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1. 发明授权

US06794364B2 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效
标题翻译：聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物
公开(公告)号：US06794364B2
公开(公告)日：2004-09-21
申请号：US10251018
申请日：2002-09-20
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
IPC分类号： A61K3800
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译：包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述聚合物。

2. 发明授权

US07005420B2 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效
公开(公告)号：US07005420B2
公开(公告)日：2006-02-28
申请号：US10900220
申请日：2004-07-27
申请人： Shalaby W. Shalaby , Ruth M. Russell , Jacques-Pierre Moreau , Steven A. Jackson , Francis X. Ignatious
发明人： Shalaby W. Shalaby , Ruth M. Russell , Jacques-Pierre Moreau , Steven A. Jackson , Francis X. Ignatious
IPC分类号： A61K38/00
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.

3. 发明授权

US06479457B2 Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效
标题翻译：聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物
公开(公告)号：US06479457B2
公开(公告)日：2002-11-12
申请号：US09169423
申请日：1998-10-09
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis X. Ignatious , Jacques-Pierre Moreau , Ruth M. Russell
IPC分类号： A61K3812
CPC分类号： C08B37/003 , A61K38/31 , A61K47/61 , C08L5/08 , C08L2666/02
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译：包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述聚合物。

4. 发明授权

US5863985A Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效
标题翻译：生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US5863985A
公开(公告)日：1999-01-26
申请号：US867308
申请日：1997-06-02
申请人： Shalaby W. Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
发明人： Shalaby W. Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
IPC分类号： A61K38/00 , C07K14/655 , A61K9/16 , A61K9/52 , A61K37/02
CPC分类号： C07K14/655 , A61K38/00 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
摘要翻译：公开了缓释药物组合物。所述组合物包括含有游离COOH基团的聚酯，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述组合物中存在的多肽的至少50重量％与所述聚酯离子共轭。

5. 发明授权

US5665702A Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效
标题翻译：聚（2-氨基-2-脱氧-D-葡萄糖）N-酰化衍生物和多肽的离子分子共轭物
公开(公告)号：US5665702A
公开(公告)日：1997-09-09
申请号：US468947
申请日：1995-06-06
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis Ignatious , Jacques-Pierre Moreau
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis Ignatious , Jacques-Pierre Moreau
IPC分类号： C07H5/04 , A61K38/04 , A61K38/14 , A61K38/31 , A61K47/48 , A61P35/00 , C07D407/14 , C07H5/06 , C07H13/02 , C07H17/04 , C07K9/00 , C08B37/00 , C08B37/08 , C08L5/00 , A61K38/12
CPC分类号： C08B37/003 , A61K38/31
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.
摘要翻译：包含N-酰化衍生物的共聚物和包含所述共聚物和多肽的组合物，所述多肽包含至少一种有效的离子型胺，其中存在于所述组合物中的所述多肽的至少50重量％离子地结合到所述聚合物。

6. 发明授权

US5821221A Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides 失效
公开(公告)号：US5821221A
公开(公告)日：1998-10-13
申请号：US929363
申请日：1997-09-09
申请人： Shalaby W. Shalaby , Steven A. Jackson , Francis Ignatious , Jacques-Pierre Moreau
发明人： Shalaby W. Shalaby , Steven A. Jackson , Francis Ignatious , Jacques-Pierre Moreau
IPC分类号： C07H5/04 , A61K38/04 , A61K38/14 , A61K38/31 , A61K47/48 , A61P35/00 , C07D407/14 , C07H5/06 , C07H13/02 , C07H17/04 , C07K9/00 , C08B37/00 , C08B37/08 , C08L5/00 , A61K38/00
CPC分类号： C08B37/003 , A61K38/31
摘要： A copolymer comprising an N-acylated derivative, and a composition comprising said copolymer and a polypeptide, said polypeptide comprising at least one effective ionogenic amine, wherein at least 50 percent, by weight, of said polypeptide present in said composition is ionically bound to said polymer.

7. 发明授权

US5672659A Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效
标题翻译：生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US5672659A
公开(公告)日：1997-09-30
申请号：US464735
申请日：1995-06-29
申请人： Shalaby W. Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
发明人： Shalaby W. Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
IPC分类号： A61K9/52 , A61K38/00 , A61K47/48 , C07K7/23 , A61K9/16 , A61K37/02
CPC分类号： A61K47/482 , A61K47/48284 , C07K7/23 , A61K38/00 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809 , Y10S514/963
摘要： A composition including a polyester containing one or more free COOH groups ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein the polyester contains a member selected from the group of L-lactic acid, D-lactic acid, DL-lactic acid, .epsilon.-caprolactone, p-dioxanone, .epsilon.-caprolic acid, alkylene oxalate, cycloalkylene oxalate, alkylene succinate, .beta.-hydroxybutyrate, substituted or unsubstituted trimethylene carbonate, 1,5-dioxopan-2-one, 1,4-dioxepan-2-one, glycolide, glycolic acid, L-lactide, D-lactide, DL-lactide, meso-lactide, and any optically active isomers, racemates or copolymers thereof, and at least 50%, by weight, of the polypeptide present in the composition is ionically conjugated to said polyester.
摘要翻译： PCT No.PCT / US94 / 00148 Sec。 371日期：1995年6月29日 102（e）日期1995年6月29日PCT 1994年1月5日PCT PCT。出版物WO94 / 15587 日期1994年7月21日包含含有一种或多种游离COOH基团的组合物的组合物，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述聚酯包含选自L-乳酸，D-乳酸酸，DL-乳酸，ε-己内酯，对二恶烷酮，ε-己内酯，草酸亚烷基酯，草酸亚环烷基酯，琥珀酸亚烷基酯，β-羟基丁酸酯，取代或未取代的三亚甲基碳酸亚乙酯，1,5-二氧杂戊-2-酮，1 ，4-二氧杂环庚烷-2-酮，乙交酯，乙醇酸，L-丙交酯，D-丙交酯，DL-丙交酯，内消旋丙交酯及其任何光学活性异构体，外消旋体或其共聚物，和至少50重量％存在于组合物中的多肽与所述聚酯离子共轭。

8. 发明授权

US06867181B1 Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效
标题翻译：生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US06867181B1
公开(公告)日：2005-03-15
申请号：US09890013
申请日：2000-01-26
申请人： Shalaby Wahba Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
发明人： Shalaby Wahba Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
IPC分类号： A61K9/38 , A61K47/48 , C07K14/655 , C08G63/08 , C08G63/64 , A61K38/00 , C08F20/00
CPC分类号： C08G63/64 , A61K47/593 , C07K14/655 , C08G63/08 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other.
摘要翻译：一种使包含游离含羧基的聚合物和游离氨基的药物彼此离子键合的持续释放离子缀合物的球化方法。

9. 发明授权

US06221958B1 Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides 失效
标题翻译：生物降解聚酯和生物活性多肽的离子分子共轭物
公开(公告)号：US06221958B1
公开(公告)日：2001-04-24
申请号：US09237405
申请日：1999-01-26
申请人： Shalaby Wahba Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
发明人： Shalaby Wahba Shalaby , Steven A. Jackson , Jacques-Pierre Moreau
IPC分类号： A61K916
CPC分类号： C07K7/23 , A61K38/00 , A61K47/593 , C07K14/655 , C08G63/06 , C08G63/08 , C08G63/64 , Y10S514/80 , Y10S514/806 , Y10S514/807 , Y10S514/808 , Y10S514/809
摘要： Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
摘要翻译：公开了缓释药物组合物。所述组合物包括含有游离COOH基团的聚酯，所述游离COOH基团与包含至少一种有效的离子型胺的生物活性多肽离子地缀合，其中所述组合物中存在的多肽的至少50重量％与所述聚酯离子共轭。

10. 发明授权

US5562375A Push type fastener 失效
标题翻译：推式紧固件
公开(公告)号：US5562375A
公开(公告)日：1996-10-08
申请号：US338111
申请日：1994-11-09
申请人： Steven A. Jackson
发明人： Steven A. Jackson
IPC分类号： F16B5/06 , F16B19/10 , F16B13/06
CPC分类号： F16B19/1081 , F16B5/0642
摘要： A push type fastener for fastening a movable structural part (41) to a fixed structural part (43), wherein the coupling and decoupling actions are both a push type operation, the fastener consisting of a plunger (12) having a shank (20) with a plunger head (18) at one end and a threaded end portion (26a) at the other end, an expandable grommet (14) adapted to receive the plunger shank (20) therethrough, and an attachable head (16) which is securable to the threaded end of the plunger shank (20). The fastener (10) requires each structural part (41, 43) to be provided with an aperture (45, 46) and the attachable head (16) to be smaller than the aperture (46) in the second structural part. The plunger (12) is extensible through the grommet (14) and is structurally configured with an external camming surface (25) which is cooperatively engageable with internal surfaces (38) of the grommet so that when the plunger is inserted in the grommet, the relative positioning of said cooperable camming surfaces determines the expansion of the grommet. Coupling of the parts is effected when the grommet is inserted in the aperture (46) in the fixed structural part (43) and expanded by pushing the plunger head (18) and plunger at least a minimal distance through the grommet. Decoupling is effected by pushing the attachable head (16).
摘要翻译：一种用于将可移动结构部件（41）紧固到固定结构部件（43）上的推动型紧固件，其中所述联接和解耦动作都是推动式操作，所述紧固件由具有柄（20）的柱塞（12）在一端具有柱塞头部（18），在另一端具有螺纹端部部分（26a），适于容纳柱塞杆（20）穿过其中的可膨胀索环（14）和可固定的可连接头部（16）到柱塞柄（20）的螺纹端。紧固件（10）需要每个结构部件（41,43）设置有孔（45,46），并且可连接头部（16）比第二结构部件中的孔口（46）小。活塞（12）可通过索环（14）伸展，并在结构上构造有外部凸轮表面（25），该外部凸轮表面可与索环的内表面（38）协作地接合，使得当柱塞插入索环中时，所述可配合的凸轮表面的相对定位决定了索环的膨胀。当将索环插入固定结构部件（43）中的孔（46）中并且通过将柱塞头（18）和柱塞推动至少最小距离通过索环而膨胀时，可实现部件的耦合。通过推动可附接头（16）实现去耦。

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