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131. 发明授权

US06479457B2 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效
标题翻译：聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物
公开(公告)号：US06479457B2
公开(公告)日：2002-11-12
申请号：US09169423
申请日：1998-10-09
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
IPC分类号： A61K3812
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译：包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述聚合物。

132. 发明授权

US06462169B1 Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom 有权
标题翻译：无定形聚合多轴引发剂和顺应性结晶共聚物
公开(公告)号：US06462169B1
公开(公告)日：2002-10-08
申请号：US09698527
申请日：2000-10-27
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： C08G6308
CPC分类号： C08G63/64 , A61L17/12 , A61L31/06 , C08G63/08 , C08L67/04
摘要： An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent.
摘要翻译：包含中心碳原子或氮原子和至少三个轴的可吸收结晶的单中心多轴共聚物，每个轴包括邻近并源自中心原子的无定形柔性组分和从无定形柔性组分向外延伸的刚性可结晶组分。公开了在可能含有生物活性剂的医疗装置中使用这种共聚物。

133. 发明授权

US06395259B1 Phosphonylated derivatives of aliphatic heterochain and acrylate erpolyms and applications thereof 有权
标题翻译：脂肪族杂链和丙烯酸酯的磷酸化衍生物及其应用
公开(公告)号：US06395259B1
公开(公告)日：2002-05-28
申请号：US09464870
申请日：1999-12-16
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61K716
CPC分类号： C08F8/40 , C08G79/02
摘要： A variety of phosphonylated heterochain polymers are disclosed, including, most preferably, phosphonylated polymethyl methacrylate. For each polymeric composition the phosphorous atom of a phosphorous-containing functional group is covalently bonded to a carbon atom of the polymeric chain. The phosphorous atoms are present in an amount of at least about 0.1 percent by weight in each polymeric composition.
摘要翻译：公开了各种膦酰化的杂链聚合物，包括最优选膦酰化的聚甲基丙烯酸甲酯。对于每个聚合物组合物，含磷官能团的磷原子共价键合到聚合物链的碳原子上。在每个聚合物组合物中，磷原子的存在量为至少约0.1重量％。

134. 发明授权

US06342065B1 High strength fibers of L-lactide copolymers &egr;-caprolactone and trimethylene carbonate and absorbable medical constructs thereof 有权
标题翻译： L-丙交酯共聚物ε-己内酯和三亚甲基碳酸酯的高强度纤维及其可吸收的医用结构
公开(公告)号：US06342065B1
公开(公告)日：2002-01-29
申请号：US09523754
申请日：2000-03-13
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61B1704
CPC分类号： C08G63/64 , A61L17/12 , A61L27/18 , A61L31/06 , C08G63/08 , C08L67/04 , C08L69/00
摘要： The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably &egr;-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 25%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.4 dl/g. A variety of surgical constructs may be formed from the present copolymers. Surgical sutures made of mono- or multifilament yarns of the present copolymers will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.
摘要翻译：本发明涉及1-丙交酯和少部分环状单体，优选ε-己内酯或三亚甲基碳酸酯或两者的结晶共聚物。本共聚物的熔融温度至少为150℃，结晶度至少为25％。优选的是具有至少1.4dl / g的特性粘度的高分子量共聚物。各种手术构建体可以由本发明的共聚物形成。由本发明共聚物的单丝或多丝纱线制成的手术缝合线将在不到三年的时间内生物吸收，并且在手术后三周将保持其初始强度的至少50％。

135. 发明授权

US06197320B1 Absorbable E-caprolactone polymers and medical devices 失效
标题翻译：可吸收的ε-己内酯聚合物和医疗器械
公开(公告)号：US06197320B1
公开(公告)日：2001-03-06
申请号：US09103142
申请日：1998-06-29
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A01N2534
CPC分类号： C08G63/912 , A61L17/12 , A61L17/145 , A61L24/046 , A61L27/18 , A61L27/34 , A61L27/50 , A61L29/085 , C08L67/04
摘要： Crystalline, low melting -Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell microporous template or constucts for tissue regeneration; the polymers bearing basic functionalities can be linked ionically or covalently to the ester chain which induces autocatalyzed hydrolysis.
摘要翻译：经历加速水解的结晶，低熔点的己内酯聚合物，以及它们作为润滑剂涂层和/或作为包含生物活性剂的涂层作为活细胞载体的用途，以及作为开放细胞微孔模板或组织用于组织再生的涂层的用途; 具有碱性官能团的聚合物可以与诱导自动催化水解的酯链离子或共价连接。

136. 发明授权

US6162895A Peracylated insulin compositions and process for making the same 有权
标题翻译：过酰基化胰岛素组合物及其制备方法
公开(公告)号：US6162895A
公开(公告)日：2000-12-19
申请号：US392416
申请日：1999-09-09
申请人： Shalaby W. Shalaby , Jacqueline M. Allan , Joel T. Corbett
发明人： Shalaby W. Shalaby , Jacqueline M. Allan , Joel T. Corbett
IPC分类号： C07K1/113 , C07K14/415 , C07K1/00 , A61K35/78
CPC分类号： C07K14/415 , C07K1/113 , Y10T428/29 , Y10T428/2913 , Y10T428/2915
摘要： A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl groups. Most preferably, the cyclic anhydride is succinic anhydride, although glutaric anhydride may also be employed. Preferably, the step of peracylating the protein or polypeptide is performed in the presence of an acid catalyst, most preferably .rho.-toluene sulfonic acid. The resultant modified protein or polypeptide may be employed in numerous applications including drug delivery, absorbable sutures, and thermoplastic films and molded articles.
摘要翻译：公开了一种修饰蛋白质或多肽的方法，其包括以下步骤：将蛋白质或多肽分散在基本上非水性的培养基中，并将所述蛋白质或多肽与具有选自以下的碳链取代基的环酸酐进行过酰化：烷基和烯基。最优选地，环状酸酐是琥珀酸酐，尽管也可以使用戊二酸酐。优选地，在酰基化蛋白质或多肽的步骤在酸催化剂，最优选Rho-甲苯磺酸的存在下进行。所得到的修饰的蛋白质或多肽可用于许多应用，包括药物递送，可吸收缝合线，以及热塑性薄膜和模塑制品。

137. 发明授权

US6069192A Low fiber-loading composites with hybridized fiber/matrix interface 有权
标题翻译：低纤维加载复合材料与杂化纤维/基质界面
公开(公告)号：US6069192A
公开(公告)日：2000-05-30
申请号：US172334
申请日：1998-10-13
申请人： Shalaby W. Shalaby , Jacqueline M. Allan , Meng Deng
发明人： Shalaby W. Shalaby , Jacqueline M. Allan , Meng Deng
IPC分类号： C04B16/06 , C08L23/06 , C08L23/10 , D06M11/55 , D06M13/288 , D06M13/332 , D06M13/368 , D06M15/263 , D06M15/65 , C08K9/00
CPC分类号： C04B16/0625 , D06M11/55 , D06M13/288 , D06M13/332 , D06M13/368 , D06M15/263 , D06M15/65 , C08F110/02 , C08L23/06 , C08L23/10
摘要： Disclosed are fiber-reinforced composites having untraditionally low fiber loading and a novel form of hybridized interface. Typical examples of fiber-matrix combinations capable of developing such interfaces include surface-phosphonylated ultrahigh molecular weight polyethylene (UHMW-PE) and polypropylene (PP) yarns (or fabric constructs) and epoxy resin, acrylic resin, and cement. For further improvement of the hybridized interface and the overall composite properties, the surface-phosphonylated fiber may be post-treated with reagents that will improve the abridging of the fibers to the matrix through physicochemically hybridized interfaces. Compared with composites having unmodified fiber, those based on modified ones, with or without post-treatment, exhibit a substantial increase in physicomechanical properties at exceptionally low fiber loading, ranging from about 0.1 to 35 percent by weight, preferably from about 0.1 to about 20 percent by weight, most preferably less than 10 percent by weight. Among these properties are maximum tensile strength, fracture toughness, and modulus.
摘要翻译：公开了具有非常低的纤维负载和新颖形式的杂化界面的纤维增强复合材料。能够开发这种界面的纤维 - 基质组合物的典型实例包括表面膦酰化的超高分子量聚乙烯（UHMW-PE）和聚丙烯（PP）纱线（或织物构造）和环氧树脂，丙烯酸树脂和水泥。为了进一步改善杂交界面和整体复合性质，可以用可以通过物理化学杂交界面改善纤维对基质的桥接的试剂对表面膦酰化的纤维进行后处理。与具有未改性纤维的复合材料相比，具有或不具有后处理的基于改性纤维的复合材料在非常低的纤维负载下显示出显着增加的物理机械性能，其范围为约0.1至35重量％，优选约0.1至约20 重量百分比，最优选小于10重量％。这些性能中的最大拉伸强度，断裂韧性和模量。

138. 发明授权

US5824411A Self-reinforced ultra-high molecular weight polyethylene composites 失效
标题翻译：自增强超高分子量聚乙烯复合材料
公开(公告)号：US5824411A
公开(公告)日：1998-10-20
申请号：US480848
申请日：1995-06-07
申请人： Shalaby W. Shalaby , Meng Deng
发明人： Shalaby W. Shalaby , Meng Deng
IPC分类号： A61L27/48 , A61L31/12 , B29C67/24 , B29C70/04 , B29C70/06 , B29C70/46 , B29C70/50 , C08L23/06 , D02G3/32
CPC分类号： C08L23/06 , A61L27/48 , A61L31/129 , B29C67/24 , B29C70/04 , B29C70/06 , B29C70/465 , B29C70/50 , B29K2023/0683 , B29K2105/101 , B29K2105/24 , B29L2031/7532 , C08L2203/02 , C08L2205/02 , C08L2205/16 , Y10S428/902 , Y10T428/2913 , Y10T428/2929 , Y10T428/2973 , Y10T428/31855
摘要： The invention provides composites of ultra-high molecular weight polyethylene reinforced with ultra-high molecular weight polyethylene anisotropic reinforcement of high strength and modulus. The composites have superior mechanical properties relative to non-filled ultra-high molecular weight polyethylene, including higher strength, impact strength, increased creep resistance, and improved modulus. The composites may be sterilized for biomedical use, using gamma radiation and other techniques. Further, the composites are resistant to the effect of body fluids and have lower creep rates so that they will provide implant life. The composites may be cross-linked by exposure to an acetylene environment. Also, the composites find use in other high strength, high impact applications such as sports equipment.
摘要翻译：本发明提供了具有高强度和模量的超高分子量聚乙烯各向异性增强材料的超高分子量聚乙烯复合材料。复合材料相对于未填充的超高分子量聚乙烯具有优异的机械性能，包括较高的强度，冲击强度，增加的抗蠕变性和改善的模量。可以使用γ辐射和其他技术将复合材料灭菌用于生物医学应用。此外，复合材料抵抗体液的作用，具有较低的蠕变速率，因此它们将提供植入寿命。复合材料可能通过暴露于乙炔环境而交联。此外，复合材料可用于其他高强度，高冲击应用，如运动器材。

139. 发明授权

US5677355A Continuous open-cell polymeric foams containing living cells 失效
标题翻译：含活细胞的连续开孔聚合物泡沫
公开(公告)号：US5677355A
公开(公告)日：1997-10-14
申请号：US475218
申请日：1995-06-07
申请人： Shalaby W. Shalaby , Susan L. Roweton
发明人： Shalaby W. Shalaby , Susan L. Roweton
IPC分类号： A61K9/12 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/56 , B01D67/00 , B01D69/14 , B29C67/20 , C08J9/26 , A61K9/14
CPC分类号： A61L27/3839 , A61K9/122 , A61L27/16 , A61L27/18 , A61L27/38 , A61L27/3847 , A61L27/3852 , A61L27/56 , B01D67/003 , B01D69/141 , B29C67/202 , C08J9/26 , B01D2323/21 , B01D2325/48 , C08J2201/042 , C08J2205/05 , Y10T428/249958 , Y10T428/31504 , Y10T428/31725 , Y10T428/31931 , Y10T428/31938
摘要： A polymeric foam with continuous, open-cell pores containing living cells suitable for medical applications and methods for preparing these foams. The microporous foams are of controlled pore size that may be utilized in a variety of applications. In general, the foams are characterized in that the pores are continuous and open-celled. In preparing the foams, an organic polymer is melted and combined with a selected solid crystalline fugitive compound, that melts above about 25.degree. C. and/or that sublimates at above about 25.degree. C. or can be extracted, to produce a substantially isotropic solution. The solution is cooled under controlled conditions to produce a foam precursor containing the solidified fugitive composition dispersed through a matrix of the organic polymer. Crystals of fugitive composition are then removed by solvent extraction and/or sublimation, or a like process to produce microcellular foams having a continuous, open-cell structure. After removing the fugitive composition, living cells capable of producing biologically active products are added to the pores to produce a foam containing living cells.
摘要翻译：具有连续的开孔细胞孔的聚合物泡沫，其含有适用于医学应用的活细胞和用于制备这些泡沫的方法。微孔泡沫具有受控的孔径，可用于各种应用中。通常，泡沫的特征在于孔是连续的和开孔的。在制备泡沫体时，将有机聚合物熔化并与选定的固体晶体化合物混合，熔融高于约25℃，和/或在高于约25℃升华或可提取，以产生基本上各向同性解。将溶液在受控条件下冷却以产生包含通过有机聚合物基质分散的固化的缓冲组合物的泡沫前体。然后通过溶剂萃取和/或升华或类似方法除去挥发性组合物的晶体，以产生具有连续的开孔结构的微孔泡沫。除去挥发性组合物后，将能够生产生物活性物质的活细胞加入到孔中以产生含有活细胞的泡沫。

140. 发明授权

US5672659A Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效
标题翻译：生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US5672659A
公开(公告)日：1997-09-30
申请号：US464735
申请日：1995-06-29
申请人： Shalaby W. Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
发明人： Shalaby W. Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
IPC分类号： A61K9/52 , A61K38/00 , A61K47/48 , C07K7/23 , A61K9/16 , A61K37/02
CPC分类号： A61K47/482 , A61K47/48284 , C07K7/23 , A61K38/00 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809 , Y10S514/963
摘要： A composition including a polyester containing one or more free COOH groups ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein the polyester contains a member selected from the group of L-lactic acid, D-lactic acid, DL-lactic acid, .epsilon.-caprolactone, p-dioxanone, .epsilon.-caprolic acid, alkylene oxalate, cycloalkylene oxalate, alkylene succinate, .beta.-hydroxybutyrate, substituted or unsubstituted trimethylene carbonate, 1,5-dioxopan-2-one, 1,4-dioxepan-2-one, glycolide, glycolic acid, L-lactide, D-lactide, DL-lactide, meso-lactide, and any optically active isomers, racemates or copolymers thereof, and at least 50%, by weight, of the polypeptide present in the composition is ionically conjugated to said polyester.
摘要翻译： PCT No.PCT / US94 / 00148 Sec。 371日期：1995年6月29日 102（e）日期1995年6月29日PCT 1994年1月5日PCT PCT。出版物WO94 / 15587 日期1994年7月21日包含含有一种或多种游离COOH基团的组合物的组合物，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述聚酯包含选自L-乳酸，D-乳酸酸，DL-乳酸，ε-己内酯，对二恶烷酮，ε-己内酯，草酸亚烷基酯，草酸亚环烷基酯，琥珀酸亚烷基酯，β-羟基丁酸酯，取代或未取代的三亚甲基碳酸亚乙酯，1,5-二氧杂戊-2-酮，1 ，4-二氧杂环庚烷-2-酮，乙交酯，乙醇酸，L-丙交酯，D-丙交酯，DL-丙交酯，内消旋丙交酯及其任何光学活性异构体，外消旋体或其共聚物，和至少50重量％存在于组合物中的多肽与所述聚酯离子共轭。

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