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111. 发明申请

US20080132991A1 Method for Ionically Cross-Linking Gellan Gum for Thin Film Applications and Medical Devices Produced Therefrom 审中-公开
标题翻译：用于薄膜应用和医疗器械的离子交联胶凝胶的方法
公开(公告)号：US20080132991A1
公开(公告)日：2008-06-05
申请号：US11565065
申请日：2006-11-30
申请人： Leonard Pinchuk , Yasushi Pedro Kato , Marc Ramer
发明人： Leonard Pinchuk , Yasushi Pedro Kato , Marc Ramer
IPC分类号： A61F2/82 , B05D7/00 , B05D3/10
CPC分类号： C08B37/006 , A61F2/06 , A61F2/07 , A61F2/82 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2420/02 , C09D105/00 , C08L5/00
摘要： A method for producing ionically cross-linked gellan gum includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial portion of the dissolving liquid. Subsequent to drying, the coating is exposed to a second liquid solution that includes a compound that promotes ionic cross-linking of the coating. In the preferred embodiment, the dissolving liquid comprises water and possibly a polar solvent. The ionic cross-linking compound preferably comprises a divalent cation such as calcium (Ca2+), or possibly strontium (Sr2+), magnesium (Mg2+), barium (Ba2+), or other multivalent ions. Such a method forms a uniform ionically cross-linked film and/or coating for diverse applications, including medical devices such as implantable vascular grafts, stent-grafts and/or stents.
摘要翻译：用于生产离子交联的结冷胶的方法包括将该材料溶解在包括溶解液的第一液体溶液中。将第一液体溶液施加到工件上以在工件上形成多糖基涂层。将涂层干燥以除去大部分溶解液。在干燥之后，将涂层暴露于包括促进涂层的离子交联的化合物的第二液体溶液中。在优选的实施方案中，溶解液体包含水和可能的极性溶剂。离子交联化合物优选包含二价阳离子如钙（Ca 2+），或可能的锶（Sr 2+），镁（Mg 2+） +），钡（Ba 2+）或其它多价离子。这种方法形成用于各种应用的均匀的离子交联膜和/或涂层，包括诸如可植入血管移植物，支架移植物和/或支架的医疗装置。

112. 发明申请

US20080127992A1 Array of Dental Flossers Coupled to Each Other by Frangible Links 审中-公开
标题翻译：通过脆弱链接相互配合的牙线钻石阵列
公开(公告)号：US20080127992A1
公开(公告)日：2008-06-05
申请号：US11564905
申请日：2006-11-30
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61C15/04
CPC分类号： A61C15/046
摘要： An array of side-by-side flossers are coupled to each other by frangible links. The user breaks off a flosser from the array prior to flossing. When finished flossing, the user disposes of the used flosser. In a preferred embodiment, the array can be about the same size as a credit card and thus can fit in a credit card pouch of a wallet.
摘要翻译：并列排列的阵列通过易碎的链接彼此连接。在牙线前，用户会从阵列中分离出一个花丝。当牙线完成时，用户处理使用过的flosser。在优选实施例中，阵列可以与信用卡大致相同的大小，并且因此可以装配在钱包的信用卡袋中。

113. 发明申请

US20070087023A1 Polymer-Based Antimicrobial Agents, Methods of Making Said Agents, and Applications Using Said Agents 审中-公开
标题翻译：基于聚合物的抗微生物剂，制备所述试剂的方法和使用所述试剂的应用
公开(公告)号：US20070087023A1
公开(公告)日：2007-04-19
申请号：US11558027
申请日：2006-11-09
申请人： Ashraf Ismail , Leonard Pinchuk , Orley Pinchuk , David Pinchuk
发明人： Ashraf Ismail , Leonard Pinchuk , Orley Pinchuk , David Pinchuk
IPC分类号： A01N59/16 , A01N25/00
CPC分类号： A01N59/16 , A01N59/20 , A01N25/10 , A01N2300/00
摘要： The present invention relates to antimicrobial agents, methods for the production of these agents, and the use of these agents. The antimicrobial agent of the present invention includes a water-soluble polymer and oligodynamic metal ions which interact with counter-ions of the polymer such that the metal ions are bound to corresponding counter-ions. The polymer controls a sustained release of the metal ions. The metal ions preferably include small size metal particles (e.g., nano-sized silver particles) that interact to the water-soluble polymer as well as metal ions derived from one or more water-soluble oligodynamic metal compositions (e.g., metal sulfates and/or metal nitrates). The agent may also include one or more acids, including organic acids and/or non-organic acids. In another aspect, antimicrobial agents that include a polymer and oligodynamic metal ions are used to treat or prevent citrus canker.
摘要翻译：本发明涉及抗微生物剂，这些制剂的制备方法以及这些试剂的用途。本发明的抗微生物剂包括与聚合物的抗衡离子相互作用的水溶性聚合物和低分子量金属离子，使得金属离子与相应的抗衡离子结合。聚合物控制金属离子的持续释放。金属离子优选包括与水溶性聚合物相互作用的小尺寸金属颗粒（例如，纳米尺寸的银颗粒）以及衍生自一种或多种水溶性低分子量金属组合物的金属离子（例如，金属硫酸盐和/或金属硝酸盐）。该试剂还可以包括一种或多种酸，包括有机酸和/或非有机酸。另一方面，包括聚合物和低分子动力学金属离子的抗微生物剂用于治疗或预防柑橘溃疡。

114. 发明申请

US20060136070A1 Elastomeric polymer filament cosmetic implant 有权
公开(公告)号：US20060136070A1
公开(公告)日：2006-06-22
申请号：US11015941
申请日：2004-12-17
申请人： Leonard Pinchuk
发明人： Leonard Pinchuk
IPC分类号： A61F2/10 , A61B17/34
CPC分类号： A61F2/0059 , A61B17/00491 , A61B17/06004 , A61B17/3468 , A61B2017/00495 , A61B2017/00792 , A61B2017/06038 , A61B2017/0618 , A61F2250/0068
摘要： A cosmetic implant comprises a filament made from a biocompatible elastomer. The elastomeric filament can be injected or pulled under one or more wrinkles. Once implanted under the wrinkle(s), the filament lifts and supports the tissue above it. Such lifting lessens (and possibly removes altogether) the appearance of the wrinkle(s). The biocompatible elastomeric filament is preferably made from a polyolefinic copolymer material having a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene, which is herein referred to as “SIBS”; or alternatively can be made from silicon rubber, expanded polytetrafluorethelyene (ePTFE), polyurethane, polyolefin, copolymers of nylon, copolymers of polyester, or elastin.

115. 发明申请

US20050125003A1 Glaucoma implant device 有权
标题翻译：青光眼植入装置
公开(公告)号：US20050125003A1
公开(公告)日：2005-06-09
申请号：US11004539
申请日：2004-12-03
申请人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes , Saul Gottlieb , John Martin , Yasushi Kato
发明人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes , Saul Gottlieb , John Martin , Yasushi Kato
IPC分类号： A61F2/00 , A61F9/007
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： A surgical implant device for treating glaucoma includes an elongate duct structure formed from a material comprising polyisobutylene and a glassy segment. The material of the elongate duct structure preferably has a general block structure with a central elastomeric polyolefinic block and thermoplastic end blocks (e.g., a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The elongate duct structure provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye. Preferably, the elongate duct structure defines a lumen channel having an inside diameter between 0.05 mm and 0.3 mm. The material of the elongate duct structure is biocompatible and biostable. Moreover, the material will not encapsulate in the eye and thus provides an unobstructed flowpath that diverts aqueous humor from the anterior chamber. Different embodiments of the implant device divert the aqueous humor to different parts of the eye (e.g., a space between the conjuctiva and sclera, Schlemm's canal, or a fluid reservoir formed on a posterior surface of the eye).
摘要翻译：用于治疗青光眼的手术植入装置包括由包含聚异丁烯和玻璃状段的材料形成的细长管道结构。细长管道结构的材料优选具有中央弹性聚烯烃嵌段和热塑性端嵌段（例如，包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）的通用嵌段结构。细长的管道结构提供用于将房水从眼睛的前房转向的流体通道。优选地，细长管道结构限定了具有在0.05mm和0.3mm之间的内径的管腔通道。细长管道结构的材料是生物相容性和生物稳定性。此外，该材料将不会包封在眼睛中，从而提供将房水从前房转移的畅通的流路。植入装置的不同实施例将房水转移到眼睛的不同部分（例如，结膜和巩膜之间的空间，施莱姆氏管或形成在眼后表面上的流体储存器）。

116. 发明授权

US06855770B2 Drug delivery compositions and medical devices containing block copolymer 有权
标题翻译：药物输送组合物和含有嵌段共聚物的医疗器械
公开(公告)号：US06855770B2
公开(公告)日：2005-02-15
申请号：US10319802
申请日：2002-12-13
申请人： Leonard Pinchuk , Sepideh Nott , Marlene Schwarz , Kalpana Kamath
发明人： Leonard Pinchuk , Sepideh Nott , Marlene Schwarz , Kalpana Kamath
IPC分类号： A61K47/32 , A61K9/22 , A61K31/337 , A61K35/12 , A61K45/00 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K48/00 , A61L27/16 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/16 , A61M37/00 , C08F2/00 , C08F293/00 , C08F297/00 , C08F297/04 , C08L53/00 , C08L53/02 , C09D153/00 , C09D153/02 , C08L23/00 , C08L23/04
CPC分类号： C08L53/00 , A61L27/16 , A61L27/54 , A61L31/048 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , C08F293/005 , C08F297/00 , C08F297/04 , C08L53/02 , C09D153/00 , C09D153/02 , C08L2666/02
摘要： A composition for delivery of a therapeutic agent is provided. The composition comprises: (a) a biocompatible block copolymer comprising one or more elastomeric blocks and one or more thermoplastic blocks and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. The block copolymer is preferably of the formula X—(AB)n, where A is an elastomeric block, B is a thermoplastic block, n is a positive whole number and X is a seed molecule. The elastomeric blocks are preferably polyolefin blocks, and the thermoplastic blocks are preferably selected from vinyl aromatic blocks and methacrylate blocks. According to another aspect of the invention, a medical device is provided, at least a portion of which is insertable or implantable into the body of a patient. The medical device comprises (a) the above biocompatible block copolymer and (b) a therapeutic agent, wherein the block copolymer is loaded with the therapeutic agent. According to another aspect of the present invention, a method of treatment is provided in which the above device is implanted or inserted into a patient, resulting in the release of therapeutic agent in the patient over an extended period. According to yet another aspect of the invention, a coated medical device is provided which comprises: (a) an intravascular or intervascular medical device and (b) a coating over at least a portion of the intravascular or intervascular a medical device, wherein the coating comprises the above biocompatible block copolymer.
摘要翻译：提供了用于递送治疗剂的组合物。所述组合物包含：（a）包含一种或多种弹性体嵌段和一种或多种热塑性嵌段的生物相容性嵌段共聚物和（b）治疗剂，其中所述嵌段共聚物负载有所述治疗剂。嵌段共聚物优选为式X-（AB）n，其中A为弹性体嵌段，B为热塑性嵌段，n为正整数，X为种子分子。弹性体嵌段优选为聚烯烃嵌段，并且热塑性嵌段优选选自乙烯基芳族嵌段和甲基丙烯酸酯嵌段。根据本发明的另一方面，提供一种医疗装置，其至少一部分可插入或植入患者体内。医疗装置包括（a）上述生物相容性嵌段共聚物和（b）治疗剂，其中嵌段共聚物负载有治疗剂。根据本发明的另一方面，提供了一种治疗方法，其中将上述装置植入或插入患者体内，导致治疗剂在患者体内长时间释放。根据本发明的另一方面，提供一种涂覆的医疗装置，其包括：（a）血管内或血管内医疗装置和（b）在血管内或血管内医疗装置的至少一部分上的涂层，其中所述涂层包括上述生物相容性嵌段共聚物。

117. 发明授权

US06309413B1 Expandable supportive endoluminal grafts 有权
标题翻译：可扩展的支持性腔内移植物
公开(公告)号：US06309413B1
公开(公告)日：2001-10-30
申请号：US09595700
申请日：2000-06-16
申请人： Jean-Pierre Georges Emile Dereume , David C. MacGregor , Leonard Pinchuk
发明人： Jean-Pierre Georges Emile Dereume , David C. MacGregor , Leonard Pinchuk
IPC分类号： A61F200
CPC分类号： A61F2/07 , A61F2/88 , A61F2/885 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2002/065 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/30329 , A61F2002/826 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2250/0039
摘要： An endoluminal graft which is both expandable and supportive is provided either in a longitudinal form or in a bifurcated form. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A cover, liner, or a liner, or both a cover and a liner are applied to the endoprosthesis in the form of a stretchable wall material that is porous, elastomeric and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. Preferably, the elastomeric wall material is a polycarbonate urethane.
摘要翻译：可膨胀和支撑的腔内移植物以纵向形式或分叉形式提供。移植物在第一直径和第二直径较大的直径之间膨胀。支撑部件是可扩张的支架内置假体。将覆盖物，衬里或衬垫，或盖子和衬垫两者以可多孔，弹性和生物相容性的可拉伸壁材料的形式施加到内假体，以便在植入时允许正常的细胞侵入，而不会出现狭窄可扩张和支持的移植物处于其第二直径。优选地，弹性体壁材料是聚碳酸酯聚氨酯。

118. 发明授权

US06273895B1 Method of measuring a body cavity 有权
标题翻译：测量体腔的方法
公开(公告)号：US06273895B1
公开(公告)日：2001-08-14
申请号：US09573294
申请日：2000-05-18
申请人： Leonard Pinchuk , David C. MacGregor
发明人： Leonard Pinchuk , David C. MacGregor
IPC分类号： A61F1100
CPC分类号： A61F2/95 , A61B5/1076 , A61B2090/061 , A61F2/90 , A61F2002/9517 , A61F2250/0097
摘要： An apparatus and method are disclosed for measuring the desired length of a prosthetic device which is to be implanted in a body cavity of a patient. The apparatus generally includes a helically coiled stent formed of a resiliently-deformable material, a plunger which is connected to the proximal end of the stent, a sheath which slides over the plunger and stent when the plunger and sheath are used to insert and removably deploy the stent into the body cavity, and a scale for measuring an indication of the length of the stent once removably deployed in the body cavity. Proximal movement of the sheath to partially deploy the stent causes a length to be indicated on the scale. According to the method of the invention, the helically coiled stent of the apparatus is placed and partially deployed within the body cavity by use of the plunger and sheath of the apparatus. Once the stent bridges the body cavity, the scale of the apparatus is used to determine the length of the deployed stent. The apparatus is then removed from the body cavity, and a stent similar to the stent of the apparatus is cut to the length indicated on the scale. In a second embodiment of the apparatus and method, the stent of the measuring apparatus is substantially non-porous to allow occlusion of side vessels extending from the body cavity. The patient is then monitored for any ill effects resulting from the occlusion.
摘要翻译：公开了一种用于测量要植入患者体腔中的假体装置的期望长度的装置和方法。该装置通常包括由可弹性变形的材料形成的螺旋卷曲的支架，连接到支架的近端的柱塞，当柱塞和护套用于插入和可移除地部署时，在柱塞和支架上滑动的护套支架进入体腔，以及用于测量一旦可移除地展开在体腔中的支架的长度指示的标尺。护套部分展开支架的近端运动会导致刻度上显示长度。根据本发明的方法，通过使用装置的柱塞和护套将装置的螺旋卷绕的支架放置并部分地展开在体腔内。一旦支架桥接体腔，则该装置的尺度用于确定展开的支架的长度。然后将该装置从体腔中取出，将与装置的支架类似的支架切割成刻度上指示的长度。在装置和方法的第二实施例中，测量装置的支架基本上是无孔的，以允许从身体腔延伸的侧容器闭塞。然后监测患者由闭塞引起的任何不良影响。

119. 发明授权

US6165212A Expandable supportive endoluminal grafts 有权
标题翻译：可扩展的支持性腔内移植物
公开(公告)号：US6165212A
公开(公告)日：2000-12-26
申请号：US340805
申请日：1999-06-28
申请人： Jean-Pierre Georges Emile Dereume , David C. MacGregor , Leonard Pinchuk
发明人： Jean-Pierre Georges Emile Dereume , David C. MacGregor , Leonard Pinchuk
IPC分类号： A61F2/00 , A61F2/06 , A61F2/82 , A61F2/88 , A61F2/90
CPC分类号： A61F2/07 , A61F2/88 , A61F2/885 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2002/065 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2002/30329 , A61F2002/826 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2250/0039
摘要： An endoluminal graft which is both expandable and supportive is provided either in a longitudinal form or in a bifurcated form. The graft expands between a first diameter and a second, larger diameter. The support component is an expandable stent endoprosthesis. A cover, liner, or a liner, or both a cover and a liner are applied to the endoprosthesis in the form of a stretchable wall material that is porous, elastomeric and biocompatible in order to allow normal cellular invasion upon implantation, without stenosis, when the expandable and supportive graft is at its second diameter. Preferably, the elastomeric wall material is a polycarbonate urethane.
摘要翻译：可膨胀和支撑的腔内移植物以纵向形式或分叉形式提供。移植物在第一直径和第二直径较大的直径之间膨胀。支撑部件是可扩张的支架内置假体。将覆盖物，衬里或衬垫，或盖子和衬垫两者以可多孔，弹性和生物相容性的可拉伸壁材料的形式施加到内假体，以便在植入时允许正常的细胞侵入，而不会出现狭窄可扩张和支持的移植物处于其第二直径。优选地，弹性体壁材料是聚碳酸酯聚氨酯。

120. 发明授权

US6027529A Protheses with selectively welded crossing strands 失效
标题翻译：带有选择性焊接交叉股线的保护套
公开(公告)号：US6027529A
公开(公告)日：2000-02-22
申请号：US60695
申请日：1998-04-15
申请人： Suranjan Roychowdhury , Leonard Pinchuk , Eugen Hofmann , Susanne Hankh , Michael G. O'Connor , Jennifer E. Raeder-Devens , Jeannine B. Baden , Daniel J. Klima
发明人： Suranjan Roychowdhury , Leonard Pinchuk , Eugen Hofmann , Susanne Hankh , Michael G. O'Connor , Jennifer E. Raeder-Devens , Jeannine B. Baden , Daniel J. Klima
IPC分类号： A61F2/00 , A61F2/90 , A61F2/95 , A61F2/958 , A61F2/06
CPC分类号： A61F2/90 , A61F2/958 , A61F2002/30451 , A61F2002/9522 , A61F2220/0058 , A61F2240/001 , Y10T29/49798 , Y10T29/49927
摘要： A body implantable stent is formed of a plurality of strands arranged in two sets of coaxial helices, wound in opposite directions to form multiple crossings. At selected crossings, the adjacent strands are welded to one another, while at the remaining crossings the strands are free for limited movement relative to one another. The welds are formed in patterns that preferably enhance radial strength and rigidity, while having a minimal impact on axial bending flexibility. Preferred weld patterns in this regard include rings or circumferential rows, and helices, particularly with a steeper pitch than that of the strands. Stent fabrication preferably involves resistance welding at the crossings, and use of a tool to reuniformly compress the stent around and against the distal end region of a balloon catheter used later to deliver the stent to a treatment site.
摘要翻译：身体可植入支架由多个绞合线构成，所述股线布置成两组同轴螺旋，沿相反方向缠绕以形成多个交叉。在所选的交叉处，相邻的线条彼此焊接，而在剩余的交叉处，线条相对于彼此有限的移动是自由的。焊缝以优选增强径向强度和刚度的图案形成，同时对轴向弯曲柔性具有最小的影响。在这方面，优选的焊接图案包括环或周向排和螺旋，特别是具有比线的陡峭的间距。支架制造优选地涉及在交叉点处的电阻焊接，以及使用工具将支架均匀地压缩在球囊导管的远端区域周围并抵靠以后用于将支架输送到治疗部位的远端区域。

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