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1. 发明申请

US20090054350A1 PROCESS FOR THE STERILE CONCENTRATION OF COLLAGEN PREPARATIONS, AND COLLAGEN PREPARATIONS OBTAINED 审中-公开
标题翻译：胶原蛋白制剂的无菌浓缩方法和获得的胶原蛋白制剂
公开(公告)号：US20090054350A1
公开(公告)日：2009-02-26
申请号：US12194100
申请日：2008-08-19
申请人： Jean-Louis Tayot , Florent Sapin
发明人： Jean-Louis Tayot , Florent Sapin
IPC分类号： A61K38/39
CPC分类号： C07K14/78
摘要： The invention relates to a process for the preparation of sterile collagen, especially injectable collagen, comprising the steps of preparing a purified acidic collagen solution, filtering that solution through a filter or a sterile membrane, precipitating the filtered solution in the form of a suspension, and concentrating the collagen suspension, in which process the suspension is placed in an elongate supple tubular filter constituting a porous filtering wall, permeable to the liquid but not permeable to the collagen fibres, and is concentrated by the slow passage of the liquid through the wall, without any pressure other than gravity, in order to prevent the filtering wall from becoming clogged by the collagen fibres, optionally with absorption of the liquid by an absorbent layer covering the wall or forming part of that wall, and the subsequent flowing-away and/or evaporation of the liquid via the face of the layer remote from the wall, and collagen preparations obtained.
摘要翻译：本发明涉及一种制备无菌胶原蛋白，特别是可注射胶原蛋白的方法，包括以下步骤：制备纯化的酸性胶原溶液，通过过滤器或无菌膜过滤该溶液，以悬浮液的形式沉淀过滤的溶液，并且将胶原悬浮液浓缩，在该过程中，将悬浮液放置在构成多孔过滤壁的细长的柔性管状过滤器中，该液体可透过液体但不能透过胶原纤维，并且通过液体缓慢通过壁，除了重力之外没有任何压力，以防止过滤壁被胶原纤维阻塞，任选地通过覆盖该壁或形成该壁的一部分的吸收层吸收液体，随后流出和 /或通过远离壁的层的表面蒸发液体和获得的胶原蛋白制剂。

2. 发明申请

US20090074736A1 IMPLANTABLE PREPARATIONS COMPRISING GLOBIN, PROCESS FOR THEIR PRODUCTION, AND USES 审中-公开
标题翻译：包括GLOBIN的可植入制剂，其生产和使用过程
公开(公告)号：US20090074736A1
公开(公告)日：2009-03-19
申请号：US12207621
申请日：2008-09-10
申请人： Jean-Louis Tayot , Florent Sapin , Jean Bernasconi
发明人： Jean-Louis Tayot , Florent Sapin , Jean Bernasconi
IPC分类号： A61K35/12 , A61K38/17
CPC分类号： A61K9/0024 , A61K35/15 , A61K35/19 , A61K38/36 , A61K38/385 , A61K38/42 , A61L15/32 , A61L24/108 , A61L27/227 , A61L27/3616 , A61L27/3645 , A61L27/3843 , A61L27/54 , A61L27/60 , A61L2300/252 , A61L2300/418 , A61K2300/00
摘要： Preparations comprising, especially, globin that is insoluble at neutral pH, and therefore at physiological pH, in which the globin has been obtained from whole blood by depigmentation in a medium that extracts or dissolves the haem but leaves the globin and the other constituents of proteinic nature in a substantially undissolved state, a process for the production of those preparations, and uses, especially for the filling, healing or regeneration of tissues, especially for chronic wounds and osseous healing or regeneration.
摘要翻译：制备物，特别是在中性pH下，因此在生理pH下不溶于珠蛋白，其中珠蛋白是通过在提取或溶解血红素但留下珠蛋白和其它成分的蛋白质的培养基中通过脱色法从全血中获得的基本上未溶解状态的性质，制备这些制剂的方法，特别是用于组织的填充，愈合或再生，特别是用于慢性伤口和骨骼愈合或再生的用途。

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