专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5800420A Analyte-controlled liquid delivery device and analyte monitor 失效
标题翻译：分析物控制液体输送装置和分析物监测器
公开(公告)号：US5800420A
公开(公告)日：1998-09-01
申请号：US769996
申请日：1996-12-19
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61M5/00 , A61B5/00 , A61K9/70 , A61M1/36 , A61M5/142 , A61M5/172 , C07C253/34 , C12Q1/25 , G01N27/327 , A61K9/22 , G01N15/06
CPC分类号： A61M5/14248 , A61B5/14865 , A61B5/6848 , A61K9/0021 , A61K9/7023 , A61M5/14244 , A61M5/1723 , C07C253/34 , A61M2005/14204 , A61M2005/14268 , A61M2005/1726 , A61M2205/8206
摘要： A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected. A reference electrode (silver/silver chloride) which rests against the subject's skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit is measured by a voltmeter and a signal from the voltmeter is amplified and communicated to the microprocessor which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject's plasma.
摘要翻译：一种液体输送装置，包括具有用于施用到受试者的皮肤的下表面的壳体，并且具有储存器和在其中由可移位膜隔开的气体生成室。在微处理器的控制下由电解池产生的气体使得气体产生室膨胀并且储存器收缩，从而通过从下表面延伸的中空输送针从储存器排出液体药物，例如胰岛素。输送针和传感器针从下表面延伸足够的距离，以便当外壳被压靠在皮肤上时穿透表皮并进入真皮。传感器针头具有用于检测受检者血浆中的分析物例如葡萄糖的酶涂层。输送针由铂 - 铱制成，并且根据检测到的葡萄糖的量，电流通过针和恒电位仪电路。靠在受试者皮肤上的参比电极（银/氯化银）增加了葡萄糖测量的准确性。通过电位计电流测量电流，电压表的信号被放大并传送到微处理器，该微处理器根据受试者血浆中检测到的分析物水平确定药物的正确传送速率。

2. 发明授权

US5848991A Intradermal drug delivery device and method for intradermal delivery of drugs 失效
公开(公告)号：US5848991A
公开(公告)日：1998-12-15
申请号：US843146
申请日：1997-04-25
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61M5/142 , A61M5/145 , A61M37/00 , A61N1/30
CPC分类号： A61M5/14248 , A61M5/14593 , A61N1/303 , A61M2005/14252 , A61M37/00 , Y10S977/801 , Y10S977/906 , Y10S977/918
摘要： An intradermal drug delivery device for delivering a liquid drug to a subject via the subject's skin includes a housing having a lower surface provided with an adhesive coating for adhering the housing to the subject's skin. An expansible-contractible chamber within the housing defines a reservoir which is expanded upon being filled with the drug and contracted to dispense the drug. A hollow needle extends through the lower surface of the housing and has an inner end which communicates with the reservoir and an outer end which projects outwardly of the housing a short distance to penetrate through the epidermis and into the dermis of the subject's skin when the housing is adhered thereto. The device permits delivery of drugs of relatively large molecular size and at slow rates which can be precisely controlled. A method of delivering a liquid drug intradermally includes adhering the intradermal delivery device to the skin of the subject and activating the means for actively discharging the at least one drug from the reservoir to the subject's skin via the needle.

3. 发明授权

US5820622A Analyte-controlled liquid delivery device and analyte monitor 失效
公开(公告)号：US5820622A
公开(公告)日：1998-10-13
申请号：US769212
申请日：1996-12-18
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61M5/00 , A61B5/00 , A61K9/70 , A61M1/36 , A61M5/142 , A61M5/172 , C07C253/34 , C12Q1/25 , G01N27/327 , A61K9/22 , G01N15/06
CPC分类号： A61M5/14248 , A61B5/14865 , A61B5/6848 , A61K9/0021 , A61K9/7023 , A61M5/14244 , A61M5/1723 , C07C253/34 , A61M2005/14204 , A61M2005/14268 , A61M2005/1726 , A61M2205/8206
摘要： A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected. A reference electrode (silver/silver chloride) which rests against the subject's skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit is measured by a voltmeter and a signal from the voltmeter is amplified and communicated to the microprocessor which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject's plasma.

4. 发明授权

US5997501A Intradermal drug delivery device 失效
标题翻译：皮内给药装置
公开(公告)号：US5997501A
公开(公告)日：1999-12-07
申请号：US647954
申请日：1996-08-19
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61M5/142 , A61M5/145 , A61M31/00
CPC分类号： A61M5/14248 , A61M5/14593 , A61M2005/14252 , A61M2005/14268
摘要： An intradermal drug delivery device comprises a housing (301a, 301b) having a drug reservoir (312) therewithin and a gas generation chamber (313) separated from the reservoir (312) by a displaceable membrane (311). A microprocessor-controlled electrolytic cell (316a, 316b, 319) provides gas to expand the gas generation chamber (313) and thereby contract the reservoir (312). A hollow needle (310), communicating at an inner end thereof with the reservoir (312), extends from a lower surface (308) of the housing (301) such that contraction of the reservoir (312) forces drug to escape therefrom via the needle (310). The device permits delivery of drugs of relatively large molecular weights at slow controllable rates. A displaceable protective cover (303) is mounted in means (307) allowing movement of the cover (303) between extended and retracted positions (305, 306). The cover (303) has an adhesive lower surface (309) for attachment to the skin of a subject. In use, a release liner is removed, the device is pressed against the skin and the cover (303) snaps back to the retracted position (306), the needle (310) thereby piercing the skin. After use the housing (301) is pulled away and the cover (303) snaps to the extended position (306) before detaching from the skin, thus concealing the needle (310) before disposal.
摘要翻译： PCT No.PCT / IE94 / 00055 Sec。 371日期：1996年8月19日 102（e）日期1996年8月19日PCT 1994年11月17日PCT PCT。公开号WO95 / 13838 日期1995年5月26日皮内药物递送装置包括其中具有药物储存器（312）的壳体（301a，301b）和通过可移位膜（311）与储存器（312）分离的气体产生室（313）。微处理器控制的电解池（316a，316b，319）提供气体以膨胀气体生成室（313），从而使储存器（312）收缩。在其内端与储存器（312）连通的空心针（310）从壳体（301）的下表面（308）延伸，使得储存器（312）的收缩迫使药物经由针（310）。该装置允许以较慢的可控速率递送较大分子量的药物。可移动的保护盖（303）安装在装置（307）中，允许盖（303）在延伸和缩回位置（305,306）之间移动。盖（303）具有用于附着到受试者皮肤的粘合剂下表面（309）。在使用中，移除剥离衬垫，该装置被压靠在皮肤上，并且盖（303）卡扣回到缩回位置（306），针（310）从而刺穿皮肤。在使用之后，将壳体（301）拉开并且在从皮肤脱离之前盖子（303）卡扣到延伸位置（306），从而在处置之前隐藏针头（310）。

5. 发明授权

US5925030A Orally administrable delivery device 失效
标题翻译：口服给药装置
公开(公告)号：US5925030A
公开(公告)日：1999-07-20
申请号：US793497
申请日：1997-09-29
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61K9/00 , A61K9/22 , A61M5/142 , A61M5/145 , A61M31/00 , A61M37/00
CPC分类号： A61M5/14593 , A61K9/0009 , A61M31/002 , A61M2005/14204
摘要： Oral drug delivery device having a housing with walls of water permeable material and having at least two chambers separated by a displaceable membrane. The first chamber receives drug and has an orifice through which the drug is expelled under pressure. The second chamber contains at least one of two spaced apart electrodes forming part of an electric circuit which is closed by the ingress of an aqueous ionic solution into the second chamber. When current flows through the circuit, gas is generated and acts on the displaceable membrane to compress the first chamber and expel the active ingredient through the orifice for progressive delivery to the gastrointestinal tract.
摘要翻译： PCT No.PCT / IE95 / 00039 Sec。 371日期：1997年9月29日 102（e）日期1997年9月29日PCT提交1995年8月4日PCT公布。出版物WO96 / 04953 日期1996年2月22日具有具有水可渗透材料壁的壳体并且具有由可置换膜隔开的至少两个室的口腔输送装置。第一个房间接受药物并具有一个孔口，药物通过该口在压力下排出。第二室包含形成电路的一部分的两个间隔开的电极中的至少一个，其通过将离子水溶液进入第二室而闭合。当电流流过电路时，产生气体并作用在可移动膜上以压缩第一室并通过孔排出活性成分以逐渐递送至胃肠道。

6. 发明授权

US5807375A Analyte-controlled liquid delivery device and analyte monitor 失效
公开(公告)号：US5807375A
公开(公告)日：1998-09-15
申请号：US556744
申请日：1995-11-02
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A61M5/00 , A61B5/00 , A61K9/70 , A61M1/36 , A61M5/142 , A61M5/172 , C07C253/34 , C12Q1/25 , G01N27/327 , A61K9/32 , A61M31/00 , A61B5/05
CPC分类号： A61M5/14248 , A61B5/14865 , A61B5/6848 , A61K9/0021 , A61K9/7023 , A61M5/14244 , A61M5/1723 , C07C253/34 , A61M2005/14204 , A61M2005/14268 , A61M2005/1726 , A61M2205/8206
摘要： A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected. A reference electrode (silver/silver chloride) which rests against the subject's skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit is measured by a voltmeter and a signal from the voltmeter is amplified and communicated to the microprocessor which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject's plasma.

7. 发明授权

US5799663A Nicotine oral delivery device 失效
标题翻译：尼古丁口服装置
公开(公告)号：US5799663A
公开(公告)日：1998-09-01
申请号：US716331
申请日：1996-12-23
申请人： Joseph Gross , John Gerard Kelly
发明人： Joseph Gross , John Gerard Kelly
IPC分类号： A24F47/00 , A61M15/06
CPC分类号： A24F47/002
摘要： A nicotine oral delivery device, which includes a hollow housing (10) and a hollow mouthpiece (14) which may be detachable connected to the housing (10) or may form with the housing a single piece. The mouthpiece includes a nicotine-containing material (16), in the form of a gel, on one or more of the outer surfaces of the mouthpiece. The housing (10) may also include flavoring (20), such as menthol. The nicotine-containing material (16) may be located as a layer on the mouthpiece (14), or in holes in the mouthpiece or under a permeable membrane (18) covering a portion of the mouthpiece (14). Where the mouthpiece and housing are separate pieces, the mouthpiece may be disposable while the housing reusable.
摘要翻译： PCT No.PCT / IE95 / 00019 Sec。 371日期：1996年12月23日 102（e）日期1996年12月23日PCT提交1995年2月17日PCT公布。公开号WO95 / 24135 日期1995年9月14日一种尼古丁口服递送装置，其包括中空的外壳（10）和中空的吸嘴（14），其可拆卸地连接到外壳（10）或者可以与外壳一体形成。所述接口管在所述接口管的一个或多个外表面上包括呈凝胶形式的含尼古丁的材料（16）。壳体（10）还可以包括调味剂（20），例如薄荷醇。含尼古丁的材料（16）可以位于接口（14）上的层，或位于接口管中的孔中，或位于覆盖接口（14）的一部分的可渗透膜（18）下方。当接口管和外壳是分开的部件时，接口管可以是一次性的，而外壳可重复使用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式