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    • 14. 发明申请
    • SUBSTITUTED AZOLIN-2-YL-AMINO COMPOUNDS
    • 取代的AZOLIN-2-YL-AMINO化合物
    • WO2008017649A1
    • 2008-02-14
    • PCT/EP2007/058109
    • 2007-08-06
    • BASF AKTIENGESELLSCHAFTKORADIN, ChristopherKORDES, MarkusLE VEZOUET, RonanCULBERTSON, Deborah L.ANSPAUGH, Douglas D.
    • KORADIN, ChristopherKORDES, MarkusLE VEZOUET, RonanCULBERTSON, Deborah L.ANSPAUGH, Douglas D.
    • C07D277/18C07D417/12A01N43/00
    • C07D417/12A01N43/50A01N43/76A01N43/78C07D277/18
    • The present invention relates to azolin-2-yl-amino compounds of formulae (I. a) and (l.b) and their salts which are useful for combating animal pest, in particular arthropod and nematodes. The present invention also relates to a method for combating such pests and for protecting crops against infestation or infection by such pests. Furthermore, the present invention relates to veterinary compositions for combating animal pests. Formula (I.a), formula (I.b) wherein n is 0 to 4; X is S, O or NR 5 ; A is -C(R 6a )(R 6b )-, O, NR 7 , S, S(O) or S(O) 2 ; B is a bond Or CH 2 ; R 1 is H, CN, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylcarbonyl, C 3 -C 6 -cycloalkyl, phenyl, benzyl, etc.; R 2a , R 2b are H, CN, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, (C 1 -C 6 -alkyl)thiocarbonyl, C(O)NR a R b , C(S)NR a R b , (SO 2 )NR a R b , phenyl, benzyl, 5 or 6 membered heterocyclic ring etc.; or R 1 together with R 2a is C 3 -C 5 -alkandiyl; or R 1 together with R 2b are C(O); R 3a , R 3b , R 3c , R 3d are H, halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino, C 3 -C 6 -cycloalkyl, phenyl, benzyl, etc.; R 4a , R 4b are H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, phenyl, benzyl, 5 or 6 membered hetaryl; or R 4a together with R 4b may also be =0, =NR C or =CR d R e ; or R 2a together with R 4a may form a bridging bivalent radical.
    • 本发明涉及用于对抗动物害虫,特别是节肢动物和线虫的式(Ⅰa)和(Ⅰ.B)的吡咯烷-2-基氨基化合物及其盐。 本发明还涉及一种防治这种害虫并防止作物抵抗这种害虫侵染或感染的方法。 此外,本发明涉及用于对抗动物害虫的兽用组合物。 式(Ⅰa),式(Ⅰb)其中n为0-4; X是S,O或NR 5; A是-C(R 6a)(R 6b) - ,O,NR 7,S,S(O)或S(O ) 2 ; B是键或CH 2 2; R 1是H,CN,C 1 -C 6 - 烷基,C 2 -C 3 - C 1 -C 6 - 亚烷基,C 1 -C 6 - 烷基羰基,C 3 -C 6 - 环烷基,苯基,苄基等; R 2a,R 2b是H,CN,C 1 -C 6 - 烷基,C 1 -C 6烷基, C 1 -C 6亚烷基,C 1 -C 6 - 烷基羰基,C 1 -C 6 - 烷基羰基,C 1 -C 6 - C 6 -C 6 - 烷氧基羰基,(C 1 -C 6 - 烷基)硫代羰基,C(O)NR a C C(S)NR a R b,(SO 2)NR a, 苯基,苄基,5或6元杂环等; 或R 1与R 2a一起为C 3 -C 5 - 亚烷基; 或R 1和R 2b一起是C(O); R 3a,R 3b,R 3c,R 3d是H,卤素,CN,C C 1 -C 6 - 烷基,C 1 -C 6 - 烷基氨基,C 3 - C 6 -C 6 - 环烷基,苯基,苄基等; R 4a,R 4b是H,卤素,C 1 -C 6 - 烷基,C 1 -C 4烷基, C 2 -C 6 - 烯基,苯基,苄基,5或6元杂芳基; 或R 4a与R 4b一起也可以是= 0,= NR C或= CR D, SUP>电子; 或R 2a与R 4a一起可以形成桥连二价基团。
    • 16. 发明申请
    • AMIDRAZONE COMPOUNDS FOR COMBATING ANIMAL PESTS
    • 用于组合动物疫苗的咪唑啉酮化合物
    • WO2006097279A8
    • 2007-05-18
    • PCT/EP2006002331
    • 2006-03-14
    • BASF AGKORADIN CHRISTOPHERDEYN WOLFGANG VONRACK MICHAELKUHN DAVID GCULBERTSON DEBORAH LANSPAUGH DOUGLASOLOUMI-SADEGHI HASSAN
    • KORADIN CHRISTOPHERVON DEYN WOLFGANGRACK MICHAELKUHN DAVID GCULBERTSON DEBORAH LANSPAUGH DOUGLASOLOUMI-SADEGHI HASSAN
    • A01N37/52A01P5/00A01P7/00A01P7/04C07C259/20
    • C07C259/20A01N37/52C07C2601/02
    • The present invention relates to new amidrazone compounds which are useful for combating animal pests, in particular insects, arachnids and nematodes. The invention also relates to a method for combating insects, nematodes and arachnids. The amidrazone compounds are of the general formula (I) including the tautomers of I and the salts thereof; wherein X and Y are hydrogen or together form a chemical bond; Ar is an aromatic radical selected from phenyl and a 5- or 6-membered heteroaryl having 1 , 2, 3 or 4 heteroatoms as ring members, which are selected, independently of one another, from O, N and S, and where the aromatic radical may have 1 , 2, 3, 4 or 5 substituents R a ; R 1 is selected from the group consisiting of C 1 -C 1O -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, cyano-C 1 -C 4 -alkyl, hydroxy-C 1- C 4 -alkyl, C 1 -C 10 -haloalkyl, tri-(C 1 -C 4 -alkyl)-silyl-C 1 - C 4 -alkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -haloalkenyl, C 2 -C 10 -alkynyl, C 2 -C 10 -haloalkynyl, C 3 -C 10 -cycloalkyl, phenyl, heteroaryl, C 3 -C 10 -cycloalkyl-C 1 C 4 -alkyl, phenyl-C 1 -C 4 - alkyl and heteroaryl-C 1 C 4 alkyl, wherein C 3 -C 10 -cycloalkyl, heteroaryl and phenyl in the last six mentioned radicals may be unsubstituted or carry 1 , 2, 3, 4 or 5 substituents R b as defined above; R 2 is selected from the group consisiting of C 1- C 1 0-alkyl, c 1- c 4 -alkoxy- C 1- C 4 -alkyl, C 1- C 10 -haloalkyl, C 2 -C 10 -alkenyl, C 2 -C 10 -haloalkenyl, C 2 -C 10 -alkynyl, C 2 -C 10 - haloalkynyl,c 3 -C 10 -cycloalkyl, phenyl, heteroaryl, C 3 -C 10 -cycloalkyl-C 1- C 4 -alkyl, phenyl-C 1 -C 4 -alkyl and heteroaryI-C 1- C 4 -alkyl, wherein C 3 -C 10 -cycloalkyl, heteroaryl and phenyl in the last six mentioned radicals may be unsubstituted or carry 1 , 2, 3, 4 or 5 substituents R b as defined above.
    • 本发明涉及可用于对抗动物害虫,特别是昆虫,蜘蛛和线虫的新的氨基腙化合物。 本发明还涉及一种防治昆虫,线虫和蜘蛛的方法。 氨基腙化合物具有通式(I),其包括I的互变异构体及其盐; 其中X和Y是氢或一起形成化学键; Ar是选自苯基和具有1,2,3或4个杂原子作为环成员的5-或6-元杂芳基的芳族基团,其彼此独立地选自O,N和S,并且其中芳族 基团可以具有1,2,3,4或5个取代基R a, R 1选自C 1 -C 10 - 烷基,C 1 -C 1 - 烷基, C 1 -C 4烷基,C 1 -C 4烷基,C 1 -C 4烷基,氰基-C 1 -C 4烷基, C 1 -C 6烷基,羟基-C 1 -C 4 - 亚烷基,C 1 -C 10 - 烷基, 卤代烷基,三 - (C 1 -C 4 - 烷基) - 甲硅烷基-C 1 -C 4 - 烷基,C 2 -C 10 - 烯基,C 2 -C 10 - 卤代烯基,C 1 -C 10 - C 2 -C 10 - 炔基,C 2 -C 10 - 卤代炔基,C 3 - C 10 - 环烷基,苯基,杂芳基,C 3 -C 10 - 环烷基-C 1 -C C 1-4烷基,苯基-C 1 -C 4 - 烷基和杂芳基-C 1 -C 4烷基, 其中C 3 -C 10 - 环烷基,杂芳基和苯基在后面六个提及的基团中可以是未取代的或携带1,2,3,4或4个 5个取代基R b如上所定义; R 2选自C 1 -C 1-4烷基,C 1 -C 4烷基, C 1-4烷基,C 1 -C 10烷基,C 1 -C 4烷基,C 1〜 亚烷基,C 2 -C 10 - 烯基,C 2 -C 10 - 卤代烯基,C C 2 -C 10 - 炔基,C 2 -C 10 - 卤代炔基,C 3 - C 1 -C 10 - 环烷基,苯基,杂芳基,C 3 -C 10 - 环烷基-C 1 - C 1 -C 4 - 烷基,苯基-C 1 -C 4 - 烷基和杂芳基C 1 -C 其中C 3 -C 10 - 环烷基,最后六个所述基团中的杂芳基和苯基可以是未取代的或携带1, 2,3,4或5个如上定义的取代基R b。
    • 19. 发明申请
    • DICYANO ALKANOIC ACID AMIDES FOR COMBATING ANIMAL PESTS
    • DICYANO ALKANOIC ACIDES用于组合动物乳制品
    • WO2007014899A1
    • 2007-02-08
    • PCT/EP2006/064728
    • 2006-07-27
    • BASF AKTIENGESELLSCHAFTHOFMANN, MichaelBASTIAANS, Henricus, Maria, MartinusLANGEWALD, JürgenOLOUMI-SADEGHI, HassanCULBERTSON, Deborah, L.
    • HOFMANN, MichaelBASTIAANS, Henricus, Maria, MartinusLANGEWALD, JürgenOLOUMI-SADEGHI, HassanCULBERTSON, Deborah, L.
    • A01N37/34C07C255/19C07C253/30
    • A01N37/34C07C255/19C07C255/20C07C255/21C07C317/44
    • Dicyano alkanoic acid amides of formula (I), wherein R 1 is H, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, or haloalkynyl; R 2 is H, CN, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, alkoxy, or haloalkoxy; R 3 and R 4 are H, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl, halocycloalkyl, cycloalkenyl, halocycloalkenyl, or R 3 and R 4 together can be alkylene, haloalkylene, alkenylene or haloalkenylene; X is O or S; R 5 and R 6 are H, alkyl, optionally substituted with 1 to 3 groups CN, NO 2 , OH, NR 7 R 8 , alkoxy, haloalkoxy, alkylthio, haloalkylthio, cycloalkyl, halocycloalkyl and optionally substituted phenyl; or haloalkyl, cycloalkyl, halocycloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, NR 7 R 8 , alkoxycarbonyl, haloalkoxycarbonyl, alkenyloxycarbonyl, haloalkenyloxycarbonyl, alkylcarbonyl, haloalkylcarbonyl, R 7 R 8 N-C(=O)-, phenylcarbonyl, benzylcarbonyl or phenyl wherein phenylcarbonyl, benzylcarbonyl and phenyl are optionally substituted; or R 5 and R 6 are a saturated, partially unsaturated or unsaturated 5- to 6-membered heterocyclic radical which may contain 1 to 4 heteroatoms selected from oxygen, nitrogen and sulfur and which radical may be bonded via a carbonyl (C(=O)) linkage, and which radical is optionally substituted; R 7 , R 8 are H, alkyl, haloalkyl, alkylcarbonyl, haloalkylcarbonyl, benzyl, phenyl, phenylcarbonyl, alkylsulfonyl, or haloalkylsulfonyl; or the enantiomers or diastereomers or salts thereof, processes for the preparation of compounds of formula (I), use of compounds of formula (I) for combating insects, acarids, or nematodes, and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites using compounds of formula (I).
    • 式(I)的二氰基链烷酸酰胺,其中R 1是H,烷基,卤代烷基,烯基,卤代烯基,炔基或卤代炔基; R 2是H,CN,烷基,卤代烷基,烯基,卤代烯基,炔基,卤代炔基,环烷基,卤代环烷基,烷氧基或卤代烷氧基。 R 3和R 4是H,烷基,卤代烷基,烯基,卤代烯基,炔基,卤代炔基,环烷基,卤代环烷基,环烯基,卤代环烯基或R 3, SO 2和R 4一起可以是亚烷基,卤代亚烷基,亚烯基或卤代亚烯基; X是O或S; R 5和R 6是H,烷基,任选被1至3个基团CN,NO 2,OH,NR 7取代 烷氧基,卤代烷氧基,烷硫基,卤代烷硫基,环烷基,卤代环烷基和任意取代的苯基; 或卤代烷基,环烷基,卤代环烷基,烯基,卤代烯基,炔基,卤代炔基,烷基亚磺酰基,卤代烷基亚磺酰基,烷基磺酰基,卤代烷基磺酰基,NR 8 R 8,烷氧基羰基,卤代烷氧基羰基,烯氧基羰基,卤代链烯氧基羰基, 烷基羰基,卤代烷基羰基,R 7 R 8 NC(= O) - ,苯基羰基,苄基羰基或苯基,其中苯基羰基,苄基羰基和苯基任选被取代; 或R 5和R 6是饱和的,部分不饱和的或不饱和的5至6元杂环基,其可以含有1至4个选自氧,氮和硫的杂原子 并且该基团可以通过羰基(C(= O))键键合,并且该基团任选被取代; R 7,R 8是H,烷基,卤代烷基,烷基羰基,卤代烷基羰基,苄基,苯基,苯基羰基,烷基磺酰基或卤代烷基磺酰基; 或其对映体或非对映异构体或其盐,式(I)化合物的制备方法,式(I)化合物用于防治昆虫,螨虫或线虫的用途,以及用于治疗,控制,预防或保护动物的方法 使用式(I)化合物对寄生虫的感染或感染。