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11. 发明授权

US06261272B1 Needle for subcutaneous delivery of fluids 有权
标题翻译：用于皮下输送流体的针
公开(公告)号：US06261272B1
公开(公告)日：2001-07-17
申请号：US09202176
申请日：1999-06-01
申请人： Joseph Gross , Haim Danon
发明人： Joseph Gross , Haim Danon
IPC分类号： A61M532
CPC分类号： A61M5/2053 , A61M5/2046 , A61M5/3291
摘要： A needle (10) for the delivery of a liquid to a subject comprises a shaft (11) having an internal surface defining a longitudinally extending internal bore open at one end (15) to receive a liquid supply, the other end (16) being sharpened for penetration of the skin of the subject. A plurality of apertures (18) are provided, each in the form of a cut extending across the external surface of the side of the shaft (11) at a sufficient depth to establish communication with the bore. The external aperture area is approximately three times greater than the internal aperture area, thereby ensuring that the liquid is delivered to a large surface area of tissue to improve absorption and eliminate fluctuations in the delivery rate. The needle (10) can be mass-produced by aligning a batch of shafts alongside one another and running a grinder across the surfaces of the shafts to create the apertures (18) in the entire batch of needles simultaneously.
摘要翻译：用于将液体输送到对象的针（10）包括轴（11），其具有限定在一端（15）处开放以纵向延伸的内孔的内表面，以接收液体供应，另一端（16）为了穿透受试者的皮肤而磨光。提供了多个孔（18），每个孔以切口的形式以足够的深度跨越轴（11）的侧面的外表面延伸，以与孔成直通。外部开口面积大约是内部开口面积的三倍，从而确保将液体输送到组织的大表面积以改善吸收并消除输送速率的波动。针（10）可以通过将一批轴彼此对准并使研磨机跨越轴的表面进行批量生产，以在整个批次中同时产生孔（18）。

12. 发明授权

US6078842A Electrode and iontophoretic device and method 失效
标题翻译：电极和离子电渗法器件及方法
公开(公告)号：US6078842A
公开(公告)日：2000-06-20
申请号：US997404
申请日：1997-12-23
申请人： Joseph Gross , Zvi Nitzan , Izrail Tsals
发明人： Joseph Gross , Zvi Nitzan , Izrail Tsals
IPC分类号： A61N1/32 , A61N1/04
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/325
摘要： An improved electrode and iontophoretic device and method where the electrode exhibits varied resistance. The electrode is made of a conductive material and applied to a flexible substrate. The variation in resistance can be achieved by varying the thickness of the electrode across its length or by varying the conductivity of the material across the area of the electrode or a combination of both. A pair of such electrodes may be used with a power source in electrical relation thereto and applied over a layer of agent to the skin to deliver the agent into the skin iontophoretically. The pair of electrodes may be shaped so as to cover a portion of the face, hands, feet or other body parts to iontophoretically apply particular agents to those areas.
摘要翻译：改进的电极和离子电渗疗法装置和方法，其中电极具有变化的电阻。电极由导电材料制成并施加到柔性基底上。电阻的变化可以通过改变电极在其长度上的厚度或通过改变电极区域上的材料的导电性或两者的组合来实现。一对这样的电极可以与电源相关联的电源使用并施加到皮肤层上以将试剂输送到皮肤中的离子电渗。一对电极可以被成形为覆盖面部，手部，脚部或其他身体部分的一部分，以将特定的药剂离子电渗应用于那些区域。

13. 发明授权

US5991655A Iontophoretic drug delivery device and method of manufacturing the same 失效
标题翻译：离子电渗药物输送装置及其制造方法
公开(公告)号：US5991655A
公开(公告)日：1999-11-23
申请号：US31335
申请日：1998-02-26
申请人： Joseph Gross , Gilad Lavi
发明人： Joseph Gross , Gilad Lavi
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/044 , A61N1/325 , A61N1/0448
摘要： An iontophoretic drug delivery device comprising a flexible reservoir sandwiched between a flexible printed circuit board and a pair of flexible electrodes. A rigid top cover is mounted on a spine on the reservoir by means of snap-fit connections. The rigid cover protects the device from damage while the flexible reservoir, circuit board and electrodes can conform to the skin of a subject. The configuration of the flexible elements allows the manufacturing process to be simplified considerably, resulting in a less expensive device with ease of fabrication.
摘要翻译：一种离子电渗药物递送装置，其包括夹在柔性印刷电路板和一对柔性电极之间的柔性储存器。通过卡扣连接将刚性顶盖安装在储存器上的脊柱上。刚性盖可以保护设备免受损伤，同时柔性储存器，电路板和电极可以符合受试者的皮肤。柔性元件的构造允许制造过程被大大简化，导致易于制造的便宜的装置。

14. 外观设计

USD405524S Drug delivery device 失效
公开(公告)号：USD405524S
公开(公告)日：1999-02-09
申请号：US87442
申请日：1998-05-01
申请人： Yael Falk , Joseph Gross
设计人： Yael Falk , Joseph Gross

15. 发明授权

US5800420A Analyte-controlled liquid delivery device and analyte monitor 失效
标题翻译：分析物控制液体输送装置和分析物监测器
公开(公告)号：US5800420A
公开(公告)日：1998-09-01
申请号：US769996
申请日：1996-12-19
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61M5/00 , A61B5/00 , A61K9/70 , A61M1/36 , A61M5/142 , A61M5/172 , C07C253/34 , C12Q1/25 , G01N27/327 , A61K9/22 , G01N15/06
CPC分类号： A61M5/14248 , A61B5/14865 , A61B5/6848 , A61K9/0021 , A61K9/7023 , A61M5/14244 , A61M5/1723 , C07C253/34 , A61M2005/14204 , A61M2005/14268 , A61M2005/1726 , A61M2205/8206
摘要： A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected. A reference electrode (silver/silver chloride) which rests against the subject's skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit is measured by a voltmeter and a signal from the voltmeter is amplified and communicated to the microprocessor which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject's plasma.
摘要翻译：一种液体输送装置，包括具有用于施用到受试者的皮肤的下表面的壳体，并且具有储存器和在其中由可移位膜隔开的气体生成室。在微处理器的控制下由电解池产生的气体使得气体产生室膨胀并且储存器收缩，从而通过从下表面延伸的中空输送针从储存器排出液体药物，例如胰岛素。输送针和传感器针从下表面延伸足够的距离，以便当外壳被压靠在皮肤上时穿透表皮并进入真皮。传感器针头具有用于检测受检者血浆中的分析物例如葡萄糖的酶涂层。输送针由铂 - 铱制成，并且根据检测到的葡萄糖的量，电流通过针和恒电位仪电路。靠在受试者皮肤上的参比电极（银/氯化银）增加了葡萄糖测量的准确性。通过电位计电流测量电流，电压表的信号被放大并传送到微处理器，该微处理器根据受试者血浆中检测到的分析物水平确定药物的正确传送速率。

16. 发明授权

US5704520A Liquid material dispenser and valve 失效
标题翻译：液体物料分配器和阀门
公开(公告)号：US5704520A
公开(公告)日：1998-01-06
申请号：US591583
申请日：1996-03-27
申请人： Joseph Gross
发明人： Joseph Gross
IPC分类号： A61M5/142 , A61M37/00 , G05D7/06
CPC分类号： A61M5/142 , A61M2005/14204
摘要： A liquid material dispenser, for use, for example, in dispensing liquid medicine over an extended period of time, which includes a housing (10) enclosing a reservoir (12) for storing the liquid to be dispensed and having an outlet (14) through which the liquid is dispensed, and a connecting passageway (16) between the reservoir and the outlet. Located in the passageway is a diaphragm (18), one side of which defines a pumping chamber (20) and the other side of which defines a pressure control chamber (22). The diaphragm (18) is cyclically displaceable through a pumping stroke for pumping liquid through the outlet (14) and a drawing stroke for drawing liquid from the reservoir (12). Also located in the passageway (16) are a pair of valves (30, 33) which serve, during the drawing stroke, to cause the diaphragm (18) to draw liquid from the reservoir (12) into the pumping chamber (20), and during the pumping stroke, to cause the diaphragm (18) to pump liquid from the pumping chamber (20) through the outlet (14). An electrolytic cell (24) generates gas at suitable times for suitable durations and rates which is supplied to the pressure control chamber (22) to drive the pumping member (18) through the pumping stroke. A vent is used for venting the gas from the pressure control chamber (22) to the atmosphere to drive the pumping member (18) through the drawing stroke. The vent has an inlet vent opening (40) inside the pressure control chamber (22), with the opening (40) being caused to open to end the pumping stroke and to close after a portion of the gas has vented.
摘要翻译： PCT No.PCT / IE94 / 00037 Sec。 371日期：1996年3月27日 102（e）1996年3月27日PCT PCT 1994年7月15日PCT公布。出版物WO95 / 03078 日期1995年2月2日一种液体物质分配器，用于例如在长时间内分配液体药物，其包括封闭储存器（12）的壳体（10），用于储存待分配的液体并具有出口（14），以及在储存器和出口之间的连接通道（16）。位于通道中的是隔膜（18），其一侧限定了泵送室（20），另一侧限定了压力控制室（22）。隔膜（18）通过抽吸冲程循环移位，用于泵送液体通过出口（14）和用于从储存器（12）抽取液体的抽取冲程。还设置在通道（16）中的一对阀（30,33），其在牵引行程中用于使隔膜（18）将液体从储存器（12）抽吸到泵送室（20）中，并且在泵送冲程期间，使隔膜（18）从泵送室（20）泵送液体通过出口（14）。电解槽（24）在合适的时间产生合适的持续时间和速率的气体，所述持续时间和速率被提供给压力控制室（22）以通过泵送冲程驱动泵送构件（18）。通气孔用于将气体从压力控制室（22）排放到大气中以通过牵引行程驱动泵送构件（18）。排气口在压力控制室（22）内具有入口通气口（40），其中开口（40）被打开以结束泵送冲程，并且在气体的一部分排气之后关闭。

17. 发明授权

US5527288A Intradermal drug delivery device and method for intradermal delivery of drugs 失效
标题翻译：皮内药物递送装置和药物皮内递送方法
公开(公告)号：US5527288A
公开(公告)日：1996-06-18
申请号：US183482
申请日：1994-01-18
申请人： Joseph Gross , John G. Kelly
发明人： Joseph Gross , John G. Kelly
IPC分类号： A61M5/00 , A61M5/142 , A61M5/145 , A61M37/00 , A61N1/30
CPC分类号： A61M5/14248 , A61M5/14593 , A61N1/303 , A61M2005/14252 , A61M2005/14268 , A61M2037/0023 , A61M37/00
摘要： An intradermal drug delivery device for delivering a liquid drug to a subject via the subject's skin includes a housing having a lower surface provided with an adhesive coating for adhering the housing to the subject's skin. An expansible-contractible chamber within the housing defines a reservoir which is expanded upon being filled with the drug and contracted to dispense the drug. A hollow needle extends through the lower surface of the housing and has an inner end which communicates with the reservoir and an outer end which projects outwardly of the housing a short distance to penetrate through the epidermis and into the dermis of the subject's skin when the housing is adhered thereto. The device permits delivery of drugs of relatively large molecular size and at slow rates which can be precisely controlled. A method of delivering a liquid drug intradermally includes adhering the intradermal delivery device to the skin of the subject and activating the means for actively discharging the at least one drug from the reservoir to the subject's skin via the needle.
摘要翻译：用于经由受试者的皮肤将液体药物递送到受试者的皮内药物递送装置包括具有下表面的壳体，所述下表面设置有用于将所述外壳粘附到受试者皮肤的粘合剂涂层。壳体内的可膨胀收缩室限定了在充满药物并且收缩以分配药物时膨胀的储存器。中空针穿过壳体的下表面延伸，并且具有与储存器连通的内端和外壳，该外端从外壳向外突出短距离，以穿透表皮并进入被检者皮肤的真皮层，粘附到其上。该装置允许递送具有相对较大分子大小的药物并以可以被精确控制的缓慢的速率递送。皮内递送液体药物的方法包括将皮内递送装置粘附到受试者的皮肤上，并且激活用于通过针头将至少一种药物从储存器主动排出到受试者的皮肤的装置。

18. 发明授权

US5475557A Method and apparatus for protecting electrical systems 失效
标题翻译：用于保护电气系统的方法和装置
公开(公告)号：US5475557A
公开(公告)日：1995-12-12
申请号：US761763
申请日：1991-07-30
申请人： Dov Larom , Joseph Gross , Zohar Avrahami , Ram Shalvi
发明人： Dov Larom , Joseph Gross , Zohar Avrahami , Ram Shalvi
IPC分类号： G01R31/02 , H01R13/713 , H02H3/04 , H02H3/33 , H02H3/32
CPC分类号： H02H3/334 , H02H3/04
摘要： Apparatus for providing an electrical system with protection against electrical shock in the event of a ground fault. The electrical system supplies power from a central mains inlet to at least one local electrical device. The central mains inlet includes a central ground fault detector and interrupter actuatable upon detection of a first predetermined level of current imbalance to interrupt the central mains inlet. A local ground fault detector is associated with the at least one local electrical device and is actuatable upon detecting a current imbalance of a second predetermined level which is lower than the first predetermined level. Controls are effective upon actuation of the local ground fault interrupter to actuate the central ground fault detector to cause it to interrupt the central mains inlet.
摘要翻译： PCT No.PCT / GB89 / 01508 Sec。 371日期1991年7月30日 102（e）1991年7月30日PCT PCT 1989年12月18日PCT公布。出版物WO90 / 07214 日期1990年6月28日。在接地故障的情况下，为电气系统提供防电击的装置。电气系统从中央电源插座向至少一个本地电气设备供电。中央电源入口包括中央接地故障检测器和断续器，其在检测到第一预定电流不平衡以中断中央电源入口时可启动。本地接地故障检测器与至少一个本地电气设备相关联，并且可以在检测到低于第一预定电平的第二预定电平的电流不平衡时被致动。控制器在启动本地接地故障断路器时有效，以致中央接地故障检测器使其中断中央电源插座。

19. 发明授权

US5221280A Electric hair removal device 失效
标题翻译：电动脱毛装置
公开(公告)号：US5221280A
公开(公告)日：1993-06-22
申请号：US773841
申请日：1991-10-09
申请人： Joseph Gross , Zohar Avrahami
发明人： Joseph Gross , Zohar Avrahami
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B2018/00452 , A61B2018/00476
摘要： An electric hair removal device includes a holder to be hand-held by the user, and a pair of tweezer arms projecting from one end of the holder for gripping a hair to be removed from the skin in which the hair is growing. An electric power supply is actuated by a control device to automatically apply electric current to the hair while gripped by the tweezer arms and tensioned by the spring until the hair is plucked from the skin at which time the current automatically terminates. In one described embodiment, the control device is a tension sensor, and in another described embodiment it is a displacement detector.
摘要翻译：电动毛发去除装置包括用户手持的保持器和从保持器的一端突出的一对镊子臂，用于夹持头发从毛发生长的皮肤上去除。电源通过控制装置启动，以便在被镊子臂抓住时由头发自动施加电流并被弹簧张紧，直到毛发从皮肤拔出，此时电流自动终止。在一个描述的实施例中，控制装置是张力传感器，在另一个描述的实施例中，它是位移检测器。

20. 发明授权

US3995021A Antigens of 5,5'alkylphenyl barbituric acids and related hydantoin compounds 失效
标题翻译： 5,5 {40烷基苯基巴比妥酸和相关乙内酰脲化合物的抗原
公开(公告)号：US3995021A
公开(公告)日：1976-11-30
申请号：US543012
申请日：1975-01-21
申请人： Stanley Joseph Gross
发明人： Stanley Joseph Gross
IPC分类号： G01N33/531 , G01N33/94 , G21H5/02 , A61K39/00
CPC分类号： G01N33/948 , G01N33/531 , G01N33/9406 , Y10S436/80 , Y10S436/804 , Y10S436/815 , Y10S436/816 , Y10S530/806
摘要： Antigens comprising 5,5'-alkylphenyl barbituric acid haptens and related 5,5'-phenylhydantoin haptens coupled to a carrier through an azo group connected meta or para on the phenyl ring are prepared by diazotization of the corresponding amine. Specific antibodies are raised in animals and used in radioimmuno assays for the corresponding hapten.
摘要翻译：通过相应的胺的重氮化制备包含5,5'-烷基苯基巴比妥酸半抗原和相关联的5,5'-苯乙内酰脲半抗原通过连接在苯环上的间位或对位的偶氮基与载体连接的抗原。在动物中培养特异性抗体，并用于相应半抗原的放射免疫测定。

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