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    • 1. 发明申请
    • SUBSTITUTED AZOLIN-2-YL-AMINO COMPOUNDS
    • 取代的AZOLIN-2-YL-AMINO化合物
    • WO2008017649A1
    • 2008-02-14
    • PCT/EP2007/058109
    • 2007-08-06
    • BASF AKTIENGESELLSCHAFTKORADIN, ChristopherKORDES, MarkusLE VEZOUET, RonanCULBERTSON, Deborah L.ANSPAUGH, Douglas D.
    • KORADIN, ChristopherKORDES, MarkusLE VEZOUET, RonanCULBERTSON, Deborah L.ANSPAUGH, Douglas D.
    • C07D277/18C07D417/12A01N43/00
    • C07D417/12A01N43/50A01N43/76A01N43/78C07D277/18
    • The present invention relates to azolin-2-yl-amino compounds of formulae (I. a) and (l.b) and their salts which are useful for combating animal pest, in particular arthropod and nematodes. The present invention also relates to a method for combating such pests and for protecting crops against infestation or infection by such pests. Furthermore, the present invention relates to veterinary compositions for combating animal pests. Formula (I.a), formula (I.b) wherein n is 0 to 4; X is S, O or NR 5 ; A is -C(R 6a )(R 6b )-, O, NR 7 , S, S(O) or S(O) 2 ; B is a bond Or CH 2 ; R 1 is H, CN, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylcarbonyl, C 3 -C 6 -cycloalkyl, phenyl, benzyl, etc.; R 2a , R 2b are H, CN, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, (C 1 -C 6 -alkyl)thiocarbonyl, C(O)NR a R b , C(S)NR a R b , (SO 2 )NR a R b , phenyl, benzyl, 5 or 6 membered heterocyclic ring etc.; or R 1 together with R 2a is C 3 -C 5 -alkandiyl; or R 1 together with R 2b are C(O); R 3a , R 3b , R 3c , R 3d are H, halogen, CN, C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino, C 3 -C 6 -cycloalkyl, phenyl, benzyl, etc.; R 4a , R 4b are H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, phenyl, benzyl, 5 or 6 membered hetaryl; or R 4a together with R 4b may also be =0, =NR C or =CR d R e ; or R 2a together with R 4a may form a bridging bivalent radical.
    • 本发明涉及用于对抗动物害虫,特别是节肢动物和线虫的式(Ⅰa)和(Ⅰ.B)的吡咯烷-2-基氨基化合物及其盐。 本发明还涉及一种防治这种害虫并防止作物抵抗这种害虫侵染或感染的方法。 此外,本发明涉及用于对抗动物害虫的兽用组合物。 式(Ⅰa),式(Ⅰb)其中n为0-4; X是S,O或NR 5; A是-C(R 6a)(R 6b) - ,O,NR 7,S,S(O)或S(O ) 2 ; B是键或CH 2 2; R 1是H,CN,C 1 -C 6 - 烷基,C 2 -C 3 - C 1 -C 6 - 亚烷基,C 1 -C 6 - 烷基羰基,C 3 -C 6 - 环烷基,苯基,苄基等; R 2a,R 2b是H,CN,C 1 -C 6 - 烷基,C 1 -C 6烷基, C 1 -C 6亚烷基,C 1 -C 6 - 烷基羰基,C 1 -C 6 - 烷基羰基,C 1 -C 6 - C 6 -C 6 - 烷氧基羰基,(C 1 -C 6 - 烷基)硫代羰基,C(O)NR a C C(S)NR a R b,(SO 2)NR a, 苯基,苄基,5或6元杂环等; 或R 1与R 2a一起为C 3 -C 5 - 亚烷基; 或R 1和R 2b一起是C(O); R 3a,R 3b,R 3c,R 3d是H,卤素,CN,C C 1 -C 6 - 烷基,C 1 -C 6 - 烷基氨基,C 3 - C 6 -C 6 - 环烷基,苯基,苄基等; R 4a,R 4b是H,卤素,C 1 -C 6 - 烷基,C 1 -C 4烷基, C 2 -C 6 - 烯基,苯基,苄基,5或6元杂芳基; 或R 4a与R 4b一起也可以是= 0,= NR C或= CR D, SUP>电子; 或R 2a与R 4a一起可以形成桥连二价基团。
    • 2. 发明申请
    • 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS
    • 1-(AZOLIN-2-YL)氨基-1,2-二苯醚化合物,用于组合动物饲料
    • WO2009004032A1
    • 2009-01-08
    • PCT/EP2008/058517
    • 2008-07-02
    • BASF SEKORDES, MarkusKORADIN, ChristopherLE VEZOUET, RonanBAUMANN, ErnstCULBERTSON, Deborah L.ANSPAUGH, Douglas D.OLOUMI-SADEGHI, HassanEBUENGA, Cecile
    • KORDES, MarkusKORADIN, ChristopherLE VEZOUET, RonanBAUMANN, ErnstCULBERTSON, Deborah L.ANSPAUGH, Douglas D.OLOUMI-SADEGHI, HassanEBUENGA, Cecile
    • C07D233/48C07D263/28C07D277/18C07D417/12C07D417/06A01N43/50A01N43/76A01N43/78
    • C07D263/28A01N43/50A01N43/76A01N43/78A01N47/12A01N47/16C07D233/48C07D277/18C07D417/06C07D417/12
    • The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and to their salts which are useful for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds, wherein A is a radical of formulae A.1 or A.2 wherein # denotes the bond to the remaining compound of formula I, X is selected from O, S and NR x , R 1 is selected from the group consisting of -OR A , -NR B1 R B2 , -C(=O)-R C , -C(=O)-OR D , -C(=O)-SR E , -C(=O)-NR B1 R B2' , -C(=S)-R C' , -C(=S)-OR D' , -C(=S)-SR E' , -C(=S)-NR B1 R B2 , -C(=NR 1a )-R C' , -C(=NR 1b )-OR D' , -C(=NR 1c )-SR E' , -C(=NR 1d )-NR B1 R B2 , -S(=O)-R F , -S(=O) 2 -R G , -S(=O) 2 -NR B1 R B2' , -P(=O)R H1 R H2 , -P(=S)R H1 R H2 , -B-C(=O)-R I , -B-O-C(=O)-R I , -B-S-C(=O)-R I , -B-N(R J )-C(=O)-R K , -B-C(=S)-R K , -B-O-C(=S)-R K , -B-S-C(=S)-R K , -B-N(R J )-C(=S)-R K , C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 3 -C 8 -cycloalkyl, which is unsubstituted or may carry 1 to 4 substituents R 1e , naphthyl, which is unsubstituted or may carry 1 to 4 substituents R 1f , a saturated or partially unsaturated heterocycle, which is unsubstituted or may carry 1 to 4 substituents R 1g , hetaryl, which is unsubstituted or may carry 1 to 4 substituents R 1h , and C 1 -C 6 -alkyl, which carries a radical selected from the group consisting of -NR 1i R 1j , C 1 -C 4 -alkoxycarbonyl, C 3 -C 8 -cycloalkyl, aryl, aryloxy, arylthio, heterocyclyl, heterocyclyloxy and heterocyclylthio, R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each independently hydrogen, halogen, OH, SH, NH 2 , SO 3 H, COOH, cyano, nitro, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino etc.
    • 本发明涉及式I的1-(吡唑-2-基)氨基-1,2-二苯基乙烷化合物及其盐,其可用于防治动物害虫。 本发明还涉及通过使用这些化合物,种子和包含所述化合物的农业和兽医组合物来控制动物害虫的方法,其中A是式A.1或A.2的基团,其中#表示与 剩余的式I化合物,X选自O,S和NR x,R1选自-ORA,-NRB1RB2,-C(= O)-RC,-C(= O)-OR,-C (= O)-SRE,-C(= O)-NRB1RB2',-C(= S)-RC',-C(= S)-OR',-C(= S)-SRE' =(NR1c)-SR',-C(= NR1d)-NRB1RB2,-S(= O) )-RF,-S(= O)2 -RG,-S(= O)2 -NRB 1 R B 2',-P(= O)RH1RH 2,-P(= S)RH1RH 2,-BC(= O) -BOC(= O)-RI,-BSC(= O)-RI,-BN(RJ)-C(= O)-RK,-BC(= S)-RK,-BOC(= S)-RK, -BSC(= S)-RK,-BN(RJ)-C(= S)-RK,C1-C8-烯基,C1-C8-炔基,C3-C8-环烷基,其未被取代或可携带1至4 取代基R 1e,萘基,其是未取代的或可以携带1至4个取代基R 1f,饱和或部分不饱和的杂环,其为未制备的 或可以携带1至4个未取代的或可以携带1至4个取代基R 1h的取代基R 1g,杂芳基,其中C 1 -C 6 - 烷基带有选自以下的基团:-NR 1 1 R 1,C 1 -C 4 - 烷氧基羰基, C 3 -C 8 - 环烷基,芳基,芳氧基,芳硫基,杂环基,杂环基氧基和杂环硫基,R 2,R 3,R 4,R 5,R 6和R 7各自独立地为氢,卤素,OH,SH,NH 2,SO 3 H,COOH,氰基,硝基, C 1 -C 6 - 烷基,C 1 -C 6 - 烷氧基,C 1 -C 6烷基氨基等
    • 5. 发明申请
    • AZOLIN-2-YLAMINO COMPOUNDS FOR COMBATING ANIMAL PESTS
    • 用于组合动物饲料的AZOLIN-2-YLAMINO化合物
    • WO2009115491A1
    • 2009-09-24
    • PCT/EP2009/053079
    • 2009-03-16
    • BASF SELE VEZOUET, RonanKORDES, MarkusKORADIN, ChristopherBAUMANN, ErnstCULBERTSON, Deborah, L.
    • LE VEZOUET, RonanKORDES, MarkusKORADIN, ChristopherBAUMANN, ErnstCULBERTSON, Deborah, L.
    • C07D233/48C07D263/28C07D277/18C07C275/24C07C335/12A01N43/50A01N43/76A01N43/78A61P33/14A61P33/10
    • C07D263/28C07C275/24C07C335/12C07D233/48C07D277/18
    • The present invention relates to azolin-2-ylamino compounds of formulae (I) and (II), wherein n is 0 to 3; Ar is phenyl; A is a radical of formulae A 1 or A 2 , wherein * indicates the point of attachment; X is S, O or N(R 10 ); R 7a-d are H, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino or C 3 -C 6 -cycloalkyl; R 8-10 are H, CN, NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, Ar 3 , -B-C(=O)R a , -B-C(=S)R a , -B-C(=NR f )R a , etc., wherein B is a single bond or C 1 -C 4 -alkanediyl; R 1 is H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, phenyl or benzyl; R 2,3 are H, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, phenyl or benzyl; R 4 is H, halogen, CN, N 3 , NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, a heterocycle, Ar 5 , -C(=O)R a, -C(=S)R a , -C(=NR f )R a , etc.; or R 4 and R 5 together form a carbocycle or heterocycle; R 5,6 are H, halogen, CN, N 3 , NO 2 , C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, heterocycle, Ar 8 , -C(=O)R a , -C(=S)R a , -C(=NR f )R a , etc.; or R 5 and R 6 together form a carbocycle or heterocycle; R a-h are H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, heterocycles or Ar 10 ; Ar 1 to 11 are phenyl, naphthyl or heteroaryl; and A' is a radical of formula A 3 , wherein W is halogen or OR 11 ; R 11 is H or -C(=O)-R i ; R i is H, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C3-C8-cycloalkyl, heterocycle or Ar 12 ; and Ar 12 is phenyl, naphthyl or heteroaryl; as well as to agricultural composition containing such compounds, the use of such compounds for controlling animal pests, seed, comprising such compounds, a method for controlling animal pests and a method for treating or protecting an animal from infestation or infection by parasites.
    • 本发明涉及式(I)和(II)的唑啉-2-基氨基化合物,其中n为0至3; Ar是苯基; A是式A1或A2的基团,其中*表示连接点; X是S,O或N(R10); R7a-d为H,卤素,C1-C6-烷基,C1-C6-烷氧基,C1-C6-烷基氨基或C3-C6-环烷基; R8-10是H,CN,NO2,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C8-环烷基,Ar3,-BC(= O)Ra,-BC(= S) Ra,-BC(= NRf)Ra等,其中B为单键或C1-C4-烷二基; R1是H,卤素,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C6-环烷基,苯基或苄基; R2,3是H,卤素,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C6-环烷基,苯基或苄基; R4是H,卤素,CN,N3,NO2,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C8-环烷基,杂环,Ar5,-C(= O) C(= S)Ra,-C(= NRf)Ra等; 或R4和R5一起形成碳环或杂环; R5,6是H,卤素,CN,N3,NO2,C1-C6-烷基,C2-C6-烯基,C2-C6-炔基,C3-C8-环烷基,杂环,Ar8,-C(= O) -C(= S)R a,-C(= NR f)R a等; 或R5和R6一起形成碳环或杂环; R h为H,C 1 -C 6烷基,C 2 -C 6 - 烯基,C 2 -C 6炔基,C 3 -C 8 - 环烷基,杂环或Ar 10; Ar 1至11是苯基,萘基或杂芳基; 并且A'是式A3的基团,其中W是卤素或OR 11; R 11为H或-C(= O)-R i; R 1是H,C 1 -C 6烷基,C 2 -C 6 - 烯基,C 2 -C 6炔基,C 3 -C 8环烷基,杂环或Ar 12; 和Ar 12是苯基,萘基或杂芳基; 以及含有这种化合物的农业组合物,这些化合物用于控制动物害虫,种子,包含这些化合物的用途,控制动物害虫的方法以及用于治疗或保护动物不受寄生虫感染或感染的方法。
    • 8. 发明申请
    • PYRAZOLE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
    • 用于控制无节幼虫的吡唑类化合物
    • WO2010034738A2
    • 2010-04-01
    • PCT/EP2009/062318
    • 2009-09-23
    • BASF SEGROß, SteffenKÖRBER, KarstenVON DEYN, WolfgangKAISER, FlorianLE VEZOUET, RonanSÖRGEL, SebastianPOHLMAN, MatthiasDESHMUKH, PrashantDICKHAUT, JoachimANSPAUGH, Douglas D.CULBERTSON, Deborah L.OLOUMI-SADEGHI, Hassan
    • GROß, SteffenKÖRBER, KarstenVON DEYN, WolfgangKAISER, FlorianLE VEZOUET, RonanSÖRGEL, SebastianPOHLMAN, MatthiasDESHMUKH, PrashantDICKHAUT, JoachimANSPAUGH, Douglas D.CULBERTSON, Deborah L.OLOUMI-SADEGHI, Hassan
    • A01N43/90A01P5/00A01P7/02A01P7/04
    • A01N43/90C07D471/04C07D487/04C07D498/04
    • The present invention relates to a method for controlling invertebrate pests which method comprises treating the pests, their food supply, their habitat or their breeding ground or a plant, seed, soil, area, material or environment in which the pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from pest attack or infestation with a pesticidally effective amount of a pyrazole compound of formulae I or II or a salt or an N-oxide thereof, wherein A is a pyrazole radical of the formulae A1 or A2, wherein # denotes the binding; D is a 5- or 6-membered heterocyclic radical fused to the pyrazole moiety; R p1 , R p2 and R px are H, halogen, CN, NO 2 , C 1 -C 10 -alkyl, C 2 -C 10 - alkenyl, C 2 -C 10 -alkynyl, etc.; n is 0 to 4; or two radicals R px bound to the same ring- member may form an oxo substituent, or two radicals R px bound to adjacent ring- members may form a 3- to 7-membered fused cyclic radical; B is N or CR 4 , wherein R 4 is H, halogen, CN, NO 2 , C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, etc.; X 1 is S, O or NR 1a , wherein R 1a is H, C 1 -C 10 -alkyl, etc.; X 2 is O 2a , NR 2b R 2c or S(O) m R 2d , wherein m is 0, 1 or 2; R 2a is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, etc.; R 2b , R 2c are H, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, etc.; R 2d is C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 3 -C 6 -cycloalkyl, etc.; R 1 is H, CN, C 1 -C 10 -alkyl, C 1 -C 10 -haloalkyl, C 3 -C 10 -cycloalkyl, etc.; R 2 , R 3 and R 5 are H, halogen, CN, NO 2 , C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy, etc.; to a method for protecting plant propagation material and/or the plants which grow therefrom, to plant propagation material comprising at least one compound of formulae I or II, to a method for treating or protecting an animal from infestation or infection by parasites, to novel pyrazole compounds of formulae I or Il and agricultural composition containing those compounds.
    • 本发明涉及一种防治无脊椎害虫的方法,该方法包括处理害虫,其食物供应,其栖息地或其繁殖地或植物,种子,土壤,区域,材料或环境 使用杀虫有效量的式I或II的吡唑化合物或其盐或N 其中A是式A1或A2的吡唑基,其中#表示结合; D是与吡唑部分稠合的5-或6-元杂环基团; R p1,R p2和R px是H,卤素,CN,NO 2,C 1,C 2, C 1 -C 10 - 烷基,C 2 -C 10 - 烯基,C 2 - C10 - 炔基等; n是0至4; 或者结合到相同环成员的两个基团R px可以形成氧代取代基,或者结合到相邻环成员的两个基团R px可以形成3-7 元素稠合的环状基团; B是N或CR 4,其中R 4是H,卤素,CN,NO 2,C 1, -C 1-4 - 烷基,C 1 -C 4 - 卤代烷基,C 1 -C 4 - 烷基,C 1 -C 4 - - 烷氧基等; X 1是S,O或NR 1a,其中R 1a是H,C 1 -C 4 - > 10 - 烷基等; X 2是O 2 2a,NR 2b R 2c或S(O)m 其中m是0,1或2; R 2是C 1 -C 4 - 烷基,C 1 -C 4 - / - 亚烷基 卤代烷基,C 3 -C 6 - 环烷基等。 R 2b,R 2c是H,C 1 -C 4 - 烷基,C 1 -C 4烷基, C 4 -C 4 - 卤代烷基,C 3 -C 6 - 环烷基等。 R 2d是C 1 -C 4 - 烷基,C 1 -C 4 - / - 亚烷基 卤代烷基,C 3 -C 6 - 环烷基等。 R 1是H,CN,C 1 -C 10 - 烷基,C 1 -C 4 - 烷基, 10-卤代烷基,C 3 -C 10 - 环烷基等。 R 2,R 3和R 5为H,卤素,CN,NO 2,C 2,C 3 H 5, C 1 -C 4 - 烷基,C 1 -C 4 - 卤代烷基,C 1 -C 4 - 烷基,C 1 -C 4 - C 4 -C 4 - 烷氧基等; 涉及保护植物繁殖材料和/或其生长的植物的方法,包含至少一种式I或II化合物的植物繁殖材料,治疗或保护动物免受寄生虫侵染或感染的方法,新颖的 式I或II的吡唑化合物和含有这些化合物的农业组合物。