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1. 发明授权

US06842648B2 System and assembly having conductive fixation features 有权
标题翻译：具有导电固定特征的系统和组件
公开(公告)号：US06842648B2
公开(公告)日：2005-01-11
申请号：US10054600
申请日：2002-01-22
申请人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
发明人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.
摘要翻译：一种具有远端电极组件的引线，其适于植入在心脏上或周围的静脉内并且用于连接到用于监测或刺激心脏活动的系统。电极组件包括与非导电固定特征组合的导电固定特征，例如导电尖齿或柔性构件。导电固定特征还包括涂覆有导电材料的尖齿。固定特征还包括可伸缩的导电尖齿。除颤线圈可选地配置在导电尖端的前端，与导电齿结合。

2. 发明授权

US08055355B2 System and assembly having conductive fixation features 失效
标题翻译：具有导电固定特征的系统和组件
公开(公告)号：US08055355B2
公开(公告)日：2011-11-08
申请号：US11031971
申请日：2005-01-07
申请人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
发明人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.
摘要翻译：一种具有远端电极组件的引线，其适于植入在心脏上或周围的静脉内并且用于连接到用于监测或刺激心脏活动的系统。电极组件包括与非导电固定特征组合的导电固定特征，例如导电尖齿或柔性构件。导电固定特征还包括涂覆有导电材料的尖齿。固定特征还包括可伸缩的导电尖齿。除颤线圈可选地配置在导电尖端的前端，与导电齿结合。

3. 发明授权

US06574514B2 System and assembly having conductive fixation features 失效
公开(公告)号：US06574514B2
公开(公告)日：2003-06-03
申请号：US09746614
申请日：2000-12-21
申请人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
发明人： Scott M. Partridge , Jeffrey T. Bartig , Bruce H. KenKnight , Peter T. Kelley , Mohan Krishnan
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61N1/0573 , A61N2001/0585
摘要： A lead having a distal end electrode assembly adapted for implantation on or about the heart or within a vein and for connection to a system for monitoring or stimulating cardiac activity. The electrode assembly includes conductive fixation features, such as conductive tines or flexible members, in combination with non-conductive fixation features. The conductive fixation features also include tines coated with a conductive material. The fixation features further include conductive tines which are retractable. A defibrillation coil is optionally disposed at the distal end of the lead in combination with the conductive tines.

4. 发明授权

US08700149B2 Estimating acute response to cardiac resynchronization therapy 失效
标题翻译：估计对心脏再同步治疗的急性反应
公开(公告)号：US08700149B2
公开(公告)日：2014-04-15
申请号：US13479979
申请日：2012-05-24
申请人： Abhilash Patangay , Krzysztof Z. Siejko , Mohan Krishnan , Gerrard M. Carlson
发明人： Abhilash Patangay , Krzysztof Z. Siejko , Mohan Krishnan , Gerrard M. Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译：响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。将估计值与阈值进行比较。该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。

5. 发明申请

US20100023104A1 POLYISOBUTYLENE URETHANE, UREA AND URETHANE/UREA COPOLYMERS AND MEDICAL DEVICES CONTAINING THE SAME 有权
标题翻译：聚异丁烯尿素，尿素和尿素/尿素共聚物和含有它的医疗装置
公开(公告)号：US20100023104A1
公开(公告)日：2010-01-28
申请号：US12492483
申请日：2009-06-26
申请人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
发明人： Shrojalkumar Desai , Marlene C. Schwarz , Mark Boden , Mohan Krishnan , Michael C. Smith , Frederick H. Strickler , Daniel J. Cooke
IPC分类号： A61N1/05 , C08F136/14 , C08F8/30 , A61L27/34
CPC分类号： C08G18/6204 , A61L27/18 , A61L31/06 , C08G18/10 , C08G18/12 , C08G18/4063 , C08G18/4854 , C08G18/4858 , C08G18/6511 , C08G18/7657 , C08L75/00 , C08G18/3206
摘要： The present invention pertains to polyisobutylene urethane, urea and urethane/urea copolymers, to methods of making such copolymers and to medical devices that contain such polymers. According to certain aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment, an additional polymeric segment that is not a polyisobutylene segment, and a segment comprising a residue of a diisocyanate. According to other aspects of the invention, polyisobutylene urethane, urea and urethane/urea copolymers are provided, which comprise a polyisobutylene segment and end groups that comprise alkyl-, alkenyl- or alkynyl-chain-containing end groups.
摘要翻译：本发明涉及聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/尿素共聚物，涉及制备这种共聚物的方法和含有这种聚合物的医疗装置。根据本发明的某些方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段，不是聚异丁烯链段的另外的聚合链段和包含二异氰酸酯残基的链段。根据本发明的其它方面，提供聚异丁烯氨基甲酸酯，脲和氨基甲酸酯/脲共聚物，其包含聚异丁烯链段和包含含有烷基，链烯基或炔基链的端基的端基。

6. 发明授权

US07650193B2 Lead assembly with porous polyethylene cover 有权
标题翻译：带多孔聚乙烯盖的导线组件
公开(公告)号：US07650193B2
公开(公告)日：2010-01-19
申请号：US11150549
申请日：2005-06-10
申请人： Rebecca Aron , Mohan Krishnan , Kevin Ely
发明人： Rebecca Aron , Mohan Krishnan , Kevin Ely
IPC分类号： A61N1/04 , A61B5/04
CPC分类号： A61N1/0565 , A61N1/056 , A61N1/0563 , B29C65/022 , B29C65/1412 , B29C65/16 , B29C65/7473 , B29K2023/06 , B29K2105/04 , B29K2105/256 , B29L2009/00 , B29L2031/753
摘要： This document discusses, among other things, a lead assembly including a porous polyethylene cover. In an example, the cover includes sections that have differing pore sizes. In an example, a section of the cover near a distal end portion of a lead assembly includes pores that are large enough to allow tissue ingrowth. In another example, a lead assembly includes two or more polyethylene covers having different porosities.
摘要翻译：本文件尤其涉及包括多孔聚乙烯盖的引线组件。在一个示例中，盖包括具有不同孔径的部分。在一个示例中，在铅组件的远端部分附近的一部分盖包括足够大以允许组织向内生长的孔。在另一个示例中，引线组件包括具有不同孔隙率的两个或更多个聚乙烯盖。

7. 发明申请

US20090222074A1 INTERCONNECTIONS OF IMPLANTABLE LEAD CONDUCTORS AND ELECTRODES AND REINFORCEMENT THEREFOR 有权
标题翻译：可导电导体和电极的互连及其加固
公开(公告)号：US20090222074A1
公开(公告)日：2009-09-03
申请号：US12467978
申请日：2009-05-18
申请人： Paul E. Zarembo , Mohan Krishnan , David Durand
发明人： Paul E. Zarembo , Mohan Krishnan , David Durand
IPC分类号： A61N1/05 , H01R43/00
CPC分类号： A61N1/056 , H01R13/18 , H01R2201/12 , Y10T29/49117
摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. The lead body includes one or more longitudinally extending lumens. A conductor is received in, and extends along, a lumen. In varying examples, the implantable lead further comprises a tubular electrode co-axial with, and overlying portions of, the lead body. In one example, a lumen wall is sized and shaped to urge an electrically conductive interposer coupled with the conductor toward an inner surface of the electrode. In another example, a ring member is disposed within a lumen and the conductor is drawn and coupled thereto. In yet another example, an electrically conductive connector couples a first and a second conductor via grooves or threads. In a further example, an axial support member couples a distal end electrode and the lead body. Methods associated with the foregoing are also discussed.
摘要翻译：可植入引线包括从引线近端部分延伸到引线远端部分的引线体。引线体包括一个或多个纵向延伸的腔。导体被容纳在内腔中并沿着其延伸。在可变示例中，可植入引线还包括与引线主体同轴并且覆盖引线主体的部分的管状电极。在一个示例中，腔壁的尺寸和形状被设计成将与导体耦合的导电插入件推向电极的内表面。在另一示例中，环构件设置在管腔内并且导体被拉伸并与其连接。在又一示例中，导电连接器通过凹槽或螺纹将第一和第二导体连接。在另一示例中，轴向支撑构件将远端电极和引线体联接。还讨论了与前述相关的方法。

8. 发明授权

US07571010B2 Cable electrode assembly for a lead terminal and method therefor 有权
标题翻译：一种用于引线端子的电缆电极组件及其方法
公开(公告)号：US07571010B2
公开(公告)日：2009-08-04
申请号：US11123321
申请日：2005-05-06
申请人： Paul E. Zarembo , Mohan Krishnan , Christopher P. Knapp , Russell L. Hoeker
发明人： Paul E. Zarembo , Mohan Krishnan , Christopher P. Knapp , Russell L. Hoeker
IPC分类号： A61N1/18 , A61N1/05 , A61B5/0402
CPC分类号： A61N1/056
摘要： A lead assembly includes a lead body and at least one cables at least partially disposed within the lead body. The cable has a non-electrode portion and an electrode portion, where the non-electrode portion extends within the lead body, and the electrode portion is external to the lead body.
摘要翻译：引线组件包括引线体和至少部分地布置在引线体内的至少一根电缆。电缆具有非电极部分和电极部分，其中非电极部分在引线体内延伸，并且电极部分在引线体外部。

9. 发明授权

US07546165B2 Interconnections of implantable lead conductors and electrodes and reinforcement therefor 有权
标题翻译：可植入引线导体和电极的互连及其加固
公开(公告)号：US07546165B2
公开(公告)日：2009-06-09
申请号：US11305925
申请日：2005-12-19
申请人： Paul E. Zarembo , Mohan Krishnan , David Durand
发明人： Paul E. Zarembo , Mohan Krishnan , David Durand
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , H01R13/18 , H01R2201/12 , Y10T29/49117
摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. The lead body includes one or more longitudinally extending lumens. A conductor is received in, and extends along, a lumen. In varying examples, the implantable lead further comprises a tubular electrode co-axial with, and overlying portions of, the lead body. In one example, a lumen wall is sized and shaped to urge an electrically conductive interposer coupled with the conductor toward an inner surface of the electrode. In another example, a ring member is disposed within a lumen and the conductor is drawn and coupled thereto. In yet another example, an electrically conductive connector couples a first and a second conductor via grooves or threads. In a further example, an axial support member couples a distal end electrode and the lead body. Methods associated with the foregoing are also discussed.
摘要翻译：可植入引线包括从引线近端部分延伸到引线远端部分的引线体。引线体包括一个或多个纵向延伸的腔。导体被容纳在内腔中并沿着其延伸。在可变示例中，可植入引线还包括与引线主体同轴并且覆盖引线主体的部分的管状电极。在一个示例中，腔壁的尺寸和形状被设计成将与导体耦合的导电插入件推向电极的内表面。在另一示例中，环构件设置在管腔内并且导体被拉伸并与其连接。在又一示例中，导电连接器通过凹槽或螺纹将第一和第二导体连接。在另一示例中，轴向支撑构件将远端电极和引线体联接。还讨论了与前述相关的方法。

10. 发明申请

US20070142890A1 Interconnections of implantable lead conductors and electrodes and reinforcement therefor 有权
标题翻译：可植入引线导体和电极的互连及其加固
公开(公告)号：US20070142890A1
公开(公告)日：2007-06-21
申请号：US11305925
申请日：2005-12-19
申请人： Paul Zarembo , Mohan Krishnan , David Durand
发明人： Paul Zarembo , Mohan Krishnan , David Durand
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , H01R13/18 , H01R2201/12 , Y10T29/49117
摘要： An implantable lead comprises a lead body extending from a lead proximal end portion to a lead distal end portion. The lead body includes one or more longitudinally extending lumens. A conductor is received in, and extends along, a lumen. In varying examples, the implantable lead further comprises a tubular electrode co-axial with, and overlying portions of, the lead body. In one example, a lumen wall is sized and shaped to urge an electrically conductive interposer coupled with the conductor toward an inner surface of the electrode. In another example, a ring member is disposed within a lumen and the conductor is drawn and coupled thereto. In yet another example, an electrically conductive connector couples a first and a second conductor via grooves or threads. In a further example, an axial support member couples a distal end electrode and the lead body. Methods associated with the foregoing are also discussed.
摘要翻译：可植入引线包括从引线近端部分延伸到引线远端部分的引线体。引线体包括一个或多个纵向延伸的腔。导体被容纳在内腔中并沿着其延伸。在可变示例中，可植入引线还包括与引线主体同轴并且覆盖引线主体的部分的管状电极。在一个示例中，腔壁的尺寸和形状被设计成将与导体耦合的导电插入件推向电极的内表面。在另一示例中，环构件设置在管腔内并且导体被拉伸并与其连接。在又一示例中，导电连接器通过凹槽或螺纹将第一和第二导体连接。在另一示例中，轴向支撑构件将远端电极和引线体联接。还讨论了与前述相关的方法。

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