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1. 发明授权

US07182957B2 Polymer blends that swell in an acidic environment and deswell in a basic environment 有权
标题翻译：聚合物混合物在酸性环境中溶胀并在基本环境中脱水
公开(公告)号：US07182957B2
公开(公告)日：2007-02-27
申请号：US10327814
申请日：2002-12-20
申请人： Gaylen M. Zentner , Jong-Seok Bark , Feng Liu
发明人： Gaylen M. Zentner , Jong-Seok Bark , Feng Liu
IPC分类号： A61K9/48
CPC分类号： C08L1/12 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , C08J3/005 , C08L5/02 , C08L5/08 , C08L2666/02
摘要： A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral administration.
摘要翻译：通过将壳聚糖和第二聚合物溶解在酸性水溶液中以形成水性聚合物共混物，使所述聚合物共混物脱水并回收所述聚合物共混物来制备聚合物共混物。第二聚合物可以选自包括聚乙二醇的聚醚二醇; 纤维素酯，包括乙酸纤维素; 泊洛沙姆多糖包括葡聚糖和瓜尔胶; 聚乙烯吡咯烷酮; 聚乙烯醇; 及其混合物或共聚物。这些聚合物混合物在酸性环境中溶胀并在较中性或碱性环境中溶解。该技术对于将生物活性物质或药物分配到周围环境，特别是在胃肠道中发现的环境是有价值的。由于本发明的各种聚合物共混物不共价或离子交联，而是物理组合，物理混合物中的每种聚合物保持其原始化学结构，因此对于口服给药是安全的。

2. 发明授权

US06730327B2 Polymer blends that swell in an acidic environment and deswell in a basic environment 有权
标题翻译：聚合物混合物在酸性环境中溶胀并在基本环境中脱水
公开(公告)号：US06730327B2
公开(公告)日：2004-05-04
申请号：US10327457
申请日：2002-12-20
申请人： Gaylen M. Zentner , Jong-Seok Bark , Feng Liu
发明人： Gaylen M. Zentner , Jong-Seok Bark , Feng Liu
IPC分类号： A61K914
CPC分类号： C08L1/12 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , C08J3/005 , C08L5/02 , C08L5/08 , C08L2666/02
摘要： A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral administration.
摘要翻译：通过将壳聚糖和第二聚合物溶解在酸性水溶液中以形成水性聚合物共混物，使所述聚合物共混物脱水并回收所述聚合物共混物来制备聚合物共混物。第二聚合物可以选自包括聚乙二醇的聚醚二醇; 纤维素酯，包括乙酸纤维素; 泊洛沙姆多糖包括葡聚糖和瓜尔胶; 聚乙烯吡咯烷酮; 聚乙烯醇; 及其混合物或共聚物。这些聚合物混合物在酸性环境中溶胀并在较中性或碱性环境中溶解。该技术对于将生物活性物质或药物分配到周围环境，特别是在胃肠道中发现的环境是有价值的。由于本发明的各种聚合物共混物不共价或离子交联，而是物理组合，物理混合物中的每种聚合物保持其原始化学结构，因此对于口服给药是安全的。

3. 发明授权

US06537584B1 Polymer blends that swell in an acidic environment and deswell in a basic environment 有权
标题翻译：聚合物混合物在酸性环境中溶胀并在基本环境中脱水
公开(公告)号：US06537584B1
公开(公告)日：2003-03-25
申请号：US09710403
申请日：2000-11-09
申请人： Gaylen M. Zentner , Jong-Seok Bark , Feng Liu
发明人： Gaylen M. Zentner , Jong-Seok Bark , Feng Liu
IPC分类号： A61K950
CPC分类号： C08L1/12 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , C08J3/005 , C08L5/02 , C08L5/08 , C08L2666/02
摘要： A polymer blend is prepared by dissolving chitosan and a second polymer in an acidic aqueous solution to form an aqueous polymer blend, dehydrating said aqueous polymer blend, and recovering said polymer blend. The second polymer may be selected from the group consisting of polyether glycols including polyethylene glycols; cellulose esters including cellulose acetate; poloxamers; polysaccharides including dextran and guar; polyvinylpyrrolidones; polyvinyl alcohols; and mixtures or copolymers thereof. These polymer blends swell in an acidic environment and deswell in a more neutral or basic environment. This technology is valuable for the dispensing of biologically active material or drugs into a surrounding environment, especially the environment as is found in the gastrointestinal tract. Since the various polymer blends of the present invention are not covalently or ionically crosslinked, but are physically combined, each polymer in the physical blend maintains its original chemical structure, and therefore, is safe for oral administration.
摘要翻译：通过将壳聚糖和第二聚合物溶解在酸性水溶液中以形成水性聚合物共混物，使所述聚合物共混物脱水并回收所述聚合物共混物来制备聚合物共混物。第二聚合物可以选自包括聚乙二醇的聚醚二醇; 纤维素酯，包括乙酸纤维素; 泊洛沙姆多糖包括葡聚糖和瓜尔胶; 聚乙烯吡咯烷酮; 聚乙烯醇; 及其混合物或共聚物。这些聚合物混合物在酸性环境中溶胀并在较中性或碱性环境中溶解。该技术对于将生物活性物质或药物分配到周围环境，特别是在胃肠道中发现的环境是有价值的。由于本发明的各种聚合物共混物不共价或离子交联，而是物理组合，物理混合物中的每种聚合物保持其原始化学结构，因此对于口服给药是安全的。

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