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1. 发明授权

US5710429A Ultrafast optical imaging of objects in or behind scattering media 失效
标题翻译：散射介质中或其后的物体的超快光学成像
公开(公告)号：US5710429A
公开(公告)日：1998-01-20
申请号：US419623
申请日：1995-04-06
申请人： Robert R. Alfano , Feng Liu , Quan-Zhen Wang , Ping P. Ho , Leming M. Wang , Xiangchun Liang
发明人： Robert R. Alfano , Feng Liu , Quan-Zhen Wang , Ping P. Ho , Leming M. Wang , Xiangchun Liang
IPC分类号： G01N21/49 , G01N21/59
CPC分类号： G01N21/49
摘要： A system for imaging an object in or behind a highly scattering medium includes a light source for illuminating the highly scattering medium with a beam of light. The light emerging form the highly scattering medium consists of a ballistic component, snake-like component and a diffuse component. A 4F Fourier imaging system including a Fourier spatial filter located at 2F is used to form a time gated image of the emerging light, the time gated image consisting primarily of the ballistic component and the snake-like component.
摘要翻译：用于对高散射介质中或其后面的物体进行成像的系统包括用光束照射高散射介质的光源。由高弹性介质形成的光由弹道组件，蛇形部件和扩散部件组成。使用包括位于2F的傅立叶空间滤波器的4F傅立叶成像系统来形成新出现的光的时间门控图像，时间门控图像主要由弹道分量和蛇形分量组成。

2. 发明授权

US5644429A 2-dimensional imaging of translucent objects in turbid media 失效
标题翻译：半透明物体在混浊介质中的二维成像
公开(公告)号：US5644429A
公开(公告)日：1997-07-01
申请号：US654800
申请日：1996-05-29
申请人： Robert R. Alfano , Ping-Pei Ho , Xiangchun Liang
发明人： Robert R. Alfano , Ping-Pei Ho , Xiangchun Liang
IPC分类号： A61B5/00 , G01N21/47 , G02B27/46
CPC分类号： A61B5/0091 , A61B5/4312 , G01N21/4795 , A61B5/7257
摘要： A method of forming 2 dimensional image of a translucent object in or behind a turbid medium. In one embodiment, the method comprises the steps of illuminating the translucent object through one side of the turbid medium with an ultrafast pulse of light, the light emergent from the opposite side of the turbid medium consisting of a ballistic component, a snake-like component and a diffuse component. The emergent light is then temporally and spatially gated to preferentially pass the ballistic component and the snake-like component. Preferably, the temporal and spatial gating is achieved by positioning the Kerr cell of an optical Kerr gate at the 2F spectral plane of a 4F Kerr-Fourier imaging system. At the appropriate time, that portion of the Kerr cell located at the focal point of the 2F spectral plane is gated open, allowing predominantly ballistic and snake-like components of the transilluminated light to pass therethrough. A cooled CCD detector is positioned at the 4F spectral plane to form a 2-dimensional image of the temporally and spatially gated light.
摘要翻译：在混浊介质中或其后形成半透明物体的二维图像的方法。在一个实施例中，该方法包括如下步骤：以超快脉冲光照射半透明物体的一侧，该光从混浊介质的相反侧出射，该混浊介质由弹道组件，蛇状部件和漫射分量。射出的光然后被时间和空间门控以优先通过弹道组件和蛇状部件。优选地，时间和空间门控通过将光学克尔门的克尔单元定位在4F克尔傅立叶成像系统的2F频谱平面来实现。在适当的时间，位于2F光谱平面的焦点处的克尔单元的该部分是开门的，允许透射的光的主要弹道和蛇状部件通过。冷却的CCD检测器位于4F光谱平面处，以形成时间和空间门控光的二维图像。

3. 发明授权

US5799656A Optical imaging of breast tissues to enable the detection therein of calcification regions suggestive of cancer 失效
标题翻译：乳腺组织的光学成像可以在其中检测钙化区域，提示癌症
公开(公告)号：US5799656A
公开(公告)日：1998-09-01
申请号：US733558
申请日：1996-10-21
申请人： Robert R. Alfano , Ping-Pei Ho , Leming Wang , Xiangchun Liang , Pierre A. Galland
发明人： Robert R. Alfano , Ping-Pei Ho , Leming Wang , Xiangchun Liang , Pierre A. Galland
IPC分类号： A61B5/00 , A61B6/00
CPC分类号： A61B5/0091 , A61B5/4312
摘要： A method for detecting the presence of one or more calcifications within a portion of a turbid medium, such as a breast tissue. According to one aspect, the method involves illuminating at least a portion of the turbid medium with light, whereby light emerges from the turbid medium consisting of a ballistic component, a snake-like component and a diffuse component, temporally and/or spatially gating the emergent light to preferentially pass the ballistic and/or snake-like components, using the temporally and/or spatially gated light to form an image of the illuminated portion of the turbid medium, and examining the image for the presence of one or more calcifications. Wavelength difference images may also be used to highlight tumors and calcification regions. The foregoing method may be used to form optical images of breast tissues, with the presence in such images of calcifications suggestive of cancer being used to identify the corresponding breast tissues as good candidates for biopsy and screening for tumors.
摘要翻译：一种用于检测在混浊介质（例如乳房组织）的一部分内存在一种或多种钙化的方法。根据一个方面，该方法包括用光照射混浊介质的至少一部分，由此光从由弹道组件，蛇形部件和扩散部件组成的混浊介质中暂时和/或空间门控使用时间和/或空间门控的光来优先地通过弹道和/或蛇状部件以形成混浊介质的被照射部分的图像，并检查图像中是否存在一种或多种钙化。波长差图像也可用于突出肿瘤和钙化区域。上述方法可以用于形成乳腺组织的光学图像，存在这样的钙化图像，暗示癌症用于鉴定相应的乳腺组织作为肿瘤活检和筛选的良好候选物。

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