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91. 发明授权

US07519408B2 Integrated receiver for continuous analyte sensor 有权
标题翻译：用于连续分析物传感器的集成接收器
公开(公告)号：US07519408B2
公开(公告)日：2009-04-14
申请号：US10991966
申请日：2004-11-17
申请人： Andrew Rasdal , James H. Brauker , Paul V. Neale , Peter C. Simpson
发明人： Andrew Rasdal , James H. Brauker , Paul V. Neale , Peter C. Simpson
IPC分类号： A61B5/05
CPC分类号： A61B5/1495 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B5/7203 , A61B2560/0456 , A61B2562/247
摘要： A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.
摘要翻译：提供一种用于监测主机中的葡萄糖的系统，包括产生指示宿主葡萄糖浓度的数据流的连续葡萄糖传感器和从连续葡萄糖传感器接收数据流并使用单点校准数据流的集成接收器与集成接收器集成的葡萄糖监测器。集成接收器从单点葡萄糖监测器获得葡萄糖值，校准从连续葡萄糖传感器接收的传感器数据流，并在用户界面上显示单点葡萄糖测量值和校准的连续葡萄糖传感器值中的一个或两个。

92. 发明申请

US20080195232A1 BIOINTERFACE WITH MACRO- AND MICRO-ARCHITECTURE 审中-公开
标题翻译：具有宏观和微观结构的生物界
公开(公告)号：US20080195232A1
公开(公告)日：2008-08-14
申请号：US12103594
申请日：2008-04-15
申请人： Victoria Carr-Brendel , Peter C. Simpson , James H. Brauker
发明人： Victoria Carr-Brendel , Peter C. Simpson , James H. Brauker
IPC分类号： A61F2/02 , A61B5/145 , A61M5/14
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/10 , B33Y80/00
摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
摘要翻译：本文公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并连接到宏结构和/或位于宏观架构的至少一部分内的微架构。宏观和微观结构共同协调管理和操纵体内异物反应的高级别组织结构和低水平细胞组织，从而增加接近装置 - 组织界面的新生血管形成，干扰屏障细胞层形成并提供良好的组织锚定，同时减少运动神经的影响，并破坏FBC的组织和/或挛缩。优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传送或测量装置中的分析物浓度的装置，和/或其组合。

93. 发明授权

US07108778B2 Electrochemical sensors including electrode systems with increased oxygen generation 有权
标题翻译：电化学传感器包括增加氧气产生的电极系统
公开(公告)号：US07108778B2
公开(公告)日：2006-09-19
申请号：US10897377
申请日：2004-07-21
申请人： Peter C. Simpson , Paul Goode , Mark A. Tapsak , Victoria Carr-Brendel
发明人： Peter C. Simpson , Paul Goode , Mark A. Tapsak , Victoria Carr-Brendel
IPC分类号： G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , C12Q1/003 , G01N27/3272
摘要： The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems with at least two electrodes in relatively close proximity to each other; wherein at least one electrode is configured to generate oxygen and at least one other electrode is configured to sense an analyte or a product of a reaction indicative of the concentration of analyte. The oxygen generated by the oxygen-generating electrode is available to the catalyst within a membrane system and/or the counter electrode, thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions.
摘要翻译：本发明一般涉及用于增加电化学传感器中的氧气产生的系统和方法，以克服氧限制。优选实施例采用电极系统，其中至少两个电极彼此相对靠近; 其中至少一个电极被配置为产生氧，并且至少一个其它电极被配置为感测分析物或指示分析物浓度的反应的产物。由氧发生电极产生的氧气可用于膜系统和/或对电极内的催化剂，从而使得优选实施方案的电化学传感器能够在缺血状态下起作用。

94. 发明授权

US07074307B2 Electrode systems for electrochemical sensors 有权
标题翻译：电化学传感器用电极系统
公开(公告)号：US07074307B2
公开(公告)日：2006-07-11
申请号：US10897312
申请日：2004-07-21
申请人： Peter C. Simpson , James R. Petisce , Victoria Carr-Brendel , James H. Brauker
发明人： Peter C. Simpson , James R. Petisce , Victoria Carr-Brendel , James H. Brauker
IPC分类号： G01N27/327 , A61B5/05
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

95. 发明授权

US06913679B1 Apparatus and methods for high resolution separation of sample components on microfabricated channel devices 有权
标题翻译：用于在微细化通道器件上高分辨率分离样品组分的装置和方法
公开(公告)号：US06913679B1
公开(公告)日：2005-07-05
申请号：US09249274
申请日：1999-02-11
申请人： Richard A. Mathies , Brian Paegel , Peter C. Simpson , Lester Hutt
发明人： Richard A. Mathies , Brian Paegel , Peter C. Simpson , Lester Hutt
IPC分类号： G01N21/64 , C12M1/00 , C12N15/09 , G01N27/447 , G01N37/00 , B01L3/02 , G01N27/453 , G01N30/02
CPC分类号： G01N27/44791
摘要： Sample component separation apparatus and methods are described. An exemplary sample component separation apparatus includes a separation channel having a turn portion configured to reduce band-broadening caused by passage of a sample through the turn portion. To reduce band broadening caused by passage of a sample through a turn portion, the turn portion may be constructed and arranged to have a sample transport characteristic that is different from the corresponding sample transport characteristic of a substantially straight portion of the separation channel. For example, the turn portion may be configured with an effective channel width that is smaller than the effective channel widths of the substantially straight portion of the separation channel. The actual channel width of the turn portion may be smaller than the channel widths of the substantially straight portion; the effective channel width of the turn portion may be reduced by placing one or more sample transport barriers or constrictions in the turn portion of the channel. Alternatively, the sample velocity through the turn portion may be controlled so as to reduce band broadening. For example, sample transport barriers may be disposed in the turn portion so that sample components of a given band travel through the turn portion at substantially the same effective rate, whereby the band orientation remains substantially aligned along radial directions characteristic of the turn portion. Other a sample transport characteristics, such as electrical resistance or fluid flow resistance, of the turn portion may be adapted to reduce band broadening caused by passage of the sample through the turn portion.
摘要翻译：描述了样品组分分离装置和方法。示例性部件分离装置包括分离通道，该分离通道具有弯曲部分，其被配置为减少由于样品通过转弯部分而导致的带宽变形。为了减少由于样品通过转弯部分而导致的带宽增加，转弯部分可以被构造和布置成具有不同于分离通道的基本直的部分的相应样品输送特性的样品输送特性。例如，转弯部分可以被配置为具有小于分离通道的基本上直的部分的有效通道宽度的有效通道宽度。转弯部分的实际通道宽度可以小于基本上直的部分的通道宽度; 可以通过在通道的转弯部分放置一个或多个样品输送屏障或收缩部来减小转弯部分的有效通道宽度。或者，可以控制通过转弯部分的采样速度，以便减小频带变宽。例如，样品输送屏障可以设置在转弯部分中，使得给定带的样品成分以基本上相同的有效速率行进通过转弯部分，由此带状取向保持基本上与转向部分的径向方向对准。转向部分的其它样品输送特性，例如电阻或流体阻力可以适于减少由于样品通过转弯部分而导致的带宽变宽。

96. 发明授权

US06261431B1 Process for microfabrication of an integrated PCR-CE device and products produced by the same 有权
标题翻译：集成PCR-CE装置的微细加工方法及其制造的产品
公开(公告)号：US06261431B1
公开(公告)日：2001-07-17
申请号：US09221436
申请日：1998-12-28
申请人： Richard A. Mathies , Peter C. Simpson , Stephen J. Williams
发明人： Richard A. Mathies , Peter C. Simpson , Stephen J. Williams
IPC分类号： G01N2726
CPC分类号： G01N27/44743 , G01N27/44791
摘要： A fully integrated monolithic small volume PCR-CE device in glass, or the like materials, is fabricated using thin film metal heaters and thermocouples to thermally cycle sub-microliter PCR volumes. Successful amplification of a PCR fragment is demonstrated on a PCR-CE chip. The process utilizes a linear polyacrylamide surface coating coupled with addition of BSA to the amplification buffer was necessary to obtain amplification efficiencies comparable to a positive control. The micro-reactor reduced significantly the time required for amplification and the reaction volume was in the sub-microlitre regime. Likewise addressed are the known problems connected with reliable microfabrication of metal coatings and the insulating layers required to shield these layers from the PCR reaction mix, and the longstanding unresolved issue of exposed metal regions in the PCR-CE chip resulting in electrolysis of water and bubble formation whenever a voltage is applied. The instant teachings employ external heaters and thermocouples and, as such, have alleviated many of these problems. Heaters and thermocouples may still be thin film deposited after chip bonding allowing for easy scale-up to multichannel devices. In addition, direct deposition of these chip components insures good thermal contact with the PCR reactor.
摘要翻译：使用薄膜金属加热器和热电偶制造玻璃或类似材料中的完全集成的单片小容量PCR-CE器件，以热循环亚微升谱体积。在PCR-CE芯片上证明PCR片段的成功扩增。该方法利用线性聚丙烯酰胺表面涂层与将BSA加入到扩增缓冲液中是必需的，以获得与阳性对照相当的扩增效率。微反应器显着减少了扩增所需的时间，反应体积处于亚微升方式。同样提到的是与金属涂层的可靠微细加工以及屏蔽这些层与PCR反应混合物所需的绝缘层相关的已知问题，以及PCR-CE芯片中暴露的金属区域的长期未解决的问题，导致水和气泡的电解施加电压时的形成。本教程使用外部加热器和热电偶，因此减轻了许多这些问题。加热器和热电偶仍然可以在芯片接合之后沉积薄膜，从而容易地扩展到多通道器件。此外，这些芯片部件的直接沉积确保与PCR反应器良好的热接触。

97. 外观设计

USD409090S Container 失效
公开(公告)号：USD409090S
公开(公告)日：1999-05-04
申请号：US71263
申请日：1997-05-21
申请人： John W. Lai , Peter C. Simpson , Thomas J. Melk
设计人： John W. Lai , Peter C. Simpson , Thomas J. Melk

98. 发明授权

US10349871B2 Systems and methods for detecting glucose level data patterns 有权
公开(公告)号：US10349871B2
公开(公告)日：2019-07-16
申请号：US13566678
申请日：2012-08-03
申请人： Phil Mayou , Hari Hampapuram , David Price , Keri Weindel , Kostyantyn Snisarenko , Michael Robert Mensinger , Leif N. Bowman , Robert J. Boock , Apurv Ullas Kamath , Eli Reihman , Peter C. Simpson
发明人： Phil Mayou , Hari Hampapuram , David Price , Keri Weindel , Kostyantyn Snisarenko , Michael Robert Mensinger , Leif N. Bowman , Robert J. Boock , Apurv Ullas Kamath , Eli Reihman , Peter C. Simpson
IPC分类号： G01N33/48 , A61B5/145 , G16H50/70 , G16H50/20 , G16H15/00
摘要： Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.

99. 发明授权

US10022078B2 Analyte sensor 有权
公开(公告)号：US10022078B2
公开(公告)日：2018-07-17
申请号：US11439630
申请日：2006-05-23
申请人： James H. Brauker , Peter C. Simpson , Robert Boock , Monica Rixman , Mark Brister
发明人： James H. Brauker , Peter C. Simpson , Robert Boock , Monica Rixman , Mark Brister
IPC分类号： A61B5/1486 , A61B5/1473 , G01N33/66 , A61B5/145 , A61B5/00 , C12Q1/00 , G01N33/543
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

100. 发明授权

US09538946B2 Integrated receiver for continuous analyte sensor 有权
标题翻译：用于连续分析物传感器的集成接收器
公开(公告)号：US09538946B2
公开(公告)日：2017-01-10
申请号：US12731965
申请日：2010-03-25
申请人： Andrew Rasdal , James H. Brauker , Paul V. Neale , Peter C. Simpson
发明人： Andrew Rasdal , James H. Brauker , Paul V. Neale , Peter C. Simpson
IPC分类号： A61B5/00 , A61B5/1486 , A61B5/07 , A61B5/145 , A61B5/1495
CPC分类号： A61B5/1495 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B5/7203 , A61B2560/0456 , A61B2562/247
摘要： A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.
摘要翻译：提供一种用于监测主机中的葡萄糖的系统，包括产生指示宿主葡萄糖浓度的数据流的连续葡萄糖传感器和从连续葡萄糖传感器接收数据流并使用单点校准数据流的集成接收器与集成接收器集成的葡萄糖监测器。集成接收器从单点葡萄糖监测器获得葡萄糖值，校准从连续葡萄糖传感器接收的传感器数据流，并在用户界面上显示单点葡萄糖测量值和校准的连续葡萄糖传感器值中的一个或两个。

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