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1. 发明申请

US20080132991A1 Method for Ionically Cross-Linking Gellan Gum for Thin Film Applications and Medical Devices Produced Therefrom 审中-公开
标题翻译：用于薄膜应用和医疗器械的离子交联胶凝胶的方法
公开(公告)号：US20080132991A1
公开(公告)日：2008-06-05
申请号：US11565065
申请日：2006-11-30
申请人： Leonard Pinchuk , Yasushi Pedro Kato , Marc Ramer
发明人： Leonard Pinchuk , Yasushi Pedro Kato , Marc Ramer
IPC分类号： A61F2/82 , B05D7/00 , B05D3/10
CPC分类号： C08B37/006 , A61F2/06 , A61F2/07 , A61F2/82 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2420/02 , C09D105/00 , C08L5/00
摘要： A method for producing ionically cross-linked gellan gum includes dissolving the material in a first liquid solution that includes a dissolving liquid. The first liquid solution is applied to a workpiece to form a polysaccharide-based coating on the workpiece. The coating is dried to remove a substantial portion of the dissolving liquid. Subsequent to drying, the coating is exposed to a second liquid solution that includes a compound that promotes ionic cross-linking of the coating. In the preferred embodiment, the dissolving liquid comprises water and possibly a polar solvent. The ionic cross-linking compound preferably comprises a divalent cation such as calcium (Ca2+), or possibly strontium (Sr2+), magnesium (Mg2+), barium (Ba2+), or other multivalent ions. Such a method forms a uniform ionically cross-linked film and/or coating for diverse applications, including medical devices such as implantable vascular grafts, stent-grafts and/or stents.
摘要翻译：用于生产离子交联的结冷胶的方法包括将该材料溶解在包括溶解液的第一液体溶液中。将第一液体溶液施加到工件上以在工件上形成多糖基涂层。将涂层干燥以除去大部分溶解液。在干燥之后，将涂层暴露于包括促进涂层的离子交联的化合物的第二液体溶液中。在优选的实施方案中，溶解液体包含水和可能的极性溶剂。离子交联化合物优选包含二价阳离子如钙（Ca 2+），或可能的锶（Sr 2+），镁（Mg 2+） +），钡（Ba 2+）或其它多价离子。这种方法形成用于各种应用的均匀的离子交联膜和/或涂层，包括诸如可植入血管移植物，支架移植物和/或支架的医疗装置。

2. 发明授权

US08585940B2 Ocular lens 有权
标题翻译：眼镜片
公开(公告)号：US08585940B2
公开(公告)日：2013-11-19
申请号：US12776138
申请日：2010-05-07
申请人： Leonard Pinchuk , Yonghua Zhou , Yongmoon Kwon , Yasushi Pedro Kato
发明人： Leonard Pinchuk , Yonghua Zhou , Yongmoon Kwon , Yasushi Pedro Kato
IPC分类号： B29D11/00
CPC分类号： A61K9/0051 , A61F2/1613 , A61F2/1635 , A61L27/16 , A61L2430/16 , C08L101/02 , C08L23/20
摘要： A method of making an ocular lens device (and resulting lens device) from a polyolefin copolymer material having a crosslinking component, wherein the material is processed to remove unwanted reaction byproducts that can contribute to reduced transparency of the polyolefin copolymer material in the ocular environment of the eye.
摘要翻译：一种由具有交联组分的聚烯烃共聚物材料制造眼用透镜装置（和所得到的透镜装置）的方法，其中处理该材料以除去不需要的反应副产物，其可有助于降低聚烯烃共聚物材料在眼睛环境中的透明度眼。

3. 发明申请

US20100283164A1 Ocular Lens 有权
标题翻译：眼镜
公开(公告)号：US20100283164A1
公开(公告)日：2010-11-11
申请号：US12776138
申请日：2010-05-07
申请人： Leonard Pinchuk , Yonghua Zhou , Yongmoon Kwon , Yasushi Pedro Kato
发明人： Leonard Pinchuk , Yonghua Zhou , Yongmoon Kwon , Yasushi Pedro Kato
IPC分类号： B29D11/00
CPC分类号： A61K9/0051 , A61F2/1613 , A61F2/1635 , A61L27/16 , A61L2430/16 , C08L101/02 , C08L23/20
摘要： A method of making an ocular lens device (and resulting lens device) from a polyolefin copolymer material having a crosslinking component, wherein the material is processed to remove unwanted reaction byproducts that can contribute to reduced transparency of the polyolefin copolymer material in the ocular environment of the eye.
摘要翻译：一种由具有交联组分的聚烯烃共聚物材料制造眼用透镜装置（和所得到的透镜装置）的方法，其中处理该材料以除去不需要的反应副产物，其可有助于降低聚烯烃共聚物材料在眼睛环境中的透明度眼。

4. 发明授权

US07431709B2 Glaucoma implant device 有权
标题翻译：青光眼植入装置
公开(公告)号：US07431709B2
公开(公告)日：2008-10-07
申请号：US11004539
申请日：2004-12-03
申请人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes , Saul Gottlieb , John B. Martin, Jr. , Yasushi Pedro Kato
发明人： Leonard Pinchuk , Jean-Marie Parel , Francisco Fantes , Saul Gottlieb , John B. Martin, Jr. , Yasushi Pedro Kato
IPC分类号： A61M5/00 , A61K9/22 , A61M31/00
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： A surgical implant device for treating glaucoma includes an elongate duct structure formed from a material comprising polyisobutylene and a glassy segment. The material of the elongate duct structure preferably has a general block structure with a central elastomeric polyolefinic block and thermoplastic end blocks (e.g., a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The elongate duct structure provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye. Preferably, the elongate duct structure defines a lumen channel having an inside diameter between 0.05 mm and 0.3 mm. The material of the elongate duct structure is biocompatible and biostable. Moreover, the material will not encapsulate in the eye and thus provides an unobstructed flowpath that diverts aqueous humor from the anterior chamber. Different embodiments of the implant device divert the aqueous humor to different parts of the eye (e.g., a space between the conjuctiva and sclera, Schlemm's canal, or a fluid reservoir formed on a posterior surface of the eye).
摘要翻译：用于治疗青光眼的手术植入装置包括由包含聚异丁烯和玻璃状段的材料形成的细长管道结构。细长管道结构的材料优选具有中央弹性聚烯烃嵌段和热塑性端嵌段（例如，包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）的通用嵌段结构。细长的管道结构提供用于将房水从眼睛的前房转向的流体通道。优选地，细长管道结构限定了具有在0.05mm和0.3mm之间的内径的管腔通道。细长管道结构的材料是生物相容性和生物稳定性。此外，该材料将不会包封在眼睛中，从而提供将房水从前房转移的畅通的流路。植入装置的不同实施例将房水转移到眼睛的不同部分（例如，结膜和巩膜之间的空间，施莱姆氏管或形成在眼后表面上的流体储存器）。

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