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101. 发明授权

US08600505B2 Implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction 有权
标题翻译：用于促进控制电刺激颈部迷走神经治疗慢性心脏功能障碍的植入式装置
公开(公告)号：US08600505B2
公开(公告)日：2013-12-03
申请号：US13314130
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/37217 , A61N1/36114
摘要： An implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. Finally, the neurostimulator includes a programmable switch configured to alter the triggering of the bi-directional action potentials in response to a magnetic signal received from outside the housing.
摘要翻译：提供了一种用于促进控制用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器还包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该循环被调谐到两者以显着激活心脏的内在神经系统，并通过触发双向激活来传入激活患者的中心反射，方向动作电位。最后，神经刺激器包括可编程开关，其被配置为响应于从壳体外部接收的磁信号来改变双向动作电位的触发。

102. 发明授权

US08483828B2 Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权
标题翻译：通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗
公开(公告)号：US08483828B2
公开(公告)日：2013-07-09
申请号：US12891674
申请日：2010-09-27
申请人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
发明人： Imad Libbus , Bruce H. KenKnight , Julia Moffitt , Yatheendhar D. Manicka
IPC分类号： A61N1/365 , A61N1/05
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译：公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。

103. 发明申请

US20130158617A1 Implantable Device For Providing Electrical Stimulation Of Cervical Vagus Nerves For Treatment Of Chronic Cardiac Dysfunction With Bounded Titration 有权
标题翻译：用于提供电刺激用于治疗慢性心脏功能障碍的子宫颈迷走神经的植入装置
公开(公告)号：US20130158617A1
公开(公告)日：2013-06-20
申请号：US13314135
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/36114 , A61N1/0556 , A61N1/36139 , A61N1/36175
摘要： An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials. The neurostimulator includes an integrated leadless heart rate sensor configured to sense heart rate and alter the triggering in response to the sensed heart rate falling outside a predetermined range.
摘要翻译：提供了一种用于通过有界滴定来提供用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的可植入装置。刺激治疗引线包括构造成符合颈部迷走神经鞘的外径的螺旋电极和电连接到螺旋电极的一组连接器引脚。神经刺激器包括一个电插座，连接器插头牢固地和电连接到该插座中。神经刺激器包括脉冲发生器，其被配置为在刺激应用和刺激抑制的交替周期中通过螺旋电极治疗性地刺激迷走神经，该周期被调谐到两者均可以激发心脏的内在神经系统，并通过触发双向的方式传入激活患者的中心反射行动潜力神经刺激器包括集成的无引线心率传感器，其被配置为响应于感测到的心率落在预定范围之外来感测心率并改变触发。

104. 发明授权

US08090442B2 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 有权
标题翻译：空间和时间分布心脏电刺激的装置和方法
公开(公告)号：US08090442B2
公开(公告)日：2012-01-03
申请号：US11931718
申请日：2007-10-31
申请人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译：一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力。为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。

105. 发明授权

US08055355B2 System and assembly having conductive fixation features 失效
标题翻译：具有导电固定特征的系统和组件
公开(公告)号：US08055355B2
公开(公告)日：2011-11-08
申请号：US11031971
申请日：2005-01-07
申请人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
发明人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.
摘要翻译：一种具有远端电极组件的引线，其适于植入在心脏上或周围的静脉内并且用于连接到用于监测或刺激心脏活动的系统。电极组件包括与非导电固定特征组合的导电固定特征，例如导电尖齿或柔性构件。导电固定特征还包括涂覆有导电材料的尖齿。固定特征还包括可伸缩的导电尖齿。除颤线圈可选地配置在导电尖端的前端，与导电齿结合。

106. 再颁专利

USRE42836E1 Method for assessing cardiac functional status 有权
标题翻译：评估心脏功能状态的方法
公开(公告)号：USRE42836E1
公开(公告)日：2011-10-11
申请号：US11906742
申请日：2007-10-03
申请人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
发明人： Weimin Sun , Veerichetty Kadhiresan , Bruce H. KenKnight , Richard S. Sanders
IPC分类号： A61N1/00
CPC分类号： A61N1/36542
摘要： A method for assessing cardiac function suitable for incorporation into an implantable cardiac rhythm management device. By measuring daily exertion levels in accordance with the invention, an assessment of cardiac function can be made that has been found to correlate well with conventional clinical classifications. The invention also provides for assessing cardiac function in conjunction with different pacing schemes designed to treat heart failure and using the assessment to select the best such scheme for the patient.
摘要翻译：一种用于评估心脏功能的方法，其适于并入植入式心律管理装置。通过测量根据本发明的每日运动水平，可以进行已经发现与常规临床分类良好相关的心脏功能的评估。本发明还提供了结合用于治疗心力衰竭的不同起搏方案和使用该评估为患者选择最佳的方案来评估心脏功能。

107. 发明授权

US07996074B2 System and method for providing closely-followed cardiac therapy management through automated patient care 失效
标题翻译：通过自动病人护理提供紧密的心脏治疗管理的系统和方法
公开(公告)号：US07996074B2
公开(公告)日：2011-08-09
申请号：US11378677
申请日：2006-03-17
申请人： Bruce H. KenKnight , Yatheendhar D. Manicka
发明人： Bruce H. KenKnight , Yatheendhar D. Manicka
IPC分类号： A61B5/04
CPC分类号： A61B5/0031 , A61B5/0006
摘要： A system and method for providing closely-followed cardiac therapy management through automated patient care is presented. A patient under remote care is enrolled in a monitoring program following commencement of a cardiac therapy regimen to be undertaken by the patient. A wearable monitor, including one or more patient physiology sensors and a wireless interface providing enabling bi-directional data exchange, is provided to the patient. Patient physiometry, including quantitative physiological measures, is periodically collected from the wearable monitor over the wireless interface concomitant to performance of the cardiac therapy regimen. The patient physiometry is evaluated to determine a trend indicating an onset, progression, regression, absence of, and status quo of patient health status.
摘要翻译：提出了一种通过自动化病人护理提供紧密相关的心脏治疗管理的系统和方法。远程护理的患者在患者进行的心脏治疗方案开始之后登记在监测程序中。包括一个或多个患者生理学传感器和提供启用双向数据交换的无线接口的可穿戴监视器被提供给患者。包括定量生理测量在内的患者物理测量，通过无线接口从耐磨监视器中定期收集，同时伴随着心脏治疗方案的表现。评估患者物理量以确定指示患者健康状况的发作，进展，回归，不存在和现状的趋势。

108. 发明授权

US07962210B2 Implantable medical device with voice responding and recording capacity 有权
标题翻译：具有语音响应和记录能力的植入式医疗设备
公开(公告)号：US07962210B2
公开(公告)日：2011-06-14
申请号：US12468648
申请日：2009-05-19
申请人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
发明人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
IPC分类号： A61N1/362
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.
摘要翻译：一种可植入医疗装置，例如心脏起搏器或植入式心律转复除颤器，具有以患者所说话语的形式接收通信的能力。声学换能器结合在该装置内，连同相关联的滤波电路使声音通信能够用于影响装置的操作或被记录以供稍后播放。

109. 发明申请

US20110106202A1 METHOD AND SYSTEM FOR SETTING CARDIAC RESYNCHRONIZATION THERAPY PARAMETERS 有权
标题翻译：用于设置心脏再生治疗参数的方法和系统
公开(公告)号：US20110106202A1
公开(公告)日：2011-05-05
申请号：US12987700
申请日：2011-01-10
申请人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译：提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

110. 发明授权

US07881789B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US07881789B2
公开(公告)日：2011-02-01
申请号：US11832552
申请日：2007-08-01
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

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