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131. 发明授权

US5447933A Xanthine derivatives 失效
标题翻译：黄嘌呤衍生物
公开(公告)号：US5447933A
公开(公告)日：1995-09-05
申请号：US973959
申请日：1992-11-09
申请人： Fumio Suzuki , Junichi Shimada , Hiromasa Kato , Akio Ishii , Shizuo Shiozaki
发明人： Fumio Suzuki , Junichi Shimada , Hiromasa Kato , Akio Ishii , Shizuo Shiozaki
IPC分类号： C07D473/06 , A61K31/52
CPC分类号： C07D473/06
摘要： A novel xanthine derivative of the formula (I): ##STR1## wherein one of R.sup.1 and R.sup.2 represents substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, substituted or unsubstituted alicyclic alkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted benzyl; and the other represents--(CH.sub.2).sub.m --Xwherein m is 2 or 3, and X is amino substituted phenyl.Q represents ##STR2## (wherein R.sup.3 and R.sup.4 are the same or different and are substituted or unsubstituted alicyclic alkyl), ##STR3## or a pharmacologically accetable salt thereof is disclosed. This derivative has anti-dementia activity.
摘要翻译：式（I）的新颖的黄嘌呤衍生物：取代或未取代的低级烷基，低级烯基，低级炔基，取代或未取代的脂环族烷基，取代或未取代的苯基或取代或未取代的苄基; 另一个表示 - （CH 2）m -X，其中m为2或3，X为氨基取代的苯基。 Q代表不同的并且是取代或未取代的脂环族烷基），IMA或其药理学上可接受的盐。该衍生物具有抗痴呆活性。

132. 发明授权

US5400547A Polishing machine and method of dissipating heat therefrom 失效
标题翻译：抛光机及其散热方法
公开(公告)号：US5400547A
公开(公告)日：1995-03-28
申请号：US22478
申请日：1993-02-25
申请人： Kohichi Tanaka , Hiromasa Hashimoto , Fumio Suzuki
发明人： Kohichi Tanaka , Hiromasa Hashimoto , Fumio Suzuki
IPC分类号： B24B37/015 , B24B37/04 , B24B37/12 , B24B37/16 , B24B49/14 , B24B55/02 , B24B7/22
CPC分类号： B24B37/16 , B24B37/015 , B24B37/12 , B24B55/02
摘要： A polishing machine for polishing a flat workpiece such as a semiconductor wafer has a rotatable reference table supporting an abrasive cloth disposed on a surface thereof, and a rotatable workpiece holder for holding a flat workpiece against the abrasive cloth. While the flat workpiece is being polished by the abrasive cloth, an abrasive compound is supplied between the abrasive cloth and the flat workpiece. The reference table has grooves defined therein for dissipating heat from the reference table and the abrasive cloth while the flat workpiece is being polished by the abrasive cloth. The grooves may be supplied with either the abrasive compound or a coolant.
摘要翻译：用于抛光诸如半导体晶片的平坦工件的抛光机具有支撑布置在其表面上的研磨布的可旋转参考台和用于将平坦工件保持在研磨布上的可旋转工件保持器。当平面工件被研磨布抛光时，研磨剂在磨料与平面工件之间供应。参考台具有限定在其中的凹槽，用于在通过研磨布抛光平坦工件时从参考台和研磨布散发热量。凹槽可以被供给研磨剂或冷却剂。

133. 发明授权

US5395836A 8-tricycloalkyl xanthine derivatives 失效
标题翻译： 8-三环烷基黄嘌呤衍生物
公开(公告)号：US5395836A
公开(公告)日：1995-03-07
申请号：US222938
申请日：1994-04-05
申请人： Junichi Shimada , Takashi Kuwabara , Tohru Yasuzawa , Hiroshi Magara , Hiromi Nonaka , Hideaki Kusaka , Fumio Suzuki
发明人： Junichi Shimada , Takashi Kuwabara , Tohru Yasuzawa , Hiroshi Magara , Hiromi Nonaka , Hideaki Kusaka , Fumio Suzuki
IPC分类号： C07D473/04 , A61K31/52 , C07D473/06
CPC分类号： C07D473/04 , Y10S514/869
摘要： There is provided a novel xanthine Compound(I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is ##STR2## wherein R.sup.3 and R.sup.4 are the same or different and each represent hydrogen or hydroxy, n is 0 or 1; provided that when both of R.sup.3 and R.sup.4 are hydrogen, at least one of R.sup.1 and R.sup.2 is hydroxy-substituted or oxo-substituted lower alkyl; or a pharmaceutically acceptable salt thereof.The xanthine compound has adenosine A.sub.1 receptor antagonizing activity, and thus shows diuretic effect, renal-protecting effect, bronchodilatory effect, cerebral function improving effect and anti-dementia effect.
摘要翻译：提供了一种新颖的黄嘌呤化合物（I）其中R 1和R 2相同或不同，各自表示羟基取代的，取代或未取代的低级烷基，Y是单键或亚烷基，Q 其中R 3和R 4相同或不同，各自表示氢或羟基，n为0或1; 条件是当R 3和R 4都是氢时，R 1和R 2中的至少一个是羟基取代的或氧代取代的低级烷基; 或其药学上可接受的盐。黄嘌呤化合物具有腺苷A1受体拮抗活性，因此具有利尿作用，肾保护作用，支气管扩张作用，脑功能改善作用和抗痴呆作用。

134. 发明授权

US5391760A Process for producing n-alkylpyrazoles 失效
标题翻译：生产正烷基吡唑的方法
公开(公告)号：US5391760A
公开(公告)日：1995-02-21
申请号：US120330
申请日：1993-09-14
申请人： Hiroshi Murakami , Susumu Yamamoto , Yoshihiro Iwasawa , Fumio Suzuki , Isao Hashiba
发明人： Hiroshi Murakami , Susumu Yamamoto , Yoshihiro Iwasawa , Fumio Suzuki , Isao Hashiba
IPC分类号： C07D521/00 , C07D231/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Disclosed herein is a process for producing N-alkylpyrazoles represented by the formula (1), which comprises reacting an alkali metal or an alkali metal-containing base with N- unsubstituted pyrazoles represented by the formula (2), to form an alkali metal salt thereof and, subsequently, reacting the obtained alkali metal salt with an alkylating agent. ##STR1##
摘要翻译：本文公开了一种制备由式（1）表示的N-烷基吡唑的方法，其包括使碱金属或含碱金属的碱与由式（2）表示的N-未取代的吡唑反应形成碱金属盐然后使得到的碱金属盐与烷基化剂反应。 R1：H，C1-C4烷基R2：C1-C4烷基n：1-3的整数

135. 发明授权

US5371225A Tetracyclic compounds 失效
标题翻译：四环化合物
公开(公告)号：US5371225A
公开(公告)日：1994-12-06
申请号：US170192
申请日：1993-12-22
申请人： Fumio Suzuki , Yoshisuke Nakasato , Hiroshi Tsumuki , Kenji Ohmori , Hiroshi Nakajima , Tadafumi Tamura , Soichiro Sato
发明人： Fumio Suzuki , Yoshisuke Nakasato , Hiroshi Tsumuki , Kenji Ohmori , Hiroshi Nakajima , Tadafumi Tamura , Soichiro Sato
IPC分类号： A61K31/00 , A61K31/47 , A61K31/55 , C07D221/18 , A61K31/44
CPC分类号： C07D221/18
摘要： The present invention relates to novel tetracyclic compounds represented by formula (I) ##STR1## (wherein each of X.sup.1 and X.sup.2 independently represents hydrogen or lower alkyl; n represents an integer of 1 to 4), or a pharmaceutically acceptable salt thereof, which are useful as immunosuppressive agents.
摘要翻译： PCT No.PCT / JP93 / 00527 Sec。 371日期：1993年12月22日 102（e）日期1993年12月22日PCT 1993年4月23日PCT公布。公开号WO93 / 22286 日本公开专利文献1：日本专利公开1 9 9 3年11月11日本发明涉及式（I）表示的新型四环化合物（Ⅰ）（其中X1和X2各自独立地表示氢或低级烷基; n表示1〜4的整数），或其药学上可接受的盐，其可用作免疫抑制剂。

136. 发明授权

US5290782A Xanthine derivatives 失效
标题翻译：黄嘌呤衍生物
公开(公告)号：US5290782A
公开(公告)日：1994-03-01
申请号：US839690
申请日：1992-02-24
申请人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka
发明人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka
IPC分类号： C07D473/06 , C07D473/08 , C07D473/20 , C07D473/22 , C07D473/02 , A61K31/52
CPC分类号： C07D473/06 , C07D473/08 , C07D473/20 , C07D473/22
摘要： Novel xanthine compounds represented by the following formula: ##STR1## wherein each of X.sup.1 and X.sup.2 independently represents oxygen or sulfur; and Q represents; ##STR2## where ----- represents a single bond or a double bond; Y represents a single bond or alkylene, n represents 0 or 1, each of W.sup.1 and W.sup.2 independently represents hydrogen, lower alkyl or amino, Z represents --CH.sub.2 -, --O--, --S-- or --NH--; represents ##STR3## each of R.sup.1 and R.sup.2 independently represents hydrogen, lower alkyl, allyl or propargyl; and R.sup.3 represents hydrogen or lower alkyl, and when Q represents the groups other than ##STR4## each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen or lower alkyl;provided that when Q is ##STR5## then R.sup.1 R.sup.2 and R.sup.3 are notsimultaneously methyl; and pharmaceutically acceptable salts thereof have a diuretic effect, a renal-protecting effect and a bronchodilatory effect.
摘要翻译：由下式表示的新型黄嘌呤化合物：其中X1和X2各自独立地表示氧或硫; 和Q表示; 其中-----表示单键或双键; Y表示单键或亚烷基，n表示0或1，W1和W2各自独立地表示氢，低级烷基或氨基，Z表示-CH2 - ， - O - ， - S-或-NH-。 R1和R2各自表示氢，低级烷基，烯丙基或炔丙基; 且R 3表示氢或低级烷基，并且当Q表示除R1之外的基团时，R 1，R 2和R 3各自独立地表示氢或低级烷基; 条件是当Q为时，则R1 + L，R2和R3不同时为甲基; 及其药学上可接受的盐具有利尿作用，肾脏保护作用和支气管扩张作用。

137. 发明授权

US5270316A Condensed purine derivatives 失效
标题翻译：凝血嘌呤衍生物
公开(公告)号：US5270316A
公开(公告)日：1993-12-14
申请号：US599758
申请日：1990-10-19
申请人： Fumio Suzuki , Junichi Shimada , Takeshi Kuroda , Kazuhiro Kubo , Akira Karasawa , Tetsuji Ohno , Kenji Ohmori
发明人： Fumio Suzuki , Junichi Shimada , Takeshi Kuroda , Kazuhiro Kubo , Akira Karasawa , Tetsuji Ohno , Kenji Ohmori
IPC分类号： A61K31/00 , A61K31/495 , A61K31/505 , A61K31/519 , A61K31/529 , A61P7/00 , A61P7/10 , A61P9/00 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/00 , A61P13/02 , A61P13/12 , A61P15/00 , C07D471/14 , C07D487/14 , A61K31/52
CPC分类号： C07D471/14 , C07D487/14
摘要： There are disclosed condensed purine derivatives represented by formula; ##STR1## in which R.sup.3 represents hydrogen, lower alkyl or benzyl; each of X.sup.1 and X.sup.2 independently represents hydrogen, lower alkyl, aralkyl or phenyl; and n is an integer of 0 or 1; R.sup.1 represents hydrogen, lower alkyl, alicyclic alkyl, noradamantan-3-yl, dicyclopropylmethyl or styryl; and R.sup.2 represents hydrogen, lower alkyl or alicyclic alkyl; or a pharmaceutically acceptable salt thereof. The derivatives and pharmaceutically acceptable salts are useful as diuretics, renal protecting agents, antiallergic agents and hypotensives.

138. 发明授权

US5248684A Certain 2-oxo-quinoline carboxylates or corresponding carboxamides useful as anti-emetics and suppressants of migraine 失效
标题翻译：某些2-氧杂喹啉羧酸酯或相应的碳酰胺作为抗微生物剂和抑制剂有用
公开(公告)号：US5248684A
公开(公告)日：1993-09-28
申请号：US703849
申请日：1991-05-21
申请人： Fumio Suzuki , Hiroaki Hayashi , Yoshikazu Miwa , Akio Ishii , Shunji Ichikawa , Ichiro Miki
发明人： Fumio Suzuki , Hiroaki Hayashi , Yoshikazu Miwa , Akio Ishii , Shunji Ichikawa , Ichiro Miki
IPC分类号： A61K31/435 , A61K31/4375 , A61K31/46 , A61K31/47 , A61K31/4704 , A61P1/08 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P43/00 , C07D451/04 , C07D451/12 , C07D451/14 , C07D519/00
CPC分类号： C07D451/04 , C07D451/12 , C07D451/14
摘要： There is disclosed a heterocyclic compound represented by general formula: ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl or aryl; R.sup.2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents --O-- or --NH--; R.sup.3 represents hydrogen, hydroxyl or lower alkyl; R.sup.4 represents lower alkyl; represents 0 or 1, or a pharmaceutically acceptable salt thereof.

139. 发明授权

US5066087A Optical fiber coupler 失效
标题翻译：光纤耦合器
公开(公告)号：US5066087A
公开(公告)日：1991-11-19
申请号：US490026
申请日：1990-03-07
申请人： Ryozo Yamauchi , Noboru Kawakami , Fumio Suzuki
发明人： Ryozo Yamauchi , Noboru Kawakami , Fumio Suzuki
IPC分类号： G02B6/28 , G02B6/34
CPC分类号： G02B6/29332 , G02B6/2835
摘要： The optical fiber coupler of the present invention is characterized in that, for a defined section in which two or more component optical fibers are thermally fused and elongated thereby forming a fused-elongated region which constitutes the optical fiber coupler, that at least one of the component optical fibers is formed from a single mode optical fiber material employed within a parameter range in which the mode field diameter increases monotonically with decrease in the diameter of the optical fiber core. The optical fiber coupler is further characterized in that, when using optical fibers from which a portion of the coating material has been removed thereby exposing the cladding, and by aligning two or more of such component optical fibers side by side in a plane and mutually thermally fusing the exposed cladding of adjacent optical fibers, after which the fused region is drawn out, thereby forming a fused-elongated region which constitutes the optical fiber coupler, for such an optical fiber coupler, optical fiber material is used in which the softening temperature of the core is higher than that of the cladding, and further, for the drawing out of the mutually fused sections, the tension employed is such that by virtue of remaining stress, the refractive index of the core is reduced.
摘要翻译：本发明的光纤耦合器的特征在于，对于其中两个或更多个组件光纤被热熔合和拉长的限定部分，由此形成构成光纤耦合器的熔融拉长区域，至少一个分量光纤由单模光纤材料形成，该单模光纤材料在模场直径随着光纤芯直径的减小而单调增加的参数范围内使用。光纤耦合器的特征还在于，当使用从其中去除了一部分涂层材料的光纤而使包层暴露的光纤，并且通过将两个或更多个这种组件光纤并排在一个平面中并相互热熔化相邻光纤的暴露的包层，之后将熔融区域拉出，从而形成构成光纤耦合器的熔融 - 伸长区域，对于这种光纤耦合器，使用光纤材料，其中软化温度该芯高于包层的芯，此外，为了从相互熔合的部分拉出，所使用的张力使得由于剩余应力，芯的折射率降低。

140. 发明授权

US5029961A Optical fiber coupler and process for manufacturing same 失效
标题翻译：光纤耦合器及其制造工艺
公开(公告)号：US5029961A
公开(公告)日：1991-07-09
申请号：US431676
申请日：1989-11-02
申请人： Fumio Suzuki , Tohru Arikawa , Noboru Kawakami , Yoshio Kikuchi , Kuniharu Himeno , Osamu Fukuda
发明人： Fumio Suzuki , Tohru Arikawa , Noboru Kawakami , Yoshio Kikuchi , Kuniharu Himeno , Osamu Fukuda
IPC分类号： G02B6/28
CPC分类号： G02B6/283 , G02B6/2826 , G02B6/2843
摘要： An optical fiber coupler is disclosed, which comprises two polished substrates each of which comprises a grooved substrate having a polished surface on the open side end thereof and adapted to hold therein an optical fiber and an optical fiber comprising a core, a cladding and two stress-applying parts arranged in the cladding so as to sandwich the core, a part of the optical fiber being polished off such that the polished surface of the fiber is close to the core so as to allow leakage of light power propagating in the core to the outside, the polished optical fiber being embedded in the grooved substrate and fixed thereto in such a manner that the polished surface of the grooved substrate is in flush with the polished surface of the polished optical fiber, with the two polished substrates being in close contact with each other at the polished surfaces thereof to allow coupling of light power, wherein said polished optical fiber is of a construction such that the polished surface thereof is perpendicular to the polarization principal axis X defined as the direction connecting the centers of said stress-applying parts. Also, a process for manufacturing the optical fiber coupler is disclosed.
摘要翻译：公开了一种光纤耦合器，其包括两个抛光衬底，每个衬底包括在其开放侧端具有抛光表面的开槽衬底，并且适于保持光纤和包括芯，包层和两个应力的光纤将布置在包层中的部件布置成夹住芯部，将光纤的一部分抛光，使得光纤的抛光表面靠近芯部，以便允许将在芯部中传播的光功率泄漏到抛光后的光纤被嵌入到带槽的基板中并以固定的方式固定，使得凹槽基板的抛光表面与抛光光纤的抛光表面齐平，两个抛光的基板与彼此在其抛光表面处以允许光功率的耦合，其中所述抛光光纤具有这样的结构， eof垂直于被定义为连接所述应力施加部分的中心的方向的偏振主轴线X. 另外，公开了一种光纤耦合器的制造方法。

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