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1. 外观设计

USD404482S Drug delivery device 失效
公开(公告)号：USD404482S
公开(公告)日：1999-01-19
申请号：US87441
申请日：1998-05-01
申请人： Yael Falk , Joseph Gross , Mario Rozanowich
设计人： Yael Falk , Joseph Gross , Mario Rozanowich

2. 外观设计

USD405524S Drug delivery device 失效
公开(公告)号：USD405524S
公开(公告)日：1999-02-09
申请号：US87442
申请日：1998-05-01
申请人： Yael Falk , Joseph Gross
设计人： Yael Falk , Joseph Gross

3. 发明授权

US09132231B2 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US09132231B2
公开(公告)日：2015-09-15
申请号：US13617126
申请日：2012-09-14
申请人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
发明人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
IPC分类号： A61M5/20 , B23P11/00 , A61M5/142 , A61M5/158 , A61K33/22 , A61M5/145 , A61M5/315 , A61M5/14
CPC分类号： A61M5/155 , A61K33/22 , A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/158 , A61M5/2046 , A61M5/31551 , A61M5/31571 , A61M5/31586 , A61M2005/1405 , A61M2005/14204 , A61M2005/1426 , A61M2005/14533 , A61M2005/31518 , Y10S128/12 , Y10T29/49826 , A61K33/14 , A61K31/135 , A61K2300/00
摘要： A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to undergo incremental advancement. The device may also be provided with manual control for delivering a bolus dose of drug when necessary.
摘要翻译：一种具有包含由电子控制器控制的气体发生器的壳体的药物输送装置。气体发生器将气体产生到可往复运动的腔室中，由此腔室的往复运动导致杆使棘爪往复运动，并且该动作导致棘轮经历增量进给。该装置还可以被提供手动控制，用于在需要时递送药丸剂量。

4. 发明申请

US20130079747A1 DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：US20130079747A1
公开(公告)日：2013-03-28
申请号：US13617041
申请日：2012-09-14
申请人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
发明人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
IPC分类号： A61M5/158
CPC分类号： A61M5/155 , A61K33/22 , A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/158 , A61M5/2046 , A61M5/31551 , A61M5/31571 , A61M5/31586 , A61M2005/1405 , A61M2005/14204 , A61M2005/1426 , A61M2005/14533 , A61M2005/31518 , Y10S128/12 , Y10T29/49826 , A61K33/14 , A61K31/135 , A61K2300/00
摘要： A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.

5. 发明授权

US06830560B1 Automatic syringe 有权
标题翻译：自动注射器
公开(公告)号：US06830560B1
公开(公告)日：2004-12-14
申请号：US09617340
申请日：2000-07-17
申请人： Joseph Gross , Gilad Lavi , Izrail Tsals
发明人： Joseph Gross , Gilad Lavi , Izrail Tsals
IPC分类号： A61M3700
CPC分类号： A61M5/2046 , A61M5/3202 , A61M5/3257 , A61M5/3272 , A61M5/46 , A61M2005/2013 , A61M2005/3247 , A61M2005/3267
摘要： A syringe comprises a barrel containing an internal cylindrical body containing a liquid and communicating with a delivery needle. The needle is covered before use by a removable sheath, and after the sheath is removed, the needle is concealed by a displaceable sleeve. In use the sleeve is pressed against the skin by applying pressure while holding the barrel. The sleeve is thereby retracted into the barrel allowing the needle to penetrate the skin. The movement of the sleeve also activates a gas generator which expels the liquid from the needle. When delivery is complete and the syringe is taken from the skin, a coil spring moves the sleeve back to the starting position again concealing the needle. The coil spring is torsionally biased before use and causes a rotational movement of the sleeve relative to the barrel when the sleeve moves into and out of the barrel. This rotational movement engages a locking mechanism which prevents further movement of the sleeve and thereby permanently conceals the needle.
摘要翻译：注射器包括容纳含有液体并与输送针连通的内部圆柱体的筒体。针在使用前被可移除的护套覆盖，并且在护套被移除之后，针被可移位的套管隐藏。在使用中，通过在保持桶的同时施加压力将套筒压靠在皮肤上。因此套筒被缩回到镜筒中，允许针穿透皮肤。套筒的运动还激活排出针头液体的气体发生器。当输送完成并且从皮肤取出注射器时，螺旋弹簧将套筒移回到再次隐藏针的起始位置。螺旋弹簧在使用前被扭转偏压，并且当套筒移入和移出筒体时，使套筒相对于筒体旋转运动。该旋转运动接合锁定机构，该锁定机构防止套筒的进一步运动，从而永久地隐藏针头。

6. 发明授权

US06595956B1 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US06595956B1
公开(公告)日：2003-07-22
申请号：US09275464
申请日：1999-03-23
申请人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
发明人： Joseph Gross , Izrail Tsals , Gilad Lavi , Gil Yigal , Ehoud Carmel
IPC分类号： A61M3700
CPC分类号： A61M5/155 , A61K33/22 , A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/158 , A61M5/2046 , A61M5/31551 , A61M5/31571 , A61M5/31586 , A61M2005/1405 , A61M2005/14204 , A61M2005/1426 , A61M2005/14533 , A61M2005/31518 , Y10S128/12 , Y10T29/49826 , A61K33/14 , A61K31/135 , A61K2300/00
摘要： A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocate chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to The device may also be provided with manually control for delivering a bolus dose of drug when necessary.
摘要翻译：一种具有包含由电子控制器控制的气体发生器的壳体的药物输送装置。气体发生器将气体产生到往复运动的腔室中，由此腔室的往复运动导致杆使棘爪往复运动，并且该动作引起棘轮。该装置还可以被提供手动控制，用于在需要时输送推注剂量的药物。

7. 发明授权

US06478771B1 Drug delivery systems and methods 失效
标题翻译：药物输送系统和方法
公开(公告)号：US06478771B1
公开(公告)日：2002-11-12
申请号：US09439963
申请日：1999-11-12
申请人： Gilad Lavi , Gil Yigal , Izrail Tsals , Joseph Gross
发明人： Gilad Lavi , Gil Yigal , Izrail Tsals , Joseph Gross
IPC分类号： A61M3700
CPC分类号： A61J1/2089 , A61J1/201 , A61J1/2013 , A61J1/2017 , A61J1/2051 , A61J1/2058 , A61J1/2082 , A61M5/148 , A61M5/162 , A61M5/1782 , A61M5/19 , A61M5/2046 , A61M5/2053 , A61M5/2425 , A61M5/2448 , A61M5/3234 , A61M2005/14252 , A61M2005/1581 , A61M2005/3128 , A61M2005/3223 , A61M2205/215 , A61M2205/583
摘要： The present invention relates to a drug delivery device for mixing and delivering a drug by injection. The device includes a housing having a first port or opening therein that receives a first container that contains a fluid or powdered drug, for example a lyophilized drug. The housing can also include a second port or opening that receives a second container that contains a fluid to be mixed with the drug to form an injectable fluid. The device includes a manifold having a channel that fluidly connects the first and second containers. A penetrating membrane such as a needle is used to inject the drug into a patient which is in fluid communication with the first container. The needle is movable from a storage position in the housing to an injection position extending through the housing.
摘要翻译：本发明涉及通过注射混合和输送药物的药物递送装置。该装置包括具有其中的第一端口或开口的壳体，其容纳包含流体或粉末状药物的第一容器，例如冻干药物。壳体还可以包括接收第二容器的第二端口或开口，第二容器包含待与药物混合以形成可注射流体的流体。该装置包括具有流体连接第一和第二容器的通道的歧管。使用诸如针的穿透膜将药物注射到与第一容器流体连通的患者体内。针可以从壳体中的存储位置移动到延伸穿过壳体的注射位置。

8. 发明授权

US06312409B1 Device for generating a pulsatile fluid drug flow 失效
标题翻译：用于产生脉动流体药物流的装置
公开(公告)号：US06312409B1
公开(公告)日：2001-11-06
申请号：US09331648
申请日：1999-09-07
申请人： Joseph Gross
发明人： Joseph Gross
IPC分类号： A61M3700
CPC分类号： A61M39/22 , A61M5/142 , A61M5/14593 , A61M2206/10
摘要： A device (10) for generating a pulsatile fluid drug flow comprises a housing (11) containing an expandable-contractible chamber (12) having an inlet (14) and an outlet (15), a valve (16) associated with the outlet (15) which is actuated by the expansion and contraction of the chamber (12), and means (13, 23) for biasing the chamber (12) to its contracted state. When the inlet (14) is connected to a pressurised fluid drug supply the chamber (12) is expanded by the drug, and this expansion of the chamber (12) actuates the valve (16) to open, thereby allowing release of the drug from the chamber (12), following which the chamber (12) contracts under the influence of the biasing means (13, 23), this contraction in turn actuating the valve (16) to close thereby allowing the chamber (12) to refill. By this mechanism, a constant supply of liquid, such as from an osmotic or elastomeric drug delivery pump, can be converted to a pulsatile flow, which may provide a more suitable delivery of certain drugs.
摘要翻译：用于产生脉动流体药物流的装置（10）包括容纳具有入口（14）和出口（15）的可膨胀收缩室（12）的壳体（11），与出口由室（12）的膨胀和收缩致动的装置（15），以及用于将室（12）偏压到其收缩状态的装置（13,23）。当进口（14）连接到加压流体药物供应时，腔室（12）被药物膨胀，并且腔室（12）的这种膨胀致动阀门（16）打开，从而允许药物从在室（12）之后，腔室（12）在偏置装置（13,23）的影响下收缩，这种收缩又使阀门（16）致动，从而允许腔室（12）再填充。通过这种机制，可以将诸如来自渗透性或弹性体药物输送泵的液体的恒定供应转化为脉动流，这可以提供某些药物的更合适的递送。

9. 发明授权

US5848991A Intradermal drug delivery device and method for intradermal delivery of drugs 失效
公开(公告)号：US5848991A
公开(公告)日：1998-12-15
申请号：US843146
申请日：1997-04-25
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61M5/142 , A61M5/145 , A61M37/00 , A61N1/30
CPC分类号： A61M5/14248 , A61M5/14593 , A61N1/303 , A61M2005/14252 , A61M37/00 , Y10S977/801 , Y10S977/906 , Y10S977/918
摘要： An intradermal drug delivery device for delivering a liquid drug to a subject via the subject's skin includes a housing having a lower surface provided with an adhesive coating for adhering the housing to the subject's skin. An expansible-contractible chamber within the housing defines a reservoir which is expanded upon being filled with the drug and contracted to dispense the drug. A hollow needle extends through the lower surface of the housing and has an inner end which communicates with the reservoir and an outer end which projects outwardly of the housing a short distance to penetrate through the epidermis and into the dermis of the subject's skin when the housing is adhered thereto. The device permits delivery of drugs of relatively large molecular size and at slow rates which can be precisely controlled. A method of delivering a liquid drug intradermally includes adhering the intradermal delivery device to the skin of the subject and activating the means for actively discharging the at least one drug from the reservoir to the subject's skin via the needle.

10. 发明授权

US5354335A Intraocular insert for implantation in the human eye 失效
标题翻译：用于植入人眼的眼内插入物
公开(公告)号：US5354335A
公开(公告)日：1994-10-11
申请号：US13387
申请日：1993-02-04
申请人： Isaac Lipshitz , Joseph Gross
发明人： Isaac Lipshitz , Joseph Gross
IPC分类号： A61F2/16
CPC分类号： A61F2/1648 , A61F2/1651 , A61F2250/0053
摘要： An intraocular insert for implantation in the interior of a human eye, characterized in that the insert includes a converging lens to face the anterior side of the eye, and a diverging lens in alignment with and spaced behind the converging lens to face the posterior side of the eye.
摘要翻译：一种用于植入人眼内部的眼内插入物，其特征在于，所述插入物包括面对眼睛前侧的会聚透镜，以及与会聚透镜对准并间隔在会聚透镜之后的发散透镜，以面向眼睛的后侧眼。

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