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91. 发明授权

US06865424B2 Implantable medical device with voice responding and recording capacity 失效
公开(公告)号：US06865424B2
公开(公告)日：2005-03-08
申请号：US10215237
申请日：2002-08-08
申请人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
发明人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
IPC分类号： A61N1/362 , A61N1/372
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.

92. 发明授权

US06810287B2 Implantable cardiac disease management device with trigger-stored polysomnogram and phonocardiogram 有权
标题翻译：具有触发储存多导睡眠图和心音图的植入性心脏病管理装置
公开(公告)号：US06810287B2
公开(公告)日：2004-10-26
申请号：US10006183
申请日：2001-12-03
申请人： Qingsheng Zhu , Jeffrey E. Stahmann , John Hatlestad
发明人： Qingsheng Zhu , Jeffrey E. Stahmann , John Hatlestad
IPC分类号： A61N1365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36542 , A61N1/3684
摘要： Currently, brady, tachy and CRT devices all provide stored electrograms that record ambulatory electrograms with programmable trigger mechanisms. The present invention comprises an implantable device with additional capability that can store polysomnograms and phonocardiograms. The polysomnograms can be obtained from an impendent sensor of the type used in minute ventilation-based rate-adaptive pacemakers. The phonocardiograms are obtained from an accelerometer transducer or other type sensors that can detect heart sound.
摘要翻译：目前，brady，tachy和CRT设备都提供存储的电描记图，记录可编程触发机制的动态电图。本发明包括具有可存储多导睡眠图和心音图的附加能力的可植入装置。多导睡眠图可以从用于基于微通气的速率自适应起搏器中使用的类型的传感器获得。心音图从加速度传感器或可以检测心音的其他类型传感器获得。

93. 发明授权

US06772009B2 Method and apparatus for adjusting the sensing threshold of a cardiac rhythm management device 失效
标题翻译：用于调节心律管理装置的感测阈值的方法和装置
公开(公告)号：US06772009B2
公开(公告)日：2004-08-03
申请号：US10152211
申请日：2002-05-20
申请人： Geng Zhang , Qingsheng Zhu , Laura Mepham , Jesse W. Hartley
发明人： Geng Zhang , Qingsheng Zhu , Laura Mepham , Jesse W. Hartley
IPC分类号： A61N1365
CPC分类号： A61N1/3704 , A61N1/368
摘要： A method and apparatus for automatically adjusting the sensing threshold of cardiac rhythm management devices. The invention is particularly suited for implementation in devices such as implantable cardiac pacemakers and implantable cardioverter/defibrillators. A method and apparatus are provided in which a noise level and signal level for a sensing channel are determined for each cardiac cycle with the sensing threshold of the channel being adjusted in accordance therewith.
摘要翻译：一种用于自动调节心律管理装置感测阈值的方法和装置。本发明特别适用于诸如可植入心脏起搏器和植入式心律转复器/去纤颤器的装置中的实现。提供了一种方法和装置，其中针对每个心动周期确定用于感测通道的噪声电平和信号电平，同时根据该通道的感测阈值进行调整。

94. 发明授权

US06748271B2 Method and system for treatment of neurocardiogenic syncope 有权
标题翻译：治疗神经心源性晕厥的方法和系统
公开(公告)号：US06748271B2
公开(公告)日：2004-06-08
申请号：US09917259
申请日：2001-07-27
申请人： Julio C. Spinelli , Qingsheng Zhu
发明人： Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N116
CPC分类号： A61N1/3627 , A61N1/36564
摘要： A method and apparatus for treating or preventing neurocardiogenic syncope is disclosed. Upon detection of bradycardia or a drop in blood pressure indicating the onset of syncope, electrostimulation pulses are delivered during the heart's refractory period. The pulses are non-excitatory but increase myocardial contractility and thereby increase cardiac output.
摘要翻译：公开了用于治疗或预防神经心源性晕厥的方法和装置。一旦检测到心动过缓或血压下降，表明晕厥发作，电刺激脉搏在心脏不应期期间输送。脉冲是非兴奋性的，但增加心肌收缩力，从而增加心输出量。

95. 发明授权

US06650940B1 Accelerometer-based heart sound detection for autocapture 有权
标题翻译：基于加速度计的心脏声音检测
公开(公告)号：US06650940B1
公开(公告)日：2003-11-18
申请号：US09496832
申请日：2000-02-02
申请人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
发明人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
IPC分类号： A61N1365
CPC分类号： A61N1/36542 , A61N1/3712
摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart. The device operates in an automatic capture verification mode, wherein a global accelerometer signal is utilized to identify heart sounds (S1 and S2) of the patient's heart. The presence or absence of one or more of the heart sounds S1 and S2 in the accelerometer signal indicates whether a stimulation pulse evokes a response by the patient's heart. The device may automatically adjust the stimulation output in accordance with a step down stimulation protocol, wherein the presence of a predetermined heart sound indicates capture. Also, the device may suspend the automatic capture verification sequence if the patient's physical activity level exceeds a predetermined threshold.
摘要翻译：一种能够自动检测患者心脏的内在和诱发反应的植入式心律管理装置。该装置以自动捕获验证模式工作，其中使用全局加速度计信号来识别患者心脏的心音（S1和S2）。加速度计信号中存在或不存在一个或多个心音S1和S2表示刺激脉冲是否引起患者心脏的反应。设备可以根据降压刺激协议自动调节刺激输出，其中预定心音的存在指示捕获。此外，如果患者的身体活动水平超过预定阈值，则设备可以暂停自动捕获验证序列。

96. 发明授权

US06427085B1 Cardiac sense amplifier for capture verification 有权
标题翻译：心脏放大器用于捕获验证
公开(公告)号：US06427085B1
公开(公告)日：2002-07-30
申请号：US09309951
申请日：1999-05-11
申请人： Scot C. Boon , Mark Gryzwa , Michael Lyden , Qingsheng Zhu , Paul Haefner
发明人： Scot C. Boon , Mark Gryzwa , Michael Lyden , Qingsheng Zhu , Paul Haefner
IPC分类号： A61N137
CPC分类号： A61N1/3712
摘要： A cardiac rhythm management device having a capture verification sensing circuit for use in either a normal beat to beat pacing mode or an autothreshold mode. The cardiac rhythm management device is coupled to one or more pacing leads having pacing/sensing electrodes coupled thereto, and includes a sensing circuit for sensing electrical activity of the patient's heart, wherein the sensing circuit includes a dedicated evoked response sense amplifier and at least one high pass coupling capacitor electrically connected as a portion of a high pass network and between a pacing/sensing electrode and a blanking switch. A plurality of high pass coupling capacitors are coupled in parallel each having a separate blanking switch, thereby creating a differential network to offset imbalance sensed from the electrode due to extraneous factors.
摘要翻译：一种具有捕获验证感测电路的心律管理装置，其用于正常搏动以节拍起搏模式或自阈值模式。心律管理装置耦合到具有与之相连的起搏/感测电极的一个或多个起搏引线，并且包括用于感测患者心脏的电活动的感测电路，其中感测电路包括专用的诱发响应读出放大器和至少一个高通耦合电容器作为高通网络的一部分并且在起搏/感测电极和消隐开关之间电连接。多个高通耦合电容器并联耦合，每个具有单独的消隐开关，由此产生差分网络以抵消由于外部因素而从电极感测的不平衡。

97. 发明授权

US06363281B1 Cardiac rhythm management system and method 有权
标题翻译：心律管理系统及方法
公开(公告)号：US06363281B1
公开(公告)日：2002-03-26
申请号：US09571786
申请日：2000-05-16
申请人： Qingsheng Zhu , Avram Scheiner
发明人： Qingsheng Zhu , Avram Scheiner
IPC分类号： A61N137
CPC分类号： A61N1/3712
摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.
摘要翻译：一种用于心律管理的系统和方法，其包括具有耦合到所述电极系统的至少一个电极和控制电路的电极系统，从所述电极系统感测到第一心脏信号。控制电路包括脉冲电路，以在第一心脏区域产生将被传送到电极系统的第一值的电脉冲。从第二心脏区域感测至少一个心脏信号，其中心脏信号包括来自第二心脏区域的心脏去极化的指示，其发生在与递送至第一心脏区域的电脉冲直接反应中。当从第二心脏区域检测到与传送到第一心脏区域的电脉冲直接反应发生的心脏去极化时，脉冲调节电路修改电脉冲的第一值。

98. 发明授权

US08915741B2 Sleep quality data collection and evaluation 有权
标题翻译：睡眠质量数据收集和评估
公开(公告)号：US08915741B2
公开(公告)日：2014-12-23
申请号：US13215592
申请日：2011-08-23
申请人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
发明人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
IPC分类号： G09B23/28 , A61B5/0205 , A61B5/00 , A61B5/0488 , A61B5/11 , A61B5/0476 , A61N1/362 , A61B5/08 , A61B5/0496
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译：睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。使用可植入装置执行检测患者状况和收集数据中的至少一个。可以使用可植入或患者外部的睡眠质量处理器收集的数据来评估睡眠质量。睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

99. 发明授权

US08880169B2 Endocardial pacing relating to conduction abnormalities 有权
标题翻译：与传导异常相关的心内膜起搏
公开(公告)号：US08880169B2
公开(公告)日：2014-11-04
申请号：US13216969
申请日：2011-08-24
申请人： Qingsheng Zhu , Daniel Felipe Ortega
发明人： Qingsheng Zhu , Daniel Felipe Ortega
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： Various systems, methods and arrangements are implemented in connection with ventricular pacing. One such method relates to a method for use in connection with ventricular pacing of a left ventricle of a heart from a pacing lead located in the right ventricle. Ventricular function of the heart is sensed. The sensed ventricular function is used to determine whether a conduction abnormality exists. The ventricular pacing is provided in response to determining a conduction abnormality exists and the ventricular pacing is inhibited in response to determining a conduction abnormality does not exist.
摘要翻译：与心室起搏有关的各种系统，方法和布置。一种这样的方法涉及一种用于与位于右心室的起搏导管的心脏左心室起搏有关的方法。检测心脏的心室功能。感测到的心室功能用于确定是否存在传导异常。响应于确定存在传导异常并且不存在响应于确定传导异常而抑制心室起搏而提供心室起搏。

100. 发明授权

US08792980B2 Cardiac resynchronization system employing mechanical measurement of cardiac walls 有权
标题翻译：心脏再同步系统采用心脏壁的机械测量
公开(公告)号：US08792980B2
公开(公告)日：2014-07-29
申请号：US12980417
申请日：2010-12-29
申请人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
发明人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/36578 , A61N1/3627 , A61N1/36542 , A61N1/3684
摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.
摘要翻译：公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。加速度计响应于心室壁位置的运动产生信号。然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

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