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1. 发明授权

US06756231B1 Diaminorhodamine derivative 有权
标题翻译：二氨基罗丹明衍生物
公开(公告)号：US06756231B1
公开(公告)日：2004-06-29
申请号：US09641350
申请日：2000-08-18
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
IPC分类号： G01N3300
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X− represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3和R 4独立地表示甲基或乙基组; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X“表示阴离子，包含所述化合物的一氧化氮。

2. 发明申请

US20060252099A1 Method for measurement by using long-lived excitation fluorescence 审中-公开
标题翻译：使用长寿命激发荧光测定方法
公开(公告)号：US20060252099A1
公开(公告)日：2006-11-09
申请号：US11486035
申请日：2006-07-14
申请人： Tetsuo Nagano , Kazuya Kikuchi , Mitsunori Koresawa , Hirotatsu Kojima
发明人： Tetsuo Nagano , Kazuya Kikuchi , Mitsunori Koresawa , Hirotatsu Kojima
IPC分类号： C07F5/00 , G01N33/53
CPC分类号： G01N33/542 , G01N21/6428 , G01N2021/6441
摘要： A method for measurement of a target substance in a sample by means of fluorescence, which comprises the step of carrying out the measurement in the presence of (1) a specific fluorescent probe which specifically reacts with the target substance to generate fluorescence, and (2) a donor which, per se, has long-lived fluorescence and is capable of inducing fluorescence resonance energy transfer to the specific fluorescent probe that acts as an acceptor, provided that the donor forms no binding to the specific fluorescent probe by means of a chemical bond; and the step of converting fluorescence, wherein said fluorescence is resulted from a reaction between the acceptor and the target substance, into long-lived excitation fluorescence by the fluorescence resonance energy transfer which is induced on the acceptor.
摘要翻译：一种通过荧光测定样品中的目标物质的方法，包括在（1）特异性荧光探针存在下进行测定的步骤的步骤，所述荧光探针与目标物质特异性反应以产生荧光，和（2 ）供体本身具有长寿命的荧光，并且能够诱导荧光共振能量转移到用作受体的特定荧光探针，条件是供体通过化学物质不与特定荧光探针结合键; 以及通过在受体上诱导的荧光共振能量转移，将受体和目标物质之间的反应产生的荧光转化为长寿命激发荧光的步骤。

3. 发明申请

US20100029010A1 Diaminorhodamine Derivative 审中-公开
标题翻译：二氨基罗丹明衍生物
公开(公告)号：US20100029010A1
公开(公告)日：2010-02-04
申请号：US12574569
申请日：2009-10-06
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
IPC分类号： G01N33/50 , C07D487/22
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X− represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3和R 4独立地表示甲基或乙基; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X表示阴离子，和含有所述化合物的一氧化氮测定用试剂。

4. 发明申请

US20070298507A1 Fluorescent Probe 审中-公开
标题翻译：荧光探针
公开(公告)号：US20070298507A1
公开(公告)日：2007-12-27
申请号：US10598250
申请日：2005-02-22
申请人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
发明人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
IPC分类号： G01N21/78 , C07D209/08 , G01N31/00 , G01N31/22 , C07D249/18
CPC分类号： C09K11/06 , C07D209/08 , C07D209/12 , C07D249/18 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , G01N31/22 , G01N2021/6439 , Y02P20/55 , Y10S436/80 , Y10T436/141111
摘要： A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided. A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(═O)—, —C(═S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M− represents a counter ion in a number required for neutralizing the charge].
摘要翻译：提供了一种能够特异地有效捕获一氧化氮，锌离子等以发出荧光的荧光探针。由以下通式（I）表示的化合物：[其中R 1和R 2表示氢原子或由下式（A）表示的基团：（其中X 1至X 4表示氢原子，烷基或氨基的保护基，m和n表示0或1）; R 3和R 4代表氢原子，C 1-6烷基或C 1-6 - 烷基烷氧基 R 5至R 12代表氢原子，磺基，磷酸基，卤素原子或C 1-6烷基; R 13和R 14代表C 1-18烷基; Z 1表示氧原子，硫原子或-N（R 15） - （其中R 15表示氢原子或C 1〜烷基）; Y - （O） - ， - （-S） - 或-C（R 16）（R 17）（其中R 16和R 17代表C 1-6烷基）; 和 - 表示中和电荷所需的数字的抗衡离子]。

5. 发明授权

US07939330B2 Fluorescent probe 失效
标题翻译：荧光探针
公开(公告)号：US07939330B2
公开(公告)日：2011-05-10
申请号：US12911348
申请日：2010-10-25
申请人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
发明人： Tetsuo Nagano , Eita Sasaki , Hirotatsu Kojima , Tomoya Hirano , Kazuya Kikuchi
IPC分类号： G01N21/78 , G01N31/00 , G01N31/22 , C07D209/08 , C07D249/18
CPC分类号： C09K11/06 , C07D209/08 , C07D209/12 , C07D249/18 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/086 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , G01N31/22 , G01N2021/6439 , Y02P20/55 , Y10S436/80 , Y10T436/141111
摘要： A fluorescent probe which specifically and efficiently traps nitrogen monoxide, zinc ion etc. to emit fluorescence is provided.A compound represented by the following general formula (I): [wherein R1 and R2 represent hydrogen atom, or a group represented by the following formula (A): (wherein X1 to X4 represent hydrogen atom, an alkyl group, or a protective group for amino group, and m and n represent 0 or 1); R3 and R4 represent hydrogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group; R5 to R12 represent hydrogen atom, sulfo group, phospho group, a halogen atom, or a C1-6 alkyl group; R13 and R14 represent a C1-18 alkyl group; Z1 represents oxygen atom, sulfur atom, or —N(R15)— (wherein R15 represents hydrogen atom, or a C1-6 alkyl group); Y1 and Y2 represent —C(═O)—, —C(═S)—, or —C(R16)(R17) (wherein R16 and R17 represent a C1-6 alkyl group); and M− represents a counter ion in a number required for neutralizing the charge].
摘要翻译：提供了一种能够特异地有效捕获一氧化氮，锌离子等以发出荧光的荧光探针。由以下通式（I）表示的化合物：[其中R1和R2表示氢原子或由下式（A）表示的基团：（其中X1至X4表示氢原子，烷基或保护基氨基，m和n表示0或1）; R3和R4表示氢原子，C1-6烷基或C1-6烷氧基; R5至R12表示氢原子，磺基，磷基，卤素原子或C1-6烷基; R13和R14表示C1-18烷基; Z1表示氧原子，硫原子或-N（R15） - （其中R15表示氢原子或C1-6烷基）; Y1和Y2表示-C（= O） - ， - C（= S） - 或-C（R16）（R17）（其中R16和R17表示C1-6烷基）。和M-表示中和电荷所需数量的抗衡离子]。

6. 发明申请

US20100330685A1 DIAMINORHODAMINE DERIVATIVE 审中-公开
公开(公告)号：US20100330685A1
公开(公告)日：2010-12-30
申请号：US12826291
申请日：2010-06-29
申请人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
发明人： Tetsuo Nagano , Hirotatsu Kojima , Kazuya Kikuchi
IPC分类号： G01N33/00 , C07D493/10 , C07D491/20
CPC分类号： C07D405/04 , C07D311/90 , C07D491/20 , C07D493/10 , G01N21/6428 , G01N2021/6439 , Y10T436/10 , Y10T436/141111 , Y10T436/17 , Y10T436/177692 , Y10T436/179228
摘要： A compound represented by the following formula (I) or (II): wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X− represents an anion, and a reagent for measurement of nitric oxide which comprises said compound.
摘要翻译：由下式（I）或（II）表示的化合物：其中，在式（I）中，R 1，R 2，R 3和R 4独立地表示甲基或乙基; 在式（II）中，R 5，R 6，R 7和R 8独立地表示甲基或乙基，X表示阴离子，和含有所述化合物的一氧化氮测定用试剂。

7. 再颁专利

USRE40572E1 Fluorescent probe for the quantitation of zinc 有权
标题翻译：用于定量锌的荧光探针
公开(公告)号：USRE40572E1
公开(公告)日：2008-11-11
申请号：US11808125
申请日：2001-02-28
申请人： Tetsuo Nagano , Kazuya Kikuchi , Tomoya Hirano
发明人： Tetsuo Nagano , Kazuya Kikuchi , Tomoya Hirano
IPC分类号： C07D311/78
CPC分类号： C07D493/10 , C07D311/82 , C09B11/24 , C09B11/245 , C09B11/28 , Y02P20/55
摘要： A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n represent 0 or 1 provided that R1 and R2 do not simultaneously represent hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; and R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7 represents a hydrogen atom or an alkyl group.
摘要翻译：用作锌荧光探针的通式（IA）表示的化合物或其盐：其中R 1和R 2表示氢原子或由式（A）其中X 1，X 2，X 3和X 4表示氢原子，烷基，2-吡啶基甲基或氨基的保护基，m和n表示0或1，条件是R 1和R 2都是不同时代表氢原子; R 3和R 4代表氢原子或卤素原子; R 5和R 6表示氢原子，烷基羰基或烷基羰氧基甲基，R 7表示氢原子或烷基。

8. 发明申请

US20080261314A1 FLUORESCENT PROBE FOR ZINC 审中-公开
标题翻译：荧光探针
公开(公告)号：US20080261314A1
公开(公告)日：2008-10-23
申请号：US12058289
申请日：2008-03-28
申请人： Tetsuo NAGANO , Kazuya Kikuchi , Tomoya Hirano , Satoko Maruyama
发明人： Tetsuo NAGANO , Kazuya Kikuchi , Tomoya Hirano , Satoko Maruyama
IPC分类号： G01N33/20 , C07D413/14 , C07D401/14
CPC分类号： C07D405/14 , C07D413/14 , C09K11/06 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1033 , C09K2211/1088 , C09K2211/188 , G01N31/22
摘要： A compound represented by the following general formula (I) or a salt thereof: wherein R1 represents hydrogen atom, an alkyl group, an alkoxy group, or hydroxy group; R2 represents a group represented by the following formula (A): wherein X1 to X4 represent hydrogen atom, an alkyl group, or 2-pyridylmethyl group, and m and n represent 0 or 1; Y represents a single bond or —CO—; R3 represents a carboxy-substituted aryl group, a carboxy-substituted heteroaryl group, benzothiazol-2-yl group, or 5-oxo-2-thioxo-4-imidazolyzinylidenmethyl group], and a fluorescent probe for zinc which comprises said compound or a salt thereof.
摘要翻译：由下列通式（I）表示的化合物或其盐：其中R 1表示氢原子，烷基，烷氧基或羟基; R 2表示由下式（A）表示的基团：其中X 1至X 4表示氢原子，烷基或 2-吡啶基甲基，m和n表示0或1; Y表示单键或-CO-; R 3表示羧基取代的芳基，羧基取代的杂芳基，苯并噻唑-2-基或5-氧代-2-硫代-4-咪唑基亚乙烯基甲基]和荧光探针对于包含所述化合物或其盐的锌。

9. 发明授权

US07074823B2 Fluorescent probe for zinc 有权
标题翻译：锌荧光探针
公开(公告)号：US07074823B2
公开(公告)日：2006-07-11
申请号：US10994380
申请日：2004-11-23
申请人： Tetsuo Nagano , Kazuya Kikuchi , Tomoya Hirano
发明人： Tetsuo Nagano , Kazuya Kikuchi , Tomoya Hirano
IPC分类号： A61K31/352 , C07D311/78 , C07D311/96
CPC分类号： C07D493/10 , C07D311/82 , C09B11/24 , C09B11/245 , C09B11/28 , Y02P20/55
摘要： A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n represent 0 or 1, provided that R1 and R2 do not simultaneously represent hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; and R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7 represents a hydrogen atom or an alkyl group
摘要翻译：用作锌荧光探针的通式（IA）表示的化合物或其盐：其中R 1和R 2表示氢原子或由式（A）其中X 1，X 2，X 3和X 4表示氢原子，烷基，2-吡啶基甲基或氨基的保护基，m和n表示0或1，条件是R 1和R 2，不同时代表氢原子; R 3和R 4代表氢原子或卤素原子; R 5和R 6表示氢原子，烷基羰基或烷基羰氧基甲基，R 7表示氢原子或烷基

10. 发明授权

US07696245B2 Fluorescent probe for zinc 失效
标题翻译：锌荧光探针
公开(公告)号：US07696245B2
公开(公告)日：2010-04-13
申请号：US10767334
申请日：2004-01-30
申请人： Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
发明人： Kensuke Komatsu , Tomoya Hirano , Kazuya Kikuchi , Tetsuo Nagano
IPC分类号： A61K31/353 , C07D311/80
CPC分类号： C07D405/12 , C07D405/14 , C07D493/10 , G01N33/582 , G01N33/84
摘要： A compound represented by the following general formula (IA) or (IB) or a salt thereof which specifically traps a zinc ion and emits fluorescence, and is useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by the following formula (A): wherein X1 to X4 represent a hydrogen atom, a 2-pyridylmethyl group, a 2-pyridylethyl group, a 2-methyl-6-pyridylmethyl group, or a 2-methyl-6-pyridylethyl group, provided that at least one is the group except a 2-pyridylmethyl group, and m and n represent 0 or 1, provided that they are not simultaneously 0; provided that R1 and R2 are not simultaneously hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group; and R7 represents a hydrogen atom or an alkyl group.
摘要翻译：由以下通式（IA）或（IB）表示的化合物或其盐特异性捕获锌离子并发射荧光，并且可用作锌的荧光探针：其中R1和R2表示氢原子或基团由下式（A）表示：其中X 1至X 4表示氢原子，2-吡啶基甲基，2-吡啶基乙基，2-甲基-6-吡啶基甲基或2-甲基-6-吡啶基乙基条件是至少一个是除2-吡啶基甲基以外的基团，m和n表示0或1，条件是它们不同时为0; 条件是R1和R2不同时为氢原子; R3和R4表示氢原子或卤素原子; R5和R6表示氢原子，烷基羰基或烷基羰氧基甲基; 并且R 7表示氢原子或烷基。

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