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11. 发明授权

US4308254A Material able to fix reversibly biologial macromolecules, its preparation and its application 失效
标题翻译：能够修复可逆生物大分子的材料及其制备及其应用
公开(公告)号：US4308254A
公开(公告)日：1981-12-29
申请号：US944121
申请日：1978-09-19
申请人： Jean-Louis Tayot , Michel Tardy
发明人： Jean-Louis Tayot , Michel Tardy
IPC分类号： C04B41/83 , A61K38/16 , A61K39/395 , B01J20/281 , B01J20/32 , B01J41/16 , C07G15/00 , C07H15/10 , C07H21/00 , C07K1/18 , C07K1/22 , C07K14/195 , C07K14/28 , C07K14/41 , C07K14/575 , C07K14/76 , C07K14/765 , C07K16/00 , C07K16/06 , C07K17/02 , C12N9/68 , C12N11/14 , G01N30/88 , G01N33/548 , G01N33/551 , A61K37/04 , A61K39/00 , A61K39/106 , A61K39/12
CPC分类号： C07H15/10 , B01J20/103 , B01J20/262 , B01J20/265 , B01J20/267 , B01J20/28057 , B01J20/28078 , B01J20/286 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3272 , B01J20/328 , B01J20/3282 , B01J20/3425 , B01J20/3475 , C07K1/18 , C07K14/28 , C07K14/765 , C07K16/065 , C12N9/6435 , C12Y304/21007 , B01J2220/54 , B01J2220/58
摘要： A process for preparing a porous solid material for use in a chromatography column and which is capable of fixing reversibly biological macromolecules comprises coating a porous inorganic support with a polysaccharide polymer having .alpha.-glycol groups which undergo oxidative scission, subjecting the polysaccharide polymer to an oxidative scission reaction, reacting the resulting oxidized polysaccharide polymer with an amino molecule or macromolecule having the formula R'--NH.sub.2 to produce a polysacchride polymer having the formula R.sub.4 --CH.dbd.N--R' and reducing the imine bond in said immediately above defined polysaccharide polymer to a stable amine bond.
摘要翻译：制备用于色谱柱并能够固定可逆生物大分子的多孔固体材料的方法包括用具有经历氧化断裂的α-二醇基团的多糖聚合物涂覆多孔无机载体，使多糖聚合物经受氧化使所得到的氧化多糖聚合物与具有式R'-NH 2的氨基分子或大分子反应，以产生具有式R4-CH = NR'的多糖聚合物，并将所述立即定义的多糖聚合物中的亚胺键还原成稳定的胺键。

12. 发明申请

US20120183501A1 NOVEL METHOD FOR TREATMENT OF SKIN WOUNDS AND PREPARATIONS FOR IMPLEMENTATION OF SAME 审中-公开
标题翻译：治疗皮肤创伤的新方法及其实施的准备
公开(公告)号：US20120183501A1
公开(公告)日：2012-07-19
申请号：US13293861
申请日：2011-11-10
申请人： Jean-Louis Tayot
发明人： Jean-Louis Tayot
IPC分类号： A61K38/17 , A61K35/00 , A61P17/02 , A61K38/42
CPC分类号： A61L26/0066 , A61K35/19 , A61K38/1858 , A61K38/42 , A61L26/0047 , A61L2300/252 , A61L2300/404 , A61L2300/64 , A61K2300/00
摘要： Method for treatment of skin wounds, in a patient needing it, in which an effective amount of an insoluble globin preparation is placed in direct contact with the skin wound, the preparation is kept in place for at least one week, without having to change or wash the wound during said time and without a local infection, which would be detrimental to the patient.
摘要翻译：用于治疗皮肤伤口的方法，在需要其的患者中，将有效量的不溶性珠蛋白制剂置于与皮肤伤口直接接触的情况下，将制剂保持在适当位置至少一周，而不必改变或在上述时间内清洗伤口，无局部感染，对患者有害。

13. 发明授权

US07709017B2 Implantable preparations 失效
标题翻译：可植入的制剂
公开(公告)号：US07709017B2
公开(公告)日：2010-05-04
申请号：US11499723
申请日：2006-08-07
申请人： Jean Louis Tayot
发明人： Jean Louis Tayot
IPC分类号： A61K9/00 , A61K38/17
CPC分类号： A61L27/227 , A61K38/39 , A61K38/42 , A61L15/32 , A61L24/108 , A61L26/0047 , A61L31/047
摘要： An implantable preparation comprises a material which can be obtained from globin that has been modified, especially chemically, to be, at least partially, soluble at physiological pH. The material is biocompatible, and biodegradable in the organism. The material may be soluble at physiological pH, or insoluble at that pH. The preparation may be in the form of a solution, suspension, paste, gel, film, sponge, powder or granules, or a solid implant. The preparation can be used for the healing, protection or filling of external skin wounds, the filling of wrinkles and skin flaws, the filling of tissue, as a device for fixing prostheses or biomaterials, or as a device for preventing adhesion.
摘要翻译：可植入制剂包括可从球状蛋白获得的材料，其已被改性，特别是在化学上至少部分地可溶于生理pH。该材料是生物相容的，并且在生物体中可生物降解。该物质可能在生理pH下可溶，或在该pH下不溶。制剂可以是溶液，悬浮液，糊剂，凝胶，薄膜，海绵，粉末或颗粒或固体植入物的形式。该制剂可用于外用皮肤伤口的愈合，保护或填充，皱纹和皮肤缺陷的填充，组织的填充，固定假体或生物材料的装置，或用作防止粘连的装置。

14. 发明申请

US20090074736A1 IMPLANTABLE PREPARATIONS COMPRISING GLOBIN, PROCESS FOR THEIR PRODUCTION, AND USES 审中-公开
标题翻译：包括GLOBIN的可植入制剂，其生产和使用过程
公开(公告)号：US20090074736A1
公开(公告)日：2009-03-19
申请号：US12207621
申请日：2008-09-10
申请人： Jean-Louis Tayot , Florent Sapin , Jean Bernasconi
发明人： Jean-Louis Tayot , Florent Sapin , Jean Bernasconi
IPC分类号： A61K35/12 , A61K38/17
CPC分类号： A61K9/0024 , A61K35/15 , A61K35/19 , A61K38/36 , A61K38/385 , A61K38/42 , A61L15/32 , A61L24/108 , A61L27/227 , A61L27/3616 , A61L27/3645 , A61L27/3843 , A61L27/54 , A61L27/60 , A61L2300/252 , A61L2300/418 , A61K2300/00
摘要： Preparations comprising, especially, globin that is insoluble at neutral pH, and therefore at physiological pH, in which the globin has been obtained from whole blood by depigmentation in a medium that extracts or dissolves the haem but leaves the globin and the other constituents of proteinic nature in a substantially undissolved state, a process for the production of those preparations, and uses, especially for the filling, healing or regeneration of tissues, especially for chronic wounds and osseous healing or regeneration.
摘要翻译：制备物，特别是在中性pH下，因此在生理pH下不溶于珠蛋白，其中珠蛋白是通过在提取或溶解血红素但留下珠蛋白和其它成分的蛋白质的培养基中通过脱色法从全血中获得的基本上未溶解状态的性质，制备这些制剂的方法，特别是用于组织的填充，愈合或再生，特别是用于慢性伤口和骨骼愈合或再生的用途。

15. 再颁专利

USRE39172E1 Method for preparing two-layer bicomposite collagen material for preventing post-operative adhesions 有权
标题翻译：制备双层双层复合胶原材料以防止手术后粘连的方法
公开(公告)号：USRE39172E1
公开(公告)日：2006-07-11
申请号：US10761055
申请日：1999-09-16
申请人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
发明人： Yves Bayon , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61L15/16 , C12N11/02 , C12M5/06 , C12M5/08 , C08H1/00
CPC分类号： A61L15/325 , A61L31/044
摘要： A bicomposite material based on collagen is prepared which has two closely bound layers and is biocompatible, non-toxic, hemostatic and biodegradable in less than a month, and can be used in surgery to achieve hemostasis and prevent post-surgical adhesion. To prepare the material, a solution of collagen or gelatin, which may contain glycerine and a hydrophilic additive such as polyethylene glycol or a polysaccharide, is poured onto an inert support to form a layer 30 μm to less than 100 μm thick. Then a polymeric porous fibrous layer is applied during gelling of the collagen or gelatin, and the resultant material is dried. The polymeric porous fibrous layer may be made of collagen or a polysaccharide, and have a density of not more than 75 mg/cm2, a pore size from 30 μm to 300 μm and a thickness of 0.2 cm to 1.5 cm.
摘要翻译：制备基于胶原的双组分材料，其具有两个紧密结合的层，并且在不到一个月的时间内具有生物相容性，无毒性，止血性和生物降解性，并且可用于手术以实现止血并防止手术后粘连。为了制备材料，将可能含有甘油和亲水性添加剂如聚乙二醇或多糖的胶原蛋白或明胶溶液倒入惰性支持体中以形成30μm至小于100μm厚的层。然后在胶原或明胶的胶凝过程中施加聚合物多孔纤维层，并将所得材料干燥。聚合物多孔纤维层可以由胶原或多糖制成，并且具有不大于75mg / cm 2的密度，30μm至300μm的孔径和0.2cm的厚度至1.5厘米。

16. 发明授权

US06949625B2 Injectable implant of insoluble globin 有权
标题翻译：注射不溶性球蛋白植入物
公开(公告)号：US06949625B2
公开(公告)日：2005-09-27
申请号：US10842462
申请日：2004-05-11
申请人： Jean-Louis Tayot
发明人： Jean-Louis Tayot
IPC分类号： A61K38/39 , A61L15/32 , A61L27/22 , A61K35/14 , A61K47/00
CPC分类号： A61L15/32 , A61K38/39 , A61L27/227
摘要： A preparation is provided which can be injected or implanted into the human or animal body, and which comprises, as main component, globin that is insoluble at physiological pH, biocompatible and sterile.
摘要翻译：提供可以注射或植入人或动物体内的制剂，其包含作为主要成分的珠蛋白，其在生理pH，生物相容性和无菌性方面是不溶的。

17. 发明授权

US06730299B1 Adhesive protein foam for surgical and/or therapeutic uses 失效
标题翻译：用于手术和/或治疗用途的粘合蛋白泡沫
公开(公告)号：US06730299B1
公开(公告)日：2004-05-04
申请号：US09787543
申请日：2001-03-20
申请人： Jean-Louis Tayot , Yves Bayon , Philippe Gravagna , Michel Marie Dubois
发明人： Jean-Louis Tayot , Yves Bayon , Philippe Gravagna , Michel Marie Dubois
IPC分类号： A61K3851
CPC分类号： C09J189/00 , A61L15/32 , A61L15/425 , A61L24/0036 , A61L24/043 , A61L24/10 , A61L26/0028 , A61L26/0052 , A61L26/0085 , C08J9/122 , C08J2207/02 , C08L89/06
摘要： A biocompatible fluid adhesive protein foam, which is bioresorbable and nontoxic, for surgical and/or therapeutic use, in particular for protecting/cicatrizing tissue wounds and for attaching biological tissues to each other or to an implanted biomaterial. The biocompatible fluid adhesive protein foam includes a biocompatible fluid adhesive protein matrix, which is bioresorbable and nontoxic, containing a biocompatible and nontoxic gas or mixture of gases. Further, a process and a kit for preparing such a foam are provided.
摘要翻译：用于手术和/或治疗用途的生物相容性流体粘合蛋白泡沫，其是生物可再吸收和无毒的，特别是用于保护/瘢痕组织伤口并将生物组织连接到植入的生物材料。生物相容性流体粘合蛋白泡沫包括生物相容性流体粘合蛋白基质，其是生物可再吸收和无毒的，含有生物相容性和无毒气体或气体混合物。此外，提供了制备这种泡沫的方法和试剂盒。

18. 发明授权

US06451032B1 Composite prosthesis for preventing post-surgical adhesions and method for obtaining same 有权
标题翻译：用于预防手术后粘连的复合假体及其获得方法
公开(公告)号：US06451032B1
公开(公告)日：2002-09-17
申请号：US09463313
申请日：2000-01-24
申请人： François Régis Ory , Michel Therin , Philippe Gravagna , Jean-Louis Tayot
发明人： François Régis Ory , Michel Therin , Philippe Gravagna , Jean-Louis Tayot
IPC分类号： A61B1704
CPC分类号： A61L31/10 , A61L31/129 , D04B21/10 , D10B2403/0112 , D10B2403/0213 , D10B2509/08 , C08L89/06 , A61B90/00 , A61L31/148 , A61L31/146 , A61L31/145 , C08L67/00 , C08L71/02 , C08L5/00
摘要： The composite prosthesis comprises a prosthetic fabric having a three-dimensional structure separating two surfaces, one of which is open to post-surgical cell colonization. The composite prosthesis further comprises at least one film of a collagenous material linked to the other surface of the prosthetic fabric. The composite prosthesis may be used to prevent post-surgical adhesion.
摘要翻译：复合假体包括具有分离两个表面的三维结构的假体织物，其中一个表面对手术后细胞定植开放。所述复合假体还包括至少一层与所述假体织物的另一表面连接的胶原材料的膜。复合假体可用于防止手术后粘连。

19. 发明授权

US06391939B1 Collagenic material useful in particular for preventing post-operative adhesions 有权
公开(公告)号：US06391939B1
公开(公告)日：2002-05-21
申请号：US09355842
申请日：1999-08-05
申请人： Jean-Louis Tayot , Michel Tardy , Philippe Gravagna
发明人： Jean-Louis Tayot , Michel Tardy , Philippe Gravagna
IPC分类号： A61L3100
摘要： The present invention relates to a biocompatible collagenous material which is non-toxic and biodegradable in less than one month, preferably in less than one week. This material comprises collagen and at least one hydrophilic macromolecular additive which is chemically non-reactive towards the collagen, with the collagen having at least partially lost its helical structure and being crosslinked. The invention also relates to a process for obtaining such a material. The collagenous material according to the invention is used, in particular, for preventing post-operative adhesions.

20. 发明授权

US06372510B1 Method for removing unconventional transmissible agents from a protein solution 有权
标题翻译：从蛋白质溶液中去除非常规传染剂的方法
公开(公告)号：US06372510B1
公开(公告)日：2002-04-16
申请号：US09142745
申请日：1998-11-10
申请人： Michel Grandgeorge , René Labatut , Jean-Marc Rouzioux , Jean-Louis Tayot , Jean-Luc Veron
发明人： Michel Grandgeorge , René Labatut , Jean-Marc Rouzioux , Jean-Louis Tayot , Jean-Luc Veron
IPC分类号： G01N3002
CPC分类号： C07K14/76 , A61L2/0017 , B01D15/327 , B01D15/36 , B01D15/363
摘要： The present invention is drawn to method for removing unconventional transmissible agents (UCTA) from aqueous protein solution. This method involves treating the aqueous protein solution with simultaneous electrostatic adsorption and hydrophobic chromatography. The method of the present invention is particularly suitable for treating calf serum or an albumin solution.
摘要翻译：本发明涉及从蛋白质水溶液中除去非常规传染剂（UCTA）的方法。该方法包括同时静电吸附和疏水色谱法处理蛋白质水溶液。本发明的方法特别适用于治疗小牛血清或白蛋白溶液。

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