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11. 发明申请

US20110111515A1 REAGENT FOR MEASUREMENT OF REACTIVE OXYGEN 审中-公开
标题翻译：用于测量反应性氧的试剂
公开(公告)号：US20110111515A1
公开(公告)日：2011-05-12
申请号：US12919059
申请日：2009-02-27
申请人： Tetsuo Nagano , Hirotatsu Kojima , Daihi Oushiki
发明人： Tetsuo Nagano , Hirotatsu Kojima , Daihi Oushiki
IPC分类号： G01N33/00 , C07D209/04
CPC分类号： C07D209/14 , G01N31/225 , G01N2021/7786 , Y10T436/177692 , Y10T436/20
摘要： A reagent for measurement of reactive oxygen, which can be used with a light of the near infrared region showing superior biological tissue permeability, wherein (i) a first cyanine compound residue and a second cyanine compound residue are bound to each other, (ii) the first cyanine compound residue has a property that it easily reacts with a reactive oxygen species and is thereby decomposed, and (iii) the second cyanine compound residue either equals or surpasses the first cyanine compound residue in its stability to the reactive oxygen species, and the first cyanine compound residue acts as a quenching group for the second cyanine compound residue.
摘要翻译：用于测量活性氧的试剂，其可以与显示出优异的生物组织通透性的近红外区域的光一起使用，其中（i）第一花青化合物残基和第二花青化合物残基彼此结合，（ii）第一花青化合物残基具有容易与活性氧物质反应并因此分解的性质，和（iii）第二花青化合物残基在其对活性氧的稳定性中等于或超过第一花青化合物残基，以及第一花青化合物残基用作第二花青化合物残基的猝灭基团。

12. 发明申请

US20070298507A1 Fluorescent Probe 审中-公开
标题翻译：荧光探针
公开(公告)号：US20070298507A1
公开(公告)日：2007-12-27
申请号：US10598250
申请日：2005-02-22
申请人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
发明人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
IPC分类号： G01N21/78 , C07D209/08 , G01N31/00 , G01N31/22 , C07D249/18
CPC分类号： C09K11/06 , C07D209/08 , C07D209/12 , C07D249/18 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , G01N31/22 , G01N2021/6439 , Y02P20/55 , Y10S436/80 , Y10T436/141111
摘要： A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided. A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(═O)—, —C(═S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M− represents a counter ion in a number required for neutralizing the charge].
摘要翻译：提供了一种能够特异地有效捕获一氧化氮，锌离子等以发出荧光的荧光探针。由以下通式（I）表示的化合物：[其中R 1和R 2表示氢原子或由下式（A）表示的基团：（其中X 1至X 4表示氢原子，烷基或氨基的保护基，m和n表示0或1）; R 3和R 4代表氢原子，C 1-6烷基或C 1-6 - 烷基烷氧基 R 5至R 12代表氢原子，磺基，磷酸基，卤素原子或C 1-6烷基; R 13和R 14代表C 1-18烷基; Z 1表示氧原子，硫原子或-N（R 15） - （其中R 15表示氢原子或C 1〜烷基）; Y - （O） - ， - （-S） - 或-C（R 16）（R 17）（其中R 16和R 17代表C 1-6烷基）; 和 - 表示中和电荷所需的数字的抗衡离子]。

13. 发明授权

US06469051B2 Diaminorhodamine derivative 有权
标题翻译：二氨基罗丹明衍生物
公开(公告)号：US06469051B2
公开(公告)日：2002-10-22
申请号：US09750055
申请日：2000-12-29
申请人： Tetsuo Nagano , Hirotatsu Kojima
发明人： Tetsuo Nagano , Hirotatsu Kojima
IPC分类号： A61K31352
CPC分类号： G01N31/223 , C07D311/82 , C09B11/24 , Y10T436/177692
摘要： A compound represented by the following general formula: wherein R1 and R2 represent amino groups present at adjacent positions each other on the phenyl ring; R3, R4, R5 and R6 independently represent a C1-6 alkyl group; R7, R8, R9 and R10 independently represent a hydrogen atom, a C1-6 alkyl group, an allyl group, or a halogen atom; R11 represents a hydrogen atom or a C1-18 alkyl group; and X− represents an anion, and an agent for nitric oxide measurement comprising said compound. The compound efficiently reacts with nitric oxide to give a fluorescent compound that emits strong fluorescence by irradiation with excitation light of a long wavelength. This fluorescent compound is characterized in that said compound is detectable in a fluorescence wavelength range hardly influenced by autofluorescence of cells, and its fluorescence intensity is not attenuated under an acidic condition.
摘要翻译：由以下通式表示的化合物：其中R 1和R 2表示在苯环上相邻位置上存在的氨基; R3，R4，R5和R6独立地表示C1-6烷基; R 7，R 8，R 9和R 10独立地表示氢原子，C 1-6烷基，烯丙基或卤素原子; R11表示氢原子或C1-18烷基; 和X-表示阴离子，和含有所述化合物的一氧化氮测定剂。化合物与一氧化氮有效反应，得到通过长波长激发光照射而发出强荧光的荧光化合物。该荧光化合物的特征在于，所述化合物在几乎不受细胞自发荧光影响的荧光波长范围内是可检测的，其荧光强度在酸性条件下不衰减。

14. 发明授权

US06201134B1 Diaminorhodamine derivatives 有权
标题翻译：二氨基罗丹明衍生物
公开(公告)号：US06201134B1
公开(公告)日：2001-03-13
申请号：US09446899
申请日：2000-04-03
申请人： Tetsuo Nagano , Hirotatsu Kojima
发明人： Tetsuo Nagano , Hirotatsu Kojima
IPC分类号： C07D31188
CPC分类号： G01N31/223 , C07D311/82 , C09B11/24 , Y10T436/177692
摘要： A compound represented by the following general formula: wherein R1 and R2 represent amino groups present at adjacent positions each other on the phenyl ring; R3, R4, R5 and R6 independently represent a C1-6 alkyl group; R7, R8, R9 and R10 independently represent a hydrogen atom, a C1-6 alkyl group, an allyl group, or a halogen atom; R11 represents a hydrogen atom or a C1-18 alkyl group; and X− represents an anion, and an agent for nitric oxide measurement comprising said compound. The compound efficiently reacts with nitric oxide to give a fluorescent compound that emits strong fluorescence by irradiation with excitation light of a long wavelength. This fluorescent compound is characterized in that said compound is detectable in a fluorescence wavelength range hardly influenced by autofluorescence of cells, and its fluorescence intensity is not attenuated under an acidic condition.
摘要翻译：由以下通式表示的化合物：其中R 1和R 2表示在苯环上相邻位置上存在的氨基; R3，R4，R5和R6独立地表示C1-6烷基; R 7，R 8，R 9和R 10独立地表示氢原子，C 1-6烷基，烯丙基或卤素原子; R11表示氢原子或C1-18烷基; 和X-表示阴离子，和含有所述化合物的一氧化氮测定剂。化合物与一氧化氮有效反应，得到通过长波长激发光照射而发出强荧光的荧光化合物。该荧光化合物的特征在于，所述化合物在几乎不受细胞自发荧光影响的荧光波长范围内是可检测的，其荧光强度在酸性条件下不衰减。

15. 发明申请

US20110038803A1 FLUORESCENT PROBE 失效
标题翻译：荧光探针
公开(公告)号：US20110038803A1
公开(公告)日：2011-02-17
申请号：US12911348
申请日：2010-10-25
申请人： Tetsuo NAGANO , Eita SASAKI , Hirotatsu KOJIMA , Tomoya HIRANO , Kazuya KIKUCHI
发明人： Tetsuo NAGANO , Eita SASAKI , Hirotatsu KOJIMA , Tomoya HIRANO , Kazuya KIKUCHI
IPC分类号： A61K49/00 , C07D403/10 , C07F3/06 , C07D403/14
CPC分类号： C09K11/06 , C07D209/08 , C07D209/12 , C07D249/18 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , G01N31/22 , G01N2021/6439 , Y02P20/55 , Y10S436/80 , Y10T436/141111
摘要： A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided.A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(═O)—, —C(═S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M− represents a counter ion in a number required for neutralizing the charge].
摘要翻译：提供了一种能够特异地有效捕获一氧化氮，锌离子等以发出荧光的荧光探针。由以下通式（I）表示的化合物：[其中R1和R2表示氢原子或由下式（A）表示的基团：（其中X1至X4表示氢原子，烷基或保护基氨基，m和n表示0或1）; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基; R5至R12表示氢原子，磺基，磷基，卤素原子或C1-6烷基; R13和R14表示C1-18烷基; Z1表示氧原子，硫原子或-N（R15） - （其中R15表示氢原子或C1-6烷基）; Y1和Y2表示-C（= O） - ， - C（= S） - 或-C（R16）（R17）（其中R16和R17表示C1-6烷基）。和M-表示中和电荷所需数量的抗衡离子]。

16. 发明申请

US20100029010A1 Diaminorhodamine Derivative 审中-公开
标题翻译：二氨基罗丹明衍生物
公开(公告)号：US20100029010A1
公开(公告)日：2010-02-04
申请号：US12574569
申请日：2009-10-06
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
IPC分类号： G01N33/50 , C07D487/22
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X− represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3和R 4独立地表示甲基或乙基; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X表示阴离子，和含有所述化合物的一氧化氮测定用试剂。

17. 发明授权

US07618997B2 Diaminofluorescein derivatives 有权
公开(公告)号：US07618997B2
公开(公告)日：2009-11-17
申请号：US11429447
申请日：2006-05-08
申请人： Tetsuo Nagano , Hirotatsu Kojima
发明人： Tetsuo Nagano , Hirotatsu Kojima
IPC分类号： A61K31/352
CPC分类号： C07D493/10 , Y10T436/177692
摘要： A compound represented by the following formula (I): wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C1-6 alkyl)-substituted amino group and the other represents an unsubstituted amino group; and R3 and R4 independently represent hydrogen atom or an acyl group, and an agent for measurement of nitrogen monoxide which comprises said compound.

18. 发明申请

US20080014147A1 Tumor specific fluorescent dye 审中-公开
标题翻译：肿瘤特异性荧光染料
公开(公告)号：US20080014147A1
公开(公告)日：2008-01-17
申请号：US11709808
申请日：2007-02-23
申请人： Tetsuo Nagano , Yasuteru Urano , Hirotatsu Kojima , Yuuta Fujikawa , Tetsuro Takamatsu , Yoshinori Harada
发明人： Tetsuo Nagano , Yasuteru Urano , Hirotatsu Kojima , Yuuta Fujikawa , Tetsuro Takamatsu , Yoshinori Harada
IPC分类号： A61K49/00 , C07D311/82
CPC分类号： C07D493/10 , A61K49/0043 , A61K49/0052
摘要： A tumor cell or tumor tissue-selective fluorescent staining agent comprising a compound represented by the following general formula (I): wherein R1 and R2 independently represent a C1-C4 alkyl group which may be substituted, a C2-C4 alkenyl group which may be substituted, a C2-C4 alkynyl group which may be substituted, an aryl group which may be substituted, or a heteroaryl group which may be substituted.
摘要翻译：包含由以下通式（I）表示的化合物的肿瘤细胞或肿瘤组织选择性荧光染色剂：其中R 1和R 2独立地表示C

19. 发明授权

US06569892B2 Diaminofluorescein derivatives 有权
标题翻译：二氨基荧光素衍生物
公开(公告)号：US06569892B2
公开(公告)日：2003-05-27
申请号：US10140059
申请日：2002-05-08
申请人： Tetsuo Nagano , Hirotatsu Kojima
发明人： Tetsuo Nagano , Hirotatsu Kojima
IPC分类号： A61K31353
CPC分类号： C07D493/10 , Y10T436/177692
摘要： A compound represented by the following formula: wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C1-6 alkyl)-substituted amino group and the other represents an unsubstituted amino group, and wherein R3 represents hydrogen atom or an alkyl group and R4 represents hydrogen atom or an acyl group, and an agent for measurement of nitrogen monoxide which comprises said compound.
摘要翻译：由下式表示的化合物：其中R 1和R 2表示在苯环的相邻位置取代的氨基，条件是R 1和R 2中的任一个表示单（C 1-6烷基）取代的氨基，另一个表示未取代的氨基，其中R3表示氢原子或烷基，R4表示氢原子或酰基，以及含有所述化合物的一氧化氮测定剂。

20. 发明授权

US09156827B2 Anticancer agent 有权
标题翻译：抗癌剂
公开(公告)号：US09156827B2
公开(公告)日：2015-10-13
申请号：US13643002
申请日：2011-04-28
申请人： Tetsuo Nagano , Takayoshi Okabe , Hirotatsu Kojima , Nae Saito , Hirofumi Nakano , Masanao Abe , Akiko Tanaka , Teruki Honma , Shigeyuki Yokoyama , Keiko Tsuganezawa , Hitomi Yuki
发明人： Tetsuo Nagano , Takayoshi Okabe , Hirotatsu Kojima , Nae Saito , Hirofumi Nakano , Masanao Abe , Akiko Tanaka , Teruki Honma , Shigeyuki Yokoyama , Keiko Tsuganezawa , Hitomi Yuki
IPC分类号： C07D405/14 , A61K31/36 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D405/06 , C07D493/04 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号： C07D405/14 , A61K31/36 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D405/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04
摘要： An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6 alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; R4 represents hydrogen atom, a C1-6 alkyl group, a C1-6 alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6 alkyl group and the like; R8 represents hydrogen atom, a C1-6 alkyl group and the like; A represents —O—, —S—, or —CH2—; D represents —C═ or —N═; X represents methylene group, —O—, or —CO—; Q represents —N═ or —C(R8)═; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.
摘要翻译：包含由式（I）表示的化合物[R 1表示氢原子，羟基，C 1-6烷氧基等]的抗癌剂， R2和R3表示氢原子，卤素原子，C1-6烷基等; R4表示氢原子，C1-6烷基，C1-6烷基磺酰基等; R5代表氢原子或取代基; 代表单键或双键; R6和R7表示氢原子，C1-6烷基等; R8表示氢原子，C1-6烷基等; A表示-O - ， - S-或-CH 2 - ; D表示-C≡或-N =; X表示亚甲基，-O-或-CO-; Q表示-N =或-C（R 8）= Y表示杂环基或氨基]，这表现出对pim-1激酶的优异抑制活性。

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