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    • 94. 发明授权
    • Polymer blends that swell in an acidic environment and deswell in a basic environment
    • 聚合物混合物在酸性环境中溶胀并在基本环境中脱水
    • US06730327B2
    • 2004-05-04
    • US10327457
    • 2002-12-20
    • Gaylen M. ZentnerJong-Seok BarkFeng Liu
    • Gaylen M. ZentnerJong-Seok BarkFeng Liu
    • A61K914
    • C08L1/12A61K9/2027A61K9/2031A61K9/205A61K9/2054C08J3/005C08L5/02C08L5/08C08L2666/02
    • A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral administration.
    • 通过将壳聚糖和第二聚合物溶解在酸性水溶液中以形成水性聚合物共混物,使所述聚合物共混物脱水并回收所述聚合物共混物来制备聚合物共混物。 第二聚合物可以选自包括聚乙二醇的聚醚二醇; 纤维素酯,包括乙酸纤维素; 泊洛沙姆 多糖包括葡聚糖和瓜尔胶; 聚乙烯吡咯烷酮; 聚乙烯醇; 及其混合物或共聚物。 这些聚合物混合物在酸性环境中溶胀并在较中性或碱性环境中溶解。 该技术对于将生物活性物质或药物分配到周围环境,特别是在胃肠道中发现的环境是有价值的。 由于本发明的各种聚合物共混物不共价或离子交联,而是物理组合,物理混合物中的每种聚合物保持其原始化学结构,因此对于口服给药是安全的。
    • 95. 发明授权
    • Polymer blends that swell in an acidic environment and deswell in a basic environment
    • 聚合物混合物在酸性环境中溶胀并在基本环境中脱水
    • US06537584B1
    • 2003-03-25
    • US09710403
    • 2000-11-09
    • Gaylen M. ZentnerJong-Seok BarkFeng Liu
    • Gaylen M. ZentnerJong-Seok BarkFeng Liu
    • A61K950
    • C08L1/12A61K9/2027A61K9/2031A61K9/205A61K9/2054C08J3/005C08L5/02C08L5/08C08L2666/02
    • A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral administration.
    • 通过将壳聚糖和第二聚合物溶解在酸性水溶液中以形成水性聚合物共混物,使所述聚合物共混物脱水并回收所述聚合物共混物来制备聚合物共混物。 第二聚合物可以选自包括聚乙二醇的聚醚二醇; 纤维素酯,包括乙酸纤维素; 泊洛沙姆 多糖包括葡聚糖和瓜尔胶; 聚乙烯吡咯烷酮; 聚乙烯醇; 及其混合物或共聚物。 这些聚合物混合物在酸性环境中溶胀并在较中性或碱性环境中溶解。 该技术对于将生物活性物质或药物分配到周围环境,特别是在胃肠道中发现的环境是有价值的。 由于本发明的各种聚合物共混物不共价或离子交联,而是物理组合,物理混合物中的每种聚合物保持其原始化学结构,因此对于口服给药是安全的。
    • 96. 发明授权
    • Polarization splitter and combiner and optical devices using the same
    • 偏振分离器和组合器和使用其的光学器件相同
    • US06493140B1
    • 2002-12-10
    • US09418136
    • 1999-10-14
    • Wei-Zhong LiYanfeng YangFeng LiuWei Luo
    • Wei-Zhong LiYanfeng YangFeng LiuWei Luo
    • G02B2728
    • G02B6/2713G02B5/3083G02B6/2773G02B27/283
    • A polarization splitter and combiner for processing a beam containing a first polarization and a second polarization to spatially separate these polarizations by using a birefringent element for receiving the beam and walking off the first polarization from the second polarization by an initial walk-off distance. A first lensing element with an optical axis is oriented to admit the first polarization at a first input point and output the first polarization at a first output angle to the optical axis and the second polarization at a second output angle to the optical axis. A second lensing element positioned after the first lensing element is oriented to receive the polarizations at input angles equal to their respective output angles, and outputs both polarizations at a first and second output point respectively. In a symmetrical arrangement, the first and second output points are separated by the initial walk-off distance. Additional walk-off control elements and optics can be interposed between the first and second lensing elements, depending on the functionality of the beam splitter and combiner or optical device employing the same.
    • 一种偏振分离器和组合器,用于处理包含第一偏振和第二偏振的光束,以通过使用用于接收光束的双折射元件和通过初始离散距离从第二偏振离开第一偏振来空间分离这些偏振。 具有光轴的第一透镜元件被定向为在第一输入点处允许第一偏振,并且以与光轴成第二输出角以第一输出角度以第一输出角输出第一偏振,并以第二输出角输出第一偏振。 定位在第一透镜元件之后的第二透镜元件被定向成以等于其各自的输出角度的输入角接收极化,并且分别在第一和第二输出点处输出两个偏振。 在对称布置中,第一和第二输出点被初始离开距离分开。 取决于使用其的分束器和组合器或光学装置的功能性,可以在第一和第二透镜元件之间插入附加的离散控制元件和光学元件。
    • 97. 发明授权
    • Method and system for providing a multi-channel optical filter
    • 用于提供多通道滤光器的方法和系统
    • US06192175B1
    • 2001-02-20
    • US09223038
    • 1998-12-30
    • Wei Zhong LiFeng LiuWenhui Wang
    • Wei Zhong LiFeng LiuWenhui Wang
    • G02B626
    • G02B6/2937
    • A system and method for filtering are disclosed. The system and method include providing first, second, third and fourth fibers for carrying a first, second, third, and fourth optical signals, respectively. The method and system also include providing a holder, a filter, and a first wedge assembly. The holder is for receiving the first fiber, the second fiber, the third fiber, and the fourth fiber therein. The filter is for filtering the first optical signal, the second optical signal, the third optical signal, and the fourth optical signal to provide a first filtered optical signal, a second filtered optical signal, a third filtered optical signal, and a fourth filtered optical signal. The first wedge assembly is disposed between the holder and the filter. The first wedge assembly is for directing the first optical signal towards the filter in a first path, for directing the second optical signal toward the filter in a second path, for directing the third optical signal towards the filter in a third path, and for directing the fourth optical signal toward the filter in a fourth path.
    • 公开了一种用于滤波的系统和方法。 该系统和方法包括提供分别用于承载第一,第二,第三和第四光信号的第一,第二,第三和第四光纤。 该方法和系统还包括提供保持器,过滤器和第一楔形组件。 保持器用于在其中接收第一光纤,第二光纤,第三光纤和第四光纤。 滤波器用于对第一光信号,第二光信号,第三光信号和第四光信号进行滤波,以提供第一滤波光信号,第二滤波光信号,第三滤波光信号和第四滤波光信号 信号。 第一楔形组件设置在保持器和过滤器之间。 第一楔形组件用于在第一路径中将第一光信号引向滤光器,用于将第二光信号以第二路径引向滤光器,用于在第三路径中将第三光信号引向滤光器,并用于引导 在第四路径中朝向滤波器的第四光信号。