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1. 发明授权

US07828728B2 Analyte sensor 有权
标题翻译：分析物传感器
公开(公告)号：US07828728B2
公开(公告)日：2010-11-09
申请号：US11675063
申请日：2007-02-14
申请人： Robert Boock , Monica Rixman , James H. Brauker , James R. Petisce , Peter C. Simpson , Mark Brister , Mark A. Tapsak , Victoria Carr-Brendel
发明人： Robert Boock , Monica Rixman , James H. Brauker , James R. Petisce , Peter C. Simpson , Mark Brister , Mark A. Tapsak , Victoria Carr-Brendel
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes.
摘要翻译：本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。更具体地说，本发明涉及新的有机硅 - 亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置。

2. 发明授权

US07074307B2 Electrode systems for electrochemical sensors 有权
标题翻译：电化学传感器用电极系统
公开(公告)号：US07074307B2
公开(公告)日：2006-07-11
申请号：US10897312
申请日：2004-07-21
申请人： Peter C. Simpson , James R. Petisce , Victoria Carr-Brendel , James H. Brauker
发明人： Peter C. Simpson , James R. Petisce , Victoria Carr-Brendel , James H. Brauker
IPC分类号： G01N27/327 , A61B5/05
CPC分类号： G01N27/3274 , A61B5/14532 , A61B5/14865 , C12Q1/001
摘要： The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.
摘要翻译：本发明一般涉及用于改进分析物的电化学测量的系统和方法。优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

3. 发明授权

US08255033B2 Oxygen enhancing membrane systems for implantable devices 有权
公开(公告)号：US08255033B2
公开(公告)日：2012-08-28
申请号：US11410392
申请日：2006-04-25
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

4. 发明授权

US08255030B2 Oxygen enhancing membrane systems for implantable devices 有权
公开(公告)号：US08255030B2
公开(公告)日：2012-08-28
申请号：US11410555
申请日：2006-04-25
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

5. 发明授权

US07364592B2 Biointerface membrane with macro-and micro-architecture 有权
标题翻译：具有宏观和微观结构的生物界面膜
公开(公告)号：US07364592B2
公开(公告)日：2008-04-29
申请号：US11055779
申请日：2005-02-09
申请人： Victoria Carr-Brendel , Peter C. Simpson , James H. Brauker
发明人： Victoria Carr-Brendel , Peter C. Simpson , James H. Brauker
IPC分类号： A61F2/02
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/10 , B33Y80/00
摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
摘要翻译：本文公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并连接到宏结构和/或位于宏观架构的至少一部分内的微架构。宏观和微观结构共同协调管理和操纵体内异物反应的高级别组织结构和低水平细胞组织，从而增加接近装置 - 组织界面的新生血管形成，干扰屏障细胞层形成并提供良好的组织锚定，同时减少运动神经的影响，并破坏FBC的组织和/或挛缩。优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传送或测量装置中的分析物浓度的装置，和/或其组合。

6. 发明申请

US20100041971A1 IMPLANTABLE ANALYTE SENSOR 审中-公开
标题翻译：可分析分析仪
公开(公告)号：US20100041971A1
公开(公告)日：2010-02-18
申请号：US12608872
申请日：2009-10-29
申请人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
发明人： Paul V. Goode, JR. , Arnold L. Holmquist , Mark A. Tapsak , Mark Shults , Victoria Carr-Brendel , James H. Brauker , Paul V. Neale , Jason D. McClure , Mark Brister , Peter C. Simpson , Rathbun K. Rhodes
IPC分类号： A61B5/1468 , H01R43/00
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： An implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
摘要翻译：包括用于测量分析物的感测区域和用于将传感器主体固定在主机中的非感测区域的可植入分析物传感器。将传感器植入精确尺寸的袋中以在体内稳定分析物传感器，并且能够在形成传感器周围的异物胶囊之前和之后测量主体中分析物的浓度。传感器还提供用于通过传感器主体，电子电路和为在小型化传感器主体中长期使用而优化的电源的RF传输的发射器。

7. 发明申请

US20080195232A1 BIOINTERFACE WITH MACRO- AND MICRO-ARCHITECTURE 审中-公开
标题翻译：具有宏观和微观结构的生物界
公开(公告)号：US20080195232A1
公开(公告)日：2008-08-14
申请号：US12103594
申请日：2008-04-15
申请人： Victoria Carr-Brendel , Peter C. Simpson , James H. Brauker
发明人： Victoria Carr-Brendel , Peter C. Simpson , James H. Brauker
IPC分类号： A61F2/02 , A61B5/145 , A61M5/14
CPC分类号： A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/10 , B33Y80/00
摘要： Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and manipulate the high-level tissue organization and the low-level cellular organization of the foreign body response in vivo, thereby increasing neovascularization close to a device-tissue interface, interfering with barrier cell layer formation, and providing good tissue anchoring, while reducing the effects of motion artifact, and disrupting the organization and/or contracture of the FBC. The biointerface membranes of the preferred embodiments can be utilized with implantable devices such as devices for the detection of analyte concentrations in a biological sample (for example, from a body), cell transplantation devices, drug delivery devices, electrical signal delivering or measuring devices, and/or combinations thereof.
摘要翻译：本文公开的是生物界面膜，其包括宏观架构和与宏结构共同连接并连接到宏结构和/或位于宏观架构的至少一部分内的微架构。宏观和微观结构共同协调管理和操纵体内异物反应的高级别组织结构和低水平细胞组织，从而增加接近装置 - 组织界面的新生血管形成，干扰屏障细胞层形成并提供良好的组织锚定，同时减少运动神经的影响，并破坏FBC的组织和/或挛缩。优选实施方案的生物界面膜可以与可植入装置一起使用，例如用于检测生物样品（例如，来自身体），细胞移植装置，药物递送装置，电信号传送或测量装置中的分析物浓度的装置，和/或其组合。

8. 发明申请

US20100145172A1 OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 有权
标题翻译：用于可植入设备的氧气增强膜系统
公开(公告)号：US20100145172A1
公开(公告)日：2010-06-10
申请号：US12688763
申请日：2010-01-15
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/1468
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

9. 发明授权

US07379765B2 Oxygen enhancing membrane systems for implantable devices 有权
标题翻译：用于可植入装置的氧增强膜系统
公开(公告)号：US07379765B2
公开(公告)日：2008-05-27
申请号：US10896639
申请日：2004-07-21
申请人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
发明人： James Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC分类号： A61B5/05 , A61B5/00 , C12M1/00 , C12N9/00 , C12N11/00 , G01N27/26 , G01N17/00 , C12Q1/00 , G01F1/64
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译：本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。

10. 再颁专利

USRE44695E1 Dual electrode system for a continuous analyte sensor 有权
标题翻译：用于连续分析物传感器的双电极系统
公开(公告)号：USRE44695E1
公开(公告)日：2014-01-07
申请号：US13461625
申请日：2012-05-01
申请人： Peter C. Simpson , James H. Brauker , Paul V. Goode , Apurv Ullas Kamath , James R. Petisce
发明人： Peter C. Simpson , James H. Brauker , Paul V. Goode , Apurv Ullas Kamath , James R. Petisce
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1495 , A61B5/7203 , A61B5/742 , A61B2560/0223 , B33Y70/00 , B33Y80/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.
摘要翻译：本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干涉域。

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