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1. 发明申请

US20080014147A1 Tumor specific fluorescent dye 审中-公开
标题翻译：肿瘤特异性荧光染料
公开(公告)号：US20080014147A1
公开(公告)日：2008-01-17
申请号：US11709808
申请日：2007-02-23
申请人： Tetsuo Nagano , Yasuteru Urano , Hirotatsu Kojima , Yuuta Fujikawa , Tetsuro Takamatsu , Yoshinori Harada
发明人： Tetsuo Nagano , Yasuteru Urano , Hirotatsu Kojima , Yuuta Fujikawa , Tetsuro Takamatsu , Yoshinori Harada
IPC分类号： A61K49/00 , C07D311/82
CPC分类号： C07D493/10 , A61K49/0043 , A61K49/0052
摘要： A tumor cell or tumor tissue-selective fluorescent staining agent comprising a compound represented by the following general formula (I): wherein R1 and R2 independently represent a C1-C4 alkyl group which may be substituted, a C2-C4 alkenyl group which may be substituted, a C2-C4 alkynyl group which may be substituted, an aryl group which may be substituted, or a heteroaryl group which may be substituted.
摘要翻译：包含由以下通式（I）表示的化合物的肿瘤细胞或肿瘤组织选择性荧光染色剂：其中R 1和R 2独立地表示C

2. 发明申请

US20060252099A1 Method for measurement by using long-lived excitation fluorescence 审中-公开
标题翻译：使用长寿命激发荧光测定方法
公开(公告)号：US20060252099A1
公开(公告)日：2006-11-09
申请号：US11486035
申请日：2006-07-14
申请人： Tetsuo Nagano , Kazuya Kikuchi , Mitsunori Koresawa , Hirotatsu Kojima
发明人： Tetsuo Nagano , Kazuya Kikuchi , Mitsunori Koresawa , Hirotatsu Kojima
IPC分类号： C07F5/00 , G01N33/53
CPC分类号： G01N33/542 , G01N21/6428 , G01N2021/6441
摘要： A method for measurement of a target substance in a sample by means of fluorescence, which comprises the step of carrying out the measurement in the presence of (1) a specific fluorescent probe which specifically reacts with the target substance to generate fluorescence, and (2) a donor which, per se, has long-lived fluorescence and is capable of inducing fluorescence resonance energy transfer to the specific fluorescent probe that acts as an acceptor, provided that the donor forms no binding to the specific fluorescent probe by means of a chemical bond; and the step of converting fluorescence, wherein said fluorescence is resulted from a reaction between the acceptor and the target substance, into long-lived excitation fluorescence by the fluorescence resonance energy transfer which is induced on the acceptor.
摘要翻译：一种通过荧光测定样品中的目标物质的方法，包括在（1）特异性荧光探针存在下进行测定的步骤的步骤，所述荧光探针与目标物质特异性反应以产生荧光，和（2 ）供体本身具有长寿命的荧光，并且能够诱导荧光共振能量转移到用作受体的特定荧光探针，条件是供体通过化学物质不与特定荧光探针结合键; 以及通过在受体上诱导的荧光共振能量转移，将受体和目标物质之间的反应产生的荧光转化为长寿命激发荧光的步骤。

3. 发明授权

US06833386B2 Diaminofluorescein derivatives 有权
标题翻译：二氨基荧光素衍生物
公开(公告)号：US06833386B2
公开(公告)日：2004-12-21
申请号：US10412300
申请日：2003-04-14
申请人： Tetsuo Nagano , Hirotatsu Kojima
发明人： Tetsuo Nagano , Hirotatsu Kojima
IPC分类号： A61K31352
CPC分类号： C07D493/10 , Y10T436/177692
摘要： A compound represented by the following formula (I): wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C1-6 alkyl)-substituted amino group and the other represents an unsubstituted amino group; and R3 and R4 independently represent hydrogen atom or an acyl group, and an agent for measurement of nitrogen monoxide which comprises said compound.
摘要翻译：由下式（I）表示的化合物：其中R 1和R 2表示在苯环的相邻位置取代的氨基，条件是R 1和R 2中的任一个表示单（C 1-6烷基） - 取代氨基，另一个表示未取代的氨基; R 3和R 4独立地表示氢原子或酰基，和含有所述化合物的一氧化氮测定剂。

4. 发明授权

US5874590A Diaminofluorescein derivative 失效
标题翻译：二氨基荧光素衍生物
公开(公告)号：US5874590A
公开(公告)日：1999-02-23
申请号：US953724
申请日：1997-10-17
申请人： Tetsuo Nagano , Hirotatsu Kojima
发明人： Tetsuo Nagano , Hirotatsu Kojima
IPC分类号： G01N31/00 , C07D493/10 , G01N21/64 , G01N21/78 , C07D311/82 , C07D487/00 , G01N21/76
CPC分类号： C07D493/10 , C09B11/24
摘要： A compound useful for the measurement of nitrogen monoxide under a substantially neutral condition which is represented by the following formula (I): ##STR1## wherein R.sup.1 and R.sup.2 represent amino groups that substitute at adjacent positions on the phenyl ring; R.sup.3 and R.sup.4 independently represent a hydrogen atom or an acyl group; R.sup.5, R.sup.6, R.sup.7, and R.sup.8 independently represent a hydrogen atom, a C.sub.1-6 alkyl group, allyl group, or a halogen atom.
摘要翻译：用于在基本中性条件下测量一氧化氮的化合物，其由下式（I）表示：ps代替苯环上的相邻位置; R3和R4独立地表示氢原子或酰基; R5，R6，R7和R8独立地表示氢原子，C1-6烷基，烯丙基或卤素原子。

5. 发明授权

US08507677B2 Fluorescent probe 失效
标题翻译：荧光探针
公开(公告)号：US08507677B2
公开(公告)日：2013-08-13
申请号：US12526677
申请日：2008-02-15
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuki Kiyose
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuki Kiyose
IPC分类号： C07D403/00 , C07D209/02
CPC分类号： C07D209/14
摘要： A compound represented by the following general formula (I): [wherein R1 and R2 represent a C1-6 alkyl group; R3, R4 and R5 represent hydrogen atom, a C1-6 alkyl group, or an aryl group; Y1 and Y2 represent —O—, —S—, —Se—, —CH═CH—, —C(R6)(R7)—, or —N(R8)— (wherein R6, R7 and R8 represent hydrogen atom or a C1-6 alkyl group); A represents a C1-3 alkylene group; n and n′ represent 0, 1 or 2; Z1 and Z2 represent a nonmetallic atom group required to form a benzo-condensed ring or a naphtho-condensed ring; L1 to L7 represent a methine group; and M− represents a counter ion in a number required for neutralizing electrical charge], which is useful as a fluorescent probe of which optical characteristics change depending on pH change.
摘要翻译：由以下通式（I）表示的化合物：[其中R 1和R 2表示C 1-6烷基; R3，R4和R5表示氢原子，C1-6烷基或芳基; Y 1和Y 2表示-O-，-S-，-Se - ， - CH = CH - ， - C（R 6）（R 7） - 或-N（R 8） - （其中R 6，R 7和R 8表示氢原子或 C 1-6烷基）; A表示C1-3亚烷基; n和n'表示0,1或2; Z 1和Z 2表示形成苯并稠合环或萘并稠环所需的非金属原子团; L1至L7代表次甲基; 并且M-表示中和电荷所需数量的抗衡离子]，其可用作其光学特性根据pH变化而变化的荧光探针。

6. 发明授权

US08465985B2 Fluorescent probe 失效
标题翻译：荧光探针
公开(公告)号：US08465985B2
公开(公告)日：2013-06-18
申请号：US12527898
申请日：2008-02-29
申请人： Tetsuo Nagano , Hirotatsu Kojima , Sakiko Aizawa , Kazuki Kiyose
发明人： Tetsuo Nagano , Hirotatsu Kojima , Sakiko Aizawa , Kazuki Kiyose
IPC分类号： G01N21/76
CPC分类号： G01N33/542 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , G01N2021/7786 , Y10T436/141111
摘要： A fluorescent probe comprising a compound represented as (Fluorophore A)-S-(Fluorophore B) (Fluorophore A and Fluorophore B are fluorophores which emit fluorescence when they are irradiated with an excitation light of a wavelength of 600 to 950 nm, Fluorophore A has a property that it shows change of fluorescence characteristic before and after a specific reaction with an substance to be measured, and S represents a spacer which connects Fluorophore A and Fluorophore B), which compound shows substantial change in efficiency of fluorescence resonance energy transfer between Fluorophore A and Fluorophore B before and after the specific reaction with the objective substance, wherein Fluorophore A is represented by the following formula (AI): which uses and shows an excitation light wavelength/fluorescence wavelength in the near infrared region, lights of which region show superior biological tissue permeability, and enables measurement of an substance to be measured by the ratio method.
摘要翻译：包含由（荧光团A）-S-（荧光团B）表示的化合物（荧光团B）和荧光团B的荧光探针是当用波长为600〜950nm的激发光照射时发出荧光的荧光团，荧光团A具有显示与待测物质的特定反应之前和之后的荧光特性变化的性质，S表示连接荧光团A和荧光团B）的间隔物，该化合物显示荧光团之间的荧光共振能量转移效率的显着变化 A和荧光团B与目标物质的特异性反应之前和之后，其中荧光团A由下式（AI）表示：其使用并显示近红外区域中的激发光波长/荧光波长，其区域显示优异的生物组织渗透性，并且能够通过比率法测量待测物质。

7. 发明申请

US20080281104A1 Membrane-Anchoring Fluorescent Probe 审中-公开
标题翻译：膜锚定荧光探针
公开(公告)号：US20080281104A1
公开(公告)日：2008-11-13
申请号：US11817609
申请日：2006-03-03
申请人： Tetsuo Nagano , Hirotatsu Kojima , Takashi Osaki
发明人： Tetsuo Nagano , Hirotatsu Kojima , Takashi Osaki
IPC分类号： C07F9/6558
CPC分类号： G01N33/6872 , G01N33/582 , G01N33/92
摘要： A membrane anchoring-type fluorescent probe consisting of a compound comprising a phospholipid residue, a fluorescent probe compound residue, and a linker which binds the residues (e.g., the compound represented by the following formula).
摘要翻译：由包含磷脂残基的化合物，荧光探针化合物残基和结合残基的接头（例如由下式表示的化合物）组成的膜锚定型荧光探针。

8. 发明申请

US20050130314A1 Diaminofluorescein derivatives 审中-公开
标题翻译：二氨基荧光素衍生物
公开(公告)号：US20050130314A1
公开(公告)日：2005-06-16
申请号：US10989280
申请日：2004-11-17
申请人： Tetsuo Nagano , Hirotatsu Kojima
发明人： Tetsuo Nagano , Hirotatsu Kojima
IPC分类号： C07D491/20 , C07D493/10 , G01N33/00 , C07D311/78
CPC分类号： C07D493/10 , Y10T436/177692
摘要： A compound represented by the following formula (I): wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2 represents a mono(C1-6 alkyl)-substituted amino group and the other represents an unsubstituted amino group; and R3 and R4 independently represent hydrogen atom or an acyl group, and an agent for measurement of nitrogen monoxide which comprises said compound.
摘要翻译：由下式（I）表示的化合物：其中R 1和R 2代表在苯环的相邻位置取代的氨基，条件是R 1， SUP> 1和R 2表示单（C 1-6烷基）取代的氨基，另一个表示未取代的氨基; R 3和R 4独立地表示氢原子或酰基，和含有所述化合物的一氧化氮测定剂。

9. 发明授权

US06756231B1 Diaminorhodamine derivative 有权
标题翻译：二氨基罗丹明衍生物
公开(公告)号：US06756231B1
公开(公告)日：2004-06-29
申请号：US09641350
申请日：2000-08-18
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
IPC分类号： G01N3300
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X− represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3和R 4独立地表示甲基或乙基组; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X“表示阴离子，包含所述化合物的一氧化氮。

10. 发明申请

US20100029010A1 Diaminorhodamine Derivative 审中-公开
标题翻译：二氨基罗丹明衍生物
公开(公告)号：US20100029010A1
公开(公告)日：2010-02-04
申请号：US12574569
申请日：2009-10-06
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
IPC分类号： G01N33/50 , C07D487/22
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X− represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3和R 4独立地表示甲基或乙基; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X表示阴离子，和含有所述化合物的一氧化氮测定用试剂。

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