, Rong , CHEN, Jian Wen
IPC分类号： H04W56/00 , H04W88/08
CPC分类号： H04W56/004 , H04W56/0055 , H04W88/085
摘要： The present invention discloses a remote radio head unit, a wireless communication system base station, and a data transmission synchronization method thereof. The wireless communication system base station comprises a remote radio head (RRH) and a baseband unit (BBU) communicably connected through a network, and wherein the BBU is used to process and transmit downlink data to the RRH, said wireless communication system base station further comprises: a time-delay measurement unit in the RRH which is used to measure a time-delay for the downlink data to arrive at the RRH from the BBU; a time-delay notification unit in the RRH for notifying from the RRH to the BBU of time-delay data on the time-delay measured by the time-delay measurement unit; a synchronization unit in the BBU for advancing the starting time for the BBU to process and transmit the downlink data by an amount of time obtained based on the time-delay data notified by the time-delay notification unit. The present invention can reduce or even eliminate the RRH reception time-delay caused by the BBU processing time-delay and data transmission jitter by measuring the time-delay for the downlink data frame to arrive at the RRH of the base station, and correcting the timing pulse for starting the downlink data processing and transmission on the BBU side.
摘要翻译：本发明公开了一种远程无线电头单元，无线通信系统基站及其数据传输同步方法。无线通信系统基站包括通过网络可通信地连接的远程无线电头（RRH）和基带单元（BBU），并且其中BBU用于处理和发送下行链路数据到RRH，所述无线通信系统基站进一步包括：RRH中的时间延迟测量单元，用于测量下行链路数据从BBU到达RRH的时间延迟; RRH中的延时通知单元，用于从RRH向BBU通知由延时测量单元测量的延时数据; BBU中的同步单元，用于使BBU的开始时间提前，以基于由延时通知单元通知的时间延迟数据获得的时间量来处理和发送下行链路数据。本发明可以通过测量下行链路数据帧的时间延迟来达到基站的RRH，从而减少甚至消除由BBU处理时延和数据传输抖动引起的RRH接收延时，用于开始BBU侧的下行链路数据处理和传输的定时脉冲。

3. 发明申请

WO2009094473A1 METHODS AND COMPOSITIONS FOR TOPICAL TREATMENT OF MEDICAL CONDITIONS INCLUDING WOUNDS AND INFLAMMATION 审中-公开
标题翻译：用于局部治疗包括伤口和炎症的医疗条件的方法和组合
公开(公告)号：WO2009094473A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/031721
申请日：2009-01-22
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L.
IPC分类号： A61K31/203 , A61K45/00 , A61P17/02
CPC分类号： A61K31/07 , A61K31/122 , A61K31/198 , A61K31/203 , A61K31/455 , A61K45/06 , A61K2300/00
摘要： A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.
摘要翻译：用于治疗患有伤口，溃疡或炎症的患者的方法包括提供包含载体和包含至少一种类视色素和至少一种血管扩张剂的活性成分的组合的局部制剂，并将该局部制剂施用于患者的皮肤导致愈合，加速愈合或预防伤口，溃疡或炎症。另外的活性成分可以包括线粒体功能的启动子或抗氧化剂。

4. 发明申请

WO2007087419A3 SUBSTITUTED 3-(5-MEMBERED UNSATURATED HETEROCYCLYL) -1, 3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：替代3-（5-MEMBERED UNSATURATED HETEROCYCLYL）-1,3-二氢吲哚-2-酮衍生物作为酪氨酸激酶抑制剂治疗癌症
公开(公告)号：WO2007087419A3
公开(公告)日：2007-09-13
申请号：PCT/US2007002088
申请日：2007-01-23
申请人： ALLERGAN INC , GUO XIALING , ZHU ZHEN , MALONE THOMAS C , WURSTER JULIE A
发明人： GUO XIALING , ZHU ZHEN , MALONE THOMAS C , WURSTER JULIE A
IPC分类号： C07D405/04 , A61K31/404 , A61P35/00 , C07D405/14
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07F7/10 , C07F7/1856
摘要： The present invention relates to organic molecules represented by one of the general formulae I-I V capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译：本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的由通式I-I V之一表示的有机分子。

5. 发明申请

WO2006034255A3 METHODS OF DEVICE-ASSISTED DRUG DELIVERY 审中-公开
标题翻译：装置辅助的药物递送方法
公开(公告)号：WO2006034255A3
公开(公告)日：2006-09-21
申请号：PCT/US2005033617
申请日：2005-09-20
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
IPC分类号： A61F13/00
CPC分类号： A61K9/0021
摘要： This invention describes the simultaneous or sequential administration of therapeutic or diagnostic agents using different devices in combination with a chemical formulation that incorporates or uses vasomodulatory chemical agents as part of the drug delivery vehicle. Methods include the addition of various vasodilatory and vasoconstructive agents to enhance the systemic or localized tissue delivery of therapeutic or diagnostic agents delivered into a body through the use of an apparatus or device.
摘要翻译：本发明描述了使用不同装置与包含或使用血管调节化学试剂作为药物递送载体的一部分的化学制剂组合的同时或顺序施用治疗剂或诊断剂。方法包括加入各种血管舒张剂和血管造影剂以增强通过使用装置或装置递送到体内的治疗剂或诊断剂的系统或局部组织递送。

6. 发明申请

WO2010141385A1 ASSAY FOR TELOMERASE ACTIVITY USING MICROFLUIDIC DEVICE 审中-公开
标题翻译：使用微流控器件测定TELOMERASE活性
公开(公告)号：WO2010141385A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/036719
申请日：2010-05-28
申请人： GERON CORPORATION , HARLEY, Calvin, B. , WANG, Hui , PIROT, Zhu, Zhen
发明人： HARLEY, Calvin, B. , WANG, Hui , PIROT, Zhu, Zhen
IPC分类号： G01N33/48
CPC分类号： C12Q1/48 , G01N2333/91245
摘要： Methods for determining the level of telomerase reverse transcriptase activity in mammalian cells are disclosed. A preferred measuring device is a microfluidic device that includes a spectrophotometer, a fluorescent detector, a fluorescence polarization detector or a scintillation counting device.
摘要翻译：公开了确定哺乳动物细胞中端粒酶逆转录酶活性水平的方法。优选的测量装置是包括分光光度计，荧光检测器，荧光偏振检测器或闪烁计数装置的微流体装置。

7. 发明申请

WO2010034019A4 TRANSDERMAL DRUG DELIVERY USING AN OSMOLYTE AND VASOACTIVE AGENT 审中-公开
标题翻译：使用渗透剂和血管活性剂的透皮药物递送
公开(公告)号：WO2010034019A4
公开(公告)日：2010-05-20
申请号：PCT/US2009057916
申请日：2009-09-22
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , MASIZ JOHN J
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , MASIZ JOHN J
IPC分类号： A61K9/70 , A61K47/02
CPC分类号： A61K31/192 , A61F2013/00906 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/455 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal, for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
摘要翻译：当施用于哺乳动物（例如患者）的皮肤或其他外部区域时或其内部时，用于递送生物活性物质的制剂和方法包括血管活性剂; 渗透剂; 和一种活性成分。该制剂具有足够的吸湿性，从而当被皮肤吸收时产生高张度状态。当制剂应用于皮肤时，血管活性剂可被递送至真皮以接触患者的脉管系统。

8. 发明申请

WO2007087419A2 SUBSTITUTED 3-(5-MEMBERED UNSATURATED HETEROCYCLYL-1,3-DIHYDRO-INDOL-2-ONE'S AND DERIVATIVES THEREOF AS KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂的取代的3-（5-成员不饱和杂环基-1,3-二氢吲哚-2-酮及其衍生物
公开(公告)号：WO2007087419A2
公开(公告)日：2007-08-02
申请号：PCT/US2007/002088
申请日：2007-01-23
申请人： ALLERGAN, INC. , GUO, Xialing , ZHU, Zhen , MALONE, Thomas, C. , WURSTER, Julie, A.
发明人： GUO, Xialing , ZHU, Zhen , MALONE, Thomas, C. , WURSTER, Julie, A.
IPC分类号： C07D405/04 , C07D405/14 , A61K31/404 , A61P35/00
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07F7/10 , C07F7/1856
摘要： The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
摘要翻译：本发明涉及能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子。

9. 发明申请

WO2006009568A2 PERIPHERALLY-ACTING VASODILATORS 审中-公开
标题翻译：外围操作器
公开(公告)号：WO2006009568A2
公开(公告)日：2006-01-26
申请号：PCT/US2004035463
申请日：2004-10-26
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
IPC分类号： A61K31/455 , A61K31/198
CPC分类号： A61K31/198 , A61K31/455
摘要： A system for the delivery of chemical vasodilators into the skin for the purpose of increasing the blood flow in a tissue that exhibits compromised circulation. The designated purpose of this increased blood flow is to transiently reverse or inhibit or prevent the onset of an associated medical affliction that may in part or in whole, be either the consequence of that medical condition or participating in the clinical symptoms and etiology of that medical condition. The process and the effect of the topical delivery of a chemical vasodilator has been previously demonstrated for other medical and pharmaceutical applications, however the specific use of this class of drug molecules for the focused effect of improving blood flow to the skin and surrounding tissue with the goal of improving the metabolic health of the tissue and to possibly affect the symptoms of a medical condition is the specific aim of this patent.
摘要翻译：用于将化学血管扩张剂输送到皮肤中的系统，用于增加显示出损害的循环的组织中的血液流动。这种增加血液流量的指定目的是短暂地逆转或抑制或预防相关的医疗困难的发作，其部分或全部可能是该医疗状况的结果或参与该医学的临床症状和病因条件。化学血管扩张剂的局部递送的过程和作用以前已经被证明用于其它医学和药物应用，然而，这类药物分子的具体用途是用于改善血液流向皮肤和周围组织的聚焦效应本专利的具体目的是提高组织的代谢健康和可能影响医疗状况的目的。

10. 发明申请

WO2011106671A1 ASSAY FOR TELOMERASE ACTIVITY 审中-公开
标题翻译：测定TELOMERASE活性
公开(公告)号：WO2011106671A1
公开(公告)日：2011-09-01
申请号：PCT/US2011/026281
申请日：2011-02-25
申请人： GERON CORPORATION , PIROT, Zhu, Zhen
发明人： PIROT, Zhu, Zhen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/48 , G01N2333/91245
摘要： The invention is directed to methods for determining the level of telomerase reverse transcriptase activity in mammalian cells.
摘要翻译：本发明涉及确定哺乳动物细胞中端粒酶逆转录酶活性水平的方法。

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