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1. 发明申请

WO2009094473A1 METHODS AND COMPOSITIONS FOR TOPICAL TREATMENT OF MEDICAL CONDITIONS INCLUDING WOUNDS AND INFLAMMATION 审中-公开
标题翻译：用于局部治疗包括伤口和炎症的医疗条件的方法和组合
公开(公告)号：WO2009094473A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/031721
申请日：2009-01-22
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane, L.
IPC分类号： A61K31/203 , A61K45/00 , A61P17/02
CPC分类号： A61K31/07 , A61K31/122 , A61K31/198 , A61K31/203 , A61K31/455 , A61K45/06 , A61K2300/00
摘要： A method for treating a patient suffering from a wound, ulcer, or inflammation includes providing a topical formulation comprising a carrier and a combination of active ingredients that includes at least one retinoid and at least one blood vessel dilator, and applying the topical formulation to the skin of the patient to cause healing, accelerated healing or prevention of the wound, ulcer or inflammation. Additional active ingredients may include a promoter of mitochondrial function or an antioxidant.
摘要翻译：用于治疗患有伤口，溃疡或炎症的患者的方法包括提供包含载体和包含至少一种类视色素和至少一种血管扩张剂的活性成分的组合的局部制剂，并将该局部制剂施用于患者的皮肤导致愈合，加速愈合或预防伤口，溃疡或炎症。另外的活性成分可以包括线粒体功能的启动子或抗氧化剂。

2. 发明申请

WO2006034255A3 METHODS OF DEVICE-ASSISTED DRUG DELIVERY 审中-公开
标题翻译：装置辅助的药物递送方法
公开(公告)号：WO2006034255A3
公开(公告)日：2006-09-21
申请号：PCT/US2005033617
申请日：2005-09-20
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
IPC分类号： A61F13/00
CPC分类号： A61K9/0021
摘要： This invention describes the simultaneous or sequential administration of therapeutic or diagnostic agents using different devices in combination with a chemical formulation that incorporates or uses vasomodulatory chemical agents as part of the drug delivery vehicle. Methods include the addition of various vasodilatory and vasoconstructive agents to enhance the systemic or localized tissue delivery of therapeutic or diagnostic agents delivered into a body through the use of an apparatus or device.
摘要翻译：本发明描述了使用不同装置与包含或使用血管调节化学试剂作为药物递送载体的一部分的化学制剂组合的同时或顺序施用治疗剂或诊断剂。方法包括加入各种血管舒张剂和血管造影剂以增强通过使用装置或装置递送到体内的治疗剂或诊断剂的系统或局部组织递送。

3. 发明申请

WO2010034019A4 TRANSDERMAL DRUG DELIVERY USING AN OSMOLYTE AND VASOACTIVE AGENT 审中-公开
标题翻译：使用渗透剂和血管活性剂的透皮药物递送
公开(公告)号：WO2010034019A4
公开(公告)日：2010-05-20
申请号：PCT/US2009057916
申请日：2009-09-22
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , MASIZ JOHN J
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , MASIZ JOHN J
IPC分类号： A61K9/70 , A61K47/02
CPC分类号： A61K31/192 , A61F2013/00906 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/455 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal, for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
摘要翻译：当施用于哺乳动物（例如患者）的皮肤或其他外部区域时或其内部时，用于递送生物活性物质的制剂和方法包括血管活性剂; 渗透剂; 和一种活性成分。该制剂具有足够的吸湿性，从而当被皮肤吸收时产生高张度状态。当制剂应用于皮肤时，血管活性剂可被递送至真皮以接触患者的脉管系统。

4. 发明申请

WO2006009568A2 PERIPHERALLY-ACTING VASODILATORS 审中-公开
标题翻译：外围操作器
公开(公告)号：WO2006009568A2
公开(公告)日：2006-01-26
申请号：PCT/US2004035463
申请日：2004-10-26
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU
IPC分类号： A61K31/455 , A61K31/198
CPC分类号： A61K31/198 , A61K31/455
摘要： A system for the delivery of chemical vasodilators into the skin for the purpose of increasing the blood flow in a tissue that exhibits compromised circulation. The designated purpose of this increased blood flow is to transiently reverse or inhibit or prevent the onset of an associated medical affliction that may in part or in whole, be either the consequence of that medical condition or participating in the clinical symptoms and etiology of that medical condition. The process and the effect of the topical delivery of a chemical vasodilator has been previously demonstrated for other medical and pharmaceutical applications, however the specific use of this class of drug molecules for the focused effect of improving blood flow to the skin and surrounding tissue with the goal of improving the metabolic health of the tissue and to possibly affect the symptoms of a medical condition is the specific aim of this patent.
摘要翻译：用于将化学血管扩张剂输送到皮肤中的系统，用于增加显示出损害的循环的组织中的血液流动。这种增加血液流量的指定目的是短暂地逆转或抑制或预防相关的医疗困难的发作，其部分或全部可能是该医疗状况的结果或参与该医学的临床症状和病因条件。化学血管扩张剂的局部递送的过程和作用以前已经被证明用于其它医学和药物应用，然而，这类药物分子的具体用途是用于改善血液流向皮肤和周围组织的聚焦效应本专利的具体目的是提高组织的代谢健康和可能影响医疗状况的目的。

5. 发明申请

WO2009152372A1 CONTROL OF BLOOD VESSEL PHYSIOLOGY TO TREAT SKIN DISORDERS 审中-公开
标题翻译：控制血管生理学治疗皮肤病
公开(公告)号：WO2009152372A1
公开(公告)日：2009-12-17
申请号：PCT/US2009/047098
申请日：2009-06-11
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , MASIZ, John, J. , STEPHENS, Laura , ZHU, Zhen , PATEL, Kanu , DONABEDIAN, David, H.
发明人： CARTER, Stephen, G. , MASIZ, John, J. , STEPHENS, Laura , ZHU, Zhen , PATEL, Kanu , DONABEDIAN, David, H.
IPC分类号： A61K31/198 , A61K31/455 , A61K41/00 , A61P17/00
CPC分类号： A61K41/0028 , A61K9/0014 , A61K31/137 , A61K31/17 , A61K31/198 , A61K31/295 , A61K31/401 , A61K31/4164 , A61K31/4166 , A61K31/425 , A61K31/455 , A61K31/522 , A61K36/14 , A61K36/16 , A61K36/185 , A61K36/28 , A61K36/53 , A61K36/62 , A61K36/734 , A61K36/752 , A61K36/88 , A61K36/886 , A61K36/8969 , A61K36/9068 , A61M37/00 , A61N5/062 , A61N7/00
摘要： In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing.
摘要翻译：在用于治疗患有皮肤病的患者的受影响的皮肤区域的方法中，将血管舒张组合物施用于患者的受影响的皮肤区域，所述受影响的皮肤区域呈现以至少一种异常血管为特征的皮肤病，然后治疗受影响的皮肤区域，以便非侵入性地破坏至少一个异常血管的组织结构，例如通过诱导缺血。然后可以将血管收缩组合物施用于皮肤区域以引起至少一个血管的血管收缩以促进愈合。

6. 发明申请

WO2010065922A3 METHODS AND COMPOSITIONS FOR TATTOO REMOVAL 审中-公开
标题翻译：去除TATTOO的方法和组合物
公开(公告)号：WO2010065922A3
公开(公告)日：2011-11-03
申请号：PCT/US2009066865
申请日：2009-12-04
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , KOZWICH DIANE L , STEPHENS LAURA , MASIZ JOHN J , DONABEDIAN DAVID H
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , KOZWICH DIANE L , STEPHENS LAURA , MASIZ JOHN J , DONABEDIAN DAVID H
IPC分类号： A61B18/20 , A61K8/02 , A61K8/49 , A61K8/67 , A61Q19/02
CPC分类号： A61K8/4926 , A61B18/203 , A61B2017/00769 , A61B2018/00452 , A61B2018/0047 , A61K8/0208 , A61K8/26 , A61K8/342 , A61K8/498 , A61K8/585 , A61K8/678 , A61K8/73 , A61K8/922 , A61K2800/51 , A61K2800/74 , A61K2800/81 , A61K2800/91 , A61M37/0092 , A61N1/325 , A61N5/062 , A61Q1/145 , A61Q19/02
摘要： Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.
摘要翻译：通过使用细胞破坏剂与血管扩张剂组合，以及任选的一种或多种渗透调节剂，螯合剂和闭塞性修饰剂来去除纹身的方法和制剂。实施方案任选进一步包括使用抗生素，麻醉剂，渗透增强剂，赋形剂，载体和载体中的一种或多种。

7. 发明申请

WO2010034019A1 TRANSDERMAL DRUG DELIVERY USING AN OSMOLYTE AND VASOACTIVE AGENT 审中-公开
标题翻译：使用OSMOLYTE和VASOACTIVE AGENT进行转运药物递送
公开(公告)号：WO2010034019A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057916
申请日：2009-09-22
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , MASIZ, John, J.
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , MASIZ, John, J.
IPC分类号： A61K9/70 , A61K47/02
CPC分类号： A61K31/192 , A61F2013/00906 , A61K9/0014 , A61K9/06 , A61K31/05 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/427 , A61K31/455 , A61K45/06 , A61K47/02 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal, for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.
摘要翻译：用于递送生物活性物质的方法和用于哺乳动物例如患者的皮肤或其它外部区域内或内部的递送生物活性物质的方法包括血管活性剂; 渗透剂和活性成分。制剂具有足够的吸湿性，以便在被皮肤吸收时产生高渗性的状况。当将配方施用于皮肤时，可以将血管活性剂递送至真皮以接触患者的脉管系统。

8. 发明申请

WO2010030821A2 IBUPROFEN FOR TOPICAL ADMINISTRATION 审中-公开
标题翻译： IBUPROFEN用于局部管理
公开(公告)号：WO2010030821A2
公开(公告)日：2010-03-18
申请号：PCT/US2009/056568
申请日：2009-09-10
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu , KOZWICH, Diane
IPC分类号： A61K47/32
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/7023 , A61K47/16 , A61K47/22 , A61K47/32
摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skm tissue Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e g, a pyrrohdone solvent or dimethylacetamide
摘要翻译：本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸））的制备。通过在药学上可接受的溶剂存在下，溶解游离酸形式的布洛芬或制备游离酸形式的布洛芬的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过skm组织布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯酮溶剂或二甲基乙酰胺

9. 发明申请

WO2006034255A2 METHODS OF DEVICE-ASSISTED DRUG DELIVERY 审中-公开
标题翻译：装置辅助药物递送方法
公开(公告)号：WO2006034255A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/033617
申请日：2005-09-20
申请人： BIOCHEMICS, INC. , CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu
发明人： CARTER, Stephen, G. , ZHU, Zhen , PATEL, Kanu
IPC分类号： A61K9/70
CPC分类号： A61K9/0021
摘要： This invention describes the simultaneous or sequential administration of therapeutic or diagnostic agents using different devices in combination with a chemical formulation that incorporates or uses vasomodulatory chemical agents as part of the drug delivery vehicle. Methods include the addition of various vasodilatory and vasoconstructive agents to enhance the systemic or localized tissue delivery of therapeutic or diagnostic agents delivered into a body through the use of an apparatus or device.
摘要翻译：本发明描述了使用不同装置同时或顺序施用与掺入或使用血管调节化学试剂作为药物递送载体的一部分的化学制剂组合的治疗或诊断试剂。方法包括添加各种血管扩张剂和血管造影剂，以通过使用装置或装置来增强递送到体内的治疗剂或诊断剂的全身或局部组织递送。

10. 发明申请

WO2010030821A3 IBUPROFEN FOR TOPICAL ADMINISTRATION 审中-公开
标题翻译： IBUPROFEN用于局部管理
公开(公告)号：WO2010030821A3
公开(公告)日：2011-01-20
申请号：PCT/US2009056568
申请日：2009-09-10
申请人： BIOCHEMICS INC , CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , KOZWICH DIANE
发明人： CARTER STEPHEN G , ZHU ZHEN , PATEL KANU , KOZWICH DIANE
IPC分类号： A61K47/32
CPC分类号： A61K31/192 , A61K9/0014 , A61K9/7023 , A61K47/16 , A61K47/22 , A61K47/32
摘要： Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skm tissue Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e g, a pyrrohdone solvent or dimethylacetamide
摘要翻译：本文所述是适用于局部给药的游离酸形式的布洛芬（2-（4-异丁基苯基）丙酸）的制剂。通过在游离酸形式的布洛芬溶解游离酸形式的布洛芬或在药学上可接受的溶剂的存在下制备游离酸形式的均匀悬浮液来制备局部布洛芬制剂，以产生与渗透2相兼容的局部药物制剂 - （4-异丁基苯基）丙酸通过skm组织布洛芬的局部制剂可以基于药学上可接受的溶剂，例如吡咯酮溶剂或二甲基乙酰胺

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